Comparative safety and effectiveness of inhaled bronchodilators and corticosteroids for treating asthma–COPD overlap: a systematic review and meta-analysis

References

• Orie NG, Slutter HJ, De Vries, Tammeling GJ. Chronic nonspecific respiratory diseases. Ned Tijdschr Geneeskd 1961;105:2136–2139.
   PubMedGoogle Scholar
• Diagnosis of asthma COPD and asthma–COPD overlap syndrome. GINA 2015 Guideline. Available from: https://ginasthma.org/wpcontent/uploads/2016/01/GINA_Report_2015_Aug11-1.pdf [last accessed 4 February 2018].
   Google Scholar
• Diagnosis of diseases of chronic airflow limitation: asthma COPD and asthma–COPD overlap global initiative for asthma. Available from: https://ginasthma.org/2017-gina/ [last accessed 4 February 2018].
   Google Scholar
• Juhn YJ. Risks for infection in patients with asthma (or other atopic conditions): is asthma more than a chronic airway disease? J Allergy Clin Immunol 2014;134(2):247–257.
   PubMed Web of Science ®Google Scholar
• Bhatt SP. Diagnosis of chronic obstructive pulmonary disease: breathing new life into an old debate. Annals ATS 2018;15(2):163–165. doi:10.1513/AnnalsATS.201709-733ED.
   Web of Science ®Google Scholar
• Soler-Cataluña JJ, Cosío B, Izquierdo JL, López-Campos JL, Marín JM, Agüero R, Baloira A, Carrizo S, Esteban C, Galdiz JB, et al. Consensus document on the overlap phenotype COPD-asthma in COPD. Arch Bronconeumol. 2012;48(9):331–337.
   PubMed Web of Science ®Google Scholar
• Louie S, Zeki AA, Schivo M, Chan AL, Yoneda KY, Avdalovic M, Morrissey BM, Albertson TE. The asthma–chronic obstructive pulmonary disease overlap syndrome: pharmacotherapeutic considerations. Expert Rev Clin Pharmacol. 2013;6(2):197–219. doi:10.1586/ecp.13.2.
   PubMed Web of Science ®Google Scholar
• Menezes AMB, Montes de Oca M, Pérez-Padilla R, Nadeau G, Wehrmeister FC, Lopez-Varela MV, Muiño A, Jardim JRB, Valdivia G, Tálamo C, et al. Increased risk of exacerbation and hospitalization in subjects with an overlap phenotype: COPD–asthma. Chest 2014;145(2):297–304. doi:10.1378/chest.13-0622.
   PubMed Web of Science ®Google Scholar
• Sin DD, Miravitlles M, Mannino DM, Soriano JB, Price D, Celli BR, Leung JM, Nakano Y, Park HY, Wark PA, et al. What is asthma–COPD overlap syndrome? Towards a consensus definition from a round table discussion. Eur Respir J. 2016;48(3):664–673. doi:10.1183/13993003.00436-2016.
   PubMed Web of Science ®Google Scholar
• van Boven JFM, Román-Rodríguez M, Palmer JF, Toledo-Pons N, Cosío BG, Soriano JB. Comorbidome, pattern, and impact of asthma–COPD overlap syndrome in real life. Chest 2016;149(4):1011–1020. doi:10.1016/j.chest.2015.12.002.
   PubMed Web of Science ®Google Scholar
• Plaza V, Álvarez F, Calle M, Casanova C, Cosío BG, López-Viña A, Pérez de Llano L, Quirce S, Román-Rodríguez M, Soler-Cataluña JJ, et al. Consensus on the asthma–COPD overlap syndrome (ACOS) between the Spanish COPD Guidelines (GesEPOC) and the Spanish Guidelines on the Management of Asthma (GEMA). Arch Bronconeumol 2017;53(8):443–449. doi:10.1016/j.arbr.2017.06.001.
   PubMed Web of Science ®Google Scholar
• Koblizek V, Milenkovic B, Barczyk A, Tkacova R, Somfay A, Zykov K, Tudoric N, Kostov K, Zbozinkova Z, Svancara J, et al. Phenotypes of COPD patients with a smoking history in Central and Eastern Europe: the POPE Study. Eur Respir J 2017;49(5):1601446. doi:10.1183/13993003.01446-2016.
   PubMed Web of Science ®Google Scholar
• Asthma, G.I.f. Global strategy for asthma management and prevention. Global Initiative for Asthma 2018. Available from: www.ginasthma.org.
   Google Scholar
• Miravitlles M. Diagnosis of asthma–COPD overlap: is it possible a global definition? Pulmonology 2018;24(3):143–145. doi:10.1016/j.pulmoe.2018.02.002.
   PubMed Web of Science ®Google Scholar
• Yilmaz I. Is asthma–COPD overlap an asthma phenotype or a COPD phenotype? Tuberk Toraks 2018;66(1):78–79. doi:10.5578/tt.66337.
   PubMed Web of Science ®Google Scholar
• Corrao S, Brunori G, Lupo U, Perticone F. Effectiveness and safety of concurrent beta-blockers and inhaled bronchodilators in COPD with cardiovascular comorbidities. Eur Respir Rev 2017;26(145):160123. doi:10.1183/16000617.0123-2016.
