Systemic meta-analysis: apigenin’s effects on lung inflammation and oxidative stress

References

• Zhang J, Tian W, Wang F, Liu J, Huang J, Duangmano S, Liu H, Liu M, Zhang Z, Jiang X. Advancements in understanding the role of microRnas in regulating macrophage polarization during acute lung injury. Cell Cycle. 2023;22(14-16):1694–1712. doi:10.1080/15384101.2023.2230018.
   PubMed Web of Science ®Google Scholar
• Long ME, Mallampalli RK, Horowitz JC. Pathogenesis of pneumonia and acute lung injury. Clin Sci. 2022;136(10):747–769. doi:10.1042/CS20210879.
   Web of Science ®Google Scholar
• Bobba CM. Strategies to model and develop therapeutics for ventilator induced lung injury. The Ohio State University; 2019.
   Google Scholar
• Singh SS, De SD, Al-Adhami A, Singh R, Hopkins PM, Curry PA. Primary graft dysfunction following lung transplantation: from pathogenesis to future frontiers. World J Transplant. 2023;13(3):58–85. doi:10.5500/wjt.v13.i3.58.
   PubMedGoogle Scholar
• Zhou Y, Li P, Goodwin AJ, Cook JA, Halushka PV, Chang E, Zingarelli B, Fan H. Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury. Crit Care. 2019;23(1):44. doi:10.1186/s13054-019-2339-3.
   PubMed Web of Science ®Google Scholar
• Yasuda H, Okano H, Mayumi T, Nakane M, Shime N. Association of noninvasive respiratory support with mortality and intubation rates in acute respiratory failure: a systematic review and network meta-analysis. J Intensive Care. 2021;9(1):32. doi:10.1186/s40560-021-00539-7.
   PubMed Web of Science ®Google Scholar
• Slutsky AS. History of mechanical ventilation. From Vesalius to ventilator-induced lung injury. Am J Respir Crit Care Med. 2015;191(10):1106–1115. doi:10.1164/rccm.201503-0421PP.
   PubMed Web of Science ®Google Scholar
• Johnson ER, Matthay MA. Acute lung injury: epidemiology, pathogenesis, and treatment. J Aerosol Med Pulm Drug Deliv. 2010;23(4):243–252. doi:10.1089/jamp.2009.0775.
   PubMed Web of Science ®Google Scholar
• Wu Y, Sun H, Qin L, Zhang X, Zhou H, Wang Y, Wang L, Li M, Liu J, Zhang J. Human amnion-derived mesenchymal stem cells attenuate acute lung injury in two different acute lung injury mice models. Front Pharmacol. 2023;14:1149659. doi:10.3389/fphar.2023.1149659.
   PubMed Web of Science ®Google Scholar
• Villalba N, Ma Y, Gahan SA, Joly-Amado A, Spence S, Yang X, Nash KR, Yuan SY. Lung infection by Pseudomonas aeruginosa induces neuroinflammation and blood–brain barrier dysfunction in mice. J Neuroinflammation. 2023;20(1):127. doi:10.1186/s12974-023-02817-7.
   PubMed Web of Science ®Google Scholar
• Xiao Z, Long J, Zhang J, Qiu Z, Zhang C, Liu H, Liu X, Wang K, Tang Y, Chen L, et al. Administration of protopine prevents mitophagy and acute lung injury in sepsis. Front Pharmacol. 2023;14:1104185. doi:10.3389/fphar.2023.1104185.
   PubMed Web of Science ®Google Scholar
• Zeng L-H, Fatima M, Syed SK, Shaukat S, Mahdy A, Hussain N, Al Haddad AHI, Said ASA, Alqahtani A, Alqahtani T, et al. Anti-inflammatory and anti-oxidant properties of Ipomoea nil (Linn.) Roth significantly alleviates cigarette smoke (CS)-induced acute lung injury via possibly inhibiting the NF-κB pathway. Biomed Pharmacother. 2022;155:113267. doi:10.1016/j.biopha.2022.113267.
   PubMed Web of Science ®Google Scholar
• Dang H, Wang S, Yang L, Fang F, Xu F. Upregulation of Shh and Ptc1 in hyperoxia‑induced acute lung injury in neonatal rats. Mol Med Rep. 2012;6(2):297–302.
