Age-related differences in associations between uncontrolled asthma, comorbidities and biomarkers in adult-onset asthma

References

• Westerhof GA, Coumou H, de Nijs SB, Weersink EJ, Bel EH. Clinical predictors of remission and persistence of adult-onset asthma. J Allergy Clin Immunol. 2018;141(1):104–109.e3. doi:10.1016/j.jaci.2017.03.034.
   PubMed Web of Science ®Google Scholar
• Almqvist L, Rönmark E, Stridsman C, Backman H, Lindberg A, Lundbäck B, Hedman L. Remission of adult-onset asthma is rare: a 15-year follow-up study. ERJ Open Res. 2020;6(4):00620–2020. doi:10.1183/23120541.00620-2020.
   PubMedGoogle Scholar
• Ilmarinen P, Pardo A, Tuomisto LE, Vähätalo I, Niemelä O, Nieminen P, Kankaanranta H. Long-term prognosis of new adult-onset asthma in obese patients. Eur Respir J. 2021;57(4):2001209. doi:10.1183/13993003.01209-2020.
   PubMed Web of Science ®Google Scholar
• Ronmark E, Perzanowski M, Platts-Mills T, Lundback B. Different sensitization profile for asthma, rhinitis, and eczema among 7–8-year-old children: report from the Obstructive Lung Disease in Northern Sweden studies. Pediatr Allergy Immunol. 2003;14(2):91–99. doi:10.1034/j.1399-3038.2003.00042.x.
   PubMed Web of Science ®Google Scholar
• Andersson M, Hedman L, Bjerg A, Forsberg B, Lundback B, Ronmark E. Remission and persistence of asthma followed from 7 to 19 years of age. Pediatrics. 2013;132(2):e435–e442. doi:10.1542/peds.2013-0741.
   PubMed Web of Science ®Google Scholar
• Warm K, Backman H, Lindberg A, Lundback B, Ronmark E. Low incidence and high remission of allergic sensitization among adults. J Allergy Clin Immunol. 2012;129(1):136–142. doi:10.1016/j.jaci.2011.08.033.
   PubMed Web of Science ®Google Scholar
• Tuomisto LE, Ilmarinen P, Niemela O, Haanpaa J, Kankaanranta T, Kankaanranta H. A 12-year prognosis of adult-onset asthma: seinajoki Adult Asthma Study. Respir Med. 2016;117:223–229. doi:10.1016/j.rmed.2016.06.017.
   PubMed Web of Science ®Google Scholar
• Ronmark E, Andersson C, Nystrom L, Forsberg B, Jarvholm B, Lundback B. Obesity increases the risk of incident asthma among adults. Eur Respir J. 2005;25(2):282–288. doi:10.1183/09031936.05.00054304.
   PubMed Web of Science ®Google Scholar
• Stridsman C, Axelsson M, Warm K, Backman H. Uncontrolled asthma occurs in all GINA treatment steps and is associated with worse physical health – a report from the OLIN adult asthma cohort. J Asthma. 2021;58(5):586–595. doi:10.1080/02770903.2020.1713150.
   PubMed Web of Science ®Google Scholar
• Aaron SD, Boulet LP, Reddel HK, Gershon AS. Underdiagnosis and overdiagnosis of asthma. Am J Respir Crit Care Med. 2018;198(8):1012–1020. doi:10.1164/rccm.201804-0682CI.
   PubMed Web of Science ®Google Scholar
• Hekking PP, Amelink M, Wener RR, Bouvy ML, Bel EH. Comorbidities in difficult-to-control asthma. J Allergy Clin Immunol Pract. 2018;6(1):108–113. doi:10.1016/j.jaip.2017.06.008.
   PubMed Web of Science ®Google Scholar
• Busse WW, Kraft M. Current unmet needs and potential solutions to uncontrolled asthma. Eur Respir Rev. 2022;31(163):210176. doi:10.1183/16000617.0176-2021.
   PubMed Web of Science ®Google Scholar
• Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, Adcock IM, Bateman ED, Bel EH, Bleecker ER, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014;43(2):343–373. doi:10.1183/09031936.00202013.
   PubMed Web of Science ®Google Scholar
• Christensen GM, Tomasallo CD, Meiman JG. Adult asthma control and self-management, Wisconsin 2012–2016. WMJ. 2019;118(4):187–190.
