Augmented angiogenic transcription factor, SOX18, is associated with asthma exacerbation

References

• Chetta A, Zanini A, Foresi A, D’Ippolito R, Tipa A, Castagnaro A, Baraldo S, Neri M, Saetta M, Olivieri D. Vascular endothelial growth factor up-regulation and bronchial wall remodelling in asthma. Clin Exp Allergy. 2005;35(11):1437–1442. doi:10.1111/j.1365-2222.2005.02360.x.
   PubMed Web of Science ®Google Scholar
• McDonald DM. Angiogenesis and remodeling of airway vasculature in chronic inflammation. Am J Respir Crit Care Med. 2001;164(10 Pt 2):S39–S45. doi:10.1164/ajrccm.164.supplement_2.2106065.
   PubMed Web of Science ®Google Scholar
• Corrigan CJ, Wang W, Meng Q, Fang C, Wu H, Reay V, Lv Z, Fan Y, An Y, Wang Y-H, et al. T-helper cell type 2 (Th2) memory T cell-potentiating cytokine IL-25 has the potential to promote angiogenesis in asthma. Proc Natl Acad Sci USA. 2011;108(4):1579–84. doi:10.1073/pnas.1014241108.
   PubMed Web of Science ®Google Scholar
• Al-Muhsen S, Johnson JR, Hamid Q. Remodeling in asthma. J Allergy Clin Immunol. 2011;128(3):451–62. doi:10.1016/j.jaci.2011.04.047.
   PubMed Web of Science ®Google Scholar
• Kristan SS, Malovrh MM, Silar M, Kern I, Flezar M, Kosnik M, Suskovic S, Korosec P. Airway angiogenesis in patients with rhinitis and controlled asthma. Clin Exp Allergy. 2009;39(3):354–360. doi:10.1111/j.1365-2222.2008.03170.x.
   PubMed Web of Science ®Google Scholar
• Li X, Wilson JW. Increased vascularity of the bronchial mucosa in mild asthma. Am J Respir Crit Care Med. 1997;156(1):229–233. doi:10.1164/ajrccm.156.1.9607066.
   PubMed Web of Science ®Google Scholar
• Hoshino M, Takahashi M, Aoike N. Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis. J Allergy Clin Immunol. 2001;107(2):295–301. doi:10.1067/mai.2001.111928.
   PubMed Web of Science ®Google Scholar
• Burgess JK, Boustany S, Moir LM, Weckmann M, Lau JY, Grafton K, Baraket M, Hansbro PM, Hansbro NG, Foster PS, et al. Reduction of tumstatin in asthmatic airways contributes to angiogenesis, inflammation, and hyperresponsiveness. Am J Respir Crit Care Med. 2010;181(2):106–115. doi:10.1164/rccm.200904-0631OC.
   PubMed Web of Science ®Google Scholar
• Bowles J, Schepers G, Koopman P. Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators. Dev Biol. 2000;227(2):239–255. doi:10.1006/dbio.2000.9883.
   PubMed Web of Science ®Google Scholar
• Wegner M. From head to toes: the multiple facets of Sox proteins. Nucleic Acids Res. 1999;27(6):1409–1420. doi:10.1093/nar/27.6.1409.
   PubMed Web of Science ®Google Scholar
• Hosking BM, Wang SC, Downes M, Koopman P, Muscat GE. The VCAM-1 gene that encodes the vascular cell adhesion molecule is a target of the Sry-related high mobility group Box gene, Sox18. J Biol Chem. 2004;279(7):5314–5322. doi:10.1074/jbc.M308512200.
   PubMed Web of Science ®Google Scholar
• Darby IA, Bisucci T, Raghoenath S, Olsson J, Muscat GE, Koopman P. Sox18 is transiently expressed during angiogenesis in granulation tissue of skin wounds with an identical expression pattern to Flk-1 mRNA. Lab Invest. 2001;81(7):937–943. doi:10.1038/labinvest.3780304.
   PubMed Web of Science ®Google Scholar
• Pennisi D, Gardner J, Chambers D, Hosking B, Peters J, Muscat G, Abbott C, Koopman P. Mutations in Sox18 underlie cardiovascular and hair follicle defects in ragged mice. Nat Genet. 2000;24(4):434–437. doi:10.1038/74301.
