Chemical cocktail party in East Greenland: A first time evaluation of human organohalogen exposure from consumption of ringed seal and polar bear tissues and possible health implications

References

• Arctic Monitoring and Assessment Programme (AMAP). 1998. AMAP Assessment Report 1998: Arctic Pollution Issues, Oslo 1998. http://www.amap.no
   Google Scholar
• Arctic Monitoring and Assessment Programme (AMAP). 2004. AMAP Assessment Report 2002: Persistent Organic Pollutants in the Arctic, Oslo 2004. http://www.amap.no
   Google Scholar
• Arctic Monitoring and Assessment Programme (AMAP). 2009. AMAP Assessment Report 2009: Human Health in the Arctic, Oslo 2009. http://www.amap.no
   Google Scholar
• Bjerregaard, P., E. Dewailly, P. Ayotte, T. Pars, L. Ferron, and G. Mulvad. 2001. “Exposure of Inuit in Greenland to Organochlorines Through the Marine Diet.” Journal of Toxicology and Environmental Health 62: 69–81.
   PubMed Web of Science ®Google Scholar
• Bossi, R., F.F. Rigét, and R. Dietz. 2005. “Temporal and Spatial Trends of Perfluorinated Compounds in Ringed Seal (Phoca Hispida) from Greenland.” Environmental Science & Technology 39: 7416–7422.
   PubMed Web of Science ®Google Scholar
• Bradley, M., S.J. Kutz, E. Jenkins, and T.M. O’Hara. 2005. “The Potential Impact of Climate Change on Infectious Diseases of Arctic Fauna.” International Journal of Circumpolar Health 64: 468–77.
   PubMedGoogle Scholar
• Côté, S., P. Ayotte, S. Dodin, C. Blanchet, G. Mulvad, H.S. Petersen, G. Gingras, and E. Dewailly. 2006. “Plasma Organochlorine Concentrations and Bone Ultrasound Measurements: A Cross-sectional Study in Peri-and Postmenopausal Inuit Women from Greenland.” Environmental Health 5: 33.
   PubMedGoogle Scholar
• Dallaire, F., E. Dewailly, C. Vézina, G. Muckle, J.P. Weber, S. Bruneau, and P. Ayotte. 2006. “Effect of Prenatal Exposure to Polychlorinated Biphenyls on Incidence of Acute Respiratory Infections in Preschool Inuit Children.” Environmental Health Perspectives 114: 1301–1305.
   PubMed Web of Science ®Google Scholar
• Deutch, B., J. Dyerberg, H.S. Pedersen, G. Asmund, P. Møller, and J.C. Hansen. 2006. “Dietary Composition and Contaminants in North Greenland in the 1970s and 2004.” Science of the Total Environment 370: 372–381.
   PubMed Web of Science ®Google Scholar
• Dietz, R., F.F. Rigét, C. Sonne, R.J. Letcher, E.W. Born, and D.C.G. Muir. 2004. “Seasonal and Temporal Trends in Polychlorinated Biphenyls and Organochlorine Pesticides in East Greenland Polar Bears (Ursus maritimus), 1990–2001.” Science of the Total Environment 331: 107–124.
   PubMed Web of Science ®Google Scholar
• Dietz, R., F.F. Rigét, C.T. Sonne, D.C.G. Muir, S. Backus, E.W. Born, M. Kirkegaard, and R.J. Letcher. 2007. “Age and Seasonal Variability of Polybrominated Diphenyl Ethers in Free-ranging East Greenland Polar Bears (Ursus maritimus).” Environmental Pollution 146: 177–184.
   Web of Science ®Google Scholar
• Dietz, R., F.F. Rigét, C. Sonne, E.W. Born, T. Bechshøft, M.A. McKinney, and R.J. Letcher. Forthcoming-a. “Three Decades (1984–2010) of Legacy Contaminant Trends in East Greenland Polar Bears (Ursus maritimus). Part I: Legacy Organochlorine Contaminants.” Environment International. http://dx.doi.org/10.1016/j.envint.2012.09.004
   Google Scholar
• Dietz, R., F.F. Rigét, C. Sonne, E.W. Born, T. Bechshøft, M.A. McKinney, R. Drimmei, D.C.G. Muir, and R.J. Letcher. Forthcoming-b. “Three Decades (1984–2010) of Flame Retardant Trends in East Greenland Polar Bears (Ursus maritimus). Part II: Brominated Flame Retardants.” Environment International. http://dx.doi.org/10.1016/j.envint.2012.09.008
   Google Scholar
• Gebbink, W.A., C. Sonne, R. Dietz, M. Kirkegaard, F.F. Rigét, E.W. Born, D.C.G. Muir, and R.J. Letcher. 2008. “Tissue-specific Congener Composition of Organohalogen and Metabolite Contaminants in East Greenland Polar Bears (Ursus maritimus).” Environmental Pollution 152: 621–629.
