558
Views
5
CrossRef citations to date
0
Altmetric
Articles

Long-term retention rate of mepolizumab treatment in severe asthma: a 36-months real-life experience

, MDORCID Icon, , MD, , MD, , BS, , MD, , MD, , MD, , MD, , MD, phd & , MD, phd show all
Pages 158-166 | Received 19 Oct 2021, Accepted 27 Jan 2022, Published online: 12 Feb 2022

References

  • Global Initiative for Asthma. Global strategy for asthma management and prevention; 2020. [accessed 2020 Sep 30]. https://ginasthma.org.
  • Mincheva R, Ekerljung L, Bossios A, Lundbäck B, Lötvall J. High prevalence of severe asthma in a large random population study. J Allergy Clin Immunol. 2018;141(6):2256–2264. doi:10.1016/j.jaci.2017.07.047.
  • GINA. Difficult to treat & severe asthma in adolescent and adult patients. Diagnosis and management; 2019. https://ginasthma.org.
  • Inoue H, Kozawa M, Milligan KL, Funakubo M, Igarashi A, Loefroth E. A retrospective cohort study evaluating healthcare resource utilization in patients with asthma in Japan. NPJ Prim Care Respir Med. 2019;29(1):13–20.
  • Israel E, Reddel HK. Severe and difficult-to-treat asthma in adults. N Engl J Med. 2017;377(10):965–976. doi:10.1056/NEJMra1608969.
  • Volmer T, Effenberger T, Trautner C, Buhl R. Consequences of long-term oral corticosteroid therapy and its side-effects in severe asthma in adults: a focused review of the impact data in the literature. Eur Respir J. 2018; 52(4):1800703. doi:10.1183/13993003.00703-2018.
  • Denton E, Price DB, Tran TN, Canonica GW, Menzies-Gow A, FitzGerald JM, Sadatsafavi M, Perez de Llano L, Christoff G, Quinton A, et al. Cluster analysis of inflammatory biomarker expression in the international severe asthma registry. J Allergy Clin Immunol Pract. 2021;9(7):2680–2688. doi:10.1016/j.jaip.2021.02.059.
  • Gauthier M, Ray A, Wenzel SE. Evolving concepts of asthma. Am J Respir Crit Care Med. 2015; 192(6):660–668. doi:10.1164/rccm.201504-0763PP.
  • Wenzel SE. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med. 2012; 18(5):716–725. doi:10.1038/nm.2678.
  • Casciano J, Krishnan JA, Small MB, Buck PO, Gopalan G, Li C, Kemp R, Dotiwala Z. Value of peripheral blood eosinophil markers to predict severity of asthma. BMC Pulm Med. 2016; 16(1):109–116. doi:10.1186/s12890-016-0271-8.
  • Lee Y, Park Y, Kim C, et al. Longitudinal outcomes of severe asthma: real-world evidence of multidimensional analyses. J Allergy Clin Immunol Pract. 2020;S2213(20):31105–31103.
  • Bel EH, Wenzel SE, Thompson PJ, Prazma CM, Keene ON, Yancey SW, Ortega HG, Pavord ID, Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma. N Engl J Med. 2014;371(13):1189–1197. doi:10.1056/NEJMoa1403291.
  • Haldar P, Brightling CE, Hargadon B, Gupta S, Monteiro W, Sousa A, Marshall RP, Bradding P, Green RH, Wardlaw AJ, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med. 2009; 360(10):973–984. doi:10.1056/NEJMoa0808991.
  • Nair P, Pizzichini MMM, Kjarsgaard M, Inman MD, Efthimiadis A, Pizzichini E, Hargreave FE, O’Byrne PM. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med. 2009; 360(10):985–993. doi:10.1056/NEJMoa0805435.
  • Harvey ES, Langton D, Katelaris C, Stevens S, Farah CS, Gillman A, Harrington J, Hew M, Kritikos V, Radhakrishna N, et al. Mepolizumab effectiveness and identification of super-responders in severe asthma. Eur Respir J. 2020; 55(5):1902420. doi:10.1183/13993003.02420-2019.
