Manifesto on united airways diseases (UAD): an Interasma (global asthma association – GAA) document

References

• Bousquet J, Van Cauwenberge P, Khaltaev N, Aria Workshop Group; World Health Organization. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 2001;108(5 Suppl):S147–S334. doi:https://doi.org/10.1067/mai.2001.118891.
   PubMed Web of Science ®Google Scholar
• Kaliner M, McFadden F. Bronchial asthma. In: Samter S, ed. Immunological diseases. 4th ed. Boston: Little Brown; 1988:1067–1118.
   Google Scholar
• Ciprandi G, Caimmi D, Miraglia Del Giudice M, La Rosa M, Salpietro C, Marseglia GL. Recent developments in united airways disease. Allergy Asthma Immunol Res 2012;4(4):171–177. doi:https://doi.org/10.4168/aair.2012.4.4.171.
   PubMed Web of Science ®Google Scholar
• Passalacqua G, Ciprandi G, Canonica GW. United airways disease: therapeutic aspects. Thorax 2000;55(90002):26S–S27. doi:https://doi.org/10.1136/thorax.55.suppl_2.s26.
   Google Scholar
• Yii ACA, Tay TR, Choo XN, Koh MSY, Tee AKH, Wang DY. Precision medicine in united airways disease: a “treatable traits” approach. Allergy 2018;73(10):1964–1978. doi:https://doi.org/10.1111/all.13496.
   PubMed Web of Science ®Google Scholar
• Giavina-Bianchi P, Aun MV, Takejima P, Kalil J, Agondi RC. United airway disease: current perspectives. J Asthma Allergy 2016;9:93–100. doi:https://doi.org/10.2147/JAA.S81541.
   PubMed Web of Science ®Google Scholar
• Gudis DA, Schlosser RJ, eds. The unified airway rhinologic disease and respiratory disorders. 2020. Heidelberg, Germany: Springer Nature.
   Google Scholar
• Kuo CR, Chan R, Lipworth B. Does unified allergic airway disease impact on lung function and type 2 biomarkers?Allergy Asthma Clin Immunol 2019;15:75. doi:https://doi.org/10.1186/s13223-019-0388-4.
   PubMed Web of Science ®Google Scholar
• Grossman J. One airway, one disease. Chest 1997;111(2 Suppl):11S–16S. doi:https://doi.org/10.1378/chest.111.2_supplement.11s.
   PubMed Web of Science ®Google Scholar
• Giovannini-Chami L, Paquet A, Sanfiorenzo C, Pons N, Cazareth J, Magnone V, Lebrigand K, Chevalier B, Vallauri A, Julia V, et al. The "one airway, one disease" concept in light of Th2 inflammation. Eur Respir J 2018;52(4):1800437. doi:https://doi.org/10.1183/13993003.00437-2018.
   PubMed Web of Science ®Google Scholar
• Cassano M, Maselli A, Mora F, Cassano P. Rhinobronchial syndrome: pathogenesis and correlation with allergic rhinitis in children. Int J Pediatr Otorhinolaryngol 2008;72(7):1053–1058. doi:https://doi.org/10.1016/j.ijporl.2008.03.017.
   PubMed Web of Science ®Google Scholar
• Fasano MB. Combined airways: impact of upper airway on lower airway. Curr Opin Otolaryngol Head Neck Surg 2010;18(1):15–20. doi:https://doi.org/10.1097/MOO.0b013e328334aa0eetc.
   PubMed Web of Science ®Google Scholar
• Tiotiu A, Plavec D, Novakova S, Mihaicuta S, Novakova P, Labor M, Bikov A. Current opinions for the management of asthma associated with ear, nose and throat comorbidities. Eur Respir Rev 2018;27(150):180056. doi:https://doi.org/10.1183/16000617.0056-2018.
   PubMed Web of Science ®Google Scholar
• Tohidinik HR, Mallah N, Takkouche B. History of allergic rhinitis and risk of asthma; a systematic review and meta-analysis. World Allergy Organ J 2019;12(10):100069. doi:https://doi.org/10.1016/j.waojou.2019.100069.
   PubMed Web of Science ®Google Scholar
• Guo H, Peng T, Luo P, Li H, Huang S, Li S, Zhao W, Zhou X. Association of FcεRIβ polymorphisms with risk of asthma and allergic rhinitis: evidence based on 29 case–control studies. Biosci Rep 2018;38(4):BSR20180177. doi:https://doi.org/10.1042/BSR20180177
   PubMed Web of Science ®Google Scholar
• Tiotiu A, Oster JP, Roux PR, Nguyen Thi PL, Peiffer G, Bonniaud P, Dalphin JC, de Blay F. Effectiveness of omalizumab in severe allergic asthma and nasal polyposis: a real-life study. J Investig Allergol Clin Immunol 2020;30(1):49–57. doi:https://doi.org/10.18176/jiaci.0391.
   PubMed Web of Science ®Google Scholar
• Bardei F, Bouziane H, Kadiri M, Rkiek B, Tebay A, Saoud A. Profils de sensibilisation cutanée aux allergènes respiratoires des patients de la ville de Tétouan (Nord Ouest du Maroc) [Skin sensitisation profiles to inhalant allergens for patients in Tétouan city (North West of Morocco. Rev Pneumol Clin 2016;72(4):221–227. doi:https://doi.org/10.1016/j.pneumo.2016.04.005.
   PubMed Web of Science ®Google Scholar
• Alimuddin S, Rengganis I, Rumende CM, Setiati S. Comparison of Specific Immunoglobulin E with the skin prick test in the diagnosis of house dust mites and cockroach sensitization in patients with asthma and/or allergic rhinitis. Acta Med Indones 2018;50(2):125–131.
   PubMed Web of Science ®Google Scholar
• Sánchez-Borges M, Capriles-Hulett A, Torres J, Ansotegui-Zubeldia IJ, Castillo A, Dhersy A, Monzón X. Diagnosis of allergic sensitization in patients with allergic rhinitis and asthma in a tropical environment. Rev Alerg Mex 2019;66(1):44–54. doi:https://doi.org/10.29262/ram.v66i1.570
   PubMedGoogle Scholar
• Coskun ZO, Erdivanlı OC, Kazıkdas KÇ, Terzi S, Sahin U, Ozgur A, Demirci M, Dursun E, Cingi C. High sensitization to house-dust mites in patients with allergic rhinitis in the eastern Black Sea region of Turkey: a retrospective study. Am J Rhinol Allergy 2016;30(5):351–355. doi:https://doi.org/10.2500/ajra.2016.30.4353
   PubMed Web of Science ®Google Scholar
• Tham EH, Lee AJ, Bever HV. Aeroallergen sensitization and allergic disease phenotypes in Asia. Asian Pac J Allergy Immunol 2016;34(3):181–189. doi:https://doi.org/10.12932/AP0770.
   PubMed Web of Science ®Google Scholar
• Okano M, Kariya S, Ohta N, Imoto Y, Fujieda S, Nishizaki K. Association and management of eosinophilic inflammation in upper and lower airways. Allergol Int 2015;64(2):131–138. doi:https://doi.org/10.1016/j.alit.2015.01.004.
   PubMed Web of Science ®Google Scholar
• Naclerio R, Ansotegui IJ, Bousquet J, Canonica GW, D’Amato G, Rosario N, Pawankar R, Peden D, Bergmann KC, Bielory L, et al. International expert consensus on the management of allergic rhinitis (AR) aggravated by air pollutants: impact of air pollution on patients with AR: current knowledge and future strategies. World Allergy Organ J 2020;13(3):100106. doi:https://doi.org/10.1016/j.waojou.2020.100106.
   PubMed Web of Science ®Google Scholar
• Wise SK, Lin SY, Toskala E, Orlandi RR, Akdis CA, Alt JA, Azar A, Baroody FM, Bachert C, Canonica GW, et al. International consensus statement on allergy and rhinology: allergic rhinitis. Int Forum Allergy Rhinol 2018;8(2):108–352. doi:https://doi.org/10.1002/alr.22073.
   PubMed Web of Science ®Google Scholar
• Oka A, Hirano T, Yamaji Y, Ito K, Oishi K, Edakuni N, Kawano R, Matsunaga K. Determinants of incomplete asthma control in patients with allergic rhinitis and asthma. J Allergy Clin Immunol Pract 2017;5(1):160–164. doi:https://doi.org/10.1016/j.jaip.2016.08.002.
   PubMed Web of Science ®Google Scholar
• Belhassen M, Demoly P, Bloch-Morot E, de Pouvourville G, Ginoux M, Chartier A, Laforest L, Serup-Hansen N, Toussi M, Van Ganse E. Costs of perennial allergic rhinitis and allergic asthma increase with severity and poor disease control. Allergy 2017;72(6):948–958. doi:https://doi.org/10.1111/all.13098.
