Severe asthma exacerbation rates are increased among female, Black, Hispanic, and younger adult patients: results from the US CHRONICLE study

References

• Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, Adcock IM, Bateman ED, Bel EH, Bleecker ER, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014;43(2):343–373. doi:10.1183/09031936.00202013.
   PubMed Web of Science ®Google Scholar
• Global Initiative for Asthma (GINA). Global Strategy for Asthma Management and Prevention. 2020. https://ginasthma.org/wp-content/uploads/2020/04/GINA-2020-full-report_-final-_wms.pdf. Accessed October 20, 2020.
   Google Scholar
• Trevor JL, Chipps BE. Severe asthma in primary care: identification and management. Am J Med. 2018;131(5):484–491. doi:10.1016/j.amjmed.2017.12.034.
   PubMed Web of Science ®Google Scholar
• Bahadori K, Doyle-Waters MM, Marra C, Lynd L, Alasaly K, Swiston J, FitzGerald JM. Economic burden of asthma: a systematic review. BMC Pulm Med. 2009;9:24. doi:10.1186/1471-2466-9-24.
   PubMedGoogle Scholar
• Cisternas MG, Blanc PD, Yen IH, Katz PP, Earnest G, Eisner MD, Shiboski S, Yelin EH. A comprehensive study of the direct and indirect costs of adult asthma. J Allergy Clin Immunol. 2003;111(6):1212–1218. doi:10.1067/mai.2003.1449.
   PubMed Web of Science ®Google Scholar
• Kerkhof M, Tran TN, Soriano JB, Golam S, Gibson D, Hillyer EV, Price DB. Healthcare resource use and costs of severe, uncontrolled eosinophilic asthma in the UK general population. Thorax. 2018;73(2):116–124. doi:10.1136/thoraxjnl-2017-210531.
   PubMed Web of Science ®Google Scholar
• Sullivan K, Thakur N. Structural and social determinants of health in asthma in developed economies: a scoping review of literature published between 2014 and 2019. Curr Allergy Asthma Rep. 2020;20(2):5. doi:10.1007/s11882-020-0899-6.
   PubMed Web of Science ®Google Scholar
• Institute of Medicine (US) Committee on Assessing Interactions Among Social Behavioral and Genetic Factors in Health. Genes, Behavior, and the Social Environment: Moving Beyond the Nature/Nurture Debate(LM Hernandez, DG Blazer, editors). Washington (DC): National Academies Press (US); 2006.
   Google Scholar
• Schatz M, Camargo CAJr. The relationship of sex to asthma prevalence, health care utilization, and medications in a large managed care organization. Ann Allergy Asthma Immunol. 2003;91(6):553–558. doi:10.1016/S1081-1206(10)61533-5.
   PubMed Web of Science ®Google Scholar
• Senna G, Latorre M, Bugiani M, Caminati M, Heffler E, Morrone D, Paoletti G, Parronchi P, Puggioni F, Blasi F, et al. Sex differences in severe asthma: results from Severe Asthma Network in Italy-SANI. Allergy Asthma Immunol Res. 2021;13(2):219–228. doi:10.4168/aair.2021.13.2.219.
   PubMed Web of Science ®Google Scholar
• Shah R, Newcomb DC. Sex bias in asthma prevalence and pathogenesis. Front Immunol. 2018;9:2997. doi:10.3389/fimmu.2018.02997.
   PubMed Web of Science ®Google Scholar
• Tsai C-L, Delclos GL, Huang JS, Hanania NA, Camargo CA. Age-related differences in asthma outcomes in the United States, 1988-2006. Ann Allergy Asthma Immunol. 2013;110(4):240–246.e1. doi:10.1016/j.anai.2013.01.002.
   PubMed Web of Science ®Google Scholar
• Tsai C-L, Lee W-Y, Hanania NA, Camargo CA. Age-related differences in clinical outcomes for acute asthma in the United States, 2006-2008. J Allergy Clin Immunol. 2012;129(5):1252–1258.e1. doi:10.1016/j.jaci.2012.01.061.
   PubMed Web of Science ®Google Scholar
• Pakkasela J, Ilmarinen P, Honkamäki J, Tuomisto LE, Andersén H, Piirilä P, Hisinger-Mölkänen H, Sovijärvi A, Backman H, Lundbäck B, et al. Age-specific incidence of allergic and non-allergic asthma. BMC Pulm Med. 2020;20(1):9. doi:10.1186/s12890-019-1040-2.
   PubMed Web of Science ®Google Scholar
• Tan DJ, Walters EH, Perret JL, Lodge CJ, Lowe AJ, Matheson MC, Dharmage SC. Age-of-asthma onset as a determinant of different asthma phenotypes in adults: a systematic review and meta-analysis of the literature. Expert Rev Respir Med. 2015;9(1):109–123. doi:10.1586/17476348.2015.1000311.