   PubMed Web of Science ®Google Scholar
• Kostikas K, Clemens A, Patalano F. Prediction and prevention of exacerbations and mortality in patients with COPD. Expert Rev Respir Med 2016;10(7):739–753. doi:10.1080/17476348.2016.1185371.
   PubMed Web of Science ®Google Scholar
• Holden V, Slack III D, McCurdy MT, Shah NG. Diagnosis and management of acute exacerbation of chronic obstructive pulmonary disease [digest]. Emerg Med Pract 2017;19(10 Suppl):S1–S2.
   PubMedGoogle Scholar
• Wallberg-Jonsson S, Ohman ML, Dahlqvist SR. Cardiovascular morbidity and mortality in patients with seropositive rheumatoid arthritis in Northern Sweden. J Rheumatol 1997;24(3):445–451.
   PubMed Web of Science ®Google Scholar
• Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev 2015;4(1):1.
   PubMed Web of Science ®Google Scholar
• Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000;283(15):2008–2012. doi:10.1001/jama.283.15.2008.
   PubMed Web of Science ®Google Scholar
• Gamble JM. An introduction to the fundamentals of cohort and case-control studies. Can J Hosp Pharm 2014;67(5):366–372. doi:10.4212/cjhp.v67i5.1391.
   PubMedGoogle Scholar
• Higgins JPT, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD, Savovic J, Schulz KF, Weeks L, Sterne JAC, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ 2011;343(2):d5928. doi:10.1136/bmj.d5928.
   PubMed Web of Science ®Google Scholar
• Higgins JPT, S G. Cochrane handbook for systematic reviews of interventions. The Cochrane Collaborations; 2011.
   Google Scholar
• Wells GA, S B, O'Connell D, Peterson J, Welch V, Losos M, Tugwell P. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
   Google Scholar
• Wu JW, Filion KB, Azoulay L, Doll MK, Suissa S. Effect of long-acting insulin analogs on the risk of cancer: a systematic review of observational studies. Dia Care 2016;39(3):486–494. doi:10.2337/dc15-1816.
   PubMed Web of Science ®Google Scholar
• Afonso A, Schmiedl S, Becker C, Tcherny-Lessenot S, Primatesta P, Plana E, Souverein P, Wang Y, Korevaar JC, Hasford J, et al. A methodological comparison of two European primary care databases and replication in a US claims database: inhaled long-acting beta-2-agonists and the risk of acute myocardial infarction. Eur J Clin Pharmacol. 2016;72(9):1105–1116. doi:10.1007/s00228-016-2071-8.
   PubMed Web of Science ®Google Scholar
• Brode SK, Campitelli MA, Kwong JC, Lu H, Marchand-Austin A, Gershon AS, Jamieson FB, Marras TK. The risk of mycobacterial infections associated with inhaled corticosteroid use. Eur Respir J 2017;50(3):1700037. doi:10.1183/13993003.00037-2017.
   PubMed Web of Science ®Google Scholar
• Fingleton J, Travers J, Williams M, Charles T, Bowles D, Strik R, Shirtcliffe P, Weatherall M, Beasley R, Fingleton J, et al. Treatment responsiveness of phenotypes of symptomatic airways obstruction in adults. J Allergy Clin Immunol 2015;136(3):601–609. doi:10.1016/j.jaci.2015.01.013.
   PubMed Web of Science ®Google Scholar
• Gershon AS, Campitelli MA, Croxford R, Stanbrook MB, To T, Upshur R, Stephenson AL, Stukel TA. Combination long-acting β-agonists and inhaled corticosteroids compared with long-acting β-agonists alone in older adults with chronic obstructive pulmonary disease. JAMA 2014;312(11):1114–1121. doi:10.1001/jama.2014.11432.
   PubMed Web of Science ®Google Scholar
• Hubbard R, Tattersfield A, Smith C, West J, Smeeth L, Fletcher A. Use of inhaled corticosteroids and the risk of fracture. Chest 2006;130(4):1082–1088. doi:10.1378/chest.130.4.1082.
   PubMed Web of Science ®Google Scholar
• Ishiura Y, Fujimura M, Shiba Y, Ohkura N, Hara J, Kasahara K. A comparison of the efficacy of once-daily fluticasone furoate/vilanterole with twice-daily fluticasone propionate/salmeterol in asthma–COPD overlap syndrome. Pulmonary Pharmacol Ther. 2015;35:28–33. doi:10.1016/j.pupt.2015.10.005.
   PubMed Web of Science ®Google Scholar
• Lim HS, Choi SM, Lee J, Park YS, Lee S-M, Yim J-J, Yoo C-G, Kim YW, Han SK, Lee C-H, et al. Responsiveness to inhaled corticosteroid treatment in patients with asthma–chronic obstructive pulmonary disease overlap syndrome. Ann Allergy Asthma Immunol 2014;113(6):652–657. doi:10.1016/j.anai.2014.08.021.