   PubMed Web of Science ®Google Scholar
• Sukhan VS. Allergic rhinitis and asthma co-morbidity. Wiad Lek 2019;72(4):622–626. doi:https://doi.org/10.36740/WLek201904122.
   PubMedGoogle Scholar
• Lin J, Gao J, Lai K, Zhou X, He B, Zhou J, Wang C. The characteristic of asthma control among nasal diseases population: results from a cross-sectional study. PLoS One 2018;13(2):e0191543. doi:https://doi.org/10.1371/journal.pone.0191543.
   PubMed Web of Science ®Google Scholar
• Ohta K, Tanaka H, Tohda Y, Kohrogi H, Chihara J, Sakakibara H, Adachi M, Tamura G. Asthma exacerbations in patients with asthma and rhinitis: factors associated with asthma exacerbation and its effect on QOL in patients with asthma and rhinitis. Allergol Int 2019;68(4):470–477. doi:https://doi.org/10.1016/j.alit.2019.04.008.
   PubMed Web of Science ®Google Scholar
• Huang K, Yang T, Xu J, Yang L, Zhao J, Zhang X, Bai C, Kang J, Ran P, Shen H, et al. Prevalence, risk factors, and management of asthma in China: a national cross-sectional study. Lancet 2019;394(10196):407–418. doi:https://doi.org/10.1016/S0140-6736(19)31147-X.
   PubMed Web of Science ®Google Scholar
• Kang HR, Song HJ, Nam JH, Hong SH, Yang SY, Ju S, Lee SW, Kim TB, Kim HL, Lee EK. Risk factors of asthma exacerbation based on asthma severity: a nationwide population-based observational study in South Korea. BMJ Open 2018;8(3):e020825. doi:https://doi.org/10.1136/bmjopen-2017-020825.
   PubMed Web of Science ®Google Scholar
• Tuomisto LE, Ilmarinen P, Niemelä O, Haanpää J, Kankaanranta T, Kankaanranta H. A 12-year prognosis of adult-onset asthma: Seinäjoki Adult Asthma Study. Respir Med 2016;117:223–229. doi:https://doi.org/10.1016/j.rmed.2016.06.017.
   PubMed Web of Science ®Google Scholar
• Chen W, FitzGerald JM, Lynd LD, Sin DD, Sadatsafavi M. Long-term trajectories of mild asthma in adulthood and risk factors of progression. J Allergy Clin Immunol Pract 2018;6(6):2024–2032.e5. doi:https://doi.org/10.1016/j.jaip.2018.04.027.
   PubMed Web of Science ®Google Scholar
• Bui DS, Lodge CJ, Burgess JA, Lowe AJ, Perret J, Bui MQ, Bowatte G, Gurrin L, Johns DP, Thompson BR, et al. Childhood predictors of lung function trajectories and future COPD risk: a prospective cohort study from the first to the sixth decade of life. Lancet Respir Med 2018;6(7):535–544. doi:https://doi.org/10.1016/S2213-2600(18)30100-0.
   PubMed Web of Science ®Google Scholar
• Iyer A, Athavale A. Nasal airway resistance and latent lower airway involvement in allergic rhinitis. J Assoc Phys India 2020;68(3):43–47.
   PubMedGoogle Scholar
• Chakir J, Laviolette M, Boutet M, Laliberté R, Dubé J, Boulet LP. Lower airways remodeling in nonasthmatic subjects with allergic rhinitis. Lab Invest 1996;75(5):735–744.
   PubMed Web of Science ®Google Scholar
• Chakir J, Laviolette M, Turcotte H, Boutet M, Boulet LP. Cytokine expression in the lower airways of nonasthmatic subjects with allergic rhinitis: influence of natural allergen exposure. J Allergy Clin Immunol 2000;106(5):904–910. doi:https://doi.org/10.1067/mai.2000.110100.
   PubMed Web of Science ®Google Scholar
• Schramm D, Reuter M, Grabenhenrich LB, Schuster A, Lex C, Bauer CP, Hoffmann U, Forster J, Zepp F, Bergmann RL, et al. What does lung function tell us about respiratory multimorbidity in childhood and early adulthood? Results from the MAS birth cohort study. Pediatr Allergy Immunol 2018;29(5):481–489. doi:https://doi.org/10.1111/pai.12901.
   PubMed Web of Science ®Google Scholar
• Takahara D, Kono T, Takeno S, Ishino T, Hamamoto T, Kubota K, Ueda T. Nasal nitric oxide in the inferior turbinate surface decreases with intranasal steroids in allergic rhinitis: a prospective study. Auris Nasus Larynx 2019;46(4):507–512. doi:https://doi.org/10.1016/j.anl.2018.11.005.
   PubMed Web of Science ®Google Scholar
• Duong-Quy S, Vu-Minh T, Hua-Huy T, Tang-Thi-Thao T, Le-Quang K, Tran-Thanh D, Doan-Thi-Quynh N, Le-Dong N-N, Craig TJ, Dinh-Xuan A-T. Study of nasal exhaled nitric oxide levels in diagnosis of allergic rhinitis in subjects with and without asthma. JAA 2017;10:75–82. doi:https://doi.org/10.2147/JAA.S129047.
   Google Scholar
• Asano T, Takemura M, Kanemitsu Y, Yokota M, Fukumitsu K, Takeda N, Ichikawa H, Hijikata H, Uemura T, Takakuwa O, et al. Combined measurements of fractional exhaled nitric oxide and nasal nitric oxide levels for assessing upper airway diseases in asthmatic patients. J Asthma 2018;55(3):300–309. doi:https://doi.org/10.1080/02770903.2017.1332203.
   PubMed Web of Science ®Google Scholar
• Ren L, Zhang W, Zhang Y, Zhang L. Nasal nitric oxide is correlated with nasal patency and nasal symptoms. Allergy Asthma Immunol Res 2019;11(3):367–380. doi:https://doi.org/10.4168/aair.2019.11.3.367.
   PubMed Web of Science ®Google Scholar
• Ciprandi G, Schiavetti I, Rindone E, Ricciardolo FLM. The impact of anxiety and depression on outpatients with asthma. Ann Allergy Asthma Immunol 2015;115(5):408–414. doi:https://doi.org/10.1016/j.anai.2015.08.007.
   PubMed Web of Science ®Google Scholar
• Dragonieri S, Quaranta VN, Carratu P, Ranieri T, Resta O. Exhaled breath profiling by electronic nose enabled discrimination of allergic rhinitis and extrinsic asthma. Biomarkers 2019;24(1):70–75. doi:https://doi.org/10.1080/1354750X.2018.1508307.
   PubMed Web of Science ®Google Scholar
• Calderón MA, Kleine-Tebbe J, Linneberg A, De Blay F, Hernandez Fernandez de Rojas D, Virchow JC, Demoly P. House dust mite respiratory allergy: an overview of current therapeutic strategies. J Allergy Clin Immunol Pract 2015;3(6):843–855. doi:https://doi.org/10.1016/j.jaip.2015.06.019.
   PubMed Web of Science ®Google Scholar
• Ansotegui IJ, Melioli G, Canonica GW, Caraballo L, Villa E, Ebisawa M, Passalacqua G, Savi E, Ebo D, Gómez RM, et al. IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper. World Allergy Organ J 2020;13(2):100080. doi:https://doi.org/10.1016/j.waojou.2019.100080.
   PubMed Web of Science ®Google Scholar
• Gunawardana NC, Durham SR. New approaches to allergen immunotherapy. Ann Allergy Asthma Immunol 2018;121(3):293–305. doi:https://doi.org/10.1016/j.anai.2018.07.014
   PubMed Web of Science ®Google Scholar
• Komlósi ZI, Kovács N, Sokolowska M, van de Veen W, Akdis M, Akdis CA. Mechanisms of subcutaneous and sublingual aeroallergen immunotherapy: what is new?Immunol Allergy Clin North Am 2020;40(1):1–14. doi:https://doi.org/10.1016/j.iac.2019.09.009.
   PubMed Web of Science ®Google Scholar
• Senti G, Kündig TM. Novel delivery routes for allergy immunotherapy: intralymphatic, epicutaneous, and intradermal. Immunol Allergy Clin North Am 2016;36(1):25–37. doi:https://doi.org/10.1016/j.iac.2015.08.006.
   PubMed Web of Science ®Google Scholar
• Dhami S, Nurmatov U, Arasi S, Khan T, Asaria M, Zaman H, Agarwal A, Netuveli G, Roberts G, Pfaar O, et al. Allergen immunotherapy for allergic rhinoconjunctivitis: a systematic review and meta-analysis. Allergy 2017;72(11):1597–1631. doi:https://doi.org/10.1111/all.13201.
