1,260
Views
5
CrossRef citations to date
0
Altmetric
Regular Articles

Aerosolization System for Experimental Inhalation Studies of Carbon-Based Nanomaterials

, , , , , & show all
Pages 94-107 | Received 25 Aug 2010, Accepted 30 Mar 2011, Published online: 16 Aug 2011

REFERENCES

  • Alivisatos , P. 2000 . Colloidal Quantum Dots from Scaling Laws to Biological Applications . Pure Appl. Chem. , 72 ( 1–2 ) : 3 – 9 .
  • Baron , P. A. , Deye , G. J. , Chen , B. T. , Schwegler-Berry , D. E. , Shvedova , A. A. and Castranova , V. 2008 . Aerosolization of Single-Walled Carbon Nanotubes for an Inhalation Study . Inhal. Toxicol. , 20 ( 8 ) : 751 – 760 .
  • Baughman , R. H. 2000 . Materials Science: Putting a New Spin on Carbon Nanotubes . Science , 290 ( 5495 ) : 1310 – 1311 .
  • Bianco , A. , Hoebeke , J. , Kostarelos , K. , Prato , M. and Partidos , C. D. 2005a . Carbon Nanotubes: On the Road to Deliver . Curr. Drug Deliv. , 2 ( 3 ) : 253 – 259 .
  • Bianco , A. , Kostarelos , K. , Partidos , C. D. and Prato , M. 2005b . Biomedical Applications of Functionalised Carbon Nanotubes . Chem. Commun. (Camb) , 5 : 571 – 577 .
  • Bianco , A. , Kostarelos , K. and Prato , M. 2005c . Applications of Carbon Nanotubes in Drug Delivery . Curr. Opin. Chem. Biol. , 9 ( 6 ) : 674 – 679 .
  • Bianco , A. and Prato , M. 2003 . Can Carbon Nanotubes be Considered Useful Tools for Biological Applications? . Adv. Mater. , 15 : 1765 – 1768 .
  • Bottini , M. , Bruckner , S. , Nika , K. , Bottini , N. , Bellucci , S. , Magrini , A. , Bergamaschi , A. and Mustelin , T. 2006 . Multi-Walled Carbon Nanotubes Induce T Lymphocyte Apoptosis . Toxicol. Lett. , 160 ( 2 ) : 121 – 126 .
  • British Standards Institution . 1993 . Workplace Atmospheres—Size Fraction Definitions for Measurement of Airborne Particles , British Standards Institution (BSI) in cooperation with the European Committee for Standardization (CEN), London . (Vol. BS EN 481:1993).
  • Brown , S. D. M. , Jorio , A. , Corio , P. , Dresselhaus , M. S. , Dresselhaus , G. , Saito , R. and Kneipp , K. 2001 . Origin of the Breit-Wigner-Fano Lineshape of the Tangential G-Band Feature of Metallic Carbon Nanotubes . Phys. Rev. B , 63 : 1554141 – 1554148 .
  • Chen , X. , Lee , G. S. , Zettl , A. and Bertozzi , C. R. 2004 . Biomimetic Engineering of Carbon Nanotubes by Using Cell Surface Mucin Mimics . Angew Chem. Int. Ed. Engl. , 43 ( 45 ) : 6111 – 6116 .
  • Cui , D. 2005 . Effect of Single Wall Carbon Nanotubes on Human HEK293 Cells . Toxicol. Lett. , 155 : 73 – 85 .
  • Dames , P. , Gleich , B. , Flemmer , A. , Hajek , K. , Seidl , N. , Wiekhorst , F. , Eberbeck , D. , Bittmann , I. , Bergemann , C. , Weyh , T. , Trahms , L. , Rosenecker , J. and Rudolph , C. 2007 . Targeted Delivery of Magnetic Aerosol Droplets to the Lung . Nat. Nanotechnol. , 2 ( 8 ) : 495 – 499 .
  • Ding , L. , Stilwell , J. , Zhang , T. , Elboudwarej , O. , Jiang , H. , Selegue , J. P. , Cooke , P. A. , Gray , J. W. and Chen , F. F. 2005 . Molecular Characterization of the Cytotoxic Mechanism of Multiwall Carbon Nanotubes and Nano-Onions on Human Skin Fibroblast . Nano Lett. , 5 ( 12 ) : 2448 – 2464 .
  • Drexler , K. E. 1992 . Nanosystems: Molecular, Machinery, Manufacturing, and Composition , New York, NY : Wiley-Interscience Publication .
