174
Views
0
CrossRef citations to date
0
Altmetric
Research Articles

AIM2 participates in house dust mite (HDM)-induced epithelial dysfunctions and ovalbumin (OVA)-induced allergic asthma in infant mice

, MM, , MM, , MM & , MM
Pages 479-490 | Received 28 Jul 2023, Accepted 25 Nov 2023, Published online: 11 Jan 2024

References

  • Dharmage SC, Perret JL, Custovic A. Epidemiology of asthma in children and adults. Front Pediatr. 2019;7:246. doi:10.3389/fped.2019.00246.
  • Holgate ST, Wenzel S, Postma DS, Weiss ST, Renz H, Sly PD. Asthma. Nat Rev Dis Primers 2015;1(1):15025. doi:10.1038/nrdp.2015.25.
  • Valero A, Quirce S, Dávila I, Delgado J, Domínguez-Ortega J. Allergic respiratory disease: different allergens, different symptoms. Allergy 2017;72(9):1306–1316. doi:10.1111/all.13141.
  • Bousquet J, Arnavielhe S, Bedbrook A, Fonseca J, Morais Almeida M, Todo Bom A, Annesi-Maesano I, Caimmi D, Demoly P, Devillier P, et al. The Allergic Rhinitis and its Impact on Asthma (ARIA) score of allergic rhinitis using mobile technology correlates with quality of life: the MASK study. Allergy 2018;73(2):505–510. doi:10.1111/all.13307.
  • Del Giacco SR, Bakirtas A, Bel E, Custovic A, Diamant Z, Hamelmann E, Heffler E, Kalayci Ö, Saglani S, Sergejeva S, et al. Allergy in severe asthma. Allergy 2017;72(2):207–220. doi:10.1111/all.13072.
  • Wittekindt OH. Tight junctions in pulmonary epithelia during lung inflammation. Pflugers Arch 2017;469(1):135–147. doi:10.1007/s00424-016-1917-3.
  • Boonpiyathad T, Satitsuksanoa P, Akdis M, Akdis CA. Immunologic mechanisms in asthma. Semin Immunol 2019;44:101326. doi:10.1016/j.smim.2019.101333.
  • Roan F, Obata-Ninomiya K, Ziegler SF. Epithelial cell-derived cytokines: more than just signaling the alarm. J Clin Invest 2019;129(4):1441–1451. doi:10.1172/JCI124606.
  • Jackson DJ, Makrinioti H, Rana BMJ, Shamji BWH, Trujillo-Torralbo MB, Footitt J, Telcian AG, Nikonova A, Zhu J, Aniscenko J, et al., IL-33-dependent type 2 inflammation during rhinovirus-induced asthma exacerbations in vivo.Am J Respir Crit Care Med 2014;190(12):1373–1382. doi:10.1164/rccm.201406-1039OC.
  • Saatian B, Rezaee F, Desando S, Emo J, Chapman T, Knowlden S, Georas SN. Interleukin-4 and interleukin-13 cause barrier dysfunction in human airway epithelial cells. Tissue Barriers 2013;1(2):e24333. doi:10.4161/tisb.24333.
  • Waldstein KA, Varga SM. Respiratory viruses and the inflammasome: the double-edged sword of inflammation. PLoS Pathog 2022;18(12):e1011014. doi:10.1371/journal.ppat.1011014.
  • Kim RY, Pinkerton JW, Gibson PG, Cooper MA, Horvat JC, Hansbro PM. Inflammasomes in COPD and neutrophilic asthma. Thorax 2015;70(12):1199–1201. doi:10.1136/thoraxjnl-2014-206736.
  • Fernandes-Alnemri T, Yu JW, Juliana C, Solorzano L, Kang S, Wu J, Datta P, McCormick M, Huang L, McDermott E, et al. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nat Immunol 2010;11(5):385–393. doi:10.1038/ni.1859.
  • Sun J, Li Y. Pyroptosis and respiratory diseases: a review of current knowledge. Front Immunol 2022;13:920464. doi:10.3389/fimmu.2022.920464.
  • Imaoka H, Gauvreau GM, Watson RM, Smith SG, Dua B, Baatjes AJ, Howie K, Hoshino T, Killian KJ, Aizawa H, et al. Interleukin-18 and interleukin-18 receptor-alpha expression in allergic asthma. Eur Respir J 2011;38(4):981–983. doi:10.1183/09031936.00033811.
  • Colarusso C, Terlizzi M, Molino A, Imitazione P, Somma P, Rega R, Saccomanno A, Aquino RP, Pinto A, Sorrentino R, et al. AIM2 inflammasome activation leads to IL-1alpha and TGF-beta release from exacerbated chronic obstructive pulmonary disease-derived peripheral blood mononuclear cells. Front Pharmacol 2019;10:257. doi:10.3389/fphar.2019.00257.
  • Saiga H, Kitada S, Shimada Y, Kamiyama N, Okuyama M, Makino M, Yamamoto M, Takeda K. Critical role of AIM2 in Mycobacterium tuberculosis infection. Int Immunol 2012;24(10):637–644. doi:10.1093/intimm/dxs062.