   PubMed Web of Science ®Google Scholar
• Aggarwal B, Shantakumar S, Hinds D, Mulgirigama A. Asia-Pacific Survey of Physicians on Asthma and Allergic Rhinitis (ASPAIR): physician beliefs and practices about diagnosis, assessment, and treatment of coexistent disease. J Asthma Allergy 2018;11:293–307. doi:https://doi.org/10.2147/JAA.S18065.
   PubMed Web of Science ®Google Scholar
• Watts AM, Cripps AW, West NP, Cox AJ. Modulation of allergic inflammation in the nasal mucosa of allergic rhinitis sufferers with topical pharmaceutical agents. Front Pharmacol 2019;10:294. doi:https://doi.org/10.3389/fphar.2019.00294.
   PubMed Web of Science ®Google Scholar
• Chen H, Lou H, Wang Y, Cao F, Zhang L, Wang C. Comparison of the efficacy and mechanisms of intranasal budesonide, montelukast, and their combination in treatment of patients with seasonal allergic rhinitis. Int Forum Allergy Rhinol 2018;8(11):1242–1252. doi:https://doi.org/10.1002/alr.22197.
   PubMed Web of Science ®Google Scholar
• Lynde CW, Sussman G, Dion PL, Guenther L, Hébert J, Rao J, Leek TV, Waserman S. Multidisciplinary real-world experience with bilastine, a second generation antihistamine. J Drugs Dermatol 2020;19(2):145–154. doi:https://doi.org/10.36849/JDD.2020.4835.
   PubMed Web of Science ®Google Scholar
• Antonijoan R, Coimbra J, García-Gea C, Puntes M, Gich I, Campo C, Valiente R, Labeaga L. Comparative efficacy of bilastine, desloratadine and rupatadine in the suppression of wheal and flare response induced by intradermal histamine in healthy volunteers. Curr Med Res Opin 2017;33(1):129–136. doi:https://doi.org/10.1080/03007995.2016.1240665.
   PubMed Web of Science ®Google Scholar
• Okubo K, Gotoh M, Asako M, Nomura Y, Togawa M, Saito A, Honda T, Ohashi Y. Efficacy and safety of bilastine in Japanese patients with perennial allergic rhinitis: a multicenter, randomized, double-blind, placebo-controlled, parallel-group phase III study. Allergol Int 2017;66(1):97–105. doi:https://doi.org/10.1016/j.alit.2016.05.014.
   PubMed Web of Science ®Google Scholar
• Demonte A, Guanti MB, Liberati S, Biffi A, Fernando F, Fainello M, Pepe P. Bilastine safety in drivers who need antihistamines: new evidence from high-speed simulator driving test on allergic patients. Eur Rev Med Pharmacol Sci 2018;22(3):820–828. doi:https://doi.org/10.26355/eurrev_201802_14318.
   PubMed Web of Science ®Google Scholar
• Reményi Á, Grósz A, Szabó SA, Tótka Z, Molnár D, Helfferich F. Comparative study of the effect of bilastine and cetirizine on cognitive functions at ground level and at an altitude of 4,000 m simulated in hypobaric chamber: a randomized, double-blind, placebo-controlled, cross-over study. Expert Opin Drug Saf 2018;17(9):859–868. doi:https://doi.org/10.1080/14740338.2018.1502268.
   PubMed Web of Science ®Google Scholar
• Valk PJ, Simons R, Jetten AM, Valiente R, Labeaga L. Cognitive performance effects of bilastine 20 mg during 6 hours at 8000 ft cabin altitude. Aerosp Med Hum Perform 2016;87(7):622–627. doi:https://doi.org/10.3357/AMHP.4522.2016.
   PubMed Web of Science ®Google Scholar
• Randall KL, Hawkins CA. Antihistamines and allergy. Aust Prescr 2018;41(2):41–45. doi:https://doi.org/10.18773/austprescr.2018.013.
   PubMed Web of Science ®Google Scholar
• Benard B, Bastien V, Vinet B, Yang R, Krajinovic M, Ducharme FM. Neuropsychiatric adverse drug reactions in children initiated on montelukast in real-life practice. Eur Respir J 2017;50(2):1700148. doi:https://doi.org/10.1183/13993003.00148-2017.
   PubMed Web of Science ®Google Scholar
• Piatti G, Ceriotti L, Cavallaro G, Ambrosetti U, Mantovani M, Pistone A, Centanni S. Effects of zafirlukast on bronchial asthma and allergic rhinitis. Pharmacol Res 2003;47(6):541–547. doi:https://doi.org/10.1016/s1043-6618(03)00017-3.
   PubMed Web of Science ®Google Scholar
• Weinstein SF, Katial R, Jayawardena S, Pirozzi G, Staudinger H, Eckert L, Joish VN, Amin N, Maroni J, Rowe P, et al. Efficacy and safety of dupilumab in perennial allergic rhinitis and comorbid asthma. J Allergy Clin Immunol 2018;142(1):171–177. doi:https://doi.org/10.1016/j.jaci.2017.11.051.
   PubMed Web of Science ®Google Scholar
• Weinstein SF, Katial RK, Bardin P, Korn S, McDonald M, Garin M, Bateman ED, Hoyte FCL, Germinaro M. Effects of reslizumab on asthma outcomes in a subgroup of eosinophilic asthma patients with self-reported chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol Pract 2019;7(2):589–596. doi:https://doi.org/10.1016/j.jaip.2018.08.021.
   PubMed Web of Science ®Google Scholar
• Qiu X, Wang HT. Safety and efficacy of omalizumab for the treatment of allergic rhinitis: meta-analysis of randomized clinical trials. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2016;30(9):694–698. doi:https://doi.org/10.13201/j.issn.1001-1781.2016.09.006.
   PubMedGoogle Scholar
• Bousquet JJ, Schünemann HJ, Togias A, Erhola M, Hellings PW, Zuberbier T, Agache I, Ansotegui IJ, Anto JM, Bachert C, MASK Study Group, et al. Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases. Clin Transl Allergy 2019;9:44. doi:https://doi.org/10.1186/s13601-019-0279-2.
   PubMed Web of Science ®Google Scholar
• Bousquet J, Arnavielhe S, Bedbrook A, Bewick M, Laune D, Mathieu-Dupas E, Murray R, Onorato GL, Pépin JL, Picard R, MASK Study Group, et al. MASK 2017: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma multimorbidity using real-world-evidence. Clin Transl Allergy 2018;8:45. doi:https://doi.org/10.1186/s13601-018-0227-6.
   PubMed Web of Science ®Google Scholar
• Bousquet J, Anto JM, Annesi-Maesano I, Dedeu T, Dupas E, Pépin J-L, Eyindanga LSZ, Arnavielhe S, Ayache J, Basagana X, et al. POLLAR: impact of air pollution on asthma and rhinitis: a European Institute of Innovation and Technology Health (EIT Health) project. Clin Transl Allergy 2018;8(1):3. doi:https://doi.org/10.1186/s13601-018-0227-6.
   PubMedGoogle Scholar
• Bousquet J, Hellings PW, Agache I, Bedbrook A, Bachert C, Bergmann KC, Bewick M, Bindslev-Jensen C, Bosnic-Anticevitch S, Bucca C, et al. ARIA 2016: care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle. Clin Transl Allergy 2016;6:47. doi:https://doi.org/10.1186/s13601-016-0137-4.
   PubMed Web of Science ®Google Scholar
• Bousquet J, Anto JM, Bachert C, Haahtela T, Zuberbier T, Czarlewski W, Bedbrook A, Bosnic-Anticevich S, Canonica GW, Cardona V, et al. ARIA digital anamorphosis: digital transformation of health and care in airway diseases from research to practice. Allergy 2021;76(1):168–190. doi:https://doi.org/10.1111/all.14422.
   PubMed Web of Science ®Google Scholar
• Bousquet J, Bedbrook A, Czarlewski W, Onorato GL, Arnavielhe S, Laune D, Mathieu-Dupas E, Fonseca J, Costa E, Lourenço O, The MASK Study Group, et al. Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma. Clin Transl Allergy 2019;9:52. doi:https://doi.org/10.1186/s13601-019-0252-0.
   PubMed Web of Science ®Google Scholar
• Hellings PW, Klimek L, Cingi C, Agache I, Akdis C, Bachert C, Bousquet J, Demoly P, Gevaert P, Hox V, et al. Non-allergic rhinitis: position paper of the European academy of allergy and clinical immunology. Allergy 2017;72(11):1657–1665. doi:https://doi.org/10.1111/all.13200.
