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Articles

Club cell 10-kDa protein (CC10) as a surrogate for identifying type 2 asthma phenotypes

, MD, PhD, , MD, PhD, , MD, PhD, , PhD, , PhD, , MD, , MD, PhD & , MD, PhD show all
Pages 203-211 | Received 08 Nov 2021, Accepted 07 Feb 2022, Published online: 15 Feb 2022

References

  • Wenzel SE. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med. 2012;18(5):716–725. doi: 10.1038/nrd3792.
  • Chung KF. Asthma phenotyping: a necessity for improved therapeutic precision and new targeted therapies. J Intern Med. 2016;279(2):192–204. doi:10.1111/joim.12382.
  • Crimi C, Campisi R, Nolasco S, Ferri S, Cacopardo G, Impellizzeri P, Pistorio MP, Fagone E, Pelaia C, Heffler E, et al. Type 2-high severe asthma with and without bronchiectasis: a prospective observational multicentre study. J Asthma Allergy. 2021;14:1441–1452. doi:10.2147/JAA.S332245.
  • Crimi C, Campisi R, Cacopardo G, Intravaia R, Nolasco S, Porto M, Pelaia C, Crimi N. Real-life effectiveness of mepolizumab in patients with severe refractory eosinophilic asthma and multiple comorbidities. World Allergy Organ J. 2020;13(9):100462. doi:10.1016/j.waojou.2020.100462.
  • Coverstone AM, Seibold MA, Peters MC. Diagnosis and management of T2-high asthma. J Allergy Clin Immunol Pract. 2020;8(2):442–450. doi:10.1016/j.jaip.2019.11.020.
  • Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, Ellwanger A, Sidhu SS, Dao-Pick TP, Pantoja C, et al. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci U S A. 2007;104(40):15858–15863. doi:10.1073/pnas.0707413104.
  • Fatemi F, Sadroddiny E, Gheibi A, Mohammadi FT, Kardar GA. Biomolecular markers in assessment and treatment of asthma. Respirology. 2014;19(4):514–523. doi:10.1111/resp.12284.
  • Busse WW, Holgate ST, Wenzel SW, Klekotka P, Chon Y, Feng J, Ingenito EP, Nirula A. Biomarker profiles in asthma with high vs low airway reversibility and poor disease control. CHEST. 2015;148(6):1489–1496. doi:10.1378/chest.14-2457.
  • Pavord ID, Afzalnia S, Menzies-Gow A, Heaney LG. The current and future role of biomarkers in type 2 cytokine-mediated asthma management. Clin Exp Allergy. 2017;47(2):148–160. doi:10.1111/cea.12881.
  • Liu Z, Lu X, Zhang XH, Bochner BS, Long XB, Zhang F, Wang H, Cui YH. Clara cell 10-kDa protein expression in chronic rhinosinusitis and its cytokine-driven regulation in sinonasal mucosa. ALLERGY. 2009;64(1):149–157. doi:10.1111/j.1398-9995.2008.01847.x.
  • Broeckaert F, Bernard A. Clara cell secretory protein (CC16): characteristics and perspectives as lung peripheral biomarker. Clin Exp Allergy. 2000;3(4):469–475. doi:10.1046/j.1365-2222.2000.00760.x.
  • Levin SW, Butler JD, Schumacher UK, Wightman PD, Mukherjee AB. Uteroglobin inhibits phospholipase A2 activity. Life Sci. 1986;38(20):1813–1819. doi:10.1016/0024-3205(86)90135-9.
  • Johansson S, Wennergren G, Aberg N, Rudin A. Clara cell 16-kd protein downregulates T(H)2 differentiation of human naive neonatal T cells. J Allergy Clin Immunol. 2007;120(2):308–314. doi:10.1016/j.jaci.2007.03.021.
  • Hung CH, Chen LC, Zhang Z, Chowdhury B, Lee WL, Plunkett B, Chen CH, Myers AC, Huang SK. Regulation of TH2 responses by the pulmonary Clara cell secretory 10-kd protein. J Allergy Clin Immunol. 2004;114(3):664–670. doi:10.1016/j.jaci.2004.05.042.
