miR-20b attenuates airway inflammation by regulating TXNIP and NLRP3 inflammasome in ovalbumin-induced asthmatic mice

References

• Papi A, Brightling C, Pedersen SE, Reddel HK. Asthma. Lancet. 2018;391(10122):783–800. doi:10.1016/S0140-6736(17)33311-1.
   PubMed Web of Science ®Google Scholar
• Patel SJ, Teach SJ. Asthma. Pediatr Rev. 2019;40(11):549–567. doi:10.1542/pir.2018-0282.
   PubMed Web of Science ®Google Scholar
• Padem N, Saltoun C. Classification of asthma. Allergy Asthma Proc. 2019;40(6):385–388. doi:10.2500/aap.2019.40.4253.
   PubMed Web of Science ®Google Scholar
• Azman S, Sekar M, Bonam SR, Gan SH, Wahidin S, Lum PT, Dhadde SB. Traditional medicinal plants conferring protection against ovalbumin-induced asthma in experimental animals: a review. J Asthma Allergy. 2021;14:641–662. doi:10.2147/JAA.S296391.
   PubMed Web of Science ®Google Scholar
• Haktanir Abul M, Phipatanakul W. Severe asthma in children: evaluation and management. Allergol Int. 2019;68(2):150–157. doi:10.1016/j.alit.2018.11.007.
   PubMed Web of Science ®Google Scholar
• Zinellu E, Piras B, Ruzittu GGM, Fois SS, Fois AG, Pirina P. Recent advances in inflammation and treatment of small airways in asthma. Int J Mol Sci. 2019;20(11):2617.
   Web of Science ®Google Scholar
• Zheng X, Chen W, Gong F, Chen Y, Chen E. The role and mechanism of pyroptosis and potential therapeutic targets in sepsis: a review. Front Immunol. 2021;12:711939. doi:10.3389/fimmu.2021.711939.
   PubMed Web of Science ®Google Scholar
• Xu P, Li F, Tang H. Pyroptosis and airway homeostasis regulation. Physiol Res. 2023;72(1):1–13. doi:10.33549/physiolres.934971.
   PubMed Web of Science ®Google Scholar
• van den Berge M, Tasena H. Role of microRNAs and exosomes in asthma. Curr Opin Pulm Med. 2019;25(1):87–93. doi:10.1097/MCP.0000000000000532.
   PubMed Web of Science ®Google Scholar
• Figueiredo Neto M, Figueiredo ML. Combination of interleukin-27 and microRNA for enhancing expression of anti-inflammatory and proosteogenic genes. Arthritis. 2017;2017:6365857.
   PubMedGoogle Scholar
• Tang J, Luo L. MicroRNA-20b-5p inhibits platelet-derived growth factor-induced proliferation of human fetal airway smooth muscle cells by targeting signal transducer and activator of transcription 3. Biomed Pharmacother. 2018;102:34–40. doi:10.1016/j.biopha.2018.03.015.
   PubMed Web of Science ®Google Scholar
• Ma H, Wang H, Luo Y, Guo S, Song C. Mir-20b-induced increase in myeloid-derived suppressor cells in the lungs of mice with chronic asthma. Ann Clin Lab Sci. 2017;47(1):76–82.
   PubMed Web of Science ®Google Scholar
• Ma H, Guo S, Luo Y, Wang Y, Wang H, He J, Tang J, Shen L, Song C. MicroRNA-20b promotes the accumulation of CD11b + Ly6G + Ly6C(low) myeloid-derived suppressor cells in asthmatic mice. Cent Eur J Immunol. 2017;42(1):30–38. doi:10.5114/ceji.2017.67316.
   PubMed Web of Science ®Google Scholar
• Lou J, Wang Y, Zhang Z, Qiu W. MiR-20b inhibits mycobacterium tuberculosis induced inflammation in the lung of mice through targeting NLRP3. Exp Cell Res. 2017;358(2):120–128. doi:10.1016/j.yexcr.2017.06.007.
   PubMed Web of Science ®Google Scholar
• Wang S, Du S, Lv Y, Wang W, Zhang F. Elevated microRNA-20b-3p and reduced thioredoxin-interacting protein ameliorate diabetic retinopathy progression by suppressing the NLRP3 inflammasomes. IUBMB Life. 2020;72(7):1433–1448. doi:10.1002/iub.2267.
