107
Views
0
CrossRef citations to date
0
Altmetric
Research Articles

Interval change in fractional exhaled nitric oxide (FENO) reflects short-term change in adherence following electronic inhaler reminders

, MBBS, FRCP, , MB BChir, MRCP, , PhD & , MBBS, FRCP
Pages 1613-1621 | Received 13 Nov 2022, Accepted 13 Jan 2023, Published online: 06 Feb 2023

References

  • Rupani H, Kent BD. Using fractional exhaled nitric oxide measurement in clinical asthma management. Chest 2022;161(4):906–917. doi:10.1016/j.chest.2021.10.015.
  • Anderson WJ, Short PM, Williamson PA, Lipworth BJ. Inhaled corticosteroid dose response using domiciliary exhaled nitric oxide in persistent asthma: the FENOtype trial. Chest 2012;142(6):1553–1561. doi:10.1378/chest.12-1310.
  • Silkoff PE, McClean P, Spino M, Erlich L, Slutsky AS, Zamel N. Dose-response relationship and reproducibility of the fall in exhaled nitric oxide after inhaled beclomethasone dipropionate therapy in asthma patients. Chest 2001;119(5):1322–1328. doi:10.1378/chest.119.5.1322.
  • Bingham Y, Sanghani N, Cook J, Hall P, Jamalzadeh A, Moore-Crouch R, Bush A, Fleming L, Saglani S. Electronic adherence monitoring identifies severe preschool wheezers who are steroid responsive. Pediatr Pulmonol 2020;55(9):2254–2260.
  • d‘Ancona G, Kavanagh J, Roxas C, Green L, Fernandes M, Thomson L, Dhariwal J, Nanzer AM, Jackson DJ, Kent BD. Adherence to corticosteroids and clinical outcomes in mepolizumab therapy for severe asthma. Eur Respir J 2020;55(5):1902259. doi:10.1183/13993003.02259-2019.
  • Klok T, Brand PLP. Can exhaled nitric oxide fraction predict adherence to inhaled corticosteroids in atopic and nonatopic children with asthma? J Allergy Clin Immunol Pract 2017;5(2):521–522. doi:10.1016/j.jaip.2016.09.038.
  • Heaney LG, Busby J, Bradding P, Chaudhuri R, Mansur AH, Niven R, Pavord ID, Lindsay JT, Costello RW. Remotely monitored therapy and nitric oxide suppression identifies nonadherence in severe asthma. Am J Respir Crit Care Med 2019;199(4):454–464.
  • McNicholl DM, Stevenson M, McGarvey LP, Heaney LG. The utility of fractional exhaled nitric oxide suppression in the identification of nonadherence in difficult asthma. Am J Respir Crit Care Med 2012;186(11):1102–1108. doi:10.1164/rccm.201204-0587OC.
  • Alahmadi F, Peel A, Keevil B, Niven R, Fowler SJ. Assessment of adherence to corticosteroids in asthma by drug monitoring or fractional exhaled nitric oxide: a literature review. Clin Exp Allergy 2021;51(1):49–62. doi:10.1111/cea.13787.
  • Dweik RA, Boggs PB, Erzurum SC, Irvin CG, Leigh MW, Lundberg JO, Olin A-C, Plummer AL, Taylor DR. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med 2011;184(5):602–615.
  • Busby J, Holweg CTJ, Chai A, Bradding P, Cai F, Chaudhuri R, Mansur AH, Lordan JL, Matthews JG, Menzies-Gow A. Change in type-2 biomarkers and related cytokines with prednisolone in uncontrolled severe oral corticosteroid dependent asthmatics: an interventional open-label study. Thorax 2019;74:806–809.
  • Cowan DC, Taylor DR, Peterson LE, Cowan JO, Palmay R, Williamson A, Hammel J, Erzurum SC, Hazen SL, Comhair SAA, et al. Biomarker-based asthma phenotypes of corticosteroid response. J Allergy Clin Immunol 2015;135(4):877–883.e1. doi:10.1016/j.jaci.2014.10.026.
  • Wagener AH, de Nijs SB, Lutter R, Sousa AR, Weersink EJM, Bel EH, Sterk PJ. External validation of blood eosinophils, FE(NO) and serum periostin as surrogates for sputum eosinophils in asthma. Thorax 2015;70(2):115–120.
  • Dixon AE, Sugar EA, Zinreich SJ, Slavin RG, Corren J, Naclerio RM, Ishii M, Cohen RI, Brown ED, Wise RA, et al. Criteria to screen for chronic sinonasal disease. Chest 2009;136(5):1324–1332. doi:10.1378/chest.08-1983.