  • Wu CJ, Chen LC, Huang WC, Chuang CL, Kuo ML. Alleviation of lung inflammatory responses by adeno-associated virus 2/9 vector carrying CC10 in OVA-sensitized mice. Hum Gene Ther. 2013;24(1):48–57. doi:10.1089/hum.2012.039.
  • Shijubo N, Itoh Y, Yamaguchi T, Sugaya F, Hirasawa M, Yamada T, Kawai T, Abe S. Serum levels of Clara cell 10-kDa protein are decreased in patients with asthma. LUNG. 1999;177(1):45–52. doi:10.1007/PL00007626.
  • Global Initiative for Asthma. Global strategy for asthma management and prevention, 2021. Available from www.ginasthma.org.
  • Sze E, Bhalla A, Nair P. Mechanisms and therapeutic strategies for non-T2 asthma. ALLERGY. 2020;75(2):311–325. doi:10.1111/all.13985.
  • Louis R, Shute J, Biagi S, Stanciu L, Marrelli F, Tenor H, Hidi R, Djukanovic R. Cell infiltration, ICAM-1 expression, and eosinophil chemotactic activity in asthmatic sputum. Am J Respir Crit Care Med. 1997;155(2):466–472. doi:10.1164/ajrccm.155.2.9032180.
  • Exhaled NO. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med. 2005;171(8):912–930. doi:10.1164/rccm.200406-710ST.
  • Thomson NC. Novel approaches to the management of noneosinophilic asthma. Ther Adv Respir Dis. 2016;10(3):211–234. doi:10.1177/1753465816632638.
  • Agusti A, Anto JM, Auffray C, Barbe F, Barreiro E, Dorca J, Escarrabill J, Faner R, Furlong LI, Garcia-Aymerich J, et al. Personalized respiratory medicine: exploring the horizon, addressing the issues. Summary of a BRN-AJRCCM workshop held in Barcelona on June 12, 2014. Am J Respir Crit Care Med. 2015;191(4):391–401. doi:10.1164/rccm.201410-1935PP.
  • Bommart S, Marin G, Molinari N, Knabe L, Petit A, Chanez P, Gamez AS, Devautour C, Vachier I, Bourdin A. Club cell secretory protein serum concentration is a surrogate marker of small-airway involvement in asthmatic patients. J Allergy Clin Immunol. 2017;140(2):581–584. doi:10.1016/j.jaci.2016.09.063.
  • Guerra S, Vasquez MM, Spangenberg A, Halonen M, Martin RJ. Club cell secretory protein in serum and bronchoalveolar lavage of patients with asthma. J Allergy Clin Immunol. 2016;138(3):932–934.e1. doi:10.1016/j.jaci.2016.03.047.
  • Laucho-Contreras ME, Polverino F, Gupta K, Taylor KL, Kelly E, Pinto-Plata V, Divo M, Ashfaq N, Petersen H, Stripp B, et al. Protective role for club cell secretory protein-16 (CC16) in the development of COPD. Eur Respir J. 2015;45(6):1544–1556. doi:10.1183/09031936.00134214.
  • Gioldassi XM, Papadimitriou H, Mikraki V, Karamanos NK. Clara cell secretory protein: determination of serum levels by an enzyme immunoassay and its importance as an indicator of bronchial asthma in children. J Pharm Biomed Anal. 2004;34(4):823–826. doi:10.1016/S0731-7085(03)00570-3.
  • Ye Q, Fujita M, Ouchi H, Inoshima I, Maeyama T, Kuwano K, Horiuchi Y, Hara N, Nakanishi Y. Serum CC-10 in inflammatory lung diseases. Respiration. 2004;71(5):505–510. doi:10.1159/000080636.
  • Wang H, Liu Y, Liu Z. Clara cell 10-kD protein in inflammatory upper airway diseases. Curr Opin Allergy Clin Immunol. 2013;13(1):25–30. doi:10.1097/ACI.0b013e32835a5b35.
  • Pavlidis S, Takahashi K, Ng KKF, Xie J, Hoda U, Sun K, Elyasigomari V, Agapow P, Loza M, Baribaud F, et al. T2-high" in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin. Eur Respir J. 2019;53(1):1800938. doi:10.1183/13993003.00938-2018.
  • Hvidtfeldt M, Sverrild A, Backer V, Porsbjerg C. Airway hyperresponsiveness to mannitol improves in both type 2 high and type 2 low asthma after specialist management. J Asthma. 2021;58(9):1221–1228. Sep doi:10.1080/02770903.2020.1780255.