  • Dumortier , H. , Lacotte , S. , Pastorin , G. , Marega , R. , Wu , W. , Bonifazi , D. , Briand , J. P. , Prato , M. , Muller , S. and Bianco , A. 2006 . Functionalized Carbon Nanotubes Are Non-Cytotoxic and Preserve the Functionality of Primary Immune Cells . Nano Lett. , 6 ( 7 ) : 1522 – 1528 .
  • El-Gendy , N. and Berkland , C. 2009 . Combination Chemotherapeutic Dry Powder Aerosols via Controlled Nanoparticle Agglomeration . Pharm. Res. , 26 ( 7 ) : 1752 – 1763 .
  • Fenoglio , I. , Greco , G. , Tomatis , M. , Muller , J. , Raymundo-Pinero , E. , Beguin , F. , Fonseca , A. , Nagy , J. B. , Lison , D. and Fubini , B. 2008 . Structural Defects Play a Major Role in the Acute Lung Toxicity of Multiwall Carbon Nanotubes: Physicochemical Aspects . Chem. Res. Toxicol. , 21 ( 9 ) : 1690 – 1697 .
  • Foldvari , M. and Bagonluri , M. 2008a . Carbon Nanotubes as Functional Excipients for Nanomedicines: I. Pharmaceutical Properties . Nanomedicine , 4 ( 3 ) : 173 – 182 .
  • Foldvari , M. and Bagonluri , M. 2008b . Carbon Nanotubes as Functional Excipients for Nanomedicines: II. Drug Delivery and Biocompatibility Issues . Nanomedicine , 4 ( 3 ) : 183 – 200 .
  • Fortina , P. , Kricka , L. J. , Surrey , S. and Grodzinski , P. 2005 . Nanobiotechnology: The Promise and Reality of New Approaches to Molecular Recognition . Trends Biotechnol. , 23 ( 4 ) : 168 – 173 .
  • Gao , M. , Huang , S. , Dai , L. , Wallace , G. , Gao , R. and Wang , Z. 2000 . Aligned Coaxial Nanowires of Carbon Nanotubes Sheathed with Conducting Polymers . Angew Chem. Int. Ed. Engl. , 39 ( 20 ) : 3664 – 3667 .
  • Hu , H. , Haddon , R. C. , Ni , Y. , Montana , V. and Parpura , V. 2004 . Chemically Functionalized Carbon Nanotubes as Substrates for Neuronal Growth . Nano Lett. , 4 : 507 – 511 .
  • Hu , J. T. , Odom , T. W. and Lieber , C. M. 1999 . Chemistry and Physics in One Dimension: Synthesis and Properties of Nanowires and Nanotubes . Accounts Chem. Res. , 32 ( 5 ) : 435 – 445 .
  • International Organization for Standardization . 1995 . Air Quality—Particle Size Fraction Definitions for Health-Related Sampling , Geneve, Switzerland : International Organization for Standardization (ISO) . [Vol. ISO 7708:1995(E)]
  • Jia , G. , Wang , H. , Yan , L. , Wang , X. , Pei , R. , Yan , T. , Zhao , Y. and Guo , X. 2005 . Cytotoxicity of Carbon Nanomaterials: Single-Wall Nanotube, Multi-Wall Nanotube, and Fullerene . Environ. Sci. Technol. , 39 ( 5 ) : 1378 – 1383 .
  • Katz , E. and Willner , I. 2004 . Biomolecule-Functionalized Carbon Nanotubes: Applications in Nanobioelectronics . Chemphyschem. , 5 ( 8 ) : 1084 – 1104 .
  • Ku , B. , Maynard , A. D. , Baron , P. A. and Deye , G. J. 2007 . Observation and Measurement of Anomalous Responses in a Differential Mobility Analyzer Caused by Ultrafine Fibrous Carbon Aerosols . J. Electrostat. , 65 : 542 – 548 .
  • Lam , C. W. , James , J. T. , McCluskey , R. and Hunter , R. L. 2004 . Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation . Toxicol. Sci. , 77 ( 1 ) : 126 – 134 .
  • Li , J. G. , Li , W. X. , Xu , J. Y. , Cai , X. Q. , Liu , R. L. , Li , Y. J. , Zhao , Q. F. and Li , Q. N. 2007 . Comparative Study of Pathological Lesions Induced by Multiwalled Carbon Nanotubes in Lungs of Mice by Intratracheal Instillation and Inhalation . Environ. Toxicol. , 22 ( 4 ) : 415 – 421 .
  • Lieber , C . 2003 . Nanoscale Science and Technology: Building a Big Future from Small Things . MRS Bull. , 28 ( 77 ) : 486 – 491 .