  • Trachalaki A, Tsitoura E, Mastrodimou S, Invernizzi R, Vasarmidi E, Bibaki E, Tzanakis N, Molyneaux PL, Maher TM, Antoniou K, et al. Enhanced IL-1beta release following NLRP3 and AIM2 inflammasome stimulation is linked to mtROS in airway macrophages in pulmonary fibrosis. Front Immunol 2021;12:661811. doi:10.3389/fimmu.2021.661811.
  • Bukhari SI, Pattnaik B, Rayees S, Kaul S, Dhar MK. Safranal of Crocus sativus L. inhibits inducible nitric oxide synthase and attenuates asthma in a mouse model of asthma. Phytother Res 2015;29(4):617–627. doi:10.1002/ptr.5315.
  • Kudo M, Ishigatsubo Y, Aoki I. Pathology of asthma. Front Microbiol 2013;4:263. doi:10.3389/fmicb.2013.00263.
  • Kalidhindi RSR, Ambhore NS, Sathish V. Cellular and biochemical analysis of bronchoalveolar lavage fluid from murine lungs. Animal models of allergic disease: methods and protocols. New York (NY): Springer US; 2021:201–215.
  • Salama A, Fayed HM, Elgohary R. L-carnitine alleviated acute lung injuries induced by potassium dichromate in rats: involvement of Nrf2/HO-1 signaling pathway. Heliyon 2021;7(6):e07207. doi:10.1016/j.heliyon.2021.e07207.
  • Lugrin J, Martinon F. The AIM2 inflammasome: sensor of pathogens and cellular perturbations. Immunol Rev 2018;281(1):99–114. doi:10.1111/imr.12618.
  • Sharma BR, Karki R, Kanneganti TD. Role of AIM2 inflammasome in inflammatory diseases, cancer and infection. Eur J Immunol 2019;49(11):1998–2011. doi:10.1002/eji.201848070.
  • Man SM, Kanneganti TD. Regulation of inflammasome activation. Immunol Rev 2015;265(1):6–21. doi:10.1111/imr.12296.
  • Strowig T, Henao-Mejia J, Elinav E, Flavell R. Inflammasomes in health and disease. Nature 2012;481(7381):278–286. doi:10.1038/nature10759.
  • Tsang MS, Hou T, Chan BCL, Wong CK, et al. Immunological roles of NLR in allergic diseases and its underlying mechanisms. Int J Mol Sci 2021;22(4):1507. doi:10.3390/ijms22041507.
  • Miller MH, Shehat MG, Alcedo KP, Spinel LP, Soulakova J, Tigno-Aranjuez JT. Frontline Science: RIP2 promotes house dust mite-induced allergic airway inflammation. J Leukoc Biol 2018;104(3):447–459. doi:10.1002/JLB.4HI0118-017RR.
  • Tsai YM, Chiang KH, Hung JY, Chang WA, Lin HP, Shieh JM, Chong IW, Hsu YL. Der f1 induces pyroptosis in human bronchial epithelia via the NLRP3 inflammasome. Int J Mol Med 2018;41(2):757–764. doi:10.3892/ijmm.2017.3310.
  • Chiappara G, Gagliardo R, Siena A, Bonsignore MR, Bousquet J, Bonsignore G, Vignola AM. Airway remodelling in the pathogenesis of asthma. Curr Opin Allergy Clin Immunol 2001;1(1):85–93. doi:10.1097/01.all.0000010990.97765.a1.
  • Siddiqui S, Bachert C, Bjermer L, Buchheit KM, Castro M, Qin Y, Rupani H, Sagara H, Howarth P, Taillé C, et al. Eosinophils and tissue remodeling: relevance to airway disease. J Allergy Clin Immunol 2023;152(4):841–857. doi:10.1016/j.jaci.2023.06.005.
  • Britt RD, Ruwanpathirana A, Ford ML, Lewis BW. Macrophages orchestrate airway inflammation, remodeling, and resolution in asthma. Int J Mol Sci 2023;24(13):10451. doi:10.3390/ijms241310451.
  • Zhang H, Luo J, Alcorn JF, Chen K, Fan S, Pilewski J, Liu A, Chen W, Kolls JK, Wang J, et al. AIM2 inflammasome is critical for influenza-induced lung injury and mortality. J Immunol 2017;198(11):4383–4393. doi:10.4049/jimmunol.1600714.
  • Tran HB, Hamon R, Jersmann H, Ween MP, Asare P, Haberberger R, Pant H, Hodge SJ. AIM2 nuclear exit and inflammasome activation in chronic obstructive pulmonary disease and response to cigarette smoke. J Inflamm (Lond) 2021;18(1):19. doi:10.1186/s12950-021-00286-4.
  • Wang LQ, Liu T, Yang S, Sun L, Zhao ZY, Li LY, She YC, Zheng YY, Ye XY, Bao Q, et al. Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome. Nat Commun 2021;12(1):2915. doi:10.1038/s41467-021-23201-0.