   PubMed Web of Science ®Google Scholar
• Qayyum N, Haseeb M, Kim MS, Choi S. Role of thioredoxin-interacting protein in diseases and its therapeutic outlook. Int J Mol Sci. 2021;22(5):2754.
   Web of Science ®Google Scholar
• Lim JO, Shin NR, Seo YS, Nam HH, Ko JW, Jung TY, Lee SJ, Kim HJ, Cho YK, Kim JC, et al. Silibinin attenuates silica dioxide nanoparticles-induced inflammation by suppressing TXNIP/MAPKs/AP-1 signaling. Cells. 2020;9(3):678. doi:10.3390/cells9030678.
   PubMed Web of Science ®Google Scholar
• Ko JW, Shin NR, Je-Oh L, Jung TY, Moon C, Kim TW, Choi J, Shin IS, Heo JD, Kim JC. Silica dioxide nanoparticles aggravate airway inflammation in an asthmatic mouse model via NLRP3 inflammasome activation. Regul Toxicol Pharmacol. 2020;112:104618. doi:10.1016/j.yrtph.2020.104618.
   PubMed Web of Science ®Google Scholar
• Jia Y, Cui R, Wang C, Feng Y, Li Z, Tong Y, Qu K, Liu C, Zhang J. Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway. Redox Biol. 2020;32:101534. doi:10.1016/j.redox.2020.101534.
   PubMed Web of Science ®Google Scholar
• Theofani E, Semitekolou M, Morianos I, Samitas K, Xanthou G. Targeting NLRP3 inflammasome activation in severe asthma. J Clin Med. 2019;8(10):1615.
   PubMed Web of Science ®Google Scholar
• Swanson KV, Deng M, Ting JP. The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat Rev Immunol. 2019;19(8):477–489. doi:10.1038/s41577-019-0165-0.
   PubMed Web of Science ®Google Scholar
• Jones-Bolin S. Guidelines for the care and use of laboratory animals in biomedical research. Curr Protoc Pharmacol. 2012;59(1). doi:10.1002/0471141755.pha04bs59.
   Google Scholar
• Han S, Ma C, Bao L, Lv L, Huang M. miR-146a mimics attenuate allergic airway inflammation by impacted group 2 innate lymphoid cells in an ovalbumin-induced asthma mouse model. Int Arch Allergy Immunol. 2018;177(4):302–310. doi:10.1159/000491438.
   PubMed Web of Science ®Google Scholar
• Chen X, Xiao Z, Jiang Z, Jiang Y, Li W, Wang M. Schisandrin B attenuates airway inflammation and airway remodeling in asthma by inhibiting NLRP3 inflammasome activation and reducing pyroptosis. Inflammation. 2021;44(6):2217–2231. doi:10.1007/s10753-021-01494-z.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Chen Z, Yang X, Cao X, Liang Z, Ma H, Zhao J. Morin attenuates pyroptosis of nucleus pulposus cells and ameliorates intervertebral disc degeneration via inhibition of the TXNIP/NLRP3/Caspase-1/IL-1beta signaling pathway. Biochem Biophys Res Commun. 2021;559:106–112. doi:10.1016/j.bbrc.2021.04.090.
   PubMed Web of Science ®Google Scholar
• Zhuang J, Cui H, Zhuang L, Zhai Z, Yang F, Luo G, He J, Zhao H, Zhao W, He Y, et al. Bronchial epithelial pyroptosis promotes airway inflammation in a murine model of toluene diisocyanate-induced asthma. Biomed Pharmacother. 2020;125:109925. doi:10.1016/j.biopha.2020.109925.
   PubMed Web of Science ®Google Scholar
• Svitich OA, Sobolev VV, Gankovskaya LV, Zhigalkina PV, Zverev VV. The role of regulatory RNAs (miRNAs) in asthma. Allergol Immunopathol (Madr). 2018;46(2):201–205. doi:10.1016/j.aller.2017.09.015.
   PubMed Web of Science ®Google Scholar
• Ma H, Luo YL, Guo SJ, Shen L, Song CW. [Inhibitory effect of miR-20b on airway inflammation in asthmatic mice]. Nan Fang Yi Ke Da Xue Xue Bao. 2015;35(10):1463–1466.
