The role of modeling studies in asthma management and clinical decision-making: a Delphi survey of physician knowledge and perceptions

References

• Egger M, Johnson L, Althaus C, Schöni A, Salanti G, Low N, Norris SL. Developing WHO guidelines: time to formally include evidence from mathematical modelling studies. F1000Res. 2017;6:1584. doi:10.12688/f1000research.12367.1.
   PubMedGoogle Scholar
• Porgo TV, Norris SL, Salanti G, Johnson LF, Simpson JA, Low N, Egger M, Althaus CL. The use of mathematical modeling studies for evidence synthesis and guideline development: a glossary. Res Synth Methods. 2019;10(1):125–133. doi:10.1002/jrsm.1333.
   PubMed Web of Science ®Google Scholar
• Allan S, Olaiya R, Burhan R. Reviewing the use and quality of machine learning in developing clinical prediction models for cardiovascular disease. Postgrad Med J. 2022;98(1161):551–558. doi:10.1136/postgradmedj-2020-139352.
   PubMed Web of Science ®Google Scholar
• WHO guideline for screening and treatment of cervical pre-cancer lesions for cervical cancer prevention. 2nd ed. Geneva: World Health Organization, 2021.
   Google Scholar
• Gauvreau CL, Fitzgerald NR, Memon S, Flanagan WM, Nadeau C, Asakawa K, Garner R, Miller AB, Evans WK, Popadiuk CM, et al. The OncoSim model: development and use for better decision-making in Canadian cancer control. Curr Oncol. 2017;24(6):401–406. doi:10.3747/co.24.3850.
   PubMed Web of Science ®Google Scholar
• Easterbrook PJ, Doherty MC, Perriëns JH, Barcarolo JL, Hirnschall GO. The role of mathematical modelling in the development of recommendations in the 2013 WHO consolidated antiretroviral therapy guidelines. AIDS. 2014;28(Supplement 1):S85–S92. doi:10.1097/QAD.0000000000000111.
   PubMed Web of Science ®Google Scholar
• Consolidated guidelines on HIV prevention, testing, treatment, service delivery and monitoring: recommendations for a public health approach. Geneva: World Health Organization; 2021.
   Google Scholar
• Wynants L, Van Calster B, Collins GS, Riley RD, Heinze G, Schuit E, Bonten MMJ, Dahly DL, Damen JAA, Debray TPA, et al. Prediction models for diagnosis and prognosis of covid-19: systematic review and critical appraisal. BMJ. 2020;369:m1328.
   PubMed Web of Science ®Google Scholar
• Ghafari M, Liu Q, Dhillon A, Katzourakis A, Weissman DB. Investigating the evolutionary origins of the first three SARS-CoV-2 variants of concern. Front Virol. 2022;2:942555.
   Google Scholar
• Daley-Yates P, Aggarwal B, Lulic Z, Fulmali S, Cruz AA, Singh D. Pharmacology versus convenience: a benefit/risk analysis of regular maintenance versus infrequent or as-needed inhaled corticosteroid use in mild asthma. Adv Ther. 2022;39(1):706–726. doi:10.1007/s12325-021-01976-4.
   PubMed Web of Science ®Google Scholar
• Singh D, Garcia G, Maneechotesuwan K, Daley-Yates P, Irusen E, Aggarwal B, Boucot I, Berend N. New versus old: the impact of changing patterns of inhaled corticosteroid prescribing and dosing regimens in asthma management. Adv Ther. 2022;39(5):1895–1914. doi:10.1007/s12325-022-02092-7.
   PubMed Web of Science ®Google Scholar
• Global Initiative for Asthma. Global strategy for asthma management and prevention. Global Initiative for Asthma (GINA); 2022. https://ginasthma.org/gina-reports/.
   Google Scholar
• British Thoracic Society, Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma; 2019. https://www.brit-thoracic.org.uk/standards-of-care/guidelines/btssign-british-guideline-on-the-management-of-asthma/
   Google Scholar
• Nakamura Y, Tamaoki J, Nagase H, Yamaguchi M, Horiguchi T, Hozawa S, Ichinose M, Iwanaga T, Kondo R, Nagata M, et al. Japanese guidelines for adult asthma 2020. Allergol Int. 2020;69(4):519–548. doi:10.1016/j.alit.2020.08.001.