  • Cho SJ, Hong KS, Jeong JH, Lee M, Choi AMK, Stout-Delgado HW, Moon JS. DROSHA-dependent AIM2 inflammasome activation contributes to lung inflammation during idiopathic pulmonary fibrosis. Cells 2019;8(8):938. doi:10.3390/cells8080938.
  • Gao J, Peng S, Shan X, Deng G, Shen L, Sun J, Jiang C, Yang X, Chang Z, Sun X, et al. Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis. Cell Death Dis 2019;10(12):957. doi:10.1038/s41419-019-2195-8.
  • Schuijs MJ, Willart MA, Hammad H, Lambrecht BN. Cytokine targets in airway inflammation. Curr Opin Pharmacol 2013;13(3):351–361. doi:10.1016/j.coph.2013.03.013.
  • Nagase H, Ueki S, Fujieda S. The roles of IL-5 and anti-IL-5 treatment in eosinophilic diseases: asthma, eosinophilic granulomatosis with polyangiitis, and eosinophilic chronic rhinosinusitis. Allergol Int 2020;69(2):178–186. doi:10.1016/j.alit.2020.02.002.
  • Hadjigol S, Netto KG, Maltby S, Tay HL, Nguyen TH, Hansbro NG, Eyers F, Hansbro PM, Yang M, Foster PS, et al. Lipopolysaccharide induces steroid-resistant exacerbations in a mouse model of allergic airway disease collectively through IL-13 and pulmonary macrophage activation. Clin Exp Allergy 2020;50(1):82–94. doi:10.1111/cea.13505.
  • Shin IS, Park JW, Shin NR, Jeon CM, Kwon OK, Kim JS, Kim JC, Oh SR, Ahn KS. Melatonin reduces airway inflammation in ovalbumin-induced asthma. Immunobiology 2014;219(12):901–908. doi:10.1016/j.imbio.2014.08.004.
  • Johnston SL, Goldblatt DL, Evans SE, Tuvim MJ, Dickey BF. Airway epithelial innate immunity. Front Physiol 2021;12:749077. doi:10.3389/fphys.2021.749077.
  • Holgate ST. Epithelium dysfunction in asthma. J Allergy Clin Immunol 2007;120(6):1233–1244. quiz 1245-6. doi:10.1016/j.jaci.2007.10.025.
  • Nagarkar DR, Poposki JA, Comeau MR, Biyasheva A, Avila PC, Schleimer RP, Kato A. Airway epithelial cells activate TH2 cytokine production in mast cells through IL-1 and thymic stromal lymphopoietin. J Allergy Clin Immunol 2012;130(1):225–232 e4. doi:10.1016/j.jaci.2012.04.019.
  • Dai M, Zhu X, Yu J, Yuan J, Zhu Y, Bao Y, Yong X. CCR3 gene knockout in bone marrow cells ameliorates combined allergic rhinitis and asthma syndrome (CARAS) by reducing airway inflammatory cell infiltration and Th2 cytokines expression in mice model. Int Immunopharmacol 2022;104:108509. doi:10.1016/j.intimp.2021.108509.
  • Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S, Sirois CM, Jin T, Latz E, Xiao TS, et al. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol 2010;11(11):997–1004. doi:10.1038/ni.1932.
  • Persson IM, Akbarshahi H, Brandelius A, Uller L, et al. Expression of type I and III interferons in experimental allergic asthma and after dsRNA-induced exacerbation. Eur Respirat Soc 2013;42:1581.
  • Danov O, Lasswitz L, Obernolte H, Hesse C, Braun A, Wronski S, Sewald K. Rupintrivir reduces RV-induced TH-2 cytokine IL-4 in precision-cut lung slices (PCLS) of HDM-sensitized mice ex vivo. Respir Res 2019;20(1):228. doi:10.1186/s12931-019-1175-y.
  • Duan X, Ponomareva L, Veeranki S, Panchanathan R, Dickerson E, Choubey D. Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts. Mol Cancer Res 2011;9(5):589–602. doi:10.1158/1541-7786.MCR-10-0565.
  • Figueira MBDA, de Lima DS, Boechat AL, Filho MGDN, Antunes IA, Matsuda JDS, Ribeiro TRDA, Felix LS, Gonçalves ASF, da Costa AG, et al. Single-nucleotide variants in the AIM2 - absent in melanoma 2 gene (rs1103577) associated with protection for tuberculosis. Front Immunol 2021;12:604975. doi:10.3389/fimmu.2021.604975.
  • Barrientos MO, Cruz ÁA, Teixeira HMP, Silva HDS, Gomes-Filho IS, Trindade SC, Soledade KR, Fernandes JS, Santana CVN, Pinheiro GP, et al. Variants in interferon gamma inducible protein 16 (IFI16) and absent in melanoma 2 (AIM2) genes that modulate inflammatory response are associated with periodontitis. Arch Oral Biol 2023;147:105640. doi:10.1016/j.archoralbio.2023.105640.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.