Redefining biomarkers in pediatric asthma: a commentary

References

• Fitzpatrick AM, Chipps BE, Holguin F, Woodruff PG. T2-"Low" asthma: overview and management strategies. J Allergy Clin Immunol Pract 2020;8(2):452–463. doi:10.1016/j.jaip.2019.11.006.
   PubMed Web of Science ®Google Scholar
• Coverstone AM, Seibold MA, Peters MC. Diagnosis and management of T2-high asthma. J Allergy Clin Immunol Pract 2020;8(2):442–450. doi:10.1016/j.jaip.2019.11.020.
   PubMed Web of Science ®Google Scholar
• Hopp RJ, Wilson MC, Pasha MA. Small airway disease in pediatric asthma: the who, what, when, where, why, and how to remediate. a review and commentary. Clin Rev Allergy Immunol 2022;62(1):145–159. doi:10.1007/s12016-020-08818-1.
   PubMed Web of Science ®Google Scholar
• Licari A, Manti S, Castagnoli R, Leonardi S, Marseglia GL. Measuring inflammation in paediatric severe asthma: biomarkers in clinical practice. Breathe (Sheff) 2020;16(1):190301. doi:10.1183/20734735.0301-2019.
   PubMedGoogle Scholar
• Wadsworth S, Sin D, Dorscheid D. Clinical update on the use of biomarkers of airway inflammation in the management of asthma. J Asthma Allergy 2011;4:77–86. doi:10.2147/JAA.S15081.
   PubMedGoogle Scholar
• Hopp RJ, Wilson MC, Pasha MA. A compendium and review of pediatric pulmonary function testing assessment opportunities for asthma. J Asthma 2022;59(8):1584–1589. doi:10.1080/02770903.2021.1941094.
   PubMed Web of Science ®Google Scholar
• Busse WW, Viswanathan R. What has been learned by cytokine targeting of asthma? J Allergy Clin Immunol. 2022;150(2):235–249. doi:10.1016/j.jaci.2022.06.010.
   PubMedGoogle Scholar
• Reddel HK, Foxley GJ, Davis SR. How to step down asthma preventer treatment in patients with well-controlled asthma – more is not always better. Aust Prescr 2022;45(4):125–129. doi:10.18773/austprescr.2022.033.
   PubMed Web of Science ®Google Scholar
• Hallas HW, Chawes BL, Arianto L, Rasmussen MA, Kunøe A, Stokholm J, Bønnelykke K, Bisgaard H. Children with asthma have fixed airway obstruction through childhood unaffected by exacerbations. J Allergy Clin Immunol Pract 2020;8(4):1263–1271.e3. doi:10.1016/j.jaip.2019.10.031.
   PubMed Web of Science ®Google Scholar
• McLaughlin AV, Bhandari A, Schramm CM. Two versus four puffs of albuterol: does dose change bronchodilator response? J Asthma Allergy 2019;12:59–65. eCollection 2019 10.2147/JAA.S151531. doi:10.2147/JAA.S151531.
   PubMed Web of Science ®Google Scholar
• Leuppi JD. Bronchoprovocation tests in asthma: direct versus indirect challenges. Curr Opin Pulm Med 2014;20(1):31–36. doi:10.1097/MCP.0000000000000009.
   PubMed Web of Science ®Google Scholar
• Szefler S, Weiss S, Tonascia J, Adkinson NF, Bender B, Cherniack R, Donithan M, Kelly HW, Reisman J, Shapiro GG, Childhood Asthma Management Program Research Group, et al. Long-term effects of budesonide or nedocromil in children with asthma. N Engl J Med 2000;343(15):1054–1063. doi:10.1056/NEJM200010123431501.
   PubMed Web of Science ®Google Scholar
• Personal communication, Alice Sternberg, Scm. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health. Johns Hopkins University 615 North Wolfe Street, Room W5025 Baltimore, MD 21205. Contacted November 2012.