  • Kavanagh JE, d’Ancona G, Elstad M, Green L, Fernandes M, Thomson L, Roxas C, Dhariwal J, Nanzer AM, Kent BD, et al. Real-world effectiveness and the characteristics of a "super-responder" to mepolizumab in severe eosinophilic asthma. Chest. 2020; 158(2):491–500. doi:10.1016/j.chest.2020.03.042.
  • Mukherjee M, Forero DF, Tran S, Boulay M-E, Bertrand M, Bhalla A, Cherukat J, Al-Hayyan H, Ayoub A, Revill SD, et al. Suboptimal treatment response to anti-IL-5 monoclonal antibodies in severe eosinophilic asthmatics with airway autoimmune phenomena. Eur Respir J. 2020; 56(4):2000117. doi:10.1183/13993003.00117-2020.
  • Schleich F, Graff S, Nekoee H, Moermans C, Henket M, Sanchez C, Paulus V, Guissard F, Donneau A‐F, Louis R, et al. Real-world experience with mepolizumab: does it deliver what it has promised? Clin Exp Allergy. 2020; 50(6):687–695. doi:10.1111/cea.13601.
  • Taillé C, Chanez P, Devouassoux G, Didier A, Pison C, Garcia G, Charriot J, Bouée S, Gruber A, Pribil C, et al. Mepolizumab in a population with severe eosinophilic asthma and corticosteroid dependence: results from a French early access programme. Eur Respir J. 2020; 55(6):1902345. doi:10.1183/13993003.02345-2019.
  • Israel E, Canonica GW, Brusselle G, et al. Real-life effectiveness of mepolizumab in severe asthma: a ­systematic literature review. J Asthma. 2021;24:1–17. doi:10.1080/02770903.2021.2008431. Epub ahead of print.
  • Pelaia C, Crimi C, Pelaia G, Nolasco S, Campisi R, Heffler E, Valenti G, Crimi N. Real-life evaluation of mepolizumab efficacy in patients with severe eosinophilic asthma, according to atopic trait and allergic phenotype. Clin Exp Allergy. 2020; 50(7):780–788. doi:10.1111/cea.13613.
  • Lombardi C, Bagnasco D, Caruso C, D’Amato M, Menzella F, Milanese M, Senna G, Canonica GW, Passalacqua G. Analysis of the drop-out rate in patients receiving mepolizumab for severe asthma in real life. Pulm Pharmacol Ther. 2019; 54:87–89. doi:10.1016/j.pupt.2018.12.003.
  • Crimi C, Campisi R, Cacopardo G, Intravaia R, Nolasco S, Porto M, Pelaia C, Crimi N. Real-life effectiveness of mepolizumab in patients with severe refractory eosinophilic asthma and multiple comorbidities. World Allergy Organ J. 2020; 13(9):100462. doi:10.1016/j.waojou.2020.100462.
  • Pavord ID, Korn S, Howarth P, Bleecker ER, Buhl R, Keene ON, Ortega H, Chanez P. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet. 2012; 380(9842):651–659. doi:10.1016/S0140-6736(12)60988-X.
  • Ortega HG, Liu MC, Pavord ID, Brusselle GG, FitzGerald JM, Chetta A, Humbert M, Katz LE, Keene ON, Yancey SW, et al. Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med. 2014; 371(13):1198–1207. doi:10.1056/NEJMoa1403290.
  • Busse W, Spector S, Rosén K, Wang Y, Alpan O. High eosinophil count: a potential biomarker for assessing successful omalizumab treatment effects. J Allergy Clin Immunol. 2013;132(2):485–486.e11. doi:10.1016/j.jaci.2013.02.032.
  • Ortega HG, Yancey SW, Mayer B, Gunsoy NB, Keene ON, Bleecker ER, Brightling CE, Pavord ID. Severe eosinophilic asthma treated with mepolizumab stratified by baseline eosinophil thresholds: a secondary analysis of the DREAM and MENSA studies. Lancet Respir Med. 2016; 4(7):549–556. doi:10.1016/S2213-2600(16)30031-5.