   PubMedGoogle Scholar
• Chapman KR, Hinds D, Piazza P, Raherison C, Gibbs M, Greulich T, Gaalswyk K, Lin J, Adachi M, Davis KJ, et al. Physician perspectives on the burden and management of asthma in six countries: the global asthma physician survey (GAPS). BMC Pulm Med. 2017;17(1):153. doi:10.1186/s12890-017-0492-5.
   PubMed Web of Science ®Google Scholar
• Corrado A, Renda T, Polese G, Rossi A, Group SAS, SERENA (Studio ossERvazionalE per il monitoraggio dell’asma non coNtrollAto)/AIPO Study Group. Assessment of asthma control: the SERENA study. Respir Med. 2013;107(11):1659–1666. doi:10.1016/j.rmed.2013.08.019.
   PubMed Web of Science ®Google Scholar
• Diamant Z, Vijverberg S, Alving K, Bakirtas A, Bjermer L, Custovic A, Dahlen S-E, Gaga M, Gerth van Wijk R, Giacco SD, et al. Toward clinically applicable biomarkers for asthma: an EAACI position paper. Allergy. 2019;74(10):1835–1851. doi:10.1111/all.13806.
   PubMed Web of Science ®Google Scholar
• Global Initiative for Asthma (GINA): Global strategy for asthma management and prevention 2021; 2020. Available from: https://ginasthma.org/wp-content/uoloads/2020//04/GINA-2020-full-report-final-wms.pdf
   Google Scholar
• Backman H, Räisänen P, Hedman L, Stridsman C, Andersson M, Lindberg A, Lundbäck B, Rönmark E. Increased prevalence of allergic asthma from 1996 to 2006 and further to 2016-results from three population surveys. Clin Exp Allergy. 2017;47(11):1426–1435. doi:10.1111/cea.12963.
   PubMed Web of Science ®Google Scholar
• Räisänen P, Backman H, Hedman L, Andersson M, Stridsman C, Kankaanranta H, Ilmarinen P, Andersen H, Piirilä P, Lindberg A, et al. High but stable incidence of adult-onset asthma in northern Sweden over the last decades. ERJ Open Res. 2021;7(3):00262–2021. doi:10.1183/23120541.00262-2021.
   PubMedGoogle Scholar
• Schyllert C, Lindberg A, Hedman L, Stridsman C, Andersson M, Andersen H, et al. Socioeconomic inequalities in asthma and respiratory symptoms in a high-income country: changes from 1996 to 2016. J Asthma. 2023;60(1):185–194.
   PubMed Web of Science ®Google Scholar
• Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CPM, Gustafsson P, et al. Standardisation of spirometry. Eur Respir J. 2005;26(2):319–338. doi:10.1183/09031936.05.00034805.
   PubMed Web of Science ®Google Scholar
• Backman H, Lindberg A, Oden A, Ekerljung L, Hedman L, Kainu A, et al. Reference values for spirometry – report from the Obstructive Lung Disease in Northern Sweden studies. Eur Clin Respir J. 2015;2. doi:10.3402/ecrj.v2.26375.
   PubMedGoogle Scholar
• Price DB, Rigazio A, Campbell JD, Bleecker ER, Corrigan CJ, Thomas M, Wenzel SE, Wilson AM, Small MB, Gopalan G, et al. Blood eosinophil count and prospective annual asthma disease burden: a UK cohort study. Lancet Respir Med. 2015;3(11):849–858. doi:10.1016/S2213-2600(15)00367-7.
   PubMed Web of Science ®Google Scholar
• Chaudhuri R, McSharry C, Heaney LG, Niven R, Brightling CE, Menzies-Gow AN, Bucknall C, Mansur AH, Lee W, Shepherd M, et al. Effects of older age and age of asthma onset on clinical and inflammatory variables in severe refractory asthma. Respir Med. 2016;118:46–52. doi:10.1016/j.rmed.2016.07.005.
   PubMed Web of Science ®Google Scholar
• Ilmarinen P, Tuomisto LE, Niemela O, Kankaanranta H. Prevalence of patients eligible for Anti-IL-5 treatment in a cohort of adult-onset asthma. J Allergy Clin Immunol Pract. 2019;7(1):165–174.e4. doi:10.1016/j.jaip.2018.05.032.
   PubMed Web of Science ®Google Scholar
• Menzies-Gow A, Mansur AH, Brightling CE. Clinical utility of fractional exhaled nitric oxide in severe asthma management. Eur Respir J. 2020;55(3):1901633. doi:10.1183/13993003.01633-2019.
