Genotoxic and cytotoxic in vitro evaluation of ivermectin and its formulation ivomec® on Aedes albopictus larvae (CCL-126™) cells

References

• Adams , RL , McKay , EL , Craig , LM and Burdon , RH . 1979 . Methylation of mosquito DNA . Biochimica et Biophysica Acta , 563 : 72 – 81 .
   PubMed Web of Science ®Google Scholar
• Bianchi , NO , Larramendy , ML and Bianchi , MS . 1988 . The asymmetric methylation of CG palindromic dinucleotides increases sister-chromatid exchanges . Mutation Research , 197 : 151 – 6 .
   PubMedGoogle Scholar
• Bianchi , NO and López-Larraza , DM . 1991 . DNA damage and repair induced by bleomycin in mammalian and insect cells . Environmental and Molecular Mutagenesis , 17 : 63 – 8 .
   PubMed Web of Science ®Google Scholar
• Bolzán , AD and Bianchi , MS . 2004 . Detection of incomplete chromosome elements and interstitial fragments induced by bleomycin in hamster cells using a telomeric PNA probe . Mutation Research , 554 : 1 – 8 .
   PubMed Web of Science ®Google Scholar
• Bolzán , AD , Bianchi , NO and Bianchi , MS . 1998 . Chromosomal response of insect and mammalian cells to streptonigrin: A comparative study . Environmental and Molecular Mutagenesis , 32 : 331 – 5 .
   PubMedGoogle Scholar
• Bolzán , AD , González , MC and Bianchi , MS . 2000 . The effect of 1,10-phenanthroline on the chromosome damage and sister-chromatid exchanges induced by streptozotocin in mammalian and insect cells . Mutation Research , 447 : 221 – 6 .
   PubMedGoogle Scholar
• Borenfreund , E and Puerner , JA . 1985 . Toxicity determined in vitro by morphological alterations and neutral red absorption . Toxicology Letters , 24 : 119 – 124 .
   PubMed Web of Science ®Google Scholar
• Campbell , WC and Benz , GW . 1984 . Ivermectin: A review of efficacy and safety . Journal of Veterinary Pharmacology Therapeutics , 7 : 1 – 16 .
   PubMed Web of Science ®Google Scholar
• Carballo , MA , Hick , AS , Soloneski , S , Larramendy , ML and Mudry , MD . 2006 . Genotoxic and aneugenic properties of an imidazole derivative . Journal of Applied Toxicology , 26 : 293 – 300 .
   PubMedGoogle Scholar
• Chabala , JC , Mrozik , H , Tolman , RL , Eskola , P , Lusi , A , Peterson , LH Woods , MF . 1980 . Ivermectin, a new broad-spectrum antiparasitic agent . Journal of Medicinal Chemistry , 23 : 1134 – 36 .
   PubMed Web of Science ®Google Scholar
• EPA 1989. Avermectin (Agri-Mek, Affirm) Pesticide Fact Sheet 9/89. Ithaca: Cornell University
   Google Scholar
• García-Rubio , L , Matas , P and Míguez , MP . 2005 . Protective effect of melatonin on paraquat-induced cytotoxicity in isolated rat hepatocytes . Human and Experimental Toxicology , 24 : 475 – 80 .
   PubMedGoogle Scholar
• Gatti , M , Santini , G , Pimpinelli , S and Olivieri , G . 1979 . Lack of spontaneous sister chromatid exchanges in somatic cells of Drosophila melanogaster . Genetics , 91 : 255 – 74 .
   PubMedGoogle Scholar
• González , NV , Soloneski , S and Larramendy , ML . 2006 . Genotoxicity analysis of the phenoxy herbicide dicamba in mammalian cells in vitro . Toxicology In Vitro , 20 : 1481 – 87 .
   PubMed Web of Science ®Google Scholar
• González , NV , Soloneski , S and Larramendy , M . 2009 . Dicamba-induced genotoxicity oh Chinese hamster ovary (CHO) cells is prevented by vitamin E . Journal of Hazardous Materials , 163 : 337 – 43 .
   PubMed Web of Science ®Google Scholar
• González , M , Soloneski , S , Reigosa , MA and Larramendy , ML . 2003 . Effect of dithiocarbamate pesticide zineb and its commercial formulation azzurro. IV. DNA damage and repair kinetic assessed by single cell gel electrophoresis (SCGE) assay on Chinese hamster ovary (CHO) cells . Mutation Research , 534 : 145 – 54 .
   PubMedGoogle Scholar
• Gupta , RC , Goad , JT and Kadel , WL . 1991 . In vivo alterations in lactate dehydrogenase (LDH) and LDH isoenzymes patterns by acute carbofuran intoxication . Archives of Environmental Contamination and Toxicology , 21 : 263 – 69 .
   PubMed Web of Science ®Google Scholar
• Kato , H . 1977 . Spontaneous and induced sister chromatid exchanges as revealed by the BUdR-labeling method . International Review of Cytology , 45 : 55 – 97 .
   Google Scholar
• Kita , K , Shiomi , K and Omura , S . 2007 . Advances in drug discovery and biochemical studies . Trends in Parasitology , 23 : 223 – 9 .
   PubMedGoogle Scholar
• Kosmider , B , Zyner , E , Osiecka , R and Ochocki , J . 2004 . Induction of apoptosis and necrosis in A549 cells by the cis-Pt(II) complex of 3-aminoflavone in comparison with cis-DDP . Mutation Research , 563 : 61 – 70 .