   PubMed Web of Science ®Google Scholar
• García-Ramírez M, Martínez-González J, Juan-Babot JO, Rodríguez C, Badimon L. Transcription factor SOX18 is expressed in human coronary atherosclerotic lesions and regulates DNA synthesis and vascular cell growth. Arterioscler Thromb Vasc Biol. 2005;25(11):2398–2403. doi:10.1161/01.ATV.0000187464.81959.23.
   PubMed Web of Science ®Google Scholar
• Lefebvre V, Dumitriu B, Penzo-MéNdez A, Han Y, Pallavi B. Control of cell fate and differentiation by Sry-related high-mobility-group box (Sox) transcription factors. Int J Biochem Cell Biol. 2007;39(12):2195–2214. doi:10.1016/j.biocel.2007.05.019.
   PubMed Web of Science ®Google Scholar
• Hosking BM, Wyeth JR, Pennisi DJ, Wang SC, Koopman P, Muscat G. Cloning and functional analysis of the Sry-related HMG box gene, Sox18. Gene. 2001;262(1–2):239–247. doi:10.1016/S0378-1119(00)00525-4.
   PubMed Web of Science ®Google Scholar
• Matsui T, Kanai-Azuma M, Hara K, Matoba S, Hiramatsu R, Kawakami H, Kurohmaru M, Koopman P, Kanai Y. Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice. J Cell Sci. 2006;119(Pt 17):3513–3526. doi:10.1242/jcs.03081.
   PubMed Web of Science ®Google Scholar
• Fontijn RD, Volger OL, Fledderus JO, Reijerkerk A, de Vries HE, Horrevoets AJ. SOX-18 controls endothelial-specific claudin-5 gene expression and barrier function. Am J Physiol Heart Circ Physiol. 2008;294(2):H891–H900. doi:10.1152/ajpheart.01248.2007.
   PubMed Web of Science ®Google Scholar
• Asai K, Kanazawa H, Kamoi H, Shiraishi S, Hirata K, Yoshikawa J. Increased levels of vascular endothelial growth factor in induced sputum in asthmatic patients. Clin Exp Allergy. 2003;33(5):595–599. doi:10.1046/j.1365-2222.2003.01576.x.
   PubMed Web of Science ®Google Scholar
• Meyer N, Akdis CA. Vascular endothelial growth factor as a key inducer of angiogenesis in the asthmatic airways. Curr Allergy Asthma Rep. 2013;13(1):1–9. doi:10.1007/s11882-012-0317-9.
   PubMed Web of Science ®Google Scholar
• Zhu SH, Shan CJ, Wu ZF, Xu SZ. Proliferation of small cell lung cancer cell line reduced by knocking-down PROX1 via shRNA in lentivirus. Anticancer Res. 2013;33(8):3169–3175.
   PubMed Web of Science ®Google Scholar
• François M, Caprini A, Hosking B, Orsenigo F, Wilhelm D, Browne C, Paavonen K, Karnezis T, Shayan R, Downes M, et.al. Sox18 induces development of the lymphatic vasculature in mice. Nature. 2008;456(7222):643–647. doi:10.1038/nature07391.
   PubMed Web of Science ®Google Scholar
• Srinivasan RS, Oliver G. Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves. Genes Dev. 2011;25(20):2187–2197. doi:10.1101/gad.16974811.
   PubMed Web of Science ®Google Scholar
• Yamazaki T, Yoshimatsu Y, Morishita Y, Miyazono K, Watabe T. COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction. Genes Cells. 2009;14(3):425–434. doi:10.1111/j.1365-2443.2008.01279.x.
   PubMed Web of Science ®Google Scholar
• Moon KY, Lee PH, Kim BG, Park CS, Leikauf GD, Jang AS. Claudin 5 in a murine model of allergic asthma: its implication and response to steroid treatment. J Allergy Clin Immunol. 2015;136(6):1694–6.e5. doi:10.1016/j.jaci.2015.08.004.