   PubMed Web of Science ®Google Scholar
• Wang W, Wu J, Mukherjee A, He T, Wang XY, Ma Y, Fang X. Lysophosphatidic acid induces tumor necrosis factor alpha to regulate a pro-inflammatory cytokine network in ovarian cancer. FASEB J. 2020;34(10):13935–13948. doi:10.1096/fj.202001136R.
   PubMed Web of Science ®Google Scholar
• Du ZA, Sun MN, Hu ZS. Saikosaponin a ameliorates LPS-induced acute lung injury in mice. Inflammation. 2018;41(1):193–198. doi:10.1007/s10753-017-0677-3.
   PubMed Web of Science ®Google Scholar
• Bratovcic A. Antioxidant enzymes and their role in preventing cell damage. Acta Sci Nutr. 2020;4(3):01–07. doi:10.31080/ASNH.2020.04.0659.
   Google Scholar
• Yonekura-Sakakibara K, Higashi Y, Nakabayashi R. The origin and evolution of plant flavonoid metabolism. Front Plant Sci. 2019;10:943. doi:10.3389/fpls.2019.00943.
   PubMed Web of Science ®Google Scholar
• Sharma V, Gupta P, Kagolla P, Hangargi B, Veershetty A, Ramrao DP, Suresh S, Narasanna R, Naik GR, Kumar A, et al. Metabolomics intervention towards better understanding of plant traits. Cells. 2021;10(2):346. doi:10.3390/cells10020346.
   PubMed Web of Science ®Google Scholar
• Madunić J, Madunić IV, Gajski G, Popić J, Garaj-Vrhovac V. Apigenin: a dietary flavonoid with diverse anticancer properties. Cancer Lett. 2018;413:11–22. doi:10.1016/j.canlet.2017.10.041.
   PubMed Web of Science ®Google Scholar
• Al-Khayri JM, Sahana GR, Nagella P, Joseph BV, Alessa FM, Al-Mssallem MQ. Flavonoids as potential anti-inflammatory molecules: a review. Molecules. 2022;27(9):2901. doi:10.3390/molecules27092901.
   PubMed Web of Science ®Google Scholar
• Salehi B, Venditti A, Sharifi-Rad M, Kręgiel D, Sharifi-Rad J, Durazzo A, Lucarini M, Santini A, Souto EB, Novellino E, et al. The therapeutic potential of apigenin. Int J Mol Sci. 2019;20(6):1305. doi:10.3390/ijms20061305.
   PubMed Web of Science ®Google Scholar
• Fernández-Rojas B, Gutiérrez-Venegas G. Flavonoids exert multiple periodontic benefits including anti-inflammatory, periodontal ligament-supporting, and alveolar bone-preserving effects. Life Sci. 2018;209:435–454. doi:10.1016/j.lfs.2018.08.029.
   PubMed Web of Science ®Google Scholar
• Fernández J, Silván B, Entrialgo-Cadierno R, Villar CJ, Capasso R, Uranga JA, Lombo F, Abalo R. Antiproliferative and palliative activity of flavonoids in colorectal cancer. Biomed Pharmacother. 2021;143:112241. doi:10.1016/j.biopha.2021.112241.
   PubMed Web of Science ®Google Scholar
• Hostetler GL, Ralston RA, Schwartz SJ. Flavones: food sources, bioavailability, metabolism, and bioactivity. Adv Nutr. 2017;8(3):423–435. doi:10.3945/an.116.012948.
   PubMed Web of Science ®Google Scholar
• Mushtaq Z, Sadeer NB, Hussain M, Mahwish, Alsagaby SA, Imran M, Mumtaz T, Umar M, Tauseef A, Al Abdulmonem W, et al. Therapeutical properties of apigenin: a review on the experimental evidence and basic mechanisms. Int J Food Prop. 2023;26(1):1914–1939. doi:10.1080/10942912.2023.2236329.
   Web of Science ®Google Scholar
• Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151(4):264–269. doi:10.7326/0003-4819-151-4-200908180-00135.
   PubMed Web of Science ®Google Scholar
• Hayden JA, Côté P, Bombardier C. Evaluation of the quality of prognosis studies in systematic reviews. Ann Intern Med. 2006;144(6):427–437. doi:10.7326/0003-4819-144-6-200603210-00010.
   PubMed Web of Science ®Google Scholar
• Higgins J, Green S. Cochrane handbook for systematic reviews of 478 interventions. Verion.
   Google Scholar
• Cicek M, Unsal V, Doganer A, Demir M. Investigation of oxidant/antioxidant and anti-inflammatory effects of apigenin on apoptosis in sepsis-induced rat lung. J Biochem Mol Toxicol. 2021;35(5):e22743. doi:10.1002/jbt.22743.
