1,953
Views
41
CrossRef citations to date
0
Altmetric
Original Articles

Experimental Measurement and Numerical Study of Particle Deposition in Highly Idealized Mouth-Throat Models

, &
Pages 361-372 | Received 01 Sep 2005, Accepted 03 Feb 2006, Published online: 23 Feb 2007

REFERENCES

  • Cass , M. R. L. , Brown , J. , Ickford , P. , Fayinka , S. , Newman , P. S. , Johansson , J. C. and Bye , A. 1999 . Pharmacoscintigraphic Evaluation of Lung Deposition of Inhaled Zanamivir in Healthy Volunteers . Clin. Pharmacokinetics , 36 ( Suppl.1 ) : 21 – 31 . [CSA]
  • Clark , A. R. and Hollingworth , A. M. 1993 . The Relationship Between Powder Inhaler Resistance and Peak Inspiratory Conditions in Healthy Volunteers Implications for In Vivo Testing . J. Aerosol Med. , 6 : 99 – 110 . [PUBMED] [INFOTRIEVE] [CSA]
  • DeHaan , W. H. and Finlay , W. H. 2001 . In Vitro Monodisperse Aerosol Deposition in a Mouth and Throat with Six Different Inhalation Devices . J. Aerosol Med. , 14 ( 3 ) : 361 – 367 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
  • DeHaan , W. H. and Finlay , W. H. 2004 . Predicting Extrathoracic Deposition from Dry Powder Inhalers . J. Aerosol Sci. , 35 : 309 – 331 . [CROSSREF] [CSA]
  • Emmett , P. C. , Aitken , R. J. and Hannan , W. J. 1982 . Measurements of the Total and Regional Deposition of Inhaled Particles in the Human Respiratory Tract . J. Aerosol Sci. , 13 : 549 – 560 . [CROSSREF] [CSA]
  • Finlay , W. H. 2001 . The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction. , London : Academic Press .
  • Finlay , W. H. , Zhang , Y. , Grgic , B. , Heenan , A. , Burnell , P. , Matida , E. A. , Pollard , A. and Lange , C. F. 2004 . “ Solving a Major In Vitro-In Vivo Correlation Problem: Impactor Induction Ports ” . In Respiratory Drug Delivery IX , Edited by: Dallby , R. N. , Byron , P. R. , Peart , J. , Suman , J. D. and Farr , S. J. volume I , pages 203 – 210 . River Grove, Illinois, USA : Palm Desert, Califonia. Respiratory Drug Delivery, Davis Healthcare Intnational Publishing, LLC .
  • Foord , N. , Black , A. and Walsh , M. 1978 . Regional Deposition of 2.5–7.5 μ m Diameter Inhaled Particles in Healthy Male Non-Smokers . J. Aerosol Sci. , 9 : 343 – 357 . [CROSSREF] [CSA]
  • Grgic , B. , Finlay , W. H. and Heenan , A. F. 2004 . Regional Aerosol Deposition and Flow Measurements in an Idealized Mouth and Throat . J. Aerosol Sci. , 35 : 21 – 32 . [CROSSREF] [CSA]
  • Heenan , A. F. , Matida , E. A. , Pollard , A. and Finlay , W. H. 2003 . Experimental Measurements and Computational Modeling of the Flow in an Idealized Extrathoracic Airway . Exp. Fluids. , 35 : 70 – 84 . [CROSSREF] [CSA]
  • Matida , E. A. , Finlay , W. H. , Lange , C. F. and Grgic , B. 2004 . Improved Numerical Simulation of Aerosol Deposition in an Idealized Mouth-Throat . J. Aerosol Sci. , 35 : 1 – 19 . [CROSSREF] [CSA]
  • McFarland , A. R. , Gong , H. , Muyshond , A. , Wente , W. B. and Anand , N. K. 1997 . Aerosol Deposition in Bends with Turbulent Flow . Environ. Sci. Technol. , 31 ( 12 ) : 3371 – 3377 . [CROSSREF] [CSA]
  • Pui , D. Y. H. , Novas , F. R. and Liu , B. Y. H. 1987 . Experimental Study of Particle Deposition in Bends of Circular Cross Section . Aerosol Sci. Technol. , 7 : 301 – 315 . [CSA]
  • Stahlhofen , W. , Gebhart , J. and Heyder , J. 1980 . Experimental Determination of the Regional Deposition of Aerosol Particles in the Human Respiratory Tract . Am. Ind. Hyg. Assoc. J. , 41 ( 6 ) : 385 – 398a . [PUBMED] [INFOTRIEVE] [CSA]
  • Stahlhofen , W. , Gebhard , J. and Heyder , J. 1981 . Biological Variability of Regional Deposition of Aerosol Particles in the Human Respiratory Tract . Am. Ind. Hyg. Assoc. J. , 42 : 348 – 352 . [PUBMED] [INFOTRIEVE] [CSA]
  • Stahlhofen , W. , Gebhard , J. , Heyder , J. and Scheuch , G. 1983 . New Regional Deposition Data of the Human Respiratory Tract . J. Aerosol Sci. , 14 : 186 – 188 . [CROSSREF] [CSA]
  • Stahlhofen , W. , Gebhard , J. , Heyder , J. , Scheuch , G. and Juraske , P. 1984 . Particle Deposition in Extrathoracic Airways of Healthy Subjects and of Patients with Early Stages of Laryngeal Carcinoma . J. Aerosol Sci. , 15 : 115 – 117 . [CSA]
  • Stahlhofen , W. , Rudolf , G. and James , A. C. 1989 . Intercomparison of Experimental Regional Aerosol Deposition Data . J. Aerosol Med. , 2 ( 3 ) : 285 – 308 . [CSA]
  • Stapleton , K. W. , Guentsch , E. , Hoskinson , M. K. and Finlay , W. H. 2000 . On the Suitability of k-ϵ Turbulence Modeling for Aerosol Deposition in the Mouth and Throat: A Comparison with Experiment . J. Aerosol Sci. , 31 ( 6 ) : 739 – 749 . [CROSSREF] [CSA]
  • Wilcox , D. C. 1988 . Reassessment of the Scale Determining Equation for Advanced Turbulence Models . AIAA J. , 26 ( 11 ) : 1299 – 1310 . [CSA]
  • Zhang , Y. , Finlay , W. H. and Matida , E. A. 2004 . Particle Deposition Measurements and Numerical Simulation in a Highly Idealized Mouth-Throat . J. Aerosol Sci. , 35 : 789 – 803 . [CROSSREF] [CSA]

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.