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Articles

Increased expression of ORMDL3 in allergic asthma: a case control and in vitro study

, MScORCID Icon, , MScORCID Icon, , PhDORCID Icon, , MSc, , MScORCID Icon, , MSc, , MScORCID Icon, , MSc, , PhDORCID Icon, , PhDORCID Icon, , MScORCID Icon, , MDORCID Icon, , MSc, , MSc, , MSc & , PhDORCID Icon show all
Pages 458-467 | Received 22 Dec 2021, Accepted 19 Mar 2022, Published online: 31 Mar 2022

References

  • Wu X-L, Li R, Zhang H-W, Jin R, Wang J-Y, Juan C-X, Lu K, Shu J, Wang L-L, Wang Y, et al. Methylation status of ORMDL3 regulates cytokine production and p-ERK/MMP9 pathway expression. Exp Cell Res. 2018;372(1):43–51. doi:10.1016/j.yexcr.2018.09.008.
  • Forno E, Wang T, Yan Q, Brehm J, Acosta-Perez E, Colon-Semidey A, Alvarez M, Boutaoui N, Cloutier M, Alcorn J, et al. A multiomics approach to identify genes associated with childhood asthma risk and morbidity. Am J Respir Cell Mol Biol. 2017;57(4):439–447. doi:10.1165/rcmb.2017-0002OC.
  • Chen J, Miller M, Unno H, Rosenthal P, Sanderson M, Broide DH. Orosomucoid-like 3 (ORMDL3) upregulates airway smooth muscle proliferation, contraction, and Ca2+ oscillations in asthma. J Allergy Clin Immunol. 2018;142(1):207–218.e6. doi:10.1016/j.jaci.2017.08.015.
  • Shi H, Cheng D, Yi L, Huo X, Zhang K, Zhen G. Association between ORMDL3 polymorphism and susceptibility to asthma: a meta-analysis. Int J Clin Exp Med. 2015;8(3):3173–3183.
  • Moffatt M, Kabesch M, Liang L, Dixon A, Strachan D, Heath S, Depner M, von Berg A, Bufe A, Rietschel E, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature. 2007;448(7152):470–473. doi:10.1038/nature06014.
  • Andiappan AK, Sio YY, Lee B, Suri BK, Matta SA, Lum J, Foo S, Koh G, Liu J, Zolezzi F, et al. Functional variants of 17q12-21 are associated with allergic asthma but not allergic rhinitis. J Allergy Clin Immunol. 2016;137(3):758–766.e3. doi:10.1016/j.jaci.2015.08.038.
  • Zhai WH, Song CY, Huang ZG, Sha H. Correlation between the genetic polymorphism of ORMDL3 gene and asthma risk: a meta-analysis. Genet Mol Res. 2015;14(2):7101–7112. doi:10.4238/2015.June.29.3.
  • Miller M, Rosenthal P, Beppu A, Mueller J, Hoffman H, Tam A, Doherty T, McGeough M, Pena C, Suzukawa M, et al. ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma. J Immunol. 2014;192(8):3475–3487. doi:10.4049/jimmunol.1303047.
  • Schedel M, Michel S, Gaertner V, Toncheva A, Depner M, Binia A, Schieck M, Rieger M, Klopp N, von Berg A, et al. Polymorphisms related to ORMDL3 are associated with asthma susceptibility, alterations in transcriptional regulation of ORMDL3, and changes in TH2 cytokine levels. J Allergy Clin Immunol. 2015;136(4):893–903.e14. doi:10.1016/j.jaci.2015.03.014.
  • Acevedo N, Reinius L, Greco D, Gref A, Orsmark-Pietras C, Persson H, Pershagen G, Hedlin G, Melén E, Scheynius A, et al. Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus. Hum Mol Genet. 2015;24(3):875–890. doi:10.1093/hmg/ddu479.
  • Moffatt M, Gut I, Demenais F, Strachan D, Bouzigon E, Heath S, von Mutius E, Farrall M, Lathrop M, Cookson W, GABRIEL Consortium, et al. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med. 2010;363(13):1211–1221. doi:10.1056/NEJMoa0906312.
  • Kang JG, Park JS, Ko J-H, Kim Y-S. Regulation of gene expression by altered promoter methylation using a CRISPR/Cas9-mediated epigenetic editing system. Sci Rep. 2019;9(1):11960. doi:10.1038/s41598-019-48130-3.