   Google Scholar
• Radford P, Hopp RJ, Degan J, Biven R, Bewtra A, Townley R. Longitudinal changes in bronchial hyperresponsiveness in asthmatic and previously asthmatic children. Chest 1992;101(3):624–629. doi:10.1378/chest.101.3.624.
   PubMed Web of Science ®Google Scholar
• Denlinger LC, Heymann P, Lutter R, Gern JE. Exacerbation-prone asthma. J Allergy Clin Immunol Pract 2020;8(2):474–482. doi:10.1016/j.jaip.2019.11.009.
   PubMed Web of Science ®Google Scholar
• Pijnenburg MW, Baraldi E, Brand PL, Carlsen KH, Eber E, Frischer T, Hedlin G, Kulkarni N, Lex C, Mäkelä MJ, et al. Monitoring asthma in children. Eur Respir J 2015;45(4):906–925. doi:10.1183/09031936.00088814.
   PubMed Web of Science ®Google Scholar
• Postma DS, Kerstjens HA. Characteristics of airway hyperresponsiveness in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998;158(5 Pt 3):S187–S192. doi:10.1164/ajrccm.158.supplement_2.13tac170.
   PubMed Web of Science ®Google Scholar
• Shim YM, Burnette A, Lucas S, Herring RC, Weltman J, Patrie JT, Weltman AL, Platts-Mills TA. Physical deconditioning as a cause of breathlessness among obese adolescents with a diagnosis of asthma. PLoS One 2013;8(4):e61022. doi:10.1371/journal.pone.0061022.
   PubMed Web of Science ®Google Scholar
• Rosi E, Stendardi L, Binazzi B, Scano G. Perception of airway obstruction and airway inflammation in asthma: a review. Lung 2006;184(5):251–258. doi:10.1007/s00408-005-2590-z.
   PubMed Web of Science ®Google Scholar
• Fauroux B, Simões EAF, Checchia PA, Paes B, Figueras-Aloy J, Manzoni P, Bont L, Carbonell-Estrany X. The burden and long-term respiratory morbidity associated with respiratory syncytial virus infection in early childhood. Infect Dis Ther 2017;6(2):173–197. doi:10.1007/s40121-017-0151-4.
   PubMed Web of Science ®Google Scholar
• Bickel S, Popler J, Lesnick B, Eid N. Impulse oscillometry: interpretation and practical applications. Chest 2014;146(3):841–847. doi:10.1378/chest.13-1875.
   PubMed Web of Science ®Google Scholar
• Desiraju K, Agrawal A. Impulse oscillometry: the state-of-art for lung function testing. Lung India 2016;33(4):410–416. doi:10.4103/0970-2113.184875.
   PubMedGoogle Scholar
• Bokov P, Bafunyembaka G, Medjahdi N, Bernard A, Essalhi M, Houdouin V, Peiffer C, Delclaux C. Cross-sectional phenotyping of small airway dysfunction in preschool asthma using the impulse oscillometry system. J Asthma 2021;58(5):573–585. doi:10.1080/02770903.2020.1719133.
   PubMed Web of Science ®Google Scholar
• Cottee AM, Seccombe LM, Thamrin C, King GG, Peters MJ, Farah CS. Oscillometry and asthma control in patients with and without fixed airflow obstruction. J Allergy Clin Immunol Pract 2022;10(5):1260–1267.e1. doi:10.1016/j.jaip.2021.12.026.
   PubMed Web of Science ®Google Scholar
• Murphy KR, Zeiger RS, Kosinski M, Chipps B, Mellon M, Schatz M, Lampl K, Hanlon JT, Ramachandran S. Test for respiratory and asthma control in kids (TRACK): a caregiver-completed questionnaire for preschool-aged children. J Allergy Clin Immunol 2009;123(4):833–839.e9. PMID: 19348922. doi:10.1016/j.jaci.2009.01.058.
