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Articles

HRCT quantitative analysis of airway remodeling and airway trapping in the small airway asthma phenotype and its correlation with pulmonary function

, MSORCID Icon, , MSORCID Icon, , MDORCID Icon, , MSORCID Icon, , MSORCID Icon, , MSORCID Icon, , MSORCID Icon, , MSORCID Icon, , MDORCID Icon, , MSORCID Icon, , MSORCID Icon & , MD, PhDORCID Icon show all
Pages 32-42 | Received 01 Aug 2021, Accepted 24 Dec 2021, Published online: 13 Jan 2022

References

  • van den Berge M, Ten Hacken N, Cohen J, Douma WR, Postma DS. Small airway disease in asthma and COPD: clinical implications. Chest. 2011;139(2):412–423. doi:10.1378/chest.10-1210.
  • Carroll N, Elliot J, Morton A, James A. The structure of large and small airways in nonfatal and fatal asthma. Am Rev Respir Dis. 1993;147(2):405–410. doi:10.1164/ajrccm/147.2.405.
  • Jiang D, Wang Z, Shen C, Jin C, Yu N, Wang J, Yin N, Guo Y. Small airway dysfunction may be an indicator of early asthma: findings from high-resolution CT. Ann Allergy Asthma Immunol. 2019;122(5):498–501. doi:10.1016/j.anai.2019.02.024.
  • In T Veen JC, Beekman AJ, Bel EH, Sterk PJ. Recurrent exacerbations in severe asthma are associated with enhanced airway closure during stable episodes. Am J Respir Crit Care Med. 2000;161(6):1902–1906.doi:10.1164/ajrccm.161.6.9906075.
  • Scichilone N, Battaglia S, Taormina S, Modica V, Pozzecco E, Bellia V. Alveolar nitric oxide and asthma control in mild untreated asthma. J Allergy Clin Immunol. 2013;131(6):1513–1517. doi:10.1016/j.jaci.2013.03.009.
  • Lipworth B, Manoharan A, Anderson W. Unlocking the quiet zone: the small airway asthma phenotype. Lancet Respir Med. 2014; 2(6):497–506. doi:10.1016/S2213-2600(14)70103-1.
  • Tashkin DP, Kim HJ, Zeidler M, Kleerup E, Goldin J. Evaluating small-airways disease in asthmatic patients: the utility of quantitative computed tomography. J Allergy Clin Immunol. 2017; 139(1):49–51. doi:10.1016/j.jaci.2016.11.010.
  • Abdo M, Trinkmann F, Kirsten AM, Pedersen F, Herzmann C, von Mutius E, Kopp MV, Hansen G, Waschki B, Rabe KF, et al. Small airway dysfunction links asthma severity with physical activity and symptom control. J Allergy Clin Immunol. 2021. doi:10.1016/j.jaip.2021.04.035.
  • Fuchs O, Bahmer T, Weckmann M, Dittrich AM, Schaub B, Rösler B, Happle C, Brinkmann F, Ricklefs I, König IR, ALLIANCE Study Group as part of the German Centre for Lung Research (DZL), et al. The all age asthma cohort (ALLIANCE) – from early beginnings to chronic disease: a longitudinal cohort study. BMC Pulm Med. 2018;18(1):140. doi:10.1186/s12890-018-0705-6.
  • Bahmer T, Waschki B, Schatz F, Herzmann C, Zabel P, Kirsten AM, Rabe KF, Watz H. Physical activity, airway resistance and small airway dysfunction in severe asthma. Eur Respir J. 2017;49(1):1601827. doi:10.1183/13993003.01827-2016.
  • Usmani OS, Singh D, Spinola M, Bizzi A, Barnes PJ. The prevalence of small airways disease in adult asthma: a systematic literature review. Respir. Med. 2016;116:19–27. doi:10.1016/j.rmed.2016.05.006.
  • Manoharan A, Anderson WJ, Lipworth J, Ibrahim I, Lipworth BJ. Small airway dysfunction is associated with poorer asthma control. Eur Respir J. 2014;44(5):1353–1355. doi:10.1183/09031936.00082314.