   PubMed Web of Science ®Google Scholar
• Wang J, Liu Y-T, Xiao L, Zhu L, Wang Q, Yan T. Anti-inflammatory effects of apigenin in lipopolysaccharide-induced inflammatory in acute lung injury by suppressing COX-2 and NF-kB pathway. Inflammation. 2014;37(6):2085–2090. doi:10.1007/s10753-014-9942-x.
   PubMed Web of Science ®Google Scholar
• Chen L, Zhao W. Apigenin protects against bleomycin‑induced lung fibrosis in rats. Exp Ther Med. 2016;11(1):230–234. doi:10.3892/etm.2015.2885.
   PubMed Web of Science ®Google Scholar
• Li K-C, Ho Y-L, Hsieh W-T, Huang S-S, Chang Y-S, Huang G-J. Apigenin-7-glycoside prevents LPS-induced acute lung injury via downregulation of oxidative enzyme expression and protein activation through inhibition of MAPK phosphorylation. Int J Mol Sci. 2015;16(1):1736–1754. doi:10.3390/ijms16011736.
   PubMed Web of Science ®Google Scholar
• Luan R-L, Meng X-X, Jiang W. Protective effects of apigenin against paraquat-induced acute lung injury in mice. Inflammation. 2016;39(2):752–758. doi:10.1007/s10753-015-0302-2.
   PubMed Web of Science ®Google Scholar
• Matute-Bello G, Frevert CW, Martin TR. Animal models of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2008;295(3):L379–L399. doi:10.1152/ajplung.00010.2008.
   PubMed Web of Science ®Google Scholar
• Bian X-X, Zhao X, Ma C-H, Shen C-P. Arbutin alleviates LPS induced sepsis pneumonia in mice. Evid Based Complement Altern Med. 2022;2022:1–8. doi:10.1155/2022/5863952.
   Web of Science ®Google Scholar
• Kemanetzoglou E, Andreadou E. CNS demyelination with TNF-α blockers. Curr Neurol Neurosci Rep. 2017;17(4):36. doi:10.1007/s11910-017-0742-1.
   PubMed Web of Science ®Google Scholar
• Ginwala R, Bhavsar R, Moore P, Bernui M, Singh N, Bearoff F, Nagarkatti M, Khan ZK, Jain P. Apigenin modulates dendritic cell activities and curbs inflammation via RelB inhibition in the context of neuroinflammatory diseases. J Neuroimmune Pharmacol. 2021;16(2):403–424. doi:10.1007/s11481-020-09933-8.
   PubMed Web of Science ®Google Scholar
• Mehri H, Aslanabadi N, Nourazarian A, Shademan B, Khaki-khatibi F. Evaluation of the serum levels of Mannose binding lectin-2, tenascin-C, and total antioxidant capacity in patients with coronary artery disease. J Clin Lab Anal. 2021;35(10):e23967. doi:10.1002/jcla.23967.
   PubMed Web of Science ®Google Scholar
• Ajoolabady A, Shademan B, Avci CB, Nikanfar M, Nourazarian A, Laghousi D. Diagnostic potential of autophagy-5 protein, apolipoprotein B-48, and oxidative stress markers in serum of patients with early-stage ischemic stroke. World Neurosurg. 2022;167:e656–e663. doi:10.1016/j.wneu.2022.08.063.
   PubMed Web of Science ®Google Scholar
• Bezerra FS, Lanzetti M, Nesi RT, Nagato AC, Silva CP, Kennedy-Feitosa E, Melo AC, Cattani-Cavalieri I, Porto LC, Valenca SS. Oxidative stress and inflammation in acute and chronic lung injuries. Antioxidants. 2023;12(3):548. doi:10.3390/antiox12030548.
   Web of Science ®Google Scholar
• Yu H, Huang X, Zhu H-H, Wang N, Xie C, Zhou Y-L, Shi H-L, Chen M-M, Wu Y-R, Ruan Z-H, et al. Apigenin ameliorates non-eosinophilic inflammation, dysregulated immune homeostasis and mitochondria-mediated airway epithelial cell apoptosis in chronic obese asthma via the ROS-ASK1-MAPK pathway. Phytomedicine. 2023;111:154646. doi:10.1016/j.phymed.2023.154646.
   PubMed Web of Science ®Google Scholar