  • Lovat , V. , Pantarotto , D. , Lagostena , L. , Cacciari , B. , Grandolfo , M. , Righi , M. , Spalluto , G. , Prato , M. and Ballerini , L. 2005 . Carbon Nanotube Substrates Boost Neuronal Electrical Signaling . Nano Lett. , 5 ( 6 ) : 1107 – 1110 .
  • Magrez , A. , Kasas , S. , Salicio , V. , Pasquier , N. , Seo , J. W. , Celio , M. , Catsicas , S. , Schwaller , B. and Forro , L. 2006 . Cellular Toxicity of Carbon-Based Nanomaterials . Nano Lett. , 6 ( 6 ) : 1121 – 1125 .
  • Ma-Hock , L. , Burkhardt , S. , Strauss , V. , Gamer , A. O. , Wiench , K. , van Ravenzwaay , B. and Landsiedel , R. 2009 . Development of a Short-Term Inhalation Test in the Rat Using Nano-Titanium Dioxide as a Model Substance . Inhal. Toxicol. , 21 ( 2 ) : 102 – 118 .
  • Manna , S. K. , Sarkar , S. , Barr , J. , Wise , K. , Barrera , E. V. , Jejelowo , O. , Rice-Ficht , A. C. and Ramesh , G. T. 2005 . Single-Walled Carbon Nanotube Induces Oxidative Stress and Activates Nuclear Transcription Factor-KappaB in Human Keratinocytes . Nano Lett. , 5 ( 9 ) : 1676 – 1684 .
  • Martin , A. R. , Thompson , R. B. and Finlay , W. H. 2008 . MRI Measurement of Regional Lung Deposition in Mice Exposed Nose-Only to Nebulized Superparamagnetic Iron Oxide Nanoparticles . J. Aerosol Med. Pulm. Drug Deliv. , 21 ( 4 ) : 335 – 342 .
  • Mattson , M. P. , Haddon , R. C. and Rao , A. M. 2000 . Molecular Functionalization of Carbon Nanotubes and Use as Substrates for Neuronal Growth . J. Mol. Neurosci. , 14 ( 3 ) : 175 – 182 .
  • Mitchell , L. A. , Gao , J. , Wal , R. V. , Gigliotti , A. , Burchiel , S. W. and McDonald , J. D. 2007 . Pulmonary and Systemic Immune Response to Inhaled Multiwalled Carbon Nanotubes . Toxicol. Sci. , 100 ( 1 ) : 203 – 214 .
  • Monteiro-Riviere , N. A. , Nemanich , R. J. , Inman , A. O. , Wang , Y. Y. and Riviere , J. E. 2005 . Multi-Walled Carbon Nanotube Interactions with Human Epidermal Keratinocytes . Toxicol. Lett. , 155 ( 3 ) : 377 – 384 .
  • Muller , J. , Huaux , F. , Fonseca , A. , Nagy , J. B. , Moreau , N. , Delos , M. , Raymundo-Pinero , E. , Beguin , F. , Kirsch-Volders , M. , Fenoglio , I. , Fubini , B. and Lison , D. 2008 . Structural Defects Play a Major Role in the Acute Lung Toxicity of Multiwall Carbon Nanotubes: Toxicological Aspects . Chem. Res. Toxicol. , 21 ( 9 ) : 1698 – 1705 .
  • Muller , J. , Huaux , F. , Moreau , N. , Misson , P. , Heilier , J. F. , Delos , M. , Arras , M. , Fonseca , A. , Nagy , J. B. and Lison , D. 2005 . Respiratory Toxicity of Multi-Wall Carbon Nanotubes . Toxicol. Appl. Pharmacol. , 207 ( 3 ) : 221 – 231 .
  • Navrotsky , A. 2001 . Thermochemistry of Nanomaterials . Nanoparticles Environ. , 44 : 73 – 103 .
  • Ostraat , M. L. , Swain , K. A. and Krajewski , J. J. 2008 . SiO2 Aerosol Nanoparticle Reactor for Occupational Health and Safety Studies . J. Occup. Environ. Hyg. , 5 ( 6 ) : 390 – 398 .
  • Park , E. J. , Brasuel , M. , Behrend , C. , Philbert , M. A. and Kopelman , R. 2003a . Ratiometric Optical PEBBLE Nanosensors for Real-Time Magnesium Ion Concentrations Inside Viable Cells . Anal. Chem. , 75 ( 15 ) : 3784 – 3791 .