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control and Prevention. 2019. 2018 National Health Interview Survey data. U.S. Department of Health & Human Services. https://www.cdc.gov/asthma/nhis/2018/data.htm. Accessed March 8, 2021.
   Google Scholar
• Asthma and Allergy Foundation of America. 2020. Asthma disparities in America: a roadmap to reducing burden on racial and ethnic minorities. aafa.org/asthmadisparities. Accessed March 8, 2021.
   Google Scholar
• Haselkorn T, Szefler SJ, Chipps BE, Bleecker ER, Harkins MS, Paknis B, Kianifard F, Ortiz B, Zeiger RS. Disease burden and long-term risk of persistent very poorly controlled asthma: TENOR II. J Allergy Clin Immunol Pract. 2020;8(7):2243–2253. doi:10.1016/j.jaip.2020.02.040.
   PubMed Web of Science ®Google Scholar
• Ambrose CS, Chipps BE, Moore WC, Soong W, Trevor J, Ledford DK, Carr WW, Lugogo N, Trudo F, Tran TN, et al. The CHRONICLE study of US adults with subspecialist-treated severe asthma: objectives, design, and initial results. Pragmat Obs Res. 2020;11:77–90. doi:10.2147/POR.S251120.
   PubMed Web of Science ®Google Scholar
• Nathan RA, Sorkness CA, Kosinski M, Schatz M, Li JT, Marcus P, Murray JJ, Pendergraft TB. Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol. 2004;113(1):59–65. doi:10.1016/j.jaci.2003.09.008.
   PubMed Web of Science ®Google Scholar
• Jones PW, Forde Y. St. George’s Respiratory Questionnaire Manual. London, UK: Division of Cardiac and Vascular Science, St George’s, University of London; 2009.
   Google Scholar
• Jones PW, Quirk FH, Baveystock CM. The St. George’s Respiratory Questionnaire. Respir Med. 1991;85 Suppl B:25–31; discussion 33–37. doi:10.1016/S0954-6111(06)80166-6.
   PubMed Web of Science ®Google Scholar
• Food and Drug Administration. Collection of race and ethnicity data in clinical trials: guidance for industry and Food and Drug Administration Staff. 2016. https://www.fda.gov/regulatory-information/search-fda-guidance-documents/collection-race-and-ethnicity-data-clinical-trials. Accessed March 8, 2021.
   Google Scholar
• Colombo D, Zagni E, Ferri F, Canonica GW. Gender differences in asthma perception and its impact on quality of life: a post hoc analysis of the PROXIMA (Patient Reported Outcomes and Xolair® In the Management of Asthma) study. Allergy Asthma Clin Immunol. 2019;15:65. doi:10.1186/s13223-019-0380-z.
   PubMed Web of Science ®Google Scholar
• Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, D’Agostino R, Castro M, Curran-Everett D, Fitzpatrick AM, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med. 2010;181(4):315–323. doi:10.1164/rccm.200906-0896OC.
   PubMed Web of Science ®Google Scholar
• Milger K, Korn S, Buhl R, Hamelmann E, Herth FJF, Gappa M, Drick N, Fuge J, Suhling H. Age- and sex-dependent differences in patients with severe asthma included in the German Asthma Net cohort. Respir Med. 2020;162:105858. doi:10.1016/j.rmed.2019.105858.
   PubMed Web of Science ®Google Scholar
• Kynyk JA, Mastronarde JG, McCallister JW. Asthma, the sex difference. Curr Opin Pulm Med. 2011;17(1):6–11. doi:10.1097/MCP.0b013e3283410038.
   PubMed Web of Science ®Google Scholar
• Haselkorn T, Lee JH, Mink DR, Weiss ST. Racial disparities in asthma-related health outcomes in severe or difficult-to-treat asthma. Ann Allergy Asthma Immunol. 2008;101(3):256–263. doi:10.1016/S1081-1206(10)60490-5.
   PubMed Web of Science ®Google Scholar
• Grossman NL, Ortega VE, King TS, Bleecker ER, Ampleford EA, Bacharier LB, Cabana MD, Cardet JC, Carr TF, Castro M, et al. Exacerbation-prone asthma in the context of race and ancestry in Asthma Clinical Research Network trials. J Allergy Clin Immunol. 2019;144(6):1524–1533. doi:10.1016/j.jaci.2019.08.033.