  • Zhu L, An L, Ran D, Lizarraga R, Bondy C, Zhou X, Harper RW, Liao SY, Chen Y. The club cell marker SCGB1A1 downstream of FOXA2 is reduced in asthma. Am J Respir Cell Mol Biol. 2019;60(6):695–704. doi:10.1165/rcmb.2018-0199OC.
  • Srisodsai A, Kurotani R, Chiba Y, Sheikh F, Young HA, Donnelly RP, Kimura S. Interleukin-10 induces uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through homeodomain transcription factor T/EBP/NKX2.1. J Biol Chem. 2004;279(52):54358–54368. doi:10.1074/jbc.M405331200.
  • Ramsay PL, Luo Z, Magdaleno SM, Whitbourne SK, Cao X, Park MS, Welty SE, Yu-Lee LY, DeMayo FJ. Transcriptional regulation of CCSP by interferon-gamma in vitro and in vivo. Am J Physiol Lung Cell Mol Physiol. 2003;284(1):L108–18. doi:10.1152/ajplung.00186.2002.
  • Zhai J, Insel M, Addison KJ, Stern DA, Pederson W, Dy A, Rojas-Quintero J, Owen CA, Sherrill DL, Morgan W, et al. Club cell secretory protein deficiency leads to altered lung function. Am J Respir Crit Care Med. 2019;199(3):302–312. doi:10.1164/rccm.201807-1345OC.
  • Rava M, Tares L, Lavi I, Barreiro E, Zock JP, Ferrer A, Muniozguren N, Nadif R, Cazzoletti L, Kauffmann F, et al. Serum levels of Clara cell secretory protein, asthma, and lung function in the adult general population. J Allergy Clin Immunol. 2013;132(1):230–232. doi:10.1016/j.jaci.2013.01.023.
  • Vestbo J, Edwards LD, Scanlon PD, Yates JC, Agusti A, Bakke P, Calverley PM, Celli B, Coxson HO, Crim C, et al. Changes in forced expiratory volume in 1 second over time in COPD. N Engl J Med. 2011;365(13):1184–1192. doi:10.1056/NEJMoa1105482.
  • Chen D, Zhang Y, Yao C, Li B, Li S, Liu W, Chen R, Shi F. Increased levels of serum IL-17 and induced sputum neutrophil percentage are associated with severe early-onset asthma in adults. Allergy Asthma Clin Immunol. 2021;17(1):64 doi:10.1186/s13223-021-00568-9.
  • Guerra S, Halonen M, Vasquez MM, Spangenberg A, Stern DA, Morgan WJ, Wright AL, Lavi I, Tares L, Carsin AE, et al. Relation between circulating CC16 concentrations, lung function, and development of chronic obstructive pulmonary disease across the lifespan: a prospective study. Lancet Respir Med. 2015;3(8):613–620. doi:10.1016/S2213-2600(15)00196-4.
  • Park HY, Churg A, Wright JL, Li Y, Tam S, Man SF, Tashkin D, Wise RA, Connett JE, Sin DD. Club cell protein 16 and disease progression in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2013;188(12):1413–1419. doi:10.1164/rccm.201305-0892OC.
  • Pang M, Liu HY, Li T, Wang D, Hu XY, Zhang XR, Yu BF, Guo R, Wang HL. Recombinant club cell protein 16 (CC16) ameliorates cigarette smoke‑induced lung inflammation in a murine disease model of COPD. Mol Med Rep. 2018;18(2):2198–2206. doi:10.3892/mmr.2018.9216.
  • Shijubo N, Itoh Y, Yamaguchi T, Shibuya Y, Morita Y, Hirasawa M, Okutani R, Kawai T, Abe S. Serum and BAL Clara cell 10 kDa protein (CC10) levels and CC10-positive bronchiolar cells are decreased in smokers. Eur Respir J. 1997 May;10(5):1108–1114. doi:10.1183/09031936.97.10051108.
  • Crimi C, Ferri S, Crimi N. Bronchiectasis and asthma: a dangerous liaison? Curr Opin Allergy Clin Immunol. 2019;19(1):46–52. doi:10.1097/ACI.0000000000000492.
  • Crimi C, Ferri S, Campisi R, Crimi N. The link between asthma and bronchiectasis: state of the art. Respiration. 2020;99(6):463–476. doi:10.1159/000507228. Epub 2020 May 28.

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