Advanced search
Publication Cover
Aerosol Science and Technology Volume 36, 2002 - Issue 7
Submit an article Journal homepage
358
Views
31
CrossRef citations to date
0
Altmetric
Original Articles

Aerosol Deposition Efficiencies and Upstream Release Positions for Different Inhalation Modes in an Upper Bronchial Airway Model

Zhe Zhang
,
Clement Kleinstreuer
&
Chong S. Kim
Pages 828-844 | Published online: 30 Nov 2010

  • Adjei , A. I. and Gupta , P. K. , eds. 1997 . Inhalation Delivery cf Therapeutic Peptides and Proteins , New York : Marcel Dekker, Inc. .
  • AEA Technology . 1998 . CFX-4.3: Solver , Oxfordshire, , UK : CFX International .
  • Balásházy , I. and Hofmann , W. 1993 . Particle Deposition in Airway Bifurcations--I. Inspiratory Flow . J. Aerosol Sci. , 24 : 745 – 772 .
  • Balásházy , I. and Hofmann , W. 1995 . Deposition of Aerosols in Asymmetric Airway Bifurcations . J. Aerosol Sci. , 26 : 273 – 292 .
  • Balásházy , I. , Hofmann , W. and Heistracher , T. 1999 . Computation of Local Enhancement Factors for the Quantification of Particle Deposition Patterns in Airway Bifurcations . J. Aerosol Sci. , 30 : 185 – 203 .
  • Buchanan , J. R. 2000 . “ Computational Particle Hemodynamics in the Rabbit Abdominal Aorta ” . Raleigh, NC : Mechanical and Aerospace Engineering Department, North Carolina State University . Ph.D. thesis,
  • Chang , H. K. 1989 . “ Flow Dynamics in the Respiratory Tract ” . In Respiratory Physiology , Edited by: Chang , H. K. and Paiva , M. 57 – 138 . New York : Marcel Dekker, Inc. .
  • Cheng , Y. S. , Zhou , Y and Chen , B. T. 1999 . Particle Deposition in a Cast of Human Oral Airways . Aerosol Sci. Technol. , 31 : 286 – 300 .
  • Clift , R. , Grace , J. R. and Weber , M. E. 1978 . Bubbles, Drops, and Particles , NY : Academic Press .
  • Comer , J. K. , Kleinstreuer , C. , Hyun , S. and Kim , C. S. 2000 . Aerosol Transport and Deposition in Sequentially Bifurcating Airways . ASME Journal of Biomechanical Engineering , 122 : 152 – 158 .
  • Comer , J. K. , Kleinstreuer , C. and Zhang , Z. 2001 . Flow Structures and Particle Deposition Patterns in Double Bifurcation Airway Models. Part 1. Air Flow Fields . J. Fluid Mech. , 435 : 25 – 54 .
  • Fenn , W. O. and Rahn , H. 1965 . Handbook of Physiology, Section 3: Respiration , Washington, D.C. : American Physiological Society .
  • Gonda , I. 1997 . “ Particle Deposition in the Human Respiratory Tract ” . In The Lung: Scientific Foundations , Edited by: Crystal , R. G. , West , J. B. , Weibel , E. R. and Barnes , P. J. 2289 – 2294 . Philadelphia : Lippincott-Raven Publishers .
  • Gurman , J. L. , Lippmann , M. and Schlesinger , R. B. 1984 . Particle Deposition in Replicate Casts of the Human Upper Tracheobronchia 1 Tree under Constant and Cyclic Inspiratory Flow . Aerosol Sci. Technol. , 3 : 245 – 252 .
  • Heistracher , T. and Hofmann , W. 1997 . Flow and Deposition Patterns in Successive Airway Bifurcations . Ann. Occup. Hyg. , 41 : 537 – 542 .
  • Katz , I. M. and Marionen , T. B. 1999 . A Numerical Study of Particle Motion within the Human Larynx and Trachea . J. Aerosol Sei. , 30 : 173 – 183 .
  • Kim , C. S. and Fisher , D. M. 1999 . Deposition of Aerosol Particles in Successively Bifurcating Airways Models . Aerosol Sci. Technol. , 31 : 198 – 220 .
  • Kim , C. S. and Garcia , L. 1991 . Particle Deposition in Cyclic Bifurcating Tube Flow . Aerosol Sci. Technol. , 14 : 302 – 315 .
  • Kim , C. S. and Iglesias , A. J. 1989 . Deposition of Inhaled Particles in Bifurcating Airways Models: I. Inspiratory Deposition . J. Aerosol Medicine , 2 : 1 – 14 .
  • Kleinstreuer , C. 1997 . Engineering Fluid Dynamics--An Interdisciplinary Systems Approach , New York : Cambridge University Press .
  • Oho , K. and Amemiya , R. 1980 . Practical Fiberoptic Bronchoscopy , Tokyo : Igaku-Shoin .
  • Oldham , M. J. , Phalen , R. F and Heistracher , T. 2000 . Computational Fluid Dynamics Predictions and Experimental Results for Particle Deposition in an Airway Model . Aerosol Sci. Technol. , 32 : 61 – 71 .
  • Pope , C. A. , Dockery , D. W. and Schwartz , J. 1995 . Review of Epidemiological Evidence of Health Effects of Particulate Air Pollution . Inhal. Toxicol. , 7 : 1 – 18 .
  • Raabe , O. G. , Yeh , H. C. , Schum , G. M. and Phalen , R. F. 1976 . Tracheobronchial Geometry: Human, Dog, Rat, Hamster, LF-53 , Lovelace Foundation Report Albuquerque, New Mexico
  • Schlesinger , R. B. , Gurman , J. L. and Lippmann , M. 1982 . Particle Deposition within Bronchial Airways: Comparisons using Constant and Cyclic Inspiratory Flows . Ann. Occup. Hyg. , 26 : 47 – 64 .
  • Schlesinger , R. B. and Lippmann , M. 1978 . Selective Particle Deposition and Bronchogeni c Carcinoma . Environ. Res. , 15 : 424 – 431 .
  • Smith , S. J. and Bernstein , J. A. 1996 . “ Therapeutic Uses of Lung Aerosols ” . In Inhalation Aerosol: Physical and Biological Basis for Therapy , Edited by: Hickey , A. J. 233 – 269 . New York : Marcel Dekker, Inc. .
  • Stapleton , K. W. , Guentsch , E. , Hoskinson , M. K. and Finlay , W. H. 2000 . On the Suitability of k-e Turbulence Modeling for Aerosol Deposition in the Mouth and Throat: A Comparison with Experiment . J. Aerosol Sci. , 31 : 739 – 749 .
  • Weibel , E. R. 1963 . Morphometry of the Human Lung , New York : Academic Press .
  • Zhang , L. , Asgharian , B. and Anjilvel , S. 1997 . Inertial Deposition of Particles in the Human Upper Airway Bifurcation . Aerosol Sci. Technol. , 26 : 97 – 110 .
  • Zhang , Z. and Kleinstreuer , C. 2001 . Effect of Particle Inlet Distribution on Deposition in a Triple Bifurcation Lung Airway Model . J. Aerosol Medicine , 14 : 13 – 29 .
  • Zhang , Z. , Kleinstreuer , C. and Kim , C. S. 2001 . Flow Structures and Particle Deposition Patterns in Triple Bifurcation Airway Models . Journal of Fluids Engineering , 123 : 320 – 330 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.