   PubMed Web of Science ®Google Scholar
• Greer, A., V. Ng, and D. Fisman. 2008. “Climate Change and Infectious Diseases in North America: the Road Ahead.” Canadian Medical Association Journal 178: 715–722.
   PubMed Web of Science ®Google Scholar
• Hertz-Picciotto, I., H.Y. Park, M. Dostal, A. Kocan, T. Trnovec, and R. Sram. 2008. “Prenatal Exposures to Persistent and Non-persistent Organic Compounds and Effects on Immune System Development.” Basic Clinical Pharmacology & Toxicology 102: 146–154.
   PubMed Web of Science ®Google Scholar
• Hueffer, K., T.M. O’Hara, and E.H. Follmann. 2011. “Adaptation of Mammalian Host-pathogen Interactions in a Changing Arctic Environment.” Acta Veterinaria Scandinavica 53: 17.
   PubMed Web of Science ®Google Scholar
• Janeway, C.A., P. Travers, M. Walport, and M. Shlomchik. 2001. Immune Biology – The Immune System in Health and Disease. 5th ed. New York: Garland Publishing, Taylor and Francis
   Google Scholar
• Jenssen, B.M. 2003. “Marine Pollution: The Future Challenge is to Link Human and Wildlife Studies.” Environmental Health Perspectives 111: A198–A199
   PubMed Web of Science ®Google Scholar
• Jenssen, B.M. 2006. “Endocrine-disrupting Chemicals and Climate Change: a Worst-case Combination for Arctic Marine Mammals and Seabirds?” Environmental Health Perspectives 114: 76–80.
   PubMed Web of Science ®Google Scholar
• Johansen, P., D.C.G. Muir, G. Asmund, and F.F. Rigét. 2004. “Human Exposure to Contaminants in the Traditional Greenland Diet.” Science of the Total Environment 331: 189–206.
   PubMed Web of Science ®Google Scholar
• Klecha, A.J., M.L. Barreiro Arcos, L. Frick, A.M. Genaro, and G. Cremaschi. 2008. “Immune-endocrine Interactions in Autoimmune Thyroid Diseases.” Neuroimmunomodulation 15: 68–75.
   Google Scholar
• Lagueux, J., D. Pereg, P. Ayotte, E. Dewailly, and G.G. Poirier. 1999. “Cytochrome P450 CYP1A1 Enzyme Activity and DNA Adducts in Placenta of Women Environmentally Exposed to Organochlorines.” Environmental Research 80: 369–382.
   PubMed Web of Science ®Google Scholar
• Letcher, R.J., J.O. Bustnes, R. Dietz, B.M. Jenssen, E.H. Jørgensen, C. Sonne, J. Verreault, M.M. Vijayan, and G.W. Gabrielsen. 2010. “Exposure and Effects Assessment of Persistent Organic Pollutants in Arctic Wildlife and Fish.” Science of the Total Environment 408: 2995–3043.
   PubMed Web of Science ®Google Scholar
• Macdonald, R.W., T. Harner, and J. Fyfe. 2005. “Recent Climate Change in the Arctic and Its Impact on Contaminant Pathways and Interpretation of Temporal Trend Data.” Science of the Total Environment 342: 5–86.
   PubMed Web of Science ®Google Scholar
• McKinney, M., S. Iverson, A. Fisk, C. Sonne, F.F. Rigét, R. Letcher, M. Arts, E.W. Born, A. Rosing-Asvid, and R. Dietz. 2013. “Causes and Consequences of Long-term Change in East Greenland Polar Bears Diets: Investigation Using Quantitative Fatty Acid Estimates and Fatty Acid Carbon Isotope Patterns.” Global Change Biology 19: 2360–2372.
   Web of Science ®Google Scholar
• Medehouenou, T.C., C. Larochelle, P. Dumas, E. Dewailly, and P. Ayotte. 2010. “Determinants of AhR-mediated Transcriptional Activity Induced by Plasma Extracts from Nunavik Inuit Adults.” Chemosphere 80: 75–82.
   Google Scholar
• Nielsen, E., J.C. Larsen, and O. Ladefoged. 2006. Risk Assessment of Contaminant Intake from Traditional Greenland Food Items. Denmark: Danish Veterinary and Food Administration. www.dfvf.dk
   Google Scholar
• Noyes, P.D., M.K. McElwee, H.D. Miller, B.W. Clark, L.A. Van Tiem, K.C. Walcott, K.N. Erwin, and E.D. Levin. 2009. “The Toxicology of Climate Change: Environmental Contaminants in a Warming World.” Environment International 35: 971–986.
   PubMed Web of Science ®Google Scholar
• Parkinson, A.J., and J.C. Butler. 2005. “Potential Impacts of Climate Change on Infectious Diseases in the Arctic.” International Journal of Circumpolar Health 64: 478–486.
   PubMedGoogle Scholar
• Pars, T., M. Osler, and P. Bjerregaard. 2001. “Contemporary Use of Traditional and Imported Food Among Greenlandic Inuit.” Arctic 54: 22–31.