   PubMed Web of Science ®Google Scholar
• Global Initiative for Asthma. 2018. Global strategy for asthma management and prevention. Available from: http://www.ginasthma.org [last accessed 10 July 2018].
   Google Scholar
• Bergeron C, Tulic MK, Hamid Q. Airway remodelling in asthma: from benchside to clinical practice. Can Respir J. 2010;17(4):e85–e93. doi:10.1155/2010/318029.
   PubMed Web of Science ®Google Scholar
• Zanini A, Chetta A, Imperatori AS, Spanevello A, Olivieri D. The role of the bronchial microvasculature in the airway remodelling in asthma and COPD. Respir Res. 2010;11:132. doi:10.1186/1465-9921-11-132.
   PubMed Web of Science ®Google Scholar
• Harkness LM, Ashton AW, Burgess JK. Asthma is not only an airway disease, but also a vascular disease. Pharmacol Ther. 2015;148:17–33. doi:10.1016/j.pharmthera.2014.11.010.
   PubMed Web of Science ®Google Scholar
• Grigoraş A, Căruntu Id Grigoraş CC, Mihăescu T, Amălinei C. Relationship between immunohistochemical assessment of bronchial mucosa microvascularization and clinical stage in asthma. Rom J Morphol Embryol. 2012;53:485–490.
   PubMed Web of Science ®Google Scholar
• Orsida BE, Li X, Hickey B, Thien F, Wilson JW, Walters EH. Vascularity in asthmatic airways: relation to inhaled steroid dose. Thorax. 1999;54(4):289–295. doi:10.1136/thx.54.4.289.
   PubMed Web of Science ®Google Scholar
• Yuksel H, Yilmaz O, Karaman M, Bagriyanik HA, Firinci F, Kiray M, Turkeli A, Karaman O. Role of vascular endothelial growth factor antagonism on airway remodeling in asthma. Ann Allergy Asthma Immunol. 2013;110(3):150–155. doi:10.1016/j.anai.2012.12.015.
   PubMed Web of Science ®Google Scholar
• Lee CG, Link H, Baluk P, Homer RJ, Chapoval S, Bhandari V, Kang MJ, Cohn L, Kim YK, McDonald DM, et al. Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat Med. 2004;10(10):1095–1103. doi:10.1038/nm1105.
   PubMed Web of Science ®Google Scholar
• Simcock DE, Kanabar V, Clarke GW, O'Connor BJ, Lee TH, Hirst SJ. Proangiogenic activity in bronchoalveolar lavage fluid from patients with asthma. Am J Respir Crit Care Med. 2007;176(2):146–153. doi:10.1164/rccm.200701-042OC.
   PubMed Web of Science ®Google Scholar
• Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med. 2000;6(4):389–395. doi:10.1038/74651.
   PubMed Web of Science ®Google Scholar
• Ribatti D, Puxeddu I, Crivellato E, Nico B, Vacca A, Levi-Schaffer F. Angiogenesis in asthma. Clin Exp Allergy. 2009;39(12):1815–1821. doi:10.1111/j.1365-2222.2009.03385.x.
   PubMed Web of Science ®Google Scholar
• Olivieri D, Chetta A. Therapeutic perspectives in vascular remodeling in asthma and chronic obstructive pulmonary disease. Chem Immunol Allergy. 2014;99:216–225. doi:10.1159/000353307.
   PubMedGoogle Scholar
• Carmeliet P. Angiogenesis in life, disease and medicine. Nature. 2005;438(7070):932–936. doi:10.1038/nature04478.
   PubMed Web of Science ®Google Scholar
• Denny P, Swift S, Connor F, Ashworth A. An SRY-related gene expressed during spermatogenesis in the mouse encodes a sequence-specific DNA-binding protein. EMBO J. 1992;11(10):3705–3712. doi:10.1002/j.1460-2075.1992.tb05455.x.
   PubMed Web of Science ®Google Scholar
• Collignon J, Sockanathan S, Hacker A, Cohen-Tannoudji M, Norris D, Rastan S, Stevanovic M, Goodfellow PN, Lovell-Badge R. Comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. Development. 1996;122(2):509–520.
