Regional Deposition of Particles in an Image-Based Airway Model: Large-Eddy Simulation and Left-Right Lung Ventilation Asymmetry

REFERENCES

• Asgharian , B. , Price , O. T. and Hofmann , W. 2006 . Prediction of Particle Deposition in the Human Lung using Realistic Models of Lung Ventilation . J. Aerosol Sci. , 37 : 1209 – 1221 .
   Web of Science ®Google Scholar
• Bennett , W. D. 1991 . Targeting Respiratory Drug Delivery with Aerosol Boluses . J. Aerosol Med. , 4 : 69 – 78 .
   Google Scholar
• Bennett , W. D. , Scheuch , G. , Zeman , K. L. , Brown , J. S. , Kim , C. , Heyder , J. and Stahlhofen , W. 1998 . Bronchial Airway Deposition and Retention of Particles in Inhaled Boluses: Effect of Anatomic Dead Space . J. Appl. Physiol. , 85 : 685 – 694 .
   PubMed Web of Science ®Google Scholar
• Bennett , W. D. , Scheuch , G. , Zeman , K. L. , Brown , J. S. , Kim , C. , Heyder , J. and Stahlhofen , W. 1999 . Regional Deposition and Retention of Particles in Shallow, Inhaled Boluses: Effect of Lung Volume . J. Appl. Physiol. , 86 : 168 – 173 .
   PubMed Web of Science ®Google Scholar
• Chan , T. and Lippmann , M. 1980 . Experimental Measurements and Empirical Modeling of the Regional Deposition of Inhaled Particles in Humans . Am. Ind. Hyg. Assoc. J. , 41 : 399 – 409 .
   PubMed Web of Science ®Google Scholar
• Cheng , Y. S. , Zhou , Y. and Chen , B. T. 1999 . Particle Deposition in a Cast of Human Oral Airways . Aerosol Sci. Technol. , 31 : 286 – 300 .
   Web of Science ®Google Scholar
• Choi , J. , Tawhai , M. H. , Hoffman , E. A. and Lin , C.-L . 2009 . On Intra- and Intersubject Variabilities of Airflow in the Human Lungs . Phys. Fluids , 21 : 101901
   PubMed Web of Science ®Google Scholar
• Choi , J. , Xia , G. , Tawhai , M. H. , Hoffman , E. A. and Lin , C.-L. 2010 . Numerical Study of High Frequency Oscillatory Air Flow and Convective Mixing in a CT-Based Human Airway Model . Annals of Biomedical Engineering , DOI:10. 1007/s10439–010–0110–7
   PubMed Web of Science ®Google Scholar
• Crowe , C. T. , Gore , R. A. and Troutt , T. R. 1985 . Particle Dispersion by Coherent Structures in Free Shear Flows . Particul. Sci. Technol. , 3 : 149 – 158 .
   Google Scholar
• Crowe , C. T. , Chung , T. N. and Troutt , T. R. 1988 . Particle Mixing in Free Shear Flows . Prog. Energy Combust. Sci. , 14 : 171 – 194 .
   Web of Science ®Google Scholar
• Farkas , A. , Balashazy , I. and Szocs , K. 2006 . Characterization of Regional and Local Deposition of Inhaled Aerosol Drugs in the Respiratory System by Computational Fluid and Particle Dynamics Methods . J. Aerosol Med. , 19 : 329 – 343 .
   PubMedGoogle Scholar
• Farkas , A. and Balashazy , I. 2008 . Quantification of Particle Deposition in Asymmetrical Tracheobronchial Model Geometry . Computers in Biology and Medicine , 38 : 508 – 518 .
   PubMed Web of Science ®Google Scholar
• Finlay , W. H. 2001 . The Mechanics of Inhaled Pharmaceutical Aerosols , New York : Academic Press .
   Google Scholar
• Fresconi , F. E. , Wexler , A. S. and Prasad , A. K. 2003 . Expiration Flow in a Symmetric Bifurcation . Exper. Fluids , 35 : 493 – 501 .