   PubMed Web of Science ®Google Scholar
• Yang CL, Hicks EA, Mitchell P, Licskai C, Dell SD, Rowe BH, Fitzgerald M, Leigh R, Watson W, Boulet LP. 2021 Canadian Thoracic Society Guideline – a focused update on the management of very mild and mild asthma. Can J Respir Crit Care Sleep Med. 2021;5(4):205–245. doi:10.1080/24745332.2021.1877043.
   Web of Science ®Google Scholar
• Plaza V, Alobid I, Alvarez C, Blanco M, Ferreira J, García G, Gómez-Outes A, Gómez F, Hidalgo A, Korta J, et al. Spanish Asthma Management Guidelines (GEMA) v.5.1. Highlights and controversies. Arch Bronconeumol. 2022;58(2):T150–T158. doi:10.1016/j.arbres.2021.05.032.
   PubMed Web of Science ®Google Scholar
• Kawamatawong T, Sangasapaviriya A, Saiphoklang N, Oer-Areemitr N, Sriprasart T, Kamalaporn H, Amnuaypattanapon K, Rerkpattanapipat T, Chirakalwasan N, Kulpraneet M, et al. Guidelines for the management of asthma in adults: evidence and recommendations. Asian Pac J Allergy Immunol. 2022;40(1):1–21.
   PubMed Web of Science ®Google Scholar
• Domingo C, Rello J, Sogo A. As-needed ICS-LABA in mild asthma: what does the evidence say? Drugs. 2019;79(16):1729–1737. doi:10.1007/s40265-019-01202-0.
   PubMed Web of Science ®Google Scholar
• Domingo C, Garcia G, Gemicioglu B, Van GV, Larenas-Linnemann D, Neffen H, Poachanukoon O, Sagara H, Berend N, Pizzichini E, et al. Consensus on mild asthma management: results of a modified Delphi study. J Asthma. 2022. doi:10.1080/02770903.2022.2034850.
   PubMed Web of Science ®Google Scholar
• Gauthier M, Wenzel SE. As-needed β agonist-inhaled corticosteroid in mild asthma. Lancet. 2019;394(10202):897–898. doi:10.1016/S0140-6736(19)31994-4.
   PubMed Web of Science ®Google Scholar
• Chapman KR, Canonica GW, Lavoie KL, Nenasheva N, Garcia G, Bosnic-Anticevich S, Bourdin A, Cano MCD, Abhijith PG, Aggarwal B. Patients’ and physicians’ perspectives on the burden and management of asthma: results from the APPaRENT 2 study. Respir Med. 2022;201:106948. doi:10.1016/j.rmed.2022.106948.
   PubMed Web of Science ®Google Scholar
• Aggarwal B, Shantakumar S, Hinds D, Mulgirigama A. Asia-Pacific Survey of Physicians on Asthma and Allergic Rhinitis (ASPAIR): physician beliefs and practices about diagnosis, assessment, and treatment of coexistent disease. J Asthma Allergy. 2018;11:293–307. doi:10.2147/JAA.S180657.
   PubMed Web of Science ®Google Scholar
• Hasson F, Keeney S, McKenna H. Research guidelines for the Delphi survey technique. J Adv Nurs. 2000;32(4):1008–1015.
   PubMed Web of Science ®Google Scholar
• Boulkedid R, Abdoul H, Loustau M, Sibony O, Alberti C. Using and reporting the Delphi method for selecting healthcare quality indicators: a systematic review. PLoS One. 2011;6(6):e20476. doi:10.1371/journal.pone.0020476.
   PubMed Web of Science ®Google Scholar
• Thompson M. Considering the implication of variations within Delphi research. Fam Pract. 2009;26(5):420–424. doi:10.1093/fampra/cmp051.
   PubMed Web of Science ®Google Scholar
• Slade SC, Dionne CE, Underwood M, Buchbinder R. Standardised method for reporting exercise programmes: protocol for a modified Delphi study. BMJ Open. 2014;4(12):e006682. doi:10.1136/bmjopen-2014-006682.