   PubMedGoogle Scholar
• Fahy JV. Type 2 inflammation in asthma–present in most, absent in many. Nat Rev Immunol. 2015;15(1):57–65. doi:10.1038/nri3786.
   PubMed Web of Science ®Google Scholar
• Tang GX, Yang MS, Xiang KM, Yang BC, Liu ZL, Zhao SP. MiR-20b-5p modulates inflammation, apoptosis and angiogenesis in severe acute pancreatitis through autophagy by targeting AKT3. Autoimmunity. 2021;54(7):460–470. doi:10.1080/08916934.2021.1953484.
   PubMed Web of Science ®Google Scholar
• Li JZ, Ye LH, Wang DH, Zhang HC, Li TY, Liu ZQ, Dai EH, Li MR. The identify role and molecular mechanism of the MALAT1/hsa-mir-20b-5p/TXNIP axis in liver inflammation caused by CHB in patients with chronic HBV infection complicated with NAFLD. Virus Res. 2021;298:198405. doi:10.1016/j.virusres.2021.198405.
   PubMed Web of Science ®Google Scholar
• Torii M, Wang L, Ma N, Saito K, Hori T, Sato-Ueshima M, Koyama Y, Nishikawa H, Katayama N, Mizoguchi A, et al. Thioredoxin suppresses airway inflammation independently of systemic Th1/Th2 immune modulation. Eur J Immunol. 2010;40(3):787–796. doi:10.1002/eji.200939724.
   PubMed Web of Science ®Google Scholar
• Yang C, Xia W, Liu X, Lin J, Wu A. Role of TXNIP/NLRP3 in sepsis-induced myocardial dysfunction. Int J Mol Med. 2019;44(2):417–426. doi:10.3892/ijmm.2019.4232.
   PubMed Web of Science ®Google Scholar
• Sun X, Jiao X, Ma Y, Liu Y, Zhang L, He Y, Chen Y. Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome. Biochem Biophys Res Commun. 2016;481(1–2):63–70. doi:10.1016/j.bbrc.2016.11.017.
   PubMed Web of Science ®Google Scholar
• Chen D, Dixon BJ, Doycheva DM, Li B, Zhang Y, Hu Q, He Y, Guo Z, Nowrangi D, Flores J, et al. IRE1alpha inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic-ischemic brain injury in rats. J Neuroinflammation. 2018;15(1):32. doi:10.1186/s12974-018-1077-9.
   PubMed Web of Science ®Google Scholar
• Heo MJ, Kim TH, You JS, Blaya D, Sancho-Bru P, Kim SG. Alcohol dysregulates miR-148a in hepatocytes through FoxO1, facilitating pyroptosis via TXNIP overexpression. Gut. 2019;68(4):708–720. doi:10.1136/gutjnl-2017-315123.
   PubMed Web of Science ®Google Scholar
• Liu Y, Gao X, Miao Y, Wang Y, Wang H, Cheng Z, Wang X, Jing X, Jia L, Dai L, et al. NLRP3 regulates macrophage M2 polarization through up-regulation of IL-4 in asthma. Biochem J. 2018;475(12):1995–2008. doi:10.1042/BCJ20180086.
   PubMed Web of Science ®Google Scholar
• Hughes MM, O'Neill LAJ. Metabolic regulation of NLRP3. Immunol Rev. 2018;281(1):88–98. doi:10.1111/imr.12608.
   PubMed Web of Science ®Google Scholar
• Wu X, Zhang H, Qi W, Zhang Y, Li J, Li Z, Lin Y, Bai X, Liu X, Chen X, et al. Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis. Cell Death Dis. 2018;9(2):171. doi:10.1038/s41419-017-0257-3.
   PubMed Web of Science ®Google Scholar
• Wang S, Yuan YH, Chen NH, Wang HB. The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson’s disease. Int Immunopharmacol. 2019;67:458–464. doi:10.1016/j.intimp.2018.12.019.
   PubMed Web of Science ®Google Scholar
• Chen X, Liu G, Yuan Y, Wu G, Wang S, Yuan L. NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-kappaB signaling. Cell Death Dis. 2019;10(12):906. doi:10.1038/s41419-019-2157-1.
   PubMed Web of Science ®Google Scholar