   PubMed Web of Science ®Google Scholar
• Amelink M, de Nijs SB, de Groot JC, van Tilburg PMB, van Spiegel PI, Krouwels FH, Lutter R, Zwinderman AH, Weersink EJM, ten Brinke A, et al. Three phenotypes of adult-onset asthma. Allergy. 2013;68(5):674–680. doi:10.1111/all.12136.
   PubMed Web of Science ®Google Scholar
• Backman H, Lindberg A, Hedman L, Stridsman C, Jansson S-A, Sandström T, Lundbäck B, Rönmark E. FEV1 decline in relation to blood eosinophils and neutrophils in a population-based asthma cohort. World Allergy Organ J. 2020;13(3):100110. doi:10.1016/j.waojou.2020.100110.
   PubMed Web of Science ®Google Scholar
• Westerhof GA, de Groot JC, Amelink M, de Nijs SB, Ten Brinke A, Weersink EJ, Bel EH. Predictors of frequent exacerbations in (ex)smoking and never smoking adults with severe asthma. Respir Med. 2016;118:122–127. doi:10.1016/j.rmed.2016.08.006.
   PubMed Web of Science ®Google Scholar
• Koebnick C, Fischer H, Daley MF, Ferrara A, Horberg MA, Waitzfelder B, Young DR, Gould MK. Interacting effects of obesity, race, ethnicity and sex on the incidence and control of adult-onset asthma. Allergy Asthma Clin Immunol. 2016;12:50. doi:10.1186/s13223-016-0155-8.
   PubMed Web of Science ®Google Scholar
• Peters U, Dixon AE, Forno E. Obesity and asthma. J Allergy Clin Immunol. 2018;141(4):1169–1179. doi:10.1016/j.jaci.2018.02.004.
   PubMed Web of Science ®Google Scholar
• Kankaanranta H, Kauppi P, Tuomisto LE, Ilmarinen P. Emerging comorbidities in adult asthma: risks, clinical associations, and mechanisms. Mediators Inflamm. 2016;2016:3690628. doi:10.1155/2016/3690628.
   PubMed Web of Science ®Google Scholar
• Phillips KM, Hoehle LP, Caradonna DS, Gray ST, Sedaghat AR. Association of severity of chronic rhinosinusitis with degree of comorbid asthma control. Ann Allergy Asthma Immunol. 2016;117(6):651–654. doi:10.1016/j.anai.2016.09.439.
   PubMed Web of Science ®Google Scholar
• Jarvis D, Newson R, Lotvall J, Hastan D, Tomassen P, Keil T, Gjomarkaj M, Forsberg B, Gunnbjornsdottir M, Minov J, et al. Asthma in adults and its association with chronic rhinosinusitis: the GA2LEN survey in Europe. Allergy. 2012;67(1):91–98. doi:10.1111/j.1398-9995.2011.02709.x.
   PubMed Web of Science ®Google Scholar
• Opolski M, Wilson I. Asthma and depression: a pragmatic review of the literature and recommendations for future research. Clin Pract Epidemiol Ment Health. 2005;1:18. doi:10.1186/1745-0179-1-18.
   PubMedGoogle Scholar
• Bozek A, Rogala B, Bednarski P. Asthma, COPD and comorbidities in elderly people. J Asthma. 2016;53(9):943–947. doi:10.3109/02770903.2016.1170139.
   PubMed Web of Science ®Google Scholar
• Lee HM, Truong ST, Wong ND. Association of adult-onset asthma with specific cardiovascular conditions. Respir Med. 2012;106(7):948–953. doi:10.1016/j.rmed.2012.02.017.
   PubMed Web of Science ®Google Scholar
• Tattersall MC, Barnet JH, Korcarz CE, Hagen EW, Peppard PE, Stein JH. Late-onset asthma predicts cardiovascular disease events: the Wisconsin sleep cohort. J Am Heart Assoc. 2016;5(9):e003448.
   PubMed Web of Science ®Google Scholar
• Boulet LP, Robitaille C, Deschesnes F, Villeneuve H, Boulay ME. Comparative clinical, physiological, and inflammatory characteristics of elderly subjects with or without asthma and young subjects with asthma. Chest. 2017;152(6):1203–1213. doi:10.1016/j.chest.2017.09.019.
   PubMed Web of Science ®Google Scholar
• Mathur SK, Schwantes EA, Jarjour NN, Busse WW. Age-related changes in eosinophil function in human subjects. Chest. 2008;133(2):412–419. doi:10.1378/chest.07-2114.
   PubMed Web of Science ®Google Scholar