   PubMed Web of Science ®Google Scholar
• Vandenplas O, Hox V, Bernstein D. Occupational rhinitis. J Allergy Clin Immunol Pract 2020;S2213–2198(20):30687–30685. doi:https://doi.org/10.1016/j.jaip.2020.06.047.
   Google Scholar
• Vandenplas O, Godet J, Hurdubaea L, Rifflart C, Suojalehto H, Wiszniewska M, Munoz X, Sastre J, Klusackova P, Moore V, European network for the PHenotyping of OCcupational ASthma (E-PHOCAS) Investigators, et al. Are high- and low-molecular-weight sensitizing agents associated with different clinical phenotypes of occupational asthma?Allergy 2019;74(2):261–272. doi:https://doi.org/10.1111/all.13542.
   PubMed Web of Science ®Google Scholar
• Moscato G, Pala G, Folletti I, Siracusa A, Quirce S. Occupational rhinitis affects occupational asthma severity. J Occup Health 2016;58(3):310–313. doi:https://doi.org/10.1539/joh.15-0067-BR.
   PubMed Web of Science ®Google Scholar
• Powell H, Murphy VE, Hensley MJ, Giles W, Clifton VL, Gibson PG. Rhinitis in pregnant women with asthma is associated with poorer asthma control and quality of life. J Asthma 2015;52(10):1023–1030. doi:https://doi.org/10.3109/02770903.2015.1054403.
   PubMed Web of Science ®Google Scholar
• Bonham CA, Patterson KC, Strek ME. Asthma outcomes and management during pregnancy. Chest 2018;153(2):515–527. doi:https://doi.org/10.1016/j.chest.2017.08.029.
   PubMed Web of Science ®Google Scholar
• Henriksen AH, Langhammer A, Steinshamn S, Mai X-M, Brumpton BM. The prevalence and symptom profile of asthma-COPD overlap: the HUNT study. COPD 2018;15(1):27–35. doi:https://doi.org/10.1080/15412555.2017.1408580.
   PubMedGoogle Scholar
• Bergqvist J, Andersson A, Olin AC, Murgia N, Schiöler L, Bove M, Hellgren J. New evidence of increased risk of rhinitis in subjects with COPD: a longitudinal population study. COPD 2016;11:2617–2623. doi:https://doi.org/10.2147/COPD.S115086.
   Google Scholar
• Singh U, Wangia-Anderson V, Bernstein JA. Chronic rhinitis is a high-risk comorbidity for 30-day hospital readmission of patients with asthma and chronic obstructive pulmonary disease. J Allergy Clin Immunol Pract 2019;7(1):279–285.e6. doi:https://doi.org/10.1016/j.jaip.2018.06.029.
   PubMed Web of Science ®Google Scholar
• Kim JK, Lee SH, Lee BH, Lee CY, Kim Do J, Min KH, Kim SK, Yoo KH, Jung KS, Hwang YI. Factors associated with exacerbation in mild- to-moderate COPD patients. Int J Chron Obstruct Pulmon Dis 2016;11:1327–1333. doi:https://doi.org/10.2147/COPD.S105583.
   PubMed Web of Science ®Google Scholar
• Román-Rodríguez M, van Boven JF, Vargas F, Contreras CC, Lamelas G, Gestoso S, Góngora M, Corredor M, Esteva M. Factors associated with inhaled corticosteroids prescription in primary care patients with COPD: a cross-sectional study in the Balearic Islands (Spain). Eur J Gen Pract 2016;22(4):232–239. doi:https://doi.org/10.1080/13814788.2016.1212011.
   PubMed Web of Science ®Google Scholar
• Calabrese C, Costigliola A, Maffei M, Simeon V, Perna F, Tremante E, Merola E, Leone CA, Bianco A. Clinical impact of nasal budesonide treatment on. COPD 2018;13:2025–2032. doi:https://doi.org/10.2147/COPD.S165857.
   Google Scholar
• Niksarlıoğlu EY, Işık R, Uysal MA, Ünal D, Çamsarı G. Prevalence of atopy and allergic rhinitis in patients with adult non-cystic fibrosis bronchiectasis. Turk J Med Sci 2019;49(2):551–557. doi:https://doi.org/10.3906/sag-1807-229.
   PubMed Web of Science ®Google Scholar
• Mac Aogáin M, Tiew PY, Lim AYH, Low TB, Tan GL, Hassan T, Ong TH, Pang SL, Lee ZY, Gwee XW, et al. Distinct "Immunoallertypes" of disease and high frequencies of sensitization in non-cystic fibrosis bronchiectasis. Am J Respir Crit Care Med 2019;199(7):842–853. doi:https://doi.org/10.1164/rccm.201807-1355OC.
   PubMed Web of Science ®Google Scholar
• Everaerts S, Lagrou K, Dubbeldam A, Lorent N, Vermeersch K, Van Hoeyveld E, Bossuyt X, Dupont LJ, Vanaudenaerde BM, Janssens W. Sensitization to Aspergillus fumigatus as a risk factor for bronchiectasis in COPD. Int J Chron Obstruct Pulm Dis 2017;12:2629–2638. doi:https://doi.org/10.2147/COPD.S141695.
   PubMed Web of Science ®Google Scholar
• Somani SN, Kwah JH, Yeh C, Conley DB, Grammer LC, 3rd, Kern RC, Prickett M, Schleimer RP, Smith SS, Stevens WW, et al. Prevalence and characterization of chronic rhinosinusitis in patients with non-cystic fibrosis bronchiectasis at a tertiary care center in the United States. Int Forum Allergy Rhinol 2019;9(12):1424–1429. doi:https://doi.org/10.1002/alr.22436.
   PubMed Web of Science ®Google Scholar
• Zemke AC, Nouraie SM, Moore J, Gaston JR, Rowan NR, Pilewski JM, Bomberger JM, Lee SE. Clinical predictors of cystic fibrosis chronic rhinosinusitis severity. Int Forum Allergy Rhinol 2019;9(7):759–765. doi:https://doi.org/10.1002/alr.22332.
   PubMed Web of Science ®Google Scholar
• Kang SH, Meotti CD, Bombardelli K, Piltcher OB, de Tarso Roth Dalcin P. Sinonasal characteristics and quality of life by SNOT-22 in adult patients with cystic fibrosis. Eur Arch Otorhinolaryngol 2017;274(4):1873–1882. doi:https://doi.org/10.1007/s00405-016-4426-2.
   PubMed Web of Science ®Google Scholar
• Xie DX, Wu J, Kelly K, Brown RF, Shannon C, Virgin FW. Evaluating the sinus and nasal quality of life survey in the pediatric cystic fibrosis patient population. Int J Pediatr Otorhinolaryngol 2017;102:133–137. doi:https://doi.org/10.1016/j.ijporl.2017.09.014.
   PubMed Web of Science ®Google Scholar
• Cao Y, Wu S, Zhang L, Yang Y, Cao S, Li Q. Association of allergic rhinitis with obstructive sleep apnea: a meta-analysis. Medicine (Baltimore) 2018;97(51):e13783. doi:https://doi.org/10.1097/MD.0000000000013783.
   PubMed Web of Science ®Google Scholar
• Liu J, Zhang X, Zhao Y, Wang Y. The association between allergic rhinitis and sleep: a systematic review and meta-analysis of observational studies. PLoS One 2020;15(2):e0228533. doi:https://doi.org/10.1371/journal.pone.0228533.
   PubMed Web of Science ®Google Scholar
• Boyer L, Philippe C, Covali-Noroc A, Dalloz MA, Rouvel-Tallec A, Maillard D, Stoica M, d’Ortho MP. OSA treatment with CPAP: randomized crossover study comparing tolerance and efficacy with and without humidification by ThermoSmart. Clin Respir J 2019;13(6):384–390. doi:https://doi.org/10.1111/crj.13022.
   PubMed Web of Science ®Google Scholar
• Cisternas A, Aguilar F, Montserrat JM, Àvila M, Torres M, Iranzo A, Berenguer J, Vilaseca I. Effects of CPAP in patients with obstructive apnoea: is the presence of allergic rhinitis relevant?Sleep Breath 2017;21(4):893–900. doi:https://doi.org/10.1007/s11325-017-1510-9.
   PubMed Web of Science ®Google Scholar
• Ryu G, Min C, Park B, Choi HG, Mo JH. Bidirectional association between asthma and chronic rhinosinusitis: two longitudinal follow-up studies using a national sample cohort. Sci Rep 2020;10(1):9589. doi:https://doi.org/10.1038/s41598-020-66479-8.