  • Berlivet S, Moussette S, Ouimet M, Verlaan D, Koka V, Al Tuwaijri A, Kwan T, Sinnett D, Pastinen T, Naumova A, et al. Interaction between genetic and epigenetic variation defines gene expression patterns at the asthma-associated locus 17q12-q21 in lymphoblastoid cell lines. Hum Genet. 2012;131(7):1161–1171. doi:10.1007/s00439-012-1142-x.
  • Moussette S, Al Tuwaijri A, Kohan-Ghadr H-R, Elzein S, Farias R, Bérubé J, Ho B, Laprise C, Goodyer C, Rousseau S, et al. Role of DNA methylation in expression control of the IKZF3-GSDMA region in human epithelial cells. PLoS One. 2017;12(2):e0172707. doi:10.1371/journal.pone.0172707.
  • Taniguchi K, Yamamoto S, Aoki S, Toda S, Izuhara K, Hamasaki Y. Epigen is induced during the interleukin-13-stimulated cell proliferation in murine primary airway epithelial cells. Exp Lung Res. 2011;37(8):461–470. doi:10.3109/01902148.2011.596894.
  • Jevnikar Z, Östling J, Ax E, Calvén J, Thörn K, Israelsson E, Öberg L, Singhania A, Lau L, Wilson S, Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes study group, et al. Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation. J Allergy Clin Immunol. 2019;143(2):577–590. doi:10.1016/j.jaci.2018.05.026.
  • Hering T. Update of the GINA-recommendations. MMW Fortschr Med. 2017;159(10):63–64. doi:10.1007/s15006-017-9710-6.
  • Standardization of Spirometry, 1994 Update. American thoracic society. Am J Respir Crit Care Med. 1995;152(3):1107–1136.
  • Pellegrino R, Viegi G, Brusasco V, Crapo RO, Burgos F, Casaburi R, Coates A, van der Grinten CPM, Gustafsson P, Hankinson J, et al. Interpretative strategies for lung function tests. Eur Respir J. 2005;26(5):948–968. doi:10.1183/09031936.05.00035205.
  • American Thoracic Society, European Respiratory Society. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med. 2005;171(8):912–930.
  • Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988;16(3):1215. doi:10.1093/nar/16.3.1215.
  • Wojdacz TK, Hansen LL, Dobrovic A. A new approach to primer design for the control of PCR bias in methylation studies. BMC Res Notes. 2008;1:54. doi:10.1186/1756-0500-1-54.
  • Hussmann D, Hansen LL. Methylation-sensitive high resolution melting (MS-HRM). Methods Mol Biol Clifton NJ. 2018;1708:551–571.
  • García-Sánchez A, Isidoro-García M, García-Solaesa V, Sanz C, Hernández-Hernández L, Padrón-Morales J, Lorente-Toledano F, Dávila I. Genome-wide association studies (GWAS) and their importance in asthma. Allergol Immunopathol (Madr). 2015;43(6):601–608. doi:10.1016/j.aller.2014.07.004.
  • Wan YI, Shrine NRG, Soler Artigas M, Wain LV, Blakey JD, Moffatt MF, Bush A, Chung KF, Cookson WOCM, Strachan DP, Australian Asthma Genetics Consortium, et al. Genome-wide association study to identify genetic determinants of severe asthma. Thorax. 2012;67(9):762–768. doi:10.1136/thoraxjnl-2011-201262.
  • Ober C, McKennan C, Magnaye K, Altman M, Washington C, Stanhope C, Naughton K, Rosasco M, Bacharier L, Billheimer D, et al. Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study. Lancet Respir Med. 2020;8(5):482–492. doi:10.1016/S2213-2600(20)30011-4.
  • Zhao C-N, Fan Y, Huang J-J, Zhang H-X, Gao T, Wang C, Wang T, Hou L-F. The association of GSDMB and ORMDL3 gene polymorphisms with asthma: a meta-analysis. Allergy Asthma Immunol Res. 2015;7(2):175–185. doi:10.4168/aair.2015.7.2.175.