   PubMed Web of Science ®Google Scholar
• Dinakar C, Chipps BE, Matsui EC, Abramson SL, Dinakar C, Irani A-M, Kim JS, Mahr TA, Pistiner M, Wang J, et al.; Section on Allergy and Immunology; Section on Pediatric Pulmonology and Sleep Medicine. Clinical tools to assess asthma control in children. Pediatrics 2017;139(1):e20163438. doi:10.1542/peds.2016-3438.
   PubMed Web of Science ®Google Scholar
• Asthma Imaging and Diagnosis https://emedicine.medscape.com/article/353436-overview. [last accessed 2 Feb 2023].
   Google Scholar
• Patel NH, Hassoun A, Chao JH. The practice of obtaining a chest X-ray in pediatric patients presenting with their first episode of wheezing in the emergency department: a survey of attending physicians. Pediatr Emerg Care 2020;36(1):16–20. doi:10.1097/PEC.0000000000002015.
   PubMed Web of Science ®Google Scholar
• Alving K, Weitzberg E, Lundberg JM. Increased amount of nitric oxide in exhaled air of asthmatics. Eur Respir J 1993;6(9):1368–1370. doi:10.1183/09031936.93.06091368.
   PubMed Web of Science ®Google Scholar
• Chibana K, Trudeau JB, Mustovich AT, Hu H, Zhao J, Balzar S, Chu HW, Wenzel SE. IL-13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells. Clin Exp Allergy 2008;38(6):936–946. doi:10.1111/j.1365-2222.2008.02969.x.
   PubMed Web of Science ®Google Scholar
• Suresh V, Mih JD, George SC. Measurement of IL-13-induced iNOS-derived gas phase nitric oxide in human bronchial epithelial cells. Am J Respir Cell Mol Biol 2007;37(1):97–104. doi:10.1165/rcmb.2006-0419OC.
   PubMed Web of Science ®Google Scholar
• Pasha MA, Smith TC, Feustel PJ, Jourd’heuil D. Effects of low-dose fluticasone propionate/salmeterol combination therapy on exhaled nitric oxide and nitrite/nitrate in breath condensates from patients with mild persistent asthma. J Asthma 2013;50(1):64–70. doi:10.3109/02770903.2012.733467.
   PubMed Web of Science ®Google Scholar
• Dweik RA, Boggs PB, Erzurum SC, Irvin CG, Leigh MW, Lundberg JO, Olin AC, Plummer AL, Taylor DR, American Thoracic Society Committee on Interpretation of Exhaled Nitric Oxide Levels (FENO) for Clinical Applications. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med 2011;184(5):602–615. doi:10.1164/rccm.9120-11ST.
   PubMed Web of Science ®Google Scholar
• Bjermer L, Alving K, Diamant Z, Magnussen H, Pavord I, Piacentini G, Price D, Roche N, Sastre J, Thomas M, et al. Current evidence and future research needs for FeNO measurement in respiratory diseases. Respir Med 2014;108(6):830–841. doi:10.1016/j.rmed.2014.02.005.
   PubMed Web of Science ®Google Scholar
• de Blic J, Midulla F, Barbato A, Clement A, Dab I, Eber E, Green C, Grigg J, Kotecha S, Kurland G, et al. Bronchoalveolar lavage in children. ERS Task Force on bronchoalveolar lavage in children. European Respiratory Society. Eur Respir J 2000;15(1):217–231. doi:10.1183/09031936.00.15121700.
   PubMed Web of Science ®Google Scholar
• Teague WG. Blood eosinophilia may not adequately estimate lung fluid eosinophilia in childhood asthma. J Allergy Clin Immunol Pract 2019;7(7):2497–2498. doi:10.1016/j.jaip.2019.05.008.
   PubMed Web of Science ®Google Scholar
• Radhakrishnan D, Yamashita C, Gillio-Meina C, Fraser DD. Translational research in pediatrics III: bronchoalveolar lavage. Pediatrics 2014;134(1):135–154. doi:10.1542/peds.2013-1911.