  • Finkas LK, Martin R. Role of small airways in asthma. Immunol Allergy Clin North Am. 2016;36(3):473–482. doi:10.1016/j.iac.2016.03.009.
  • Cottini M, Licini A, Lombardi C, Berti A. Clinical characterization and predictors of IOS-defined small-airway dysfunction in asthma. J Allergy Clin Immunol. 2020;8(3):997–1004. doi:10.1016/j.jaip.2019.10.040.
  • Gove K, Wilkinson T, Jack S, Ostridge K, Thompson B, Conway J. Systematic review of evidence for relationships between physiological and CT indices of small airways and clinical outcomes in COPD. Respir Med. 2018;139:117–125. doi:10.1016/j.rmed.2018.05.005.
  • Konstantinos Katsoulis K, Kostikas K, Kontakiotis T. Techniques for assessing small airways function: Possible applications in asthma and COPD. Respir Med. 2016;119:e2–e9. doi:10.1016/j.rmed.2013.05.003.
  • Cosio M, Ghezzo H, Hogg JC, Corbin R, Loveland M, Dosman J, Macklem PT. The relations between structural changes in small airways and pulmonary-function tests. N Engl J Med. 1978;298(23):1277–1281. doi:10.1056/NEJM197806082982303.
  • Niimi A, Matsumoto H, Amitani R, Nakano Y, Mishima M, Minakuchi M, Nishimura K, Itoh H, Izumi T. Airway wall thickness in asthma assessed by computed tomography. Relation to clinical indices. Am J Respir Crit Care Med. 2000;162(4):1518–1523. doi:10.1164/ajrccm.162.4.9909044.
  • Asker S, Asker M, Ozbay B. Evaluation of airway wall thickness via high-resolution computed tomography in mild intermittent asthma. Respir Care. 2014;59(4):550–556. doi:10.4187/respcare.02780.
  • Jiang D, Wang Z, Yu N, Shen C, Deng L, Guo Y. Airway remodeling in asthma: evaluation in 5 consecutive bronchial generations by using high-resolution computed tomography. Respir Care. 2018;63(11):1399–1406. doi:10.4187/respcare.06050.
  • Aysola RS, Hoffman EA, Gierada D, Wenzel S, Cook-Granroth J, Tarsi J, Zheng J, Schechtman KB, Ramkumar TP, Cochran R, et al. Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathology. Chest. 2008; 134(6):1183–1191. doi:10.1378/chest.07-2779.
  • Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention. Update 2015. Available at http://www.ginasthma.com.
  • Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P, ATS/ERS Task Force, et al. Standardisation of spirometry. Eur Respir J. 2005;26(2):319–338. doi:10.1183/09031936.05.00034805.
  • Oostveen E, MacLeod D, Lorino H, Farré R, Hantos Z, Desager K, Marchal F, The forced oscillation technique in clinical practice: methodology, recommendations and future developments. Eur Respir J. 2003;22(6):1026–1041. doi:10.1183/09031936.03.00089403.
  • Gupta S, Hartley R, Khan UT, Singapuri A, Hargadon B, Monteiro W, Pavord ID, Sousa AR, Marshall RP, Subramanian D, et al. Quantitative computed tomography-derived clusters: redefining airway remodeling in asthmatic patients. J Allergy Clin Immunol. 2014;133(3):729–738. doi:10.1016/j.jaci.2013.09.039.
  • Gono H, Fujimoto K, Kawakami S, Kubo K. Evaluation of airway wall thickness and air trapping by HRCT in asymptomatic asthma. Eur Respir J. 2003;22(6):965–971. doi:10.1183/09031936.03.00085302.