   Web of Science ®Google Scholar
• Grigic , B. , Finlay , W. H. , Burnell , P. K. P. and Heenan , A. F. 2004 . In Vitro Intersubject and Intrasubject Deposition Measurements in Realistic Mouth-Throat Geometries . J. Aerosol Sci. , 35 : 1025 – 1040 .
   Web of Science ®Google Scholar
• Hinds , W. C. 1999 . Aerosol Technology:Properties, Behavior, and Measurement of Airborne Particles , 07030 – 5774 . Hoboken, NJ : John Wiley & Sons .
   Google Scholar
• Hoffman , E. A. , Clough , A. V. , Christensen , G. E. , Lin , C.-L. , McLennan , G. , Reinhardt , J. M. , Simon , B. A. , Sonka , M. , Tawhai , M. H. , van Beek , E. J. R. and Wang , G. 2004 . The Comprehensive Imaging Based Analysis of the Lung: A Forum for Team Science . Acad. Radiol. , 11 : 1370 – 1380 .
   PubMed Web of Science ®Google Scholar
• Jayaraju , S. T. , Brouns , M. , Lacor , C. , Belkassem , B. and Verbanck , S. 2008 . Large Eddy and Detached Eddy Simulations of Fluid Flow and Particle Deposition in a Human Mouth-Throat . J. Aerosol Sci. , 39 : 862 – 875 .
   Web of Science ®Google Scholar
• Kleinstreuer , C. and Zhang , Z. 2010 . Airflow and Particle Transport in the Human Respiratory System . Ann. Rev. Fluid Mechan. , 42 : 301 – 334 .
   Web of Science ®Google Scholar
• Kumar , H. , Lin , C.-L. , Tawhai , M. and Hoffman , E. 2009 . The Effects of Geometry on Airflow in the Acinar Region of the Human Lung . J. Biomechan. , 42 : 1635 – 1642 .
   PubMed Web of Science ®Google Scholar
• Lambert , A. R. , Lin , C.-L. , Mardorf , E. and O'shaughnessy , P. 2009 . CFD Simulation of Contaminant Decay for High Reynolds Flow in a Controlled Environment . Ann. Occupat. Hyg. , 54 ( 1 ) : 88 – 99 .
   PubMedGoogle Scholar
• Li , Z. , Kleinstreuer , C. and Zhang , Z. 2007 . Particle Deposition in the Human Tracheobronchial Airways Due to Transient Inspiratory Flow Patterns . J. Aerosol Sci. , 38 : 624 – 644 .
   Web of Science ®Google Scholar
• Lin , C.-L. , Lee , H. , Lee , T. and Weber , L. J. 2005 . A Level Set Characteristic Galerkin Finite Element Method for Free Surface Flows . Int. J. Numer. Methods Fluid. , 49 : 521 – 548 .
   Web of Science ®Google Scholar
• Lin , C.-L. , Tawhai , M. H. , McLennon , G. and Horrman , E. A. 2007 . Characteristics of the Turbulent Laryngeal Jet and Its Effect on Airflow in the Human Intra-Thoracic Airways . Respir. Physiol. & Neurobiol. , 157 : 295 – 309 .
   PubMed Web of Science ®Google Scholar
• Lin , C.-L. , Tawhai , M. H. , McLennon , G. and Hoffman , E. A. 2009 . Multiscale Simulation of Gas Flow in Subject Specific Models of the Human Lung . IEEE Engineering in Medicine and Biol. , 28 : 25 – 33 .
   PubMed Web of Science ®Google Scholar
• Longest , P. W. , Hindle , M. , Choudhuri , S. D. and Xi , J. 2008 . Comparison of Ambient and Spray Aerosol Deposition in a Standard Induction port And More Realistic Mouth–Throat Geometry . J. Aerosol Sci. , 39 : 572 – 591 .
   Web of Science ®Google Scholar
• Longest , P. W. and Vinchurkar , S. 2007 . Validating CFD Predictions of Respiratory Aerosol Deposition: Effects of Upstream Transition and Turbulence . J. Biomech. , 40 : 305 – 316 .
   PubMed Web of Science ®Google Scholar
• Longmire , E. K. and Eaton , J. K. 1992 . Structure of a Particle-Laden Round Jet . J. Fluid Mech , 236 : 217 – 257 .