   PubMed Web of Science ®Google Scholar
• Magnussen H, Bugnas B, van Noord J, Schmidt P, Gerken F, Kesten S. Improvements with tiotropium in COPD patients with concomitant asthma. Respir Med. 2008;102(1):50–56. doi:10.1016/j.rmed.2007.08.003.
   PubMed Web of Science ®Google Scholar
• Su VY, Yang KY, Yang YH, Tsai YH, Perng DW, Su WJ, Chou KT, Su KC, Yen YF, Chen PC. Use of ICS/LABA combinations or LAMA is associated with a lower risk of acute exacerbation in patients with coexistent COPD and asthma. J Allergy Clin Immunol Practice 2018;6(6):1927–1935.e3.
   PubMed Web of Science ®Google Scholar
• Uddin MJ, Groenwold RHH, de Boer A, Afonso ASM, Primatesta P, Becker C, Belitser SV, Hoes AW, Roes KCB, Klungel OH, et al. Evaluating different physician's prescribing preference based instrumental variables in two primary care databases: a study of inhaled long-acting beta2-agonist use and the risk of myocardial infarction. Pharmacoepidemiol Drug Saf 2016;25(Suppl 1):132–141. doi:10.1002/pds.3860.
   PubMed Web of Science ®Google Scholar
• Lougheed MD, Lemiere C, Dell S, Ducharme F, FitzGerald JM, Leigh R, Licskai C, Rowe BH, Bowie D, Becker A, et al. Canadian Thoracic Society Asthma Committee commentary on long-acting beta-2 agonist use for asthma in Canada. Can Respir J 2010;17(2):57–60. doi:10.1155/2010/378289.
   PubMed Web of Science ®Google Scholar
• Morjaria JB, Rigby A, Morice AH. Inhaled corticosteroid use and the risk of pneumonia and COPD exacerbations in the UPLIFT study. Lung 2017;195(3):281–288. doi:10.1007/s00408-017-9990-8.
   PubMed Web of Science ®Google Scholar
• Gonzalez AV, Coulombe J, Ernst P, Suissa S. Long-term use of inhaled corticosteroids in COPD and the risk of fracture. Chest 2018;153(2):321–328. doi:10.1016/j.chest.2017.07.002.
   PubMed Web of Science ®Google Scholar
• Szefler SJ, Murphy K, Harper T, Boner A, Laki I, Engel M, El Azzi G, Moroni-Zentgraf P, Finnigan H, Hamelmann E, et al. A phase III randomized controlled trial of tiotropium add-on therapy in children with severe symptomatic asthma. J Allergy Clin Immunol 2017;140(5):1277–1287. doi:10.1016/j.jaci.2017.01.014.
   PubMed Web of Science ®Google Scholar
• Kerstjens HAM, Engel M, Dahl R, Paggiaro P, Beck E, Vandewalker M, Sigmund R, Seibold W, Moroni-Zentgraf P, Bateman ED, et al. Tiotropium in asthma poorly controlled with standard combination therapy. N Engl J Med 2012;367(13):1198–1207. doi:10.1056/NEJMoa1208606.
   PubMed Web of Science ®Google Scholar
• Postma DS, Rabe KF. The asthma–COPD overlap syndrome. N Engl J Med 2015;373(13):1241–1249. doi:10.1056/NEJMra1411863.
   PubMed Web of Science ®Google Scholar
• O'Donnell DE, Hernandez P, Kaplan A, Aaron S, Bourbeau J, Marciniuk D, Balter M, Ford G, Gervais A, Lacasse Y, et al. Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease – 2008 update – highlights for primary care. Can Respir J. 2008;15(Suppl A):1A–8A.
   PubMed Web of Science ®Google Scholar
• Miravitlles M, Soler-Cataluña JJ, Calle M, Molina J, Almagro P, Quintano JA, Riesco JA, Trigueros JA, Piñera P, Simón A, et al. Spanish COPD Guidelines (GesEPOC): pharmacological treatment of stable COPD. Spanish Society of Pulmonology and Thoracic Surgery. Arch Bronconeumol. 2012;48(7):247–257. doi:10.1016/j.arbr.2012.05.003.
   PubMed Web of Science ®Google Scholar
• Hurst JR, Vestbo J, Anzueto A, Locantore N, Müllerova H, Tal-Singer R, Miller B, Lomas DA, Agusti A, MacNee W, et al. Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med 2010;363(12):1128–1138. doi:10.1056/NEJMoa0909883.
   PubMed Web of Science ®Google Scholar
• Ernst P, Gonzalez AV, Brassard P, Suissa S. Inhaled corticosteroid use in chronic obstructive pulmonary disease and the risk of hospitalization for pneumonia. Am J Respir Crit Care Med 2007;176(2):162–166. doi:10.1164/rccm.200611-1630OC.
   PubMed Web of Science ®Google Scholar
• Pouw EM, Prummel MF, Oosting H, Roos CM, Endert E. Beclomethasone inhalation decreases serum osteocalcin concentrations. BMJ 1991;302(6777):627–628. doi:10.1136/bmj.302.6777.627.
   PubMed Web of Science ®Google Scholar