  • Hartley RA, Barker BL, Newby C, Pakkal M, Baldi S, Kajekar R, Kay R, Laurencin M, Marshall RP, Sousa AR, et al. Relationship between lung function and quantitative computed tomographic parameters of airway remodeling, air trapping, and emphysema in patients with asthma and chronic obstructive pulmonary disease: a single-center study. J Allergy Clin Immunol. 2016;137(5):1413–1422. doi:10.1016/j.jaci.2016.02.001.
  • Chen H, Zeng QS, Zhang M, Chen RC, Xia TT, Wang W, Xu X, Guan Y. Quantitative low-dose computed tomography of the lung parenchyma and airways for the differentiation between chronic obstructive pulmonary disease and asthma patients. Respiration. 2017;94(4):366–374. doi:10.1159/000478531.
  • Postma DS, Brightling C, Fabbri L, van der Molen T, Nicolini G, Papi A, Rabe KF, Siddiqui S, Singh D, van den Berge M, et al. Unmet needs for the assessment of small airways dysfunction in asthma: introduction to the ATLANTIS study. Eur Respir J. 2015;45(6):1534–1538. doi:10.1183/09031936.00214314.
  • Postma DS, Brightling C, Baldi S, Van den Berge M, Fabbri LM, Gagnatelli A, Papi A, Van der Molen T, Rabe KF, Siddiqui S, ATLANTIS study group, et al. Exploring the relevance and extent of small airways dysfunction in asthma (ATLANTIS): baseline data from a prospective cohort study. Lancet Respir Med. 2019;7(5):402–416. doi:10.1016/S2213-2600(19)30049-9.
  • Hough KP, Curtiss ML, Blain TJ, Liu RM, Trevor J, Deshane JS, Thannickal VJ. Airway remodeling in asthma. Front Med (Lausanne). 2020;7:191. doi:10.3389/fmed.2020.00191.
  • Sorkness RL, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Chung KF, Curran-Everett D, Erzurum SC, Gaston BM, Israel E, et al. Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation. J Appl Physiol. 2008;104(2):394–403. doi:10.1152/japplphysiol.00329.2007.
  • Sutherland ER, Martin RJ, Bowler RP, Zhang Y, Rex MD, Kraft M. Physiologic correlates of distal lung inflammation in asthma. J Allergy Clin Immunol. 2004;113(6):1046–1050. doi:10.1016/j.jaci.2004.03.016.
  • Bickel S, Popler J, Lesnick B, Eid N. Impulse oscillometry: interpretation and practical applications. Chest. 2014;146(3):841–847. doi:10.1378/chest.13-1875.
  • McNulty W, Usmani OS. Techniques of assessing small airways dysfunction. Eur Clin Respir J. 2014;1(1):25898. doi:10.3402/ecrj.v1.25898.
  • Brashier B, Salvi S. Measuring lung function using sound waves: role of the forced oscillation technique and impulse oscillometry system. Breathe (Sheff.) 2015;11(1):57–65. doi:10.1183/20734735.020514.
  • Fuso L, Macis G, Condoluci C, Sbarra M, Contu C, Conte EG, Angeletti G, Montuschi P. Impulse oscillometry and nitrogen washout test in the assessment of small airway dysfunction in asthma: correlation with quantitative computed tomography. J Asthma. 2019;56(3):323–331. doi:10.1080/02770903.2018.1452032.
  • Nakano Y, Muro S, Sakai H, Hirai T, Chin K, Tsukino M, Nishimura K, Itoh H, Paré PD, Hogg JC, et al. Computed tomographic measurements of airway dimensions and emphysema in smokers. correlation with lung function. Am J Respir Crit Care Med. 2000;162(3 Pt 1):1102–1108. doi:10.1164/ajrccm.162.3.9907120.
  • Siddiqui S, Gupta S, Cruse G, Haldar P, Entwisle J, Mcdonald S, Whithers PJ, Hainsworth SV, Coxson HO, Brightling C. Airway wall geometry in asthma and nonasthmatic eosinophilic bronchitis. Allergy. 2009; 64(6):951–958. doi:10.1111/j.1398-9995.2009.01951.x.

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