   Web of Science ®Google Scholar
• Lulu , D. J. and Lawson , L. J. 1964 . Carcinoma of the Lung: A Review of 321 Cases . American Medical Association Arch. Surg , 88 ( 2 ) : 213 – 217 .
   PubMedGoogle Scholar
• Luo , K. , Klein , M. , Fan , J.-R. and Cen , K.-F . 2006 . Effects on Particle Dispersion by Turbulent Transition in a Jet . Physics Letters A , 357 : 345 – 350 .
   Web of Science ®Google Scholar
• Ma , B. and Lutchen , K. R. 2008 . CFD Simulation of Aerosol Deposition in an Anatomically Based Human Large-Medium Airway Model . Ann. Biomed. Engineer. , 37 : 271 – 285 .
   PubMed Web of Science ®Google Scholar
• Matida , E. A. , Finlay , W. H. , Lange , C. F. and Grgic , B. 2002 . Improved Numerical Simulation of Aerosol Deposition in an Idealized Mouth-Throat . J. Aerosol Sci. , 35 : 1 – 19 .
   Web of Science ®Google Scholar
• Maxey , M. R. and Riley , J. J. 1983 . Equation of Motion for a Small Rigid Sphere in a Nonuniform Flow . Phys. Fluids , 26 : 883 – 889 .
   Web of Science ®Google Scholar
• Möller , W. , Meyer , G. , Scheuch , G. , Kreyling , W. G. and Bennett , W. D. 2009 . Left-to-Right Asymmetry of Aerosol Deposition after Shallow Bolus Inhalation Depends on Lung Ventilation . J. Aerosol Med. and Pulmonary Drug Deliv. , 22 : 1 – 7 .
   Web of Science ®Google Scholar
• Möller , W. , HäuBinger , K. , Winkler-Heil , R. , Stahlhofen , T. M. , Hofmann , W. and Heyder , J. 2004 . Mucociliary and Long-Term Particle Clearance in the Airways of Healthy Nonsmoker Subjects . J. Appl. Physiol. , 97 : 220 – 2206 .
   Web of Science ®Google Scholar
• Morsi , S. A. and Alexander , A. J. 1972 . An Investigation of Particle Trajectories in Two-Phase Flow Systems . J. Fluid Mechanics , 55 : 193 – 208 .
   Web of Science ®Google Scholar
• Nowak , N. , Kakade , P. P. and Annapragada , A. V. 2003 . Computational Fluid Dynamics Simulation of Airflow and Aerosol Deposition in Human Lungs . Ann. Biomed. Engineer. , 31 : 374 – 390 .
   PubMed Web of Science ®Google Scholar
• Park , S. S. and Wexler , A. S. 2007a . Particle Deposition in the Pulmonary Region of the Human Lung: A Semi-Empirical Model of Single Breath Transport and Deposition . J. Aerosol Sci. , 38 : 228 – 245 .
   Web of Science ®Google Scholar
• Park , S. S. and Wexler , A. S. 2007b . Particle Deposition in the Pulmonary Region of the Human Lung: Multiple Breath Aerosol Transport and Deposition . J. Aerosol Sci. , 38 : 509 – 519 .
   Web of Science ®Google Scholar
• Park , S. S. and Wexler , A. S. 2008 . Size-Dependent Deposition of Particles in the Human Lung at Steady-State Breathing . J. Aerosol Sci. , 39 : 266 – 276 .
   Web of Science ®Google Scholar
• Parkash , O. 1977 . Lung Cancer: A Statistical Study Based on Autopsy Data from 1928 to 1972 . Respiration , 34 : 295 – 304 .
   PubMed Web of Science ®Google Scholar
• Russo , J. , Robinson , R. and Oldham , M. J. 2008 . Effects of Cartilage Rings on Airflow and Particle Deposition in the Trachea and Main Bronchi . Medical Engineer. & Phys. , 30 : 581 – 589 .
   PubMed Web of Science ®Google Scholar
• Subramaniam , R. P. , Asgharian , B. , Freijer , J. I. , Miller , F. J. and Anjilvel , S. 2003 . Analysis of Lobar Differences in Particle Deposition in the Human Lung . Inhal. Technol. , 15 : 1 – 21 .