   PubMed Web of Science ®Google Scholar
• Rumpel JA, Ahmedani BK, Peterson EL, Wells KE, Yang M, Levin AM, Yang JJ, Kumar R, Burchard EG, Williams LK, et al. Genetic ancestry and its association with asthma exacerbations among African American subjects with asthma. J Allergy Clin Immunol. 2012;130(6):1302–1306. doi:10.1016/j.jaci.2012.09.001.
   PubMed Web of Science ®Google Scholar
• National Center for Health Statistics. 2017. National Hospital Ambulatory Medical Care Survey: 2017 emergency department summary tables. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention. https://www.cdc.gov/nchs/data/nhamcs/web_tables/2017_ed_web_tables-508.pdf. Accessed March 8, 2021.
   Google Scholar
• Fitzpatrick AM, Gillespie SE, Mauger DT, Phillips BR, Bleecker ER, Israel E, Meyers DA, Moore WC, Sorkness RL, Wenzel SE, et al. Racial disparities in asthma-related health care use in the National Heart, Lung, and Blood Institute’s Severe Asthma Research Program. J Allergy Clin Immunol. 2019;143(6):2052–2061. doi:10.1016/j.jaci.2018.11.022.
   PubMed Web of Science ®Google Scholar
• Cabana MD, Lara M, Shannon J. Racial and ethnic disparities in the quality of asthma care. Chest. 2007;132(5 Suppl):810S–817S. doi:10.1378/chest.07-1910.
   PubMed Web of Science ®Google Scholar
• Canino G, McQuaid EL, Rand CS. Addressing asthma health disparities: a multilevel challenge. J Allergy Clin Immunol. 2009;123(6):1209–1217; quiz 1218–1219. doi:10.1016/j.jaci.2009.02.043.
   PubMed Web of Science ®Google Scholar
• Wechsler ME, Castro M, Lehman E, Chinchilli VM, Sutherland ER, Denlinger L, Lazarus SC, Peters SP, Israel E. Impact of race on asthma treatment failures in the asthma clinical research network. Am J Respir Crit Care Med. 2011;184(11):1247–1253. doi:10.1164/rccm.201103-0514OC.
   PubMed Web of Science ®Google Scholar
• Rosser FJ, Forno E, Cooper PJ, Celedón JC. Asthma in Hispanics. An 8-year update. Am J Respir Crit Care Med. 2014;189(11):1316–1327. doi:10.1164/rccm.201401-0186PP.
   PubMed Web of Science ®Google Scholar
• Tessum CW, Apte JS, Goodkind AL, Muller NZ, Mullins KA, Paolella DA, Polasky S, Springer NP, Thakrar SK, Marshall JD, et al. Inequity in consumption of goods and services adds to racial-ethnic disparities in air pollution exposure. Proc Natl Acad Sci U S A. 2019;116(13):6001–6006. doi:10.1073/pnas.1818859116.
   PubMed Web of Science ®Google Scholar
• Lu X, Li R, Yan X. Airway hyperresponsiveness development and the toxicity of PM2.5. Environ Sci Pollut Res Int. 2021;28(6):6374–6391. doi:10.1007/s11356-020-12051-w.
   PubMed Web of Science ®Google Scholar
• Orellano P, Quaranta N, Reynoso J, Balbi B, Vasquez J. Effect of outdoor air pollution on asthma exacerbations in children and adults: Systematic review and multilevel meta-analysis. PLoS One. 2017;12(3):e0174050. doi:10.1371/journal.pone.0174050.
   PubMed Web of Science ®Google Scholar
• Zheng X-Y, Ding H, Jiang L-N, Chen S-W, Zheng J-P, Qiu M, Zhou Y-X, Chen Q, Guan W-J. Association between air pollutants and asthma emergency room visits and hospital admissions in time series studies: a systematic review and meta-analysis. PLoS One. 2015;10(9):e0138146. doi:10.1371/journal.pone.0138146.
   PubMed Web of Science ®Google Scholar
• Teague WG, Phillips BR, Fahy JV, Wenzel SE, Fitzpatrick AM, Moore WC, Hastie AT, Bleecker ER, Meyers DA, Peters SP, et al. Baseline features of the Severe Asthma Research Program (SARP III) cohort: differences with age. J Allergy Clin Immunol Pract. 2018;6(2):545–554.e4. doi:10.1016/j.jaip.2017.05.032.
   PubMed Web of Science ®Google Scholar
• Zein JG, Udeh BL, Teague WG, Koroukian SM, Schlitz NK, Bleecker ER, Busse WB, Calhoun WJ, Castro M, Comhair SA, et al. Impact of age and sex on outcomes and hospital cost of acute asthma in the United States, 2011–2012. PLoS One. 2016;11(6):e0157301. doi:10.1371/journal.pone.0157301.
   PubMed Web of Science ®Google Scholar