   PubMed Web of Science ®Google Scholar
• Soullier S, Jay P, Poulat F, Vanacker JM, Berta P, Laudet V. Diversification pattern of the HMG and SOX family members during evolution. J Mol Evol. 1999;48(5):517–527. doi:10.1007/pl00006495.
   PubMed Web of Science ®Google Scholar
• Uwanogho D, Rex M, Cartwright EJ, Pearl G, Healy C, Scotting PJ, Sharpe PT. Embryonic expression of the chicken Sox2, Sox3 and Sox11 genes suggests an interactive role in neuronal development. Mech Dev. 1995;49(1–2):23–36. doi:10.1016/0925-4773(94)00299-3.
   PubMed Web of Science ®Google Scholar
• Malas S, Duthie SM, Mohri F, Lovell-Badge R, Episkopou V. Cloning and mapping of the human SOX1: a highly conserved gene expressed in the developing brain. Mamm Genome. 1997;8(11):866–868. doi:10.1007/s003359900597.
   PubMed Web of Science ®Google Scholar
• Pusch C, Hustert E, Pfeifer D, Südbeck P, Kist R, Roe B, Wang Z, Balling R, Blin N, Scherer G. The SOX10/Sox10 gene from human and mouse: sequence, expression, and transactivation by the encoded HMG domain transcription factor. Hum Genet. 1998;103(2):115–123. doi:10.1007/s004390050793.
   PubMed Web of Science ®Google Scholar
• Jay P, Sahly I, Gozé C, Taviaux S, Poulat F, Couly G, Abitbol M, Berta P. SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue. Hum Mol Genet. 1997;6(7):1069–1077. doi:10.1093/hmg/6.7.1069.
   PubMed Web of Science ®Google Scholar
• Arsic N, Rajic T, Stanojcic S, Goodfellow PN, Stevanovic M. Characterisation and mapping of the human SOX14 gene. Cytogenet Cell Genet. 1998;83(1–2):139–146. doi:10.1159/000015149.
   PubMedGoogle Scholar
• Dunn TL, Mynett-Johnson L, Wright EM, Hosking BM, Koopman PA, Muscat GE. Sequence and expression of Sox-18 encoding a new HMG-box transcription factor. Gene. 1995;161(2):223–225. doi:10.1016/0378-1119(95)00280-j.
   PubMed Web of Science ®Google Scholar
• Wang G, Wei Z, Jia H, Zhao W, Yang G, Zhao H. Knockdown of SOX18 inhibits the proliferation, migration and invasion of hepatocellular carcinoma cells. Oncol Rep. 2015;34(3):1121–1128. doi:10.3892/or.2015.4112.
   PubMed Web of Science ®Google Scholar
• Ornat M, Kobierzycki C, Grzegrzolka J, Pula B, Zamirska A, Bieniek A, Szepietowski JC, Dziegiel P, Okolow MP. SOX18 expression in non-melanoma skin cancer. Anticancer Res. 2016;36:2379–2383.
   PubMed Web of Science ®Google Scholar
• Olbromski M, Rzechonek A, Grzegrzolka J, Glatzel-Plucinska N, Chachaj A, Werynska B, Podhorska-Okolow M, Dziegiel P. Influence of miR-7a and miR-24-3p on the SOX18 transcript in lung adenocarcinoma. Oncol Rep. 2018;39:201–208. doi:10.3892/or.2017.6077.
   PubMed Web of Science ®Google Scholar
• Ding W, Zhang Y, Cai H, Liu G, Ye Y, Xu G, Wang H, Xiong D, Zhang C, Huang Z, et al. Overexpression of COUP‑TFII suppresses proliferation and metastasis of human gastric cancer cells. Mol Med Rep. 2018;17(2):2393–2401. doi:10.3892/mmr.2017.8164.
   PubMed Web of Science ®Google Scholar
• Roche N, Chinet TC, Huchon GJ. Allergic and nonallergic interactions between house dust mite allergens and airway mucosa. Eur Respir J. 1997;10(3):719–726.
   PubMed Web of Science ®Google Scholar