442
Views
2
CrossRef citations to date
0
Altmetric
Pharmacotherapy

Use of inhaled corticosteroids on an intermittent or as-needed basis in pediatric asthma: a systematic review of the literature

, MD, MSC, PhD, , MD, MSC & , MD
Pages 2189-2200 | Received 05 Jul 2021, Accepted 16 Nov 2021, Published online: 26 Nov 2021

References

  • Akinbami LJ, Moorman JE, Garbe PL, Sondik EJ. Status of childhood asthma in the United States, 1980–2007. Pediatrics. 2009;123 Suppl 3:S131–S145. doi:10.1542/peds.2008-2233C.
  • Dennis RJ, Caraballo L, García E, Rojas MX, Rondon MA, Pérez A, Aristizabal G, Peñaranda A, Barragan AM, Ahumada V, et al. Prevalence of asthma and other allergic conditions in Colombia 2009-2010: a cross-sectional study. BMC Pulm Med. 2012;12:17. doi:10.1186/1471-2466-12-17.
  • Chipps B, Taylor B, Bayer V, Shaikh A, Mosnaim G, Trevor J, Rogers S, Del Aguila M, Paek D, Wechsler ME, et al. Relative efficacy and safety of inhaled corticosteroids in patients with asthma: Systematic review and network meta-analysis. Ann Allergy Asthma Immunol. 2020;125(2):163–170.e3. doi:10.1016/j.anai.2020.04.006.
  • Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. 2020. Available at: www.ginasthma.org. (Accessed February 4, 2021).
  • Boulet LP, Vervloet D, Magar Y, Foster JM. Adherence: the goal to control asthma. Clin Chest Med. 2012;33(3):405–417. doi:10.1016/j.ccm.2012.06.002.
  • de Benedictis FM, Bush A. Corticosteroids in respiratory diseases in children. Am J Respir Crit Care Med. 2012;185(1):12–23. doi:10.1164/rccm.201107-1174CI.
  • Rodrigo GJ. Rapid effects of inhaled corticosteroids in acute asthma: an evidence-based evaluation. Chest. 2006;130(5):1301–1311. doi:10.1378/chest.130.5.1301.
  • Reddel HK. Response: The most fundamental change in asthma management in 30 years? Eur Respir J. 2019;54(5):1901860. doi:10.1183/13993003.01860-2019.
  • Reddel HK, FitzGerald JM, Bateman ED, Bacharier LB, Becker A, Brusselle G, Buhl R, Cruz AA, Fleming L, Inoue H, et al. GINA 2019: a fundamental change in asthma management: Treatment of asthma with short-acting bronchodilators alone is no longer recommended for adults and adolescents. Eur Respir J. 2019;53(6):1901046. doi:10.1183/13993003.01046-2019.
  • Bisgaard H, Le Roux P, Bjåmer D, Dymek A, Vermeulen JH, Hultquist C. Budesonide/formoterol maintenance plus reliever therapy: a new strategy in pediatric asthma. Chest. 2006;130(6):1733–1743. doi:10.1378/chest.130.6.1733.
  • Martinez FD, Chinchilli VM, Morgan WJ, Boehmer SJ, Lemanske RF, Mauger DT, Strunk RC, Szefler SJ, Zeiger RS, Bacharier LB, et al. Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA): a randomised, double-blind, placebo-controlled trial. Lancet. 2011;377(9766):650–657. doi:10.1016/S0140-6736(10)62145-9.
  • Zeiger RS, Mauger D, Bacharier LB, Guilbert TW, Martinez FD, Lemanske RF, Strunk RC, Covar R, Szefler SJ, Boehmer S, Jr., et al. Daily or intermittent budesonide in preschool children with recurrent wheezing. N Engl J Med. 2011;365(21):1990–2001. doi:10.1056/NEJMoa1104647.
  • Szefler SJ. Update on the NAEPPCC Asthma Guidelines: the wait is over, or is it? J Allergy Clin Immunol. 2020;146(6):1275–1280. doi:10.1016/j.jaci.2020.01.025.
  • Chauhan BF, Chartrand C, Ducharme FM; Cochrane Airways Group. Intermittent versus daily inhaled corticosteroids for persistent asthma in children and adults. Cochrane Database Syst Rev. 2013;(2):CD009611. doi:10.1002/14651858.CD009611.pub3.
  • Rodrigo GJ, Castro-Rodríguez JA. Daily vs. intermittent inhaled corticosteroids for recurrent wheezing and mild persistent asthma: a systematic review with meta-analysis. Respir Med. 2013;107(8):1133–1140. doi:10.1016/j.rmed.2013.05.005.
  • Shea BJ, Reeves BC, Wells G, Thuku M, Hamel C, Moran J, Moher D, Tugwell P, Welch V, Kristjansson E, et al. AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ. 2017;358:j4008. doi:10.1136/bmj.j4008.
  • Connett G, Lenney W. Prevention of viral induced asthma attacks using inhaled budesonide. Arch Dis Child. 1993;68(1):85–87. doi:10.1136/adc.68.1.85.
  • Svedmyr J, Nyberg E, Asbrink-Nilsson E, Hedlin G. Intermittent treatment with inhaled steroids for deterioration of asthma due to upper respiratory tract infections. Acta Paediatr. 1995;84(8):884–888. doi:10.1111/j.1651-2227.1995.tb13786.x.