  • Miller M, Rosenthal P, Weng N, Pham A, Hur G-Y, Elliot J, Green F, James A, Broide D. Chromosome 17q21 SNP rs8076131 risk allele associates with airway smooth muscle hypertrophy in fatal asthma. Clin Exp Allergy. 2020;50(11):1270–1273. doi:10.1111/cea.13708.
  • Tomita K, Sakashita M, Hirota T, Tanaka S, Masuyama K, Yamada T, Fujieda S, Miyatake A, Hizawa N, Kubo M, et al. Variants in the 17q21 asthma susceptibility locus are associated with allergic rhinitis in the Japanese population. Allergy. 2013;68(1):92–100. doi:10.1111/all.12066.
  • Weng N, Miller M, Pham AK, Komor AC, Broide DH. Single-base editing of rs12603332 on chromosome 17q21 with a cytosine base editor regulates ORMDL3 and ATF6α expression. Allergy. 2021;doi:10.1111/all.15092.
  • Naumova A, Al Tuwaijri A, Morin A, Vaillancourt V, Vaillancout V, Madore A-M, Berlivet S, Kohan-Ghadr H-R, Moussette S, Laprise C, et al. Sex- and age-dependent DNA methylation at the 17q12-q21 locus associated with childhood asthma. Hum Genet. 2013;132(7):811–822. doi:10.1007/s00439-013-1298-z.
  • Al Tuwaijri A, Gagné-Ouellet V, Madore A-M, Laprise C, Naumova AK. Local genotype influences DNA methylation at two asthma-associated regions, 5q31 and 17q21, in a founder effect population. J Med Genet. 2016; 53(4):232–241. doi:10.1136/jmedgenet-2015-103313.
  • Ono JG, Worgall TS, Worgall S. 17q21 locus and ORMDL3: an increased risk for childhood asthma. Pediatr Res. 2014;75(1–2):165–170. doi:10.1038/pr.2013.186.
  • Li Y, Cao L, Yu Q, Xue H, Lu Y. Association between peripheral blood mononuclear cell ORMDL3 expression and the asthma predictive index in preschool children. J Int Med Res. 2019;47(8):3727–3736. doi:10.1177/0300060519862674.
  • Wang H, Liu Y, Shi J, Cheng Z. ORMDL3 knockdown in the lungs alleviates airway inflammation and airway remodeling in asthmatic mice via JNK1/2-MMP-9 pathway. Biochem Biophys Res Commun. 2019;516(3):739–746. doi:10.1016/j.bbrc.2019.06.122.
  • Stein M, Thompson E, Schoettler N, Helling B, Magnaye K, Stanhope C, Igartua C, Morin A, Washington C, Nicolae D, et al. A decade of research on the 17q12-21 asthma locus: piecing together the puzzle. J Allergy Clin Immunol. 2018;142(3):749–764.e3. doi:10.1016/j.jaci.2017.12.974.
  • Manson M, Säfholm J, James A, Johnsson A-K, Bergman P, Al-Ameri M, Orre A-C, Kärrman-Mårdh C, Dahlén S-E, Adner M, et al. IL-13 and IL-4, but not IL-5 nor IL-17A, induce hyperresponsiveness in isolated human small airways. J Allergy Clin Immunol. 2020;145(3):808–817.e2. doi:10.1016/j.jaci.2019.10.037.
  • Ogi K, Takabayashi T, Tomita K, Sakashita M, Morikawa T, Ninomiya T, Okamoto M, Narita N, Fujieda S. ORMDL3 overexpression facilitates FcεRI-mediated transcription of proinflammatory cytokines and thapsigargin-mediated PERK phosphorylation in RBL-2H3 cells. Immun Inflamm Dis. 2021;9(4):1394–1405. doi:10.1002/iid3.489.
  • Chen R, Michaeloudes C, Liang Y, Bhavsar PK, Chung KF, Ip MSM, et al. ORMDL3 regulates cigarette smoke-induced endoplasmic reticulum stress in airway smooth muscle cells. J Allergy Clin Immunol. 2021; 5S0091-6749(21)01514-1.
  • Zhang Y-M. Orosomucoid-like protein 3, rhinovirus and asthma. World J Crit Care Med. 2021;10(5):170–182. doi:10.5492/wjccm.v10.i5.170.
  • Smit LAM, Bouzigon E, Pin I, Siroux V, Monier F, Aschard H, Bousquet J, Gormand F, Just J, Le Moual N, the EGEA Cooperative Group, et al. 17q21 variants modify the association between early respiratory infections and asthma. Eur Respir J. 2010;36(1):57–64. doi:10.1183/09031936.00154509.

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