   PubMed Web of Science ®Google Scholar
• Zeleník K, Matoušek P, Formánek M, Urban O, Komínek P. Patients with chronic rhinosinusitis and simultaneous bronchial asthma suffer from significant extraesophageal reflux. Int Forum Allergy Rhinol 2015;5(10):944–949. doi:https://doi.org/10.1002/alr.21560.
   PubMed Web of Science ®Google Scholar
• Majima S, Wakahara K, Nishio T, Nishio N, Teranishi M, Iwano S, Hirakawa A, Hashimoto N, Sone M, Hasegawa Y. Bronchial wall thickening is associated with severity of chronic rhinosinusitis. Respir Med 2020;170:106024. doi:https://doi.org/10.1016/j.rmed.2020.106024.
   PubMed Web of Science ®Google Scholar
• Sprio AE, Carriero V, Levra S, Botto C, Bertolini F, Di Stefano A, Maniscalco M, Ciprandi G, Ricciardolo FLM. Clinical characterization of the frequent exacerbator phenotype in asthma. JCM 2020; 9(7):2226. doi:https://doi.org/10.3390/jcm9072226.
   Google Scholar
• Gleadhill C, Speth MM, Gengler I, Phillips KM, Hoehle LP, Caradonna DS, Gray ST, Sedaghat AR. Chronic rhinosinusitis disease burden is associated with asthma-related emergency department usage. Eur Arch Otorhinolaryngol 2021;278(1):93–99. doi:https://doi.org/10.1007/s00405-020-06259-2.
   PubMedGoogle Scholar
• Kim YC, Won HK, Lee JW, Sohn KH, Kim MH, Kim TB, Chang YS, Lee BJ, Cho SH, Bachert C, et al. Staphylococcus aureus nasal colonization and asthma in adults: systematic review and meta-analysis. J Allergy Clin Immunol Pract 2019;7(2):606–615.e9. doi:https://doi.org/10.1016/j.jaip.2018.08.020.
   PubMed Web of Science ®Google Scholar
• Chen F, Hong H, Sun Y, Hu X, Zhang J, Xu G, Zhao W, Li H, Shi J. Nasal interleukin 25 as a novel biomarker for patients with chronic rhinosinusitis with nasal polyps and airway hypersensitiveness: a pilot study. Ann Allergy Asthma Immunol 2017;119(4):310–316e2. doi:https://doi.org/10.1016/j.anai.2017.07.012.
   PubMed Web of Science ®Google Scholar
• Farhood Z, Schlosser RJ, Pearse ME, Storck KA, Nguyen SA, Soler ZM. Twenty-two-item sino-nasal outcome test in a control population: a cross-sectional study and systematic review. Int Forum Allergy Rhinol 2016;6(3):271–277. doi:https://doi.org/10.1002/alr.21668.
   PubMed Web of Science ®Google Scholar
• Wu D, Bleier B, Wei Y. Definition and characteristics of acute exacerbation in adult patients with chronic rhinosinusitis: a systematic review. J Otolaryngol Head Neck Surg 2020;49(1):62. doi:https://doi.org/10.1186/s40463-020-00459-w.
   PubMed Web of Science ®Google Scholar
• Kwah JH, Somani SN, Stevens WW, Kern RC, Smith SS, Welch KC, Conley DB, Tan BK, Grammer LC, Yang A, et al. Clinical factors associated with acute exacerbations of chronic rhinosinusitis. J Allergy Clin Immunol 2020;145(6):1598–1605. doi:https://doi.org/10.1016/j.jaci.2020.01.023.
   PubMed Web of Science ®Google Scholar
• Kobayashi Y, Kanda A, Yun Y, Dan Van B, Suzuki K, Sawada S, Asako M, Iwai H. Reduced local response to corticosteroids in eosinophilic chronic rhinosinusitis with asthma. Biomolecules 2020;10(2):326. doi:https://doi.org/10.3390/biom10020326.
   Web of Science ®Google Scholar
• Ho J, Li W, Grayson JW, Alvarado R, Rimmer J, Sewell WA, Harvey RJ. Systemic medication requirement in post-surgical patients with eosinophilic chronic rhinosinusitis. Rhinology. 2020;0(0):0–0. doi:https://doi.org/10.4193/Rhin20.073.
   Google Scholar
• Nakamaru Y, Suzuki M, Honma A, Nakazono A, Kimura S, Fujiwara K, Morita S, Konno S, Homma A. Preoperative pulmonary function testing to predict recurrence of chronic rhinosinusitis with nasal polyps. Allergy Rhinol (Providence) 2020. doi:https://doi.org/10.1177/2152656720946994.
   Google Scholar
• Fraczek M, Guzinski M, Morawska-Kochman M, Krecicki T. Investigation of sinonasal anatomy via low-dose multidetector CT examination in chronic rhinosinusitis patients with higher risk for perioperative complications. Eur Arch Otorhinolaryngol 2017;274(2):787–793. doi:https://doi.org/10.1007/s00405-016-4268-y.
   PubMed Web of Science ®Google Scholar
• Yan B, Lou H, Wang Y, Li Y, Meng Y, Qi S, Wang M, Xiao L, Wang C, Zhang L. Epithelium-derived cystatin SN enhances eosinophil activation and infiltration through IL-5 in patients with chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol 2019;144(2):455–469. doi:https://doi.org/10.1016/j.jaci.2019.03.026.
   PubMed Web of Science ®Google Scholar
• Imoto Y, Kato A, Takabayashi T, Stevens W, Norton JE, Suh LA, Carter RG, Weibman AR, Hulse KE, Harris KE, et al. Increased thrombin-activatable fibrinolysis inhibitor levels in patients with chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol 2019;144(6):1566–1574. doi:https://doi.org/10.1016/j.jaci.2019.08.040.
   PubMed Web of Science ®Google Scholar
• Steelant B, Farré R, Wawrzyniak P, Belmans J, Dekimpe E, Vanheel H, Van Gerven L, Kortekaas Krohn I, Bullens DMA, Ceuppens JL, et al. Impaired barrier function in patients with house dust mite-induced allergic rhinitis is accompanied by decreased occludin and zonula occludens-1 expression. J Allergy Clin Immunol 2016;137(4):1043–1053.e5. doi:https://doi.org/10.1016/j.jaci.2015.10.050.
   PubMed Web of Science ®Google Scholar
• Pezato R, Świerczyńska-Krępa M, Niżankowska-Mogilnicka E, Holtappels G, De Ruyck N, Sanak M, Derycke L, Van Crombruggen K, Bachert C, Pérez-Novo CA. Systemic expression of inflammatory mediators in patients with chronic rhinosinusitis and nasal polyps with and without aspirin exacerbated respiratory disease. Cytokine 2016;77:157–167. doi:https://doi.org/10.1016/j.cyto.2015.10.011.
   PubMed Web of Science ®Google Scholar
• Esmaeilzadeh H, Nabavi M, Aryan Z, Arshi S, Bemanian MH, Fallahpour M, Mortazavi N. Aspirin desensitization for patients with aspirin-exacerbated respiratory disease: a randomized double-blind placebo-controlled trial. Clin Immunol 2015;160(2):349–357. doi:https://doi.org/10.1016/j.clim.2015.05.012.
   PubMed Web of Science ®Google Scholar
• Majak P, Molińska K, Latek M, Rychlik B, Wachulec M, Błauż A, Budniok A, Gruchała M, Lach J, Sobalska-Kwapis M, et al. Upper-airway dysbiosis related to frequent sweets consumption increases the risk of asthma in children with chronic rhinosinusitis. Pediatr Allergy Immunol 2020. doi:https://doi.org/10.1111/pai.13417.
   Google Scholar
• Zhou Y, Jackson D, Bacharier LB, Mauger D, Boushey H, Castro M, Durack J, Huang Y, Lemanske RFJr, Storch GA, et al. The upper-airway microbiota and loss of asthma control among asthmatic children. Nat Commun 2019;10(1):5714. doi:https://doi.org/10.1038/s41467-019-13698-x.
   PubMed Web of Science ®Google Scholar
• Toivonen L, Karppinen S, Schuez-Havupalo L, Waris M, He Q, Hoffman KL, Petrosino JF, Dumas O, Camargo CAJr, Hasegawa K, et al. Longitudinal changes in early nasal microbiota and the risk of childhood asthma. Pediatrics 2020;146(4):e20200421. doi:https://doi.org/10.1542/peds.2020-0421.
   PubMed Web of Science ®Google Scholar
• Barac A, Ong DSY, Jovancevic L, Peric A, Surda P, Tomic Spiric V, Rubino S. Fungi-induced upper and lower respiratory tract allergic diseases: one entity. Front Microbiol 2018;9:583. doi:https://doi.org/10.3389/fmicb.2018.00583.