  • Svedmyr J, Nyberg E, Thunqvist P, Asbrink-Nilsson E, Hedlin G. Prophylactic intermittent treatment with inhaled corticosteroids of asthma exacerbations due to airway infections in toddlers. Acta Paediatr. 2007;88(1):42–47. doi:10.1111/j.1651-2227.1999.tb01266.x.
  • Ducharme FM, Lemire C, Noya FJD, Davis GM, Alos N, Leblond H, Savdie C, Collet J-P, Khomenko L, Rivard G, et al. Preemptive use of high-dose fluticasone for virus-induced wheezing in young children. N Engl J Med. 2009;360(4):339–353. doi:10.1056/NEJMoa0808907.
  • Fitzpatrick AM, Jackson DJ, Mauger DT, Boehmer SJ, Phipatanakul W, Sheehan WJ, Moy JN, Paul IM, Bacharier LB, Cabana MD, et al. Individualized therapy for persistent asthma in young children. J Allergy Clin Immunol. 2016;138(6):1608–1618.e12. doi:10.1016/j.jaci.2016.09.028.
  • O’Byrne PM, Bisgaard H, Godard PP, Pistolesi M, Palmqvist M, Zhu Y, Ekström T, Bateman ED. Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma. Am J Respir Crit Care Med. 2005;171(2):129–136. doi:10.1164/rccm.200407-884OC.
  • Bisgaard H, Hermansen MN, Loland L, Halkjaer LB, Buchvald F. Intermittent inhaled corticosteroids in infants with episodic wheezing. N Engl J Med. 2006;354(19):1998–2005. doi:10.1056/NEJMoa054692.
  • Turpeinen M, Nikander K, Pelkonen AS, Syvänen P, Sorva R, Raitio H, Malmberg P, Juntunen-Backman K, Haahtela T. Daily versus as-needed inhaled corticosteroid for mild persistent asthma (The Helsinki early intervention childhood asthma study). Arch Dis Child. 2008;93(8):654–659. doi:10.1136/adc.2007.116632.
  • Bacharier LB, Phillips BR, Zeiger RS, Szefler SJ, Martinez FD, Lemanske RF, Sorkness CA, Bloomberg GR, Morgan WJ, Paul IM, Jr., et al. Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing. J Allergy Clin Immunol. 2008;122(6):1127–1135.e8. doi:10.1016/j.jaci.2008.09.029.
  • Papi A, Nicolini G, Baraldi E, Boner AL, Cutrera R, Rossi GA, Fabbri LM; BEclomethasone and Salbutamol Treatment (BEST) for Children Study Group. Regular vs prn nebulized treatment in wheeze preschool children. Allergy. 2009;64(10):1463–1471. doi:10.1111/j.1398-9995.2009.02134.x.
  • Turpeinen M, Pelkonen AS, Nikander K, Sorva R, Selroos O, Juntunen-Backman K, Haahtela T. Bone mineral density in children treated with daily or periodical inhaled budesonide: the Helsinki Early Intervention Childhood Asthma study. Pediatr Res. 2010;68(2):169–173. doi:10.1203/PDR.0b013e3181e69e36.
  • Camargos P, Affonso A, Calazans G, Ramalho L, Ribeiro ML, Jentzsch N, Senna S, Stein RT. On-demand intermittent beclomethasone is effective for mild asthma in Brazil. Clin Transl Allergy. 2018;8:7. doi:10.1186/s13601-018-0192-0.
  • Sumino K, Bacharier LB, Taylor J, Chadwick-Mansker K, Curtis V, Nash A, Jackson-Triggs S, Moen J, Schechtman KB, Garbutt J, et al. A pragmatic trial of symptom-based inhaled corticosteroid use in African-American children with mild asthma. J Allergy Clin Immunol Practice. 2020;8(1):176–185.e2. doi:10.1016/j.jaip.2019.06.030.
  • Jorup C, Lythgoe D, Bisgaard H. Budesonide/formoterol maintenance and reliever therapy in adolescent patients with asthma. Eur Respir J. 2018;51(1):1701688. doi:10.1183/13993003.01688-2017.
  • Szefler SJ, Chipps B. Challenges in the treatment of asthma in children and adolescents. Ann Allergy Asthma Immunol. 2018;120(4):382–388. doi:10.1016/j.anai.2018.01.003.
  • Papi A, Canonica GW, Maestrelli P, Paggiaro P, Olivieri D, Pozzi E, Crimi N, Vignola AM, Morelli P, Nicolini G, et al. Rescue use of beclomethasone and albuterol in a single inhaler for mild asthma. N Engl J Med. 2007;356(20):2040–2052. doi:10.1056/NEJMoa063861.
  • Kew KM, Karner C, Mindus SM, Ferrara G; Cochrane Airways Group. Combination formoterol and budesonide as maintenance and reliever therapy versus combination inhaler maintenance for chronic asthma in adults and children. Cochrane Database Syst Rev. 2013;(12):CD009019. doi:10.1002/14651858.CD009019.pub2.
  • Wang G, Zhang X, Zhang HP, Wang L, Kang DY, Barnes PJ, Wang G. Corticosteroid plus β2-agonist in a single inhaler as reliever therapy in intermittent and mild asthma: a proof-of-concept systematic review and meta-analysis. Respir Res. 2017;18(1):203. doi:10.1186/s12931-017-0687-6.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.