   PubMed Web of Science ®Google Scholar
• Diamond IR, Grant RC, Feldman BM, Pencharz PB, Ling SC, Moore AM, Wales PW. Defining consensus: a systematic review recommends methodologic criteria for reporting of Delphi studies. J Clin Epidemiol. 2014;67(4):401–409. doi:10.1016/j.jclinepi.2013.12.002.
   PubMed Web of Science ®Google Scholar
• Vogel C, Zwolinsky S, Griffiths C, Hobbs M, Henderson E, Wilkins E. A Delphi study to build consensus on the definition and use of big data in obesity research. Int J Obes (Lond). 2019;43(12):2573–2586. doi:10.1038/s41366-018-0313-9.
   PubMed Web of Science ®Google Scholar
• Wessler BS, Lai Yh L, Kramer W, Cangelosi M, Raman G, Lutz JS, Kent DM. Clinical prediction models for cardiovascular disease: tufts predictive analytics and comparative effectiveness clinical prediction model database. Circ Cardiovasc Qual Outcomes. 2015;8(4):368–375. doi:10.1161/CIRCOUTCOMES.115.001693.
   PubMed Web of Science ®Google Scholar
• Rutter CM, Knudsen AB, Marsh TL, Doria-Rose VP, Johnson E, Pabiniak C, Kuntz KM, van Ballegooijen M, Zauber AG, Lansdorp-Vogelaar I. Validation of models used to inform colorectal cancer screening guidelines: accuracy and Implications. Med Decis Making. 2016;36(5):604–614. doi:10.1177/0272989X15622642.
   PubMed Web of Science ®Google Scholar
• Bernard A. Clinical prediction models: a fashion or a necessity in medicine? J Thorac Dis. 2017;9(10):3456–3457. doi:10.21037/jtd.2017.09.42.
   PubMed Web of Science ®Google Scholar
• Lo NC, Andrejko K, Shukla P, Baker T, Sawin V, Norris S, Lewnard J. Contribution and quality of mathematical modeling evidence in World Health Organization guidelines: a systematic review. Epidemics. 2022;39:100570. doi:10.1016/j.epidem.2022.100570.
   PubMed Web of Science ®Google Scholar
• OCEBM Levels of Evidence Working Group. The Oxford 2011 levels of evidence. Oxford Centre for Evidence-Based Medicine. [accessed 2023 Jan 29]. Available from: https://www.cebm.ox.ac.uk/resources/levels-of-evidence/ocebm-levels-of-evidence
   Google Scholar
• Food and Drug Administration. Exposure-response relationships—study design, data analysis, and regulatory applications. Guidance for industry; 2003. Available from: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/exposure-response-relationships-study-design-data-analysis-and-regulatory-applications
   Google Scholar
• Younis T, Thana M, Skedgel C. Evidence in medicine: math versus biology! Curr Oncol. 2017;24(6):349–351. doi:10.3747/co.24.3970.
   PubMed Web of Science ®Google Scholar
• Coldman A, Pader J, Gauvreau C, Memon S, Fitzgerald N, Flanagan W, Nadeau C, Earle C, Wolfson M, Miller A, et al. simulating results from trials of sigmoidoscopy screening using the OncoSim microsimulation model. J Cancer Policy. 2018;15:52–58. doi:10.1016/j.jcpo.2017.12.006.
   Web of Science ®Google Scholar
• Haidich AB. Meta-analysis in medical research. Hippokratia. 2010;14(1):29–37.
   PubMed Web of Science ®Google Scholar
• Boulet LP. Asymptomatic airway hyperresponsiveness: a curiosity or an opportunity to prevent asthma? Am J Respir Crit Care Med. 2003;167(3):371–378. doi:10.1164/rccm.200111-084PP.
   PubMed Web of Science ®Google Scholar
• Woolcock AJ. What are the important questions in the treatment of asthma? Clin Exp Allergy Rev. 2001;1(2):62–64. _doi:10.1046/j.1472-9725.2001.00007.x.
   Google Scholar
• Gibbons DC, Aggarwal B, Fairburn-Beech J, Hinds D, Fletcher M, Bosnic-Anticevich S, Price D. Treatment patterns among non-active users of maintenance asthma medication in the United Kingdom: a retrospective cohort study in the Clinical Practice Research Datalink. J Asthma. 2021;58(6):793–804. doi:10.1080/02770903.2020.1728767.