   PubMed Web of Science ®Google Scholar
• Just J, Fournier L, Momas I, Zambetti C, Sahraoui F, Grimfeld A. Clinical significance of bronchoalveolar eosinophils in childhood asthma. J Allergy Clin Immunol 2002;110(1):42–44. doi:10.1067/mai.2002.123304.
   PubMed Web of Science ®Google Scholar
• Guiddir T, Saint-Pierre P, Purenne-Denis E, Lambert N, Laoudi Y, Couderc R, Gouvis-Echraghi R, Amat F, Just J. Neutrophilic steroid-refractory recurrent wheeze and eosinophilic steroid-refractory asthma in children. J Allergy Clin Immunol Pract 2017;5(5):1351–1361.e2. doi:10.1016/j.jaip.2017.02.003.
   PubMed Web of Science ®Google Scholar
• Kantar A, Chang AB, Shields MD, Marchant JM, Grimwood K, Grigg J, Priftis KN, Cutrera R, Midulla F, Brand PLP, et al. ERS statement on protracted bacterial bronchitis in children. Eur Respir J 2017;50(2):1602139. PMID: 28838975. doi:10.1183/13993003.02139-2016.
   PubMed Web of Science ®Google Scholar
• Kostikas K, Brindicci C, Patalano F. Blood eosinophils as biomarkers to drive treatment choices in asthma and COPD. Curr Drug Targets 2018;19(16):1882–1896. PMID: 29437007; PMCID: PMC6225326. doi:10.2174/1389450119666180212120012.
   PubMed Web of Science ®Google Scholar
• Harvey ES, Langton D, Katelaris C, Stevens S, Farah CS, Gillman A, Harrington J, Hew M, Kritikos V, Radhakrishna N, et al. Mepolizumab effectiveness and identification of super-responders in severe asthma. Eur Respir J 2020;55(5):1902420. doi:10.1183/13993003.02420-2019.
   PubMed Web of Science ®Google Scholar
• Chang TS, Lemanske RF, Jr, Guilbert TW, Gern JE, Coen MH, Evans MD, Gangnon RE, David Page C, Jackson DJ. Evaluation of the modified asthma predictive index in high-risk preschool children. J Allergy Clin Immunol Pract 2013;1(2):152–156. doi:10.1016/j.jaip.2012.10.008.
   PubMed Web of Science ®Google Scholar
• Licari A, Castagnoli R, Brambilla I, Marseglia A, Tosca MA, Marseglia GL, Ciprandi G. Asthma endotyping and biomarkers in childhood asthma. Pediatr Allergy Immunol Pulmonol 2018;31(2):44–55. doi:10.1089/ped.2018.0886.
   PubMed Web of Science ®Google Scholar
• Sorkness CA, Curry MD, Massanari M, Wildfire J. Eligibility for omalizumab dosing in children and young adults based on IgE and body weight. J Allergy Clin Immunol 2009;123(2):S80. doi:10.1016/j.jaci.2008.12.281.
   Web of Science ®Google Scholar
• Arasi S, Porcaro F, Renato CR, Alessandro G, Fiocchi AG. Severe asthma and allergy: a pediatric perspective. Front Pediatr. 2019;7(28). doi:10.3389/fped.2019.00028.
   PubMedGoogle Scholar
• The biology of IgE. UpToDate https://www.uptodate.com/contents/the-biology-of-Ige/print. [accessed 10 Feb 2023].
   Google Scholar
• Mümmler C, Suhling H, Kneidinger N, Buhl R, Kayser M, Drick N, Behr J, Welte T, Korn S, Milger K. Overall response to anti-IL5/anti-IL5Rα treatment in severe asthma does not depend on initial bronchodilator responsiveness. J Allergy Clin Immunol Pract 2022;21:1894–2198. doi:10.1016/j.jaip.2022.07.007.
   Google Scholar