  • Asano T, Takemura M, Kanemitsu Y, Yokota M, Fukumitsu K, Takeda N, Ichikawa H, Hijikata H, Uemura T, Takakuwa O, et al. Combined measurements of fractional exhaled nitric oxide and nasal nitric oxide levels for assessing upper airway diseases in asthmatic patients. J Asthma 2018;55(3):300–309.
  • Canonica GW, Malvezzi L, Blasi F, Paggiaro P, Mantero M, Senna G, Heffler E. Chronic rhinosinusitis with nasal polyps impact in severe asthma patients: Evidences from the Severe Asthma Network Italy (SANI) registry. Respir Med 2020;166(105947):105947.
  • Zaigham S, Zhou X, Molin M, Sjölander A, Movérare R, Janson C, Malinovschi A. Importance of type and degree of IgE sensitisation for defining fractional exhaled nitric oxide reference values. Respir Med 2021;188(106621):106621.
  • Kharitonov SA, Donnelly LE, Montuschi P, Corradi M, Collins JV, Barnes PJ. Dose-dependent onset and cessation of action of inhaled budesonide on exhaled nitric oxide and symptoms in mild asthma. Thorax 2002;57(10):889–896. doi:10.1136/thorax.57.10.889.
  • Beck-Ripp J, Griese M, Arenz S, Köring C, Pasqualoni B, Bufler P. Changes of exhaled nitric oxide during steroid treatment of childhood asthma. Eur Respir J 2002;19:1015–1019.
  • Boddy CE, Naveed S, Craner M, Murphy AC, Siddiqui S, Bradding P. Clinical outcomes in people with difficult-to-control asthma using electronic monitoring to support medication adherence. J Allergy Clin Immunol Pract 2021;9(4):1529–1538.e2. doi:10.1016/j.jaip.2020.10.059.
  • Silkoff PE, Laviolette M, Singh D, FitzGerald JM, Kelsen S, Backer V, Porsbjerg C, Girodet PO, Berger P, Kline JN, et al. Longitudinal stability of asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study. Respir Res 2016;17(43):43.
  • Kharitonov SA, Gonio F, Kelly C, Meah S, Barnes PJ. Reproducibility of exhaled nitric oxide measurements in healthy and asthmatic adults and children. Eur Respir J 2003;21(3):433–438. doi:10.1183/09031936.03.00066903a.
  • Shrestha SK, Drews A, Sharma L, Pant S, Shrestha S, Neopane A. Relationship between total serum immunoglobulin E levels, fractional exhaled breath nitric oxide levels and absolute blood eosinophil counts in atopic and non-atopic asthma: a controlled comparative study. J Breath Res 2018;12(2):026009. doi:10.1088/1752-7163/aa95da.
  • Diamant Z, Vijverberg S, Alving K, Bakirtas A, Bjermer L, Custovic A, Dahlen S-E, Gaga M, Gerth van Wijk R, Giacco SD, et al. Toward clinically applicable biomarkers for asthma: An EAACI position paper. Allergy 2019;74(10):1835–1851.
  • Lommatzsch M, Klein M, Stoll P, Virchow JC. Impact of an increase in the inhaled corticosteroid dose on blood eosinophils in asthma. Thorax 2019;74(4):417–418. doi:10.1136/thoraxjnl-2018-212233.
  • Anderson WC, 3rd, Gondalia R, De Keyser HE, Kaye L, Szefler SJ, Stempel DA. Digital assessment of medication utilization by age and diagnosis of asthma or COPD. J Allergy Clin Immunol Pract 2021;9(4):1723–1725. doi:10.1016/j.jaip.2020.10.065.
  • Tay TR, van Boven JFM, Chan A, Hew M. Electronic Inhaler Monitoring for Chronic Airway Disease: Development and Application of a Multidimensional Efficacy Framework. J Allergy Clin Immunol Pract. 2022;10(5):1189–1201.e1. doi:10.1016/j.jaip.2021.11.027.
  • Dekhuijzen R, Lavorini F, Usmani OS, van Boven JFM. Addressing the Impact and Unmet Needs of Nonadherence in Asthma and Chronic Obstructive Pulmonary Disease: Where Do We Go From Here? J Allergy Clin Immunol Pract. 2018;6(3):785–793. doi:10.1016/j.jaip.2017.11.027.
  • van Boven JFM, Koponen M, Lalic S, George J, Bell JS, Hew M, Ilomaki J. Trajectory analyses of adherence patterns in a real-life moderate to severe asthma population. J Allergy Clin Immunol Pract 2020;8:1961–1969.e6.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.