   Google Scholar
• Polder, A., G.W. Gabrielsen, J.Ø. Odland, T.N. Savinova, A. Tkachev, K.B. Løken, and J.U. Skaare. 2008. “Spatial and Temporal Changes of Chlorinated Pesticides, PCBs, Dioxins (PCDDs/PCDFs) and Brominated Flame Retardants in Human Breast Milk from Northern Russia.” Science of the Total Environment 391: 41–54.
   PubMed Web of Science ®Google Scholar
• Rigét, F., J. Vikelsøe, and R. Dietz. 2005. “Levels and Temporal Trends of PCDD/PCDFs and Non-ortho PCBs in Ringed Seals from East Greenland.” Marine Pollution Bulletin 50: 1523–1529.
   PubMed Web of Science ®Google Scholar
• Rigét, F.F., K. Vorkamp, R. Dietz, and S.C. Rastogi. 2006. “Temporal Trend Studies on Polybrominated Diphenyl Ethers (PBDEs) and Polychlorinated Biphenyls (PCBs) in Ringed Seals from East Greenland.” Journal of Environmental Monitoring 8: 1000–1005.
   PubMed Web of Science ®Google Scholar
• Sandau, C.D., P. Ayotte, E. Dewailly, J. Duffe, and R.J. Norstrom. 2002. “Pentachlorophenol and Hydroxylated Polychlorinated Biphenyl Metabolites in Umbilical cord Plasma of Neonates from Coastal Populations in Québec.” Environmental Health Perspectives 110: 411–417.
   PubMed Web of Science ®Google Scholar
• Simmonds, M.P., K. Haraguchi, T. Endo, F. Cipriano, S.R. Palumbi, and G.M. Troisi. 2002. “Human Health Significance of Organochlorine and Mercury Contaminants in Japanese Whale Meat.” Journal of Toxicology and Environmental Health 65: 1211–1235.
   PubMed Web of Science ®Google Scholar
• Sonne, C. 2010. “Health Effects from Long-range Transported Contaminants in Arctic Top Predators: An Integrated Review Based on Studies of Polar Bears and Relevant Model Species.” Environment International 36: 461–491.
   PubMed Web of Science ®Google Scholar
• Sonne, C., K. Gustavson, F.F. Rigét, R. Dietz, M. Birkved, R.J. Letcher, D.C.G. Muiret al., 2009. “Reproductive Performance in East Greenland Polar Bears (Ursus maritimus) may be Affected by Organohalogen Contaminants as Shown by Physiologically Based Pharmacokinetic (PBPK) Modelling.” Chemosphere 77: 1558–1568.
   Google Scholar
• Sonne, C., P.S. Leifsson, R. Dietz, E.W. Born, R.J. Letcher, M. Kirkegaard, D.C.G. Muir, L.W. Andersen, F.F. Rigét, and L. Hyldstrup. 2005. “Enlarged Clitoris in Wild Polar Bears (Ursus maritimus) can be Misdiagnosed as Pseudohermaphroditism.” Science of the Total Environment 337: 45–58.
   PubMed Web of Science ®Google Scholar
• Sonne, C., R.J. Letcher, T.Ø. Bechshøft, F.F. Rigét, D.C.G. Muir, P.S. Leifsson, E.W. Born et al., 2012. “Two Decades of Biomonitoring Polar Bear Health in Greenland: A Review.” Acta Veterinaria Scandinavica 54: S15.
   PubMedGoogle Scholar
• Tryphonas, H. 1994. “Immunotoxicity of Polychlorinated-biphenyls - Present Status and Future Considerations”. Experimental and Clinical Immunogenetics 11: 149–162.
   PubMedGoogle Scholar
• van den Berg, M., L. Birnbaum, A.T.C. Bosveld, B. Brunstrom, P. Cook, M. Freely, J.P. Giesy, et al. 1998. “Toxic Equivalency Factors (TEFs) for PCBs, PCDDs, PCDFs for Humans and Wildlife.” Environmental Health Perspectives 106: 775–792.
   PubMed Web of Science ®Google Scholar
• van Leeuwen, F.X., M. Feeley, D. Schrenk, J.C. Larsen, W. Fraland, and M. Younes.2000. “Dioxins: WHO's tolerable daily intake (TDI) revisited.” Chemosphere 40: 1095–1101.</comment>
   PubMed Web of Science ®Google Scholar
• Vorkamp, K., R. Bossi, F.F. Rigét, and R. Dietz. 2011. “Time Trends of Hexabromocyclododecane, Polybrominated Diphenyl Ethers and Polychlorinated Biphenyls in Ringed Seals from East Greenland.” Environmental Science & Technology 45: 1243–1249.
   PubMed Web of Science ®Google Scholar
• Vos, J.G., and M.I. Luster. 1989. “Immune Alterations.” In Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins, and Related Products, edited by R.D. Kimbrough, and A.D. Jensen, 295–322. Amsterdam: Elsevier.
   Google Scholar