Mycobacterium vaccae nebulization protects Balb/c mice against bronchial asthma through neural mechanisms

References

• Yang YG, Tian WM, Zhang H, Li M, Shang YX. Nerve growth factor exacerbates allergic lung inflammation and airway remodeling in a rat model of chronic asthma. Exp Ther Med. 2013;6(5):1251–1258. doi:10.3892/etm.2013.1284.
   PubMed Web of Science ®Google Scholar
• Kytikova O, Novgorodtseva T, Antonyuk M, Denisenko Y, Gvozdenko T. Molecular targets of fatty acid ethanolamides in asthma. Medicina (Kaunas). 2019;55(4):87. doi:10.3390/medicina55040087.
   Web of Science ®Google Scholar
• Braun A, Lommatzsch M, Lewin GR, Virchow JC, Renz H. Neurotrophins: a link between airway inflammation and airway smooth muscle contractility in asthma? Int Arch Allergy Immunol. 1999;118(2–4):163–165. doi:10.1159/000024056.
   PubMed Web of Science ®Google Scholar
• Virchow JC, Julius P, Lommatzsch M, Luttmann W, Renz H, Braun A. Neurotrophins are increased in bronchoalveolar lavage fluid after segmental allergen provocation. Am J Respir Crit Care Med. 1998;158(6):2002–2005. doi:10.1164/ajrccm.158.6.9803023.
   PubMed Web of Science ®Google Scholar
• Feng S, Chen B, Yin XW, Li FJ. [Association between brain-derived neurotrophic factor and severity of asthma in children]. Zhongguo Dang Dai Er Ke Za Zhi. 2017;19:167–170. [In Chinese].
   PubMedGoogle Scholar
• Watanabe T, Fajt ML, Trudeau JB, Voraphani N, Hu H, Zhou X, Holguin F, Wenzel SE. Brain-derived neurotrophic factor expression in asthma. Association with severity and type 2 inflammatory processes. Am J Respir Cell Mol Biol. 2015;53(6):844–852. doi:10.1165/rcmb.2015-0015OC.
   PubMed Web of Science ®Google Scholar
• Hahn C, Islamian AP, Renz H, Nockher WA. Airway epithelial cells produce neurotrophins and promote the survival of eosinophils during allergic airway inflammation. J Allergy Clin Immunol. 2006;117(4):787–794. doi:10.1016/j.jaci.2005.12.1339.
   PubMed Web of Science ®Google Scholar
• Nassenstein C, Braun A, Erpenbeck VJ, Lommatzsch M, Schmidt S, Krug N, Luttmann W, Renz H, Virchow JC. The neurotrophins nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 are survival and activation factors for eosinophils in patients with allergic bronchial asthma. J Exp Med. 2003;198(3):455–467. doi:10.1084/jem.20010897.
   PubMed Web of Science ®Google Scholar
• She W, Mei Z, Zhao H, Li G, Lin Y. Nebulized inhalation of anti-nerve growth factor microspheres inhibits airway remodeling in an ovalbumin-induced rat asthma model. J Aerosol Med Pulm Drug Deliv. 2019;32(2):70–77. doi:10.1089/jamp.2018.1453.
   PubMed Web of Science ®Google Scholar
• Lu J, Xiong L, Zhang X, Liu Z, Wang S, Zhang C, Zheng J, Wang G, Zheng R, Simpson JL, et al. The role of lower airway dysbiosis in asthma: dysbiosis and asthma. Mediat Inflamm. 2017;2017:1–10. doi:10.1155/2017/3890601.
   Web of Science ®Google Scholar
• Brooks C, Pearce N, Douwes J. The hygiene hypothesis in allergy and asthma: an update. Curr Opin Allergy Clin Immunol. 2013;13(1):70–77. doi:10.1097/ACI.0b013e32835ad0d2.
   PubMed Web of Science ®Google Scholar
• Yang IV, Lozupone CA, Schwartz DA. The environment, epigenome, and asthma. J Allergy Clin Immunol. 2017;140(1):14–23. doi:10.1016/j.jaci.2017.05.011.
   PubMed Web of Science ®Google Scholar
• Shirakawa T, Enomoto T, Shimazu S, Hopkin JM. The inverse association between tuberculin responses and atopic disorder. Science. 1997;275(5296):77–79. doi:10.1126/science.275.5296.77.
   PubMed Web of Science ®Google Scholar
• Obihara CC, Kimpen JLL, Gie RP, Lill SW, Hoekstra MO, Marais BJ, Schaaf HS, Lawrence K, Potter PC, Bateman ED, et al. Mycobacterium tuberculosis infection may protect against allergy in a tuberculosis endemic area. Clin Exp Allergy. 2006;36(1):70–76. doi:10.1111/j.1365-2222.2005.02408.x.
   PubMed Web of Science ®Google Scholar
• Kowalewicz-Kulbat M, Locht C. BCG and protection against inflammatory and auto-immune diseases. Expert Rev Vaccines. 2017;16(7):1–10. doi:10.1080/14760584.2017.1333906.
   PubMed Web of Science ®Google Scholar
• Huang CY, Hsieh WY. Efficacy of Mycobacterium vaccae immunotherapy for patients with tuberculosis: a systematic review and meta-analysis. Hum Vaccin Immunother. 2017;13(9):1960–1971. doi:10.1080/21645515.2017.1335374.
   PubMed Web of Science ®Google Scholar
• Akkoc T, Genc D, Zibandeh N, Akkoc T. Intranasal ovalbumin immunotherapy with mycobacterial adjuvant promotes regulatory T cell accumulation in lung tissues. Microbiol Immunol. 2018;62(8):531–540. doi:10.1111/1348-0421.12634.
   PubMed Web of Science ®Google Scholar
• Li C, Jiang X, Luo M, Feng G, Sun Q, Chen Y. Mycobacterium vaccae nebulization can protect against asthma in Balb/c mice by regulating Th9 expression. PLoS One. 2016;11(8):e0161164. doi:10.1371/journal.pone.0161164.
   PubMed Web of Science ®Google Scholar
• Samary C. d S, Antunes MA, Silva JD, da Silva AL, de Araújo CC, Bakker-Abreu I, Diaz BL, Fernezlian S, Parra ER, Capelozzi VL, et al. Impact of bacillus calmette-guerin moreau vaccine on lung remodeling in experimental asthma. Respir Physiol Neurobiol. 2013;189(3):614–623. doi:10.1016/j.resp.2013.07.025.
   PubMed Web of Science ®Google Scholar
• Gong P, Li Y, Tan YP, Li H. Pretreatment with inactivated bacillus calmette-guerin increases CD4 + CD25+ regulatory T cell function and decreases functional and structural effects of asthma induction in a rat asthma model. Artif Organs. 2016;40(4):360–367. doi:10.1111/aor.12566.
   PubMed Web of Science ®Google Scholar
• Prakash YS, Martin RJ. Brain-derived neurotrophic factor in the airways. Pharmacol Ther. 2014;143(1):74–86. doi:10.1016/j.pharmthera.2014.02.006.
   PubMed Web of Science ®Google Scholar
• Yang Y-G, Tian W-M, Zhang H, Li M, Shang Y-X. Nerve growth factor exacerbates allergic lung inflammation and airway remodeling in a rat model of chronic asthma. Exp Ther Med. 2013;6(5):1251–1258. doi:10.3892/etm.2013.1284.
   PubMed Web of Science ®Google Scholar