   PubMed Web of Science ®Google Scholar
• Kobayashi Y, Yasuba H, Asako M, Yamamoto T, Takano H, Tomoda K, Kanda A, Iwai H. HFA-BDP metered-dose inhaler exhaled through the nose improves eosinophilic chronic rhinosinusitis with bronchial asthma: a blinded, placebo-controlled study. Front Immunol 2018;9:2192. doi:https://doi.org/10.3389/fimmu.2018.02192.
   PubMed Web of Science ®Google Scholar
• Leopold DA, Elkayam D, Messina JC, Kosik-Gonzalez C, Djupesland PG, Mahmoud RA. NAVIGATE II: randomized, double-blind trial of the exhalation delivery system with fluticasone for nasal polyposis. J Allergy Clin Immunol 2019;143(1):126–134. doi:https://doi.org/10.1016/j.jaci.2018.06.010.
   PubMed Web of Science ®Google Scholar
• Jonstam K, Swanson BN, Mannent LP, Cardell LO, Tian N, Wang Y, Zhang D, Fan C, Holtappels G, Hamilton JD, et al. Dupilumab reduces local type 2 pro-inflammatory biomarkers in chronic rhinosinusitis with nasal polyposis. Allergy 2019;74(4):743–752. doi:https://doi.org/10.1111/all.13685.
   PubMed Web of Science ®Google Scholar
• Bachert C, Han JK, Desrosiers M, Hellings PW, Amin N, Lee SE, Mullol J, Greos LS, Bosso JV, Laidlaw TM, et al. Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials. Lancet 2019;394(10209):1638–1650. doi:https://doi.org/10.1016/S0140-6736(19)31881-1.
   PubMed Web of Science ®Google Scholar
• Karp J, Dhillon I, Panchmatia R, Javer A. Subcutaneous mepolizumab injection: an adjunctive treatment for recalcitrant allergic fungal rhinosinusitis patients with asthma. Am J Rhinol Allergy 2020;Aug 20:1945892420951486. doi:https://doi.org/10.1177/1945892420951486.
   Google Scholar
• Lombardo N, Pelaia C, Ciriolo M, Della Corte M, Piazzetta G, Lobello N, Viola P, Pelaia G. Real-life effects of benralizumab on allergic chronic rhinosinusitis and nasal polyposis associated with severe asthma. Int J Immunopathol Pharmacol 2020;34:205873842095085. doi:https://doi.org/10.1177/2058738420950851.
   Web of Science ®Google Scholar
• Chong LY, Piromchai P, Sharp S, Snidvongs K, Philpott C, Hopkins C, Burton MJ. Biologics for chronic rhinosinusitis. Cochrane Database Syst Rev 2020;2(2):CD013513. doi:https://doi.org/10.1002/14651858.CD013513.pub2.
   PubMedGoogle Scholar
• Sindwani R, Han JK, Soteres DF, Messina JC, Carothers JL, Mahmoud RA, Djupesland PG. NAVIGATE I: randomized, placebo-controlled, double-blind trial of the exhalation delivery system with fluticasone for chronic rhinosinusitis with nasal polyps. Am J Rhinol Allergy 2019;33(1):69–82. doi:https://doi.org/10.1177/1945892418810281.
   PubMed Web of Science ®Google Scholar
• Messina J, Offman E, Carothers J, Mahmoud R. A randomized comparison of the pharmacokinetics and bioavailability of fluticasone propionate delivered via Xhance exhalation delivery system versus flonase nasal spray and flovent HFA inhalational aerosol. Clin Ther 2019;41(11):2343–2356. doi:https://doi.org/10.1016/j.clinthera.2019.09.013.
   PubMed Web of Science ®Google Scholar
• Passali D, Spinosi MC, Crisanti A, Bellussi LM. Mometasone furoate nasal spray: a systematic review. Multidiscip Respir Med 2016;11:18. doi:https://doi.org/10.1186/s40248-016-0054-3.
   PubMedGoogle Scholar
• Van Gerven L, Langdon C, Cordero A, Cardelús S, Mullol J, Alobid I. Lack of long-term add-on effect by montelukast in postoperative chronic rhinosinusitis patients with nasal polyps. Laryngoscope 2018;128(8):1743–1751. doi:https://doi.org/10.1002/lary.26989.
   PubMed Web of Science ®Google Scholar
• Singh A, Luong AU, Fong KJ, Ow RA, Han JK, Gerencer R, Stolovitzky JP, Stambaugh JW, Raman A. Bioabsorbable steroid-releasing implants in the frontal sinus ostia: a pooled analysis. Int Forum Allergy Rhinol 2018;9(2):131–139. doi:https://doi.org/10.1002/alr.22238.
   PubMed Web of Science ®Google Scholar
• Neubauer PD, Schwam ZG, Manes RP. Comparison of intranasal fluticasone spray, budesonide atomizer, and budesonide respules in patients with chronic rhinosinusitis with polyposis after endoscopic sinus surgery. Int Forum Allergy Rhinol 2016;6(3):233–237. doi:https://doi.org/10.1002/alr.21688.
   PubMed Web of Science ®Google Scholar
• Soler ZM, Rosenbloom JS, Skarada D, Gutman M, Hoy MJ, Nguyen SA. Prospective, multicenter evaluation of balloon sinus dilation for treatment of pediatric chronic rhinosinusitis. Int Forum Allergy Rhinol 2017;7(3):221–229. doi:https://doi.org/10.1002/alr.21889.
   PubMed Web of Science ®Google Scholar
• Cao Y, Hong H, Sun Y, Lai Y, Xu R, Shi J, Chen F. The effects of endoscopic sinus surgery on pulmonary function in chronic rhinosinusitis patients with asthma: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol 2019;276(5):1405–1411. doi:https://doi.org/10.1007/s00405-019-05337-4.
   PubMed Web of Science ®Google Scholar
• Pinto Bezerra Soter AC, Bezerra TF, Pezato R, Teles Abdo TR, Pilan RM, Pinna FR, Gevaert P, van Zele T, Bachert C, Voegels RL. Prospective open-label evaluation of long-term low-dose doxycycline for difficult-to-treat chronic rhinosinusitis with nasal polyps. Rhinology 2017;55(2):175–180. doi:https://doi.org/10.4193/Rhin15.291.
   PubMed Web of Science ®Google Scholar
• Parasher AK, Kidwai SM, Konuthula N, Goljo E, Pan S, Saini AT, Del Signore A, Iloreta AM, Govindaraj S, Malkin BD. The role of doxycycline in the management of chronic rhinosinusitis with nasal polyps. Am J Otolaryngol 2019;40(4):467–472. doi:https://doi.org/10.1016/j.amjoto.2019.03.004.
   PubMed Web of Science ®Google Scholar
• Lal D, Jategaonkar AA, Borish L, Chambliss LR, Gnagi SH, Hwang PH, Rank MA, Stankiewicz JA, Lund VJ. Management of rhinosinusitis during pregnancy: systematic review and expert panel recommendations. Rhinology 2016;54(2):99–104. doi:https://doi.org/10.4193/Rhin15.228.
   PubMed Web of Science ®Google Scholar
• Arndal E, Sørensen AL, Lapperre TS, Said N, Trampedach C, Aanaes K, Alanin MC, Christensen KB, Backer V, von Buchwald C. Chronic rhinosinusitis in COPD: a prevalent but unrecognized comorbidity impacting health related quality of life. Respir Med 2020;171:106092.
   PubMed Web of Science ®Google Scholar
• Øie MR, Dahlslett SB, Sue-Chu M, Helvik AS, Steinsvåg SK, Thorstensen WM. Rhinosinusitis without nasal polyps in COPD. ERJ Open Res 2020;6(2):00015-2020. doi:https://doi.org/10.1183/23120541.00015-2020.
   PubMedGoogle Scholar
• Handley E, Nicolson CH, Hew M, Lee AL. Prevalence and clinical implications of chronic rhinosinusitis in people with bronchiectasis: a systematic review. J Allergy Clin Immunol Pract 2019;7(6):2004–2012.e1. doi:https://doi.org/10.1016/j.jaip.2019.02.026.
   PubMed Web of Science ®Google Scholar
• Wang Y, Yang HB. Effects of functional endoscopic sinus surgery on the treatment of bronchiectasis combined with chronic rhino-sinusitis. Acta Oto-Laryngol 2016;136(8):860–863. doi:https://doi.org/10.3109/00016489.2016.1157730.