   PubMed Web of Science ®Google Scholar
• Sears MR. Lung function decline in asthma. Eur Respir J. 2007;30(3):411–413. doi:10.1183/09031936.00080007.
   PubMed Web of Science ®Google Scholar
• Eakin MN, Rand CS. Improving patient adherence with asthma self-management practices: what works? Ann Allergy Asthma Immunol. 2012;109(2):90–92. doi:10.1016/j.anai.2012.06.009.
   PubMed Web of Science ®Google Scholar
• Dhruve H. Management of asthma: adherence, inhaler technique and self-management. Pract Nurs. 2018;29(10):465–468. doi:10.12968/pnur.2018.29.10.465.
   Google Scholar
• Amirav I, Newhouse MT. Asthma and COVID-19: in defense of evidence-based SABA. J Asthma Allergy. 2020;13:505–508. doi:10.2147/JAA.S279061.
   PubMed Web of Science ®Google Scholar
• Charriot J, Gaga M, Suehs C, Bourdin A. Asthma rescue treatments, time to reboot. Eur Respir J. 2020;55(4):2000542. doi:10.1183/13993003.00542-2020.
   PubMed Web of Science ®Google Scholar
• Royal College of Physicians. Why asthma still kills: the National Review of Asthma Deaths (NRAD) Confidential Enquiry report. http://www.rcplondon.ac.uk/sites/default/files/why-asthma-still-kills-full-report.pdf. 2014.
   Google Scholar
• Fletcher M, van der Molen T, Lenney W, Boucot I, Aggarwal B, Pizzichini E. Primary care management of asthma exacerbations or attacks: impact of the COVID-19 pandemic. Adv Ther. 2022;39(4):1457–1473. doi:10.1007/s12325-022-02056-x.
   PubMed Web of Science ®Google Scholar
• Sriprasart T, Waterer G, Garcia G, Rubin A, Andrade MAL, Roguska A, Phansalkar A, Fulmali S, Martin A, Mittal L, et al. Safety of SABA monotherapy in asthma management: a systematic review and meta-analysis. Adv Ther. 2023;40(1):133–158. doi:10.1007/s12325-022-02356-2.
   PubMed Web of Science ®Google Scholar
• Aggarwal B, Jones PW, Yunus F, Lan LTT, Boonsawat W, Ismaila A, Ascioglu S. Direct healthcare costs associated with management of asthma: comparison of two treatment regimens in Indonesia, Thailand and Vietnam. J Asthma. 2022;59(6):1213–1220. doi:10.1080/02770903.2021.1903915.
   PubMed Web of Science ®Google Scholar
• Busse W, Stempel D, Aggarwal B, Boucot I, Forth R, Raphiou I, Rabe KF, Reddel HK. Insights from the AUSTRI study on reliever use before and after asthma exacerbations. J Allergy Clin Immunol Pract. 2022;10(7):1916–1918.e2. doi:10.1016/j.jaip.2022.03.029.
   PubMed Web of Science ®Google Scholar
• Bousquet J, Winchester C, Papi A, Virchow JC, Haughney J, Costa D, Usmani O, Bjermer L, Price D. Inhaled corticosteroid/long-acting? ?-Agonist combination therapy for asthma: attitudes of specialists in Europe. Int Arch Allergy Immunol. 2012;157(3):303–310. doi:10.1159/000329519.
   PubMed Web of Science ®Google Scholar
• Harding G, Leidy NK, Meddis D, Kleinman L, Wagner S, O’Brien CD. Interpreting clinical trial results of patient-perceived onset of effect in asthma: methods and results of a Delphi panel. Curr Med Res Opin. 2009;25(6):1563–1571. doi:10.1185/03007990902914403.
   PubMed Web of Science ®Google Scholar
• Sheikh A, Major P, Holgate ST. Developing consensus on national respiratory research priorities: key findings from the UK Respiratory Research Collaborative’s e-Delphi exercise. Respir Med. 2008;102(8):1089–1092. doi:10.1016/j.rmed.2008.03.006.
   PubMed Web of Science ®Google Scholar
• Fink-Hafner D, Dagen T, Doušak M, Novak M, Hafner-Fink M. Delphi method: strengths and weaknesses. Adv Meth Stat. 2019;16(2):1–19. doi:10.51936/fcfm6982.
   Google Scholar