   PubMed Web of Science ®Google Scholar
• Lamberti , L , Bigatti-Ponzetto , P and Ardito , G . 1983 . Cell kinetics and sister chromatid exchange frequency in human lymphocytes . Mutation Research , 120 : 193 – 9 .
   PubMed Web of Science ®Google Scholar
• Larramendy , ML and Knuutila , S . 1990 . Immunophenotype and sister chromatid differentiation: A combined methodology for analyzing cell proliferation in unfractionated lymphocyte cultures . Experimental Cell Research , 188 : 209 – 13 .
   PubMed Web of Science ®Google Scholar
• Larramendy , ML , López-Larraza , D , Vidal-Rioja , L and Bianchi , NO . 1989 . Effect of the metal chelating agent 0-phenanthroline on the DNA and chromosome damage induced by bleomycin in Chinese hamster ovary cells . Cancer Research , 49 : 6583 – 86 .
   PubMedGoogle Scholar
• López-Larraza , DM , Padrón , J , Ronci , NE and Vidal Rioja , LA . 2006 . Chromatin condensation and differential sensitivity of mammalian and insect cells to DNA strand breaks induced by bleomycin . Mutation Research , 600 : 93 – 101 .
   PubMedGoogle Scholar
• Mattei , R and Rodriguez , MALR . 1994 . Effects of ivermectin on the activity of enzymes in mammalian cell in vitro . Ecotoxicology and Environmental Safety , 29 : 251 – 4 .
   PubMedGoogle Scholar
• McCavera , S , Walsh , TK and Wolstenholme , AJ . 2007 . Nematode ligand-gated chloride channels: An appraisal of their involvement in macrocyclic lactone resistance and prospects for developing molecular markers . Parasitology , 134 : 1111 – 21 .
   PubMed Web of Science ®Google Scholar
• Miller , BM and Adler , ID . 1989 . Suspect spindle poisons: Analysis of c-mitotic effects in mouse bone marrow cells . Mutagenesis , 4 : 208 – 15 .
   PubMed Web of Science ®Google Scholar
• Molinari , G , Soloneski , S , Reigosa , MA and Larramendy , ML . 2009 . In vitro genotoxic and cytotoxic effects of ivermectin and its formulation ivomec® on Chinese hamster ovary (CHOK1) cells . Journal of Hazardous Materials , 165 : 1074 – 82 .
   PubMed Web of Science ®Google Scholar
• Mukherjee , AB , Herrera , RJ and Luckett , DC . 1986 . Spontaneous and induced sister-chromatid exchanges in cultured mosquito cells . Cytobios , 46 : 181 – 7 .
   PubMedGoogle Scholar
• Omura , S . 2002 . “ Mode of action of avermectin ” . In Macrolide antibiotics: Chemistry, biology and practice , Edited by: Omura , S . New York : Academic Press .
   Google Scholar
• Omura , S . 2008 . Ivermectin: 25 years and still going strong . International Journal of Antimicrobial Agents , 31 : 91 – 8 .
   PubMed Web of Science ®Google Scholar
• Omura , S and Crump , A . 2004 . The life and times of ivermectin – A success story . Nature Reviews. Microbiology , 2 : 984 – 9 .
   PubMed Web of Science ®Google Scholar
• Orian , A , Abed , M , Kenyagin-Karsenti , D and Boico , O . 2009 . DamID: A methylation-based chromatin profiling approach . Methods in Molecular Biology , 567 : 155 – 69 .
   PubMedGoogle Scholar
• Rodriguez , MALR and Mattei , R . 1988 . Toxicity assessment of the antiparasitic ivermectin . Toxicity Assessment , 3 : 379 – 84 .
   Google Scholar
• Sánchez , J , Bianchi , MS and Bolzán , AD . 2009 . Effect of bleomycin on interstitial telomeric sequences of immortalized Chinese hamster ovary cells . Mutation Research , 669 : 139 – 46 .
   PubMedGoogle Scholar
• Soloneski , S , González , M , Piaggio , E , Apezteguía , M , Reigosa , MA and Larramendy , ML . 2001 . Effect of the dithiocarbamate pesticide zineb and its commercial formulation azzurro: I. Genotoxic evaluation on cultured human lymphocytes exposed in vitro . Mutagenesis , 16 : 487 – 93 .
   PubMedGoogle Scholar
• Soloneski , S , González , M , Piaggio , E , Reigosa , MA and Larramendy , ML . 2002 . Effect of dithiocarbamate pesticide zineb and its commercial formulation, azzurro: III. Genotoxic evaluation on Chinese hamster ovary (CHO) cells . Mutation Research , 514 : 201 – 12 .
   PubMedGoogle Scholar
• Soloneski , S , González , NV , Reigosa , MA and Larramendy , ML . 2007 . Herbicide 2,4-dichlorophenoxyacetic acid (2,4-D)-induced cytogenetic damage in human lymphocytes in vitro in presence of erythrocytes . Cell Biology International , 31 : 1316 – 22 .
   PubMed Web of Science ®Google Scholar
• Watson , WP , Munter , T and Golding , BT . 2004 . A new role for glutathione: protection of vitamin B12 from depletion by xenobiotics . Chemical Research in Toxicology , 17 : 1562 – 67 .
   PubMedGoogle Scholar
• Wei , LY , Hou , RF , Jan , KY and Wang , TC . 1993 . Factors affecting zero background frequency of sister-chromatid exchange in mosquito cells . Mutagenesis , 8 : 179 – 82 .
   PubMedGoogle Scholar
• Wilson , DMR and Thompson , LH . 2007 . Molecular mechanisms of sister-chromatid exchange . Mutation Research , 616 : 11 – 23 .
   PubMed Web of Science ®Google Scholar