   PubMed Web of Science ®Google Scholar
• Mainz JG, Schien C, Schiller I, Schädlich K, Koitschev A, Koitschev C, Riethmüller J, Graepler-Mainka U, Wiedemann B, Beck JF. Sinonasal inhalation of dornase alfa administered by vibrating aerosol to cystic fibrosis patients: a double-blind placebo-controlled cross-over trial. J Cyst Fibros 2014;13(4):461–470. doi:https://doi.org/10.1016/j.jcf.2014.02.005.
   PubMed Web of Science ®Google Scholar
• Mainz JG, Schumacher U, Schädlich K, Hentschel J, Koitschev C, Koitschev A, Riethmüller J, Prenzel F, Sommerburg O, Wiedemann B, Cooperators, et al. Sino nasal inhalation of isotonic versus hypertonic saline (6.0%) in CF patients with chronic rhinosinusitis – results of a multicenter, prospective, randomized, double-blind, controlled trial. J Cyst Fibros 2016;15(6):e57–e66. doi:https://doi.org/10.1016/j.jcf.2016.05.003.
   PubMedGoogle Scholar
• Mahdavinia M, Schleimer R, Keshavarzian A. Sleep disruption in chronic rhinosinusitis. Expert Rev Anti Infect Ther 2017;15(5):457–465. doi:https://doi.org/10.1080/14787210.2017.1294063.
   PubMed Web of Science ®Google Scholar
• Alt JA, Ramakrishnan VR, Platt MP, Kohli P, Storck KA, Schlosser RJ, Soler ZM. Sleep quality outcomes after medical and surgical management of chronic rhinosinusitis. Int Forum Allergy Rhinol 2017;7(2):113–118. doi:https://doi.org/10.1002/alr.21860.
   PubMed Web of Science ®Google Scholar
• Sukato DC, Abramowitz JM, Boruk M, Goldstein NA, Rosenfeld RM. Endoscopic sinus surgery improves sleep quality in chronic rhinosinusitis: a systematic review and meta-analysis. Otolaryngol Head Neck Surg 2018;158(2):249–256. doi:https://doi.org/10.1177/0194599817737977.
   PubMed Web of Science ®Google Scholar
• Langdon C, Mullol J. Nasal polyps in patients with asthma: prevalence, impact, and management challenges. J Asthma Allergy 2016;9:45–53. doi:https://doi.org/10.2147/JAA.S86251.
   PubMed Web of Science ®Google Scholar
• Canonica GW, Blasi F, Paggiaro P, Senna G, Passalacqua G, Spanevello A, Aliberti S, Bagnasco D, Bonavia M, Bonini M, SANI (Severe Asthma Network Italy), et al. Oral Corticosteroid sparing with biologics in severe asthma: a remark of the Severe Asthma Network in Italy (SANI). World Allergy Organ J 2020;13(10):100464. doi:https://doi.org/10.1016/j.waojou.2020.100464.
   PubMed Web of Science ®Google Scholar
• Wu D, Bleier BS, Li L, Zhan X, Zhang L, Lv Q, Wang J, Wei Y. Clinical phenotypes of nasal polyps and comorbid asthma based on cluster analysis of disease history. J Allergy Clin Immunol Pract 2018;6(4):1297–1305.e1. doi:https://doi.org/10.1016/j.jaip.2017.09.020.
   PubMed Web of Science ®Google Scholar
• Canonica GW, Malvezzi L, Blasi F, Paggiaro P, Mantero M, Senna G, Heffler E, Severe Asthma Network Italy (SANI). Chronic rhinosinusitis with nasal polyps impact in severe asthma patients: evidences from the Severe Asthma Network Italy (SANI) registry. Respir Med 2020;166:105947. doi:https://doi.org/10.1016/j.rmed.2020.105947.
   PubMed Web of Science ®Google Scholar
• Venkatesan N, Lavigne P, Lavigne F, Hamid Q. Effects of fluticasone furoate on clinical and immunological outcomes (IL-17) for patients with nasal polyposis naive to steroid treatment. Ann Otol Rhinol Laryngol 2016;125(3):213–218. doi:https://doi.org/10.1177/0003489415606449.
   PubMed Web of Science ®Google Scholar
• Bachert C, Mannent L, Naclerio RM, Mullol J, Ferguson BJ, Gevaert P, Hellings P, Jiao L, Wang L, Evans RR, et al. Effect of subcutaneous dupilumab on nasal polyp burden in patients with chronic sinusitis and nasal polyposis: a randomized clinical trial. JAMA 2016;315(5):469–479. doi:https://doi.org/10.1001/jama.2015.19330.
   PubMed Web of Science ®Google Scholar
• Rivero A, Liang J. Anti-IgE and Anti-IL5 biologic therapy in the treatment of nasal polyposis: a systematic review and meta-analysis. Ann Otol Rhinol Laryngol 2017;126(11):739–747. doi:https://doi.org/10.1177/0003489417731782.
   PubMed Web of Science ®Google Scholar
• Bleecker ER, Wechsler ME, FitzGerald JM, Menzies-Gow A, Wu Y, Hirsch I, Goldman M, Newbold P, Zangrilli JG. Baseline patient factors impact on the clinical efficacy of benralizumab for severe asthma. Eur Respir J 2018;52(4):1800936. doi:https://doi.org/10.1183/13993003.00936-2018.
   PubMed Web of Science ®Google Scholar
• Hayashi H, Fukutomi Y, Mitsui C, Kajiwara K, Watai K, Kamide Y, Nakamura Y, Hamada Y, Tomita Y, Sekiya K, et al. Omalizumab for aspirin hypersensitivity and leukotriene overproduction in aspirin-exacerbated Respiratory Disease. A randomized controlled trial. Am J Respir Crit Care Med 2020;201(12):1488–1498. doi:https://doi.org/10.1164/rccm.201906-1215OC.
   PubMed Web of Science ®Google Scholar
• Le PT, Soler ZM, Jones R, Mattos JL, Nguyen SA, Schlosser RJ. Systematic review and meta-analysis of SNOT-22 outcomes after surgery for chronic rhinosinusitis with nasal polyposis. Otolaryngol Head Neck Surg 2018;159(3):414–423. doi:https://doi.org/10.1177/0194599818773065.
   PubMed Web of Science ®Google Scholar
• Kelemence A, Abadoglu O, Gumus C, Berk S, Epozturk K, Akkurt I. The frequency of chronic rhinosinusitis/nasal polyp in COPD and its effect on the severity of COPD. COPD 2011;8(1):8–12. doi:https://doi.org/10.3109/15412555.2010.540272.
   PubMedGoogle Scholar
• Zamarron E, Romero D, Fernández-Lahera J, Villasante C, Pinilla I, Barranco P, Dominguez-Ortega J, Álvarez-Sala Walther RR. Should we consider paranasal and chest computed tomography in severe asthma patients?Respir Med 2020;169:106013. doi:https://doi.org/10.1016/j.rmed.2020.106013.
   PubMed Web of Science ®Google Scholar
• Kang SH, Dalcin P. d T R, Piltcher OB, Migliavacca R. d O. Migliavacca Rde O. Chronic rhinosinusitis and nasal polyposis in cystic fibrosis: update on diagnosis and treatment. J Bras Pneumol 2015;41(1):65–76. doi:https://doi.org/10.1590/S1806-37132015000100009.
   PubMed Web of Science ®Google Scholar
• Torre C, Capasso R, Zaghi S, Williams R, Liu SY-C. High incidence of posterior nasal cavity obstruction in obstructive sleep apnea patients. Sleep Sci Pract 2017;1(1):8. doi:https://doi.org/10.1186/s41606-016-0002-3.
   Google Scholar
• Migueis DP, Lacerda GCB, Lopes MC, Azevedo-Soster LMSF, Thuler LCS, Lemes LNA, Araujo-Melo MH. Obstructive sleep apnea in patients with chronic rhinosinusitis with nasal polyps: a cross-sectional study. Sleep Med 2019;64:43–47. doi:https://doi.org/10.1016/j.sleep.2019.06.006.
   PubMed Web of Science ®Google Scholar
• Jian L, Yi W, Zhang N, Wen W, Krysko O, Song WJ, Bachert C. Perspective: COVID-19, implications of nasal diseases and consequences for their management. J Allergy Clin Immunol 2020;146(1):67–69. doi:https://doi.org/10.1016/j.jaci.2020.04.030.
   PubMed Web of Science ®Google Scholar
• Scadding GK, Hellings PW, Bachert C, Bjermer L, Diamant Z, Gevaert P, Kjeldsen A, Kleine-Tebbe J, Klimek L, Muraro A, Wahn U, et al. Allergic respiratory disease care in the COVID-19 era: a EUFOREA statement. World Allergy Org J 2020;13(5):100124. doi:https://doi.org/10.1016/j.waojou.2020.100124.