  • Bourdin A, Shaw D, Menzies-Gow A, FitzGerald JM, Bleecker ER, Busse WW, Ferguson GT, Brooks L, Barker P, Gil EG, et al. Two-year integrated steroid-sparing analysis and safety of benralizumab for severe asthma. J Asthma. 2021;58(4):514–522. doi:10.1080/02770903.2019.1705333.
  • Price DB, Trudo F, Voorham J, Xu X, Kerkhof M, Ling Zhi Jie J, Tran TN. Adverse outcomes from initiation of systemic corticosteroids for asthma: long-term observational study. J Asthma Allergy. 2018;11:193–204. doi:10.2147/JAA.S176026.
  • Huang C-C, Chang P-H, Wu P-W, Wang C-H, Fu C-H, Huang C-C, Tseng H-J, Lee T-J. Impact of nasal symptoms on the evaluation of asthma control. Medicine. 2017; 96(8):e6147. doi:10.1097/MD.0000000000006147.
  • Karatzanis A, Chatzidakis A, Milioni A, Vlaminck S, Kawauchi H, Velegrakis S, Prokopakis E. Contemporary use of corticosteroids in rhinology. Curr Allergy Asthma Rep. 2017;17(2):11–22. doi:10.1007/s11882-017-0679-0.
  • Hopkins C, Browne JP, Slack R, Lund V, Brown P. The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict? Otolaryngol Head Neck Surg. 2007; 137(4):555–661. doi:10.1016/j.otohns.2007.02.004.
  • Humbert M, Albers FC, Bratton DJ, Yancey SW, Liu MC, Hozawa S, Llanos J-P, Kwon N. Effect of mepolizumab in severe eosinophilic asthma according to omalizumab eligibility. Respir Med. 2019; 154:69–75. doi:10.1016/j.rmed.2019.06.004.
  • Sposato B, Scalese M, Camiciottoli G, Carpagnano GE, Pelaia C, Santus P, Maniscalco M, Corsico A, Grosso A, Baglioni S, et al. Mepolizumab effectiveness and allergic status in real life. Int Arch Allergy Immunol. 2021;182(4):311–318. doi: 10.1159/000511147.
  • Matucci A, Vultaggio A, Maggi E, Kasujee I. Is IgE or eosinophils the key player in allergic asthma pathogenesis? Are we asking the right question? Respir Res. 2018;19(1):113–123. doi:10.1186/s12931-018-0813-0.
  • Wen T, Rothenberg ME. The regulatory function of eosinophils. Microbiol Spectr. 2016; 4(5):10–1128. doi:10.1128/microbiolspec.MCHD-0020-2015.
  • Berek C. Eosinophils can more than kill. J Exp Med. 2018; 215(8):1967–1969. doi:10.1084/jem.20181152.
  • Abdala-Valencia H, Coden ME, Chiarella SE, Jacobsen EA, Bochner BS, Lee JJ, Berdnikovs S. Shaping eosinophil identity in the tissue contexts of development, homeostasis, and disease. J Leukoc Biol. 2018; 104(1):95–108. doi:10.1002/JLB.1MR1117-442RR.
  • Akdis CA, Arkwright PD, Brüggen MC, Busse W, Gadina M, Guttman-Yassky E, Kabashima K, Mitamura Y, Vian L, Wu J, et al. Type 2 immunity in the skin and lungs. Allergy. 2020; 75(7):1582–1605. doi:10.1111/all.14318.
  • Schmid-Grendelmeier P, Altznauer F, Fischer B, Bizer C, Straumann A, Menz G, Blaser K, Wüthrich B, Simon H-U. Eosinophils express functional IL-13 in eosinophilic inflammatory diseases. J Immunol. 2002; 169(2):1021–1027. doi:10.4049/jimmunol.169.2.1021.
  • Choi Y, Sim S, Park HS. Distinct functions of eosinophils in severe asthma with type 2 phenotype: clinical implications. Korean J Intern Med. 2020;35(4):823–833. doi:10.3904/kjim.2020.022.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.