   PubMed Web of Science ®Google Scholar
• Tawhai , M. H. , Hoffman , E. A. and Lin , C.-L . 2009 . The Lung Physiome: Merging Imaging-Based Measures with Predictive Computational Models of Structure and Function: Wiley Interdisciplinary Reviews . Sys. Biol. Med. , 1 : 61 – 72 .
   Google Scholar
• Vattulainen , I. , Karttunen , M. , Besold , G. and Polson , J. M. 2002 . Integrating Schemes For Dissipative Particle Dynamics Simulations: From Softly Interacting Systems Towards Hybrid Models . J. Chem. Phys. , 116 : 3967 – 3979 .
   Web of Science ®Google Scholar
• Vreman , A. 2004 . An Eddy-Viscosity Subgrid-Scale Model for Turbulent Shear Flow: Algebraic Theory and Applications . Phys. Fluids , 16 ( 10 ) : 3670 – 3681 .
   Web of Science ®Google Scholar
• Wang , B. , Zhang , H. Q. and Wang , X. L. 2006 . Large Eddy Simulation of Particle Response to Turbulence Along Its Trajectory in a Backward-Facing Step Turbulent Flow . Intl. J. Heat and Mass Trans. , 49 : 415 – 420 .
   Web of Science ®Google Scholar
• Xi , J. and Longest , P. W. 2008 . Evaluation of a Drift Flux Model for Simulating Submicrometer Aerosol Dynamics in Human Upper Tracheobronchial Airways . Ann. Biomed. Engineer. , 36 ( 10 ) : 1714 – 1734 .
   PubMed Web of Science ®Google Scholar
• Xi , J. , Longest , P. W. and Martonen , T. B. 2008 . Effects of the Laryngeal Jet on Nano- and Microparticle Transport and Deposition in an Approximate Model of the Upper Tracheobronchial Airways . J. Appl. Physiol. , 104 : 1761 – 1777 .
   PubMed Web of Science ®Google Scholar
• Yang , X. , Thomas , N. H. and Guo , L. J. 2000 . Particle Dispersion in Organized Vortex Structures Within Turbulent Free Shear Flows . Chem. Engineer. Sci. , 55 : 1305 – 1324 .
   Web of Science ®Google Scholar
• Yin , Y. , Hoffman , E. A. and Lin , C.-L. 2009a . “ Local Tissue-Weight-Based Nonrigid Registration of Lung Images With Application to Regional Ventilation ” . In SPIE Medical Imaging’09 , Edited by: Hu , X. P. and Clough , A. V. 72620C Bellingham, WA : SPIE . 7262
   Google Scholar
• Yin , Y. , Hoffman , E. A. and Lin , C.-L . 2009b . Mass Preserving Nonrigid Registration of CT Lung Images Using Cubic B-spline . Med. Phys. 36 , 9 : 4213 – 4222 .
   Web of Science ®Google Scholar
• Yin , Y. , Choi , J. , Hoffman , E. A. , Tawhai , M. H. and Lin , C.-L. 2010 . Simulation of Pulmonary Air Flow with a Subject Specific Boundary Condition . J. Biomechan. , doi: doi:10.1016/j.jbiomech.2010.03.048
   Web of Science ®Google Scholar
• Zhang , Z. and Finlay , W. H. 2005 . Experimental Measurements of Particle Deposition in Three Proximal Lung Bifurcations Models with an Idealized Mouth-Throat . J. Aerosol Med. , 18 : 460 – 475 .
   PubMedGoogle Scholar
• Zhang , Z. , Kleinstreuer , C. and Kim , C. S. 2002 . Micro-Particle Transport and Deposition in a Human Oral Airway Model . J. Aerosol Sci. , 33 : 1635 – 1652 .
   Web of Science ®Google Scholar
• Zhou , Y. and Cheng , Y. S. 2005 . Particle Deposition in a Cast of Human Tracheobronchial Airways . Aerosol Sci. Technol. , 39 : 492 – 500 .
   Web of Science ®Google Scholar