   PubMed Web of Science ®Google Scholar
• Bousquet J, Jutel M, Akdis CA, Klimek L, Pfaar O, Nadeau KC, Eiwegger T, Bedbrook A, Ansotegui IJ, Anto JM, et al. ARIA-EAACI statement on asthma and COVID-19 (June 2, 2020). Allergy 2020. doi:https://doi.org/10.1111/all.14471.
   Web of Science ®Google Scholar
• Heffler E, Detoraki A, Contoli M, Papi A, Paoletti G, Malipiero G, Brussino L, Crimi C, Morrone D, Padovani M, et al. COVID-19 in Severe Asthma Network in Italy (SANI) patients: clinical features, impact of comorbidities and treatments. Allergy 2020. doi:https://doi.org/10.1111/all.14532.
   Web of Science ®Google Scholar
• Matucci A, Caminati M, Vivarelli E, Vianello A, Micheletto C, Menzella F, Crisafulli E, Passalacqua G, Bagnasco D, Lombardi C, et al. COVID-19 in severe asthmatic patients during ongoing treatment with biologicals targeting type 2 inflammation: results from a multicenter Italian survey. Allergy 2020. doi: doi:https://doi.org/10.1111/all.14516.
   Google Scholar
• Chhiba KD, Patel GB, Vu THT, Chen MM, Guo A, Kudlaty E, Mai Q, Yeh C, Muhammad LN, Harris KE, et al. Prevalence and characterization of asthma in hospitalized and nonhospitalized patients with COVID-19. J Allergy Clin Immunol 2020;146(2):307–314.e4. doi:https://doi.org/10.1016/j.jaci.2020.06.010.
   PubMed Web of Science ®Google Scholar
• Zhang JJ, Dong X, Cao YY, Yuan YD, Yang YB, Yan YQ, Akdis CA, Gao YD. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy 2020;75(7):1730–1741. doi:https://doi.org/10.1111/all.14238.
   PubMed Web of Science ®Google Scholar
• Antonicelli L, Tontini C, Manzotti G, Ronchi L, Vaghi A, Bini F, Scartabellati A, Menzella F, De Michele F, Musarra A, et al. Severe asthma in adults does not significantly affect the outcome of COVID-19 disease: results from the Italian Severe Asthma Registry. Allergy 2020. doi: doi:https://doi.org/10.1111/all.14558.
   Google Scholar
• Halpin DMG, Singh D, Hadfield RM. Inhaled corticosteroids and COVID-19: a systematic review and clinical perspective. Eur Respir J 2020;55(5):2001009. doi:https://doi.org/10.1183/13993003.01009-2020.
   PubMed Web of Science ®Google Scholar
• Bhalla A, Mukherjee M, Radford K, Nazy I, Kjarsgaard M, Bowdish DME, Nair P. Dupilumab, severe asthma airway responses, and SARS-CoV-2 serology. Allergy 2020. doi: doi:https://doi.org/10.1111/all.14534.
   Google Scholar
• Sajuthi SP, DeFord P, Li Y, Jackson ND, Montgomery MT, Everman JL, Rios CL, Pruesse E, Nolin JD, Plender EG, et al. Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium. Nat Commun 2020;11(1):5139. doi:https://doi.org/10.1038/s41467-020-18781-2.
   PubMed Web of Science ®Google Scholar
• DuBuske L, Newbold P, Wu Y, Trudo F. Seasonal variability of exacerbations of severe, uncontrolled eosinophilic asthma and clinical benefits of benralizumab. Allergy Asthma Proc 2018;39(5):345–349. doi:https://doi.org/10.2500/aap.2018.39.4162.
   PubMed Web of Science ®Google Scholar
• Thangaraju P, Venkatesan N, Sudha TYS, Venkatesan S, Thangaraju E. Role of Dupilumab in approved indications of COVID-19 patient: an efficacy-based nonsystematic critical analysis. SN Compr Clin Med 2020;10:1–5. doi:https://doi.org/10.1007/s42399-020-00510-x.
   Google Scholar
• Morais-Almeida M, Aguiar R, Martin B, Ansotegui IJ, Ebisawa M, Arruda LK, Caminati M, Canonica GW, Carr T, Chupp G, et al. COVID-19, asthma, and biological therapies: what we need to know. World Allergy Organ J 2020;13(5):100126. doi:https://doi.org/10.1016/j.waojou.2020.100126.
   PubMed Web of Science ®Google Scholar
• Cariou B, Hadjadj S, Wargny M, Pichelin M, Al-Salameh A, Allix I, Amadou C, Arnault G, Baudoux F, Bauduceau B, CORONADO Investigators, et al. Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study. Diabetologia 2020;63(8):1500–1515. doi:https://doi.org/10.1007/s00125-020-05180-x.
   PubMed Web of Science ®Google Scholar
• Jain V, Yuan JM. Predictive symptoms and comorbidities for severe COVID-19 and intensive care unit admission: a systematic review and meta-analysis. Int J Public Health 2020;65(5):533–546. doi:https://doi.org/10.1007/s00038-020-01390-7.
   PubMed Web of Science ®Google Scholar
• Alqahtani JS, Oyelade T, Aldhahir AM, Alghamdi SM, Almehmadi M, Alqahtani AS, Quaderi S, Mandal S, Hurst JR. Prevalence, severity and mortality associated with COPD and smoking in patients with COVID-19: a rapid systematic review and meta-analysis. PLoS One 2020;15(5):e0233147. doi:https://doi.org/10.1371/journal.pone.0233147.
   PubMed Web of Science ®Google Scholar
• Guan WJ, Liang WH, Zhao Y, Liang HR, Chen ZS, Li YM, Liu XQ, Chen RC, Tang CL, Wang T, et al. China Medical Treatment Expert Group for COVID-19. Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis. Eur Respir J 2020;55(5):2000547. doi:https://doi.org/10.1183/13993003.00547-2020.
   PubMed Web of Science ®Google Scholar
• Song J, Zeng M, Wang H, Qin C, Hou HY, Sun ZY, Xu SP, Wang GP, Guo CL, Deng YK, et al. Distinct effects of asthma and COPD comorbidity on disease expression and outcome in patients with COVID-19. Allergy 2020. doi:https://doi.org/10.1111/all.14517.
   Web of Science ®Google Scholar
• Attaway AA, Zein J, Hatipoğlu US. SARS-CoV-2 infection in the COPD population is associated with increased healthcare utilization: an analysis of Cleveland clinic’s COVID-19 registry. E Clin Med 2020;26:100515. doi:https://doi.org/10.1016/j.eclinm.2020.100515.
   Google Scholar
• Wu F, Zhou Y, Wang Z, Xie M, Shi Z, Tang Z, Li X, Lei C, Li Y, Ni Z, Medical Treatment Expert Group for COPD and COVID-19, et al. Clinical characteristics of COVID-19 infection in chronic obstructive pulmonary disease: a multicenter, retrospective, observational study. J Thorac Dis 2020;12(5):1811–1823. doi:https://doi.org/10.21037/jtd-20-1914.
   PubMed Web of Science ®Google Scholar
• Giorgi Rossi P, Marino M, Formisano D, Venturelli F, Vicentini M, Grilli R, Reggio Emilia COVID-19 Working Group. Characteristics and outcomes of a cohort of COVID-19 patients in the Province of Reggio Emilia. Plos One 2020;15(8):e0238281. doi:https://doi.org/10.1371/journal.pone.0238281.
   PubMed Web of Science ®Google Scholar
• Smith AA, Fridling J, Ibhrahim D, Porter PSJr. Identifying patients at greatest risk of mortality due to COVID-19: a New England perspective. West J Emerg Med 2020;21(4):785–789. doi:https://doi.org/10.5811/westjem.2020.6.47957.
   PubMed Web of Science ®Google Scholar
• Radtke T, Haile SR, Dressel H, Benden C. Recommended shielding against COVID-19 impacts physical activity levels in adults with cystic fibrosis. J Cyst Fibros 2020;(20):30828–30826. doi:https://doi.org/10.1016/j.jcf.2020.08.013.
   Google Scholar
• Mondejar-Lopez P, Quintana-Gallego E, Giron-Moreno RM, Cortell-Aznar I, Ruiz de Valbuena-Maiz M, Diab-Caceres L, Prados-Sanchez C, Alvarez-Fernandez A, Garcia-Marcos PW, Peñalver-Mellado C, CF-COVID19-Spain Registry Group, et al. Impact of SARS-CoV-2 infection in patients with cystic fibrosis in Spain: incidence and results of the national CF-COVID19-Spain survey. Respir Med 2020;170:106062. doi:https://doi.org/10.1016/j.rmed.2020.106062.
   PubMed Web of Science ®Google Scholar