  • Park , K. H. , Chhowalla , M. , Iqbal , Z. and Sesti , F. 2003b . Single-Walled Carbon Nanotubes Are a New Class of Ion Channel Blockers . J. Biol. Chem. , 278 ( 50 ) : 50212 – 50216 .
  • Poland , C. A. , Duffin , R. , Kinloch , I. , Maynard , A. , Wallace , W. A. , Seaton , A. , Stone , V. , Brown , S. , Macnee , W. and Donaldson , K. 2008 . Carbon Nanotubes Introduced into the Abdominal Cavity of Mice Show Asbestos-Like Pathogenicity in a Pilot Study . Nat. Nanotechnol. , 3 ( 7 ) : 423 – 428 .
  • Ryman-Rasmussen , J. P. , Tewksbury , E. W. , Moss , O. R. , Cesta , M. F. , Wong , B. A. and Bonner , J. C. 2008 . Inhaled Multi-Walled Carbon Nanotubes Potentiate Airway Fibrosis in Murine Allergic Asthma . Am. J. Respir. Cell Mol. Biol. , 40 ( 3 ) : 349 – 358 .
  • Saito , N. and Kataura , H. 2001 . “ Optical Properties and Raman Spectroscopy of Carbon Nanotubes ” . In Carbon Nanotubes , Edited by: Dresselhaus , M. S. , Dresselhaus , G. and Avouris , P. 213 – 246 . Berlin : Springer-Verlag Berlin .
  • Sayes , C. M. , Marchione , A. A. , Reed , K. L. and Warheit , D. B. 2007 . Comparative Pulmonary Toxicity Assessments of C60 Water Suspensions in Rats: Few Differences in Fullerene Toxicity In Vivo in Contrast to In Vitro Profiles . Nano Lett. , 7 ( 8 ) : 2399 – 2406 .
  • Schipper , M. L. , Nakayama-Ratchford , N. , Davis , C. R. , Kam , N. W. , Chu , P. , Liu , Z. , Sun , X. , Dai , H. and Gambhir , S. S. 2008 . A Pilot Toxicology Study of Single-Walled Carbon Nanotubes in a Small Sample of Mice . Nat. Nanotechnol. , 3 ( 4 ) : 216 – 221 .
  • Schmoll , L. H. , Elzey , S. , Grassian , V. H. and O’Shaughnessy , P. T. 2009 . Nanoparticle Aerosol Generation Methods from Bulk Powders for Inhalation Exposure Studies . Nanotoxicol. , 3 ( 4 ) : 265 – 275 .
  • Shen , K. , Curran , S. , Xu , H. , Rogelj , S. , Jiang , Y. , Dewald , J. and Pietrass , T. 2005 . Single-Walled Carbon Nanotube Purification, Pelletization, and Surfactant-Assisted Dispersion: A Combined TEM and Resonant Micro-Raman Spectroscopy Study . J. Phys. Chem. B , 109 : 4455 – 4463 .
  • Shvedova , A. A. , Kisin , E. , Murray , A. R. , Johnson , V. J. , Gorelik , O. , Arepalli , S. , Hubbs , A. F. , Mercer , R. R. , Keohavong , P. , Sussman , N. , Jin , J. , Yin , J. , Stone , S. , Chen , B. T. , Deye , G. , Maynard , A. , Castranova , V. , Baron , P. A. and Kagan , V. E. 2008 . Inhalation vs. Aspiration of Single-Walled Carbon Nanotubes in C57BL/6 Mice: Inflammation, Fibrosis, Oxidative Stress, and Mutagenesis . Am. J. Physiol. Lung Cell. Mol. Physiol , 295 ( 4 ) : L552 – L565 .
  • Singh , R. , Pantarotto , D. , Lacerda , L. , Pastorin , G. , Klumpp , C. , Prato , M. , Bianco , A. and Kostarelos , K. 2006 . Tissue Biodistribution and Blood Clearance Rates of Intravenously Administered Carbon Nanotube Radiotracers . Proc. Natl. Acad. Sci. USA , 103 ( 9 ) : 3357 – 3362 .
  • Smalley , R. 2001 . Wires of Wonder . Technol. Rev. , 104 ( 2 ) : 86 – 91 .
  • Strano , M. S. , Dyke , C. A. , Usrey , M. L. , Barone , P. W. , Allen , M. J. , Hongwei Shan , H. , Kittrell , C. , Hauge , R. H. , Tour , J. M. and Smalley , R. E. 2003 . Electronic Structure Control of Single-Walled Carbon Nanotube Functionalization . Science , 301 : 1519 – 1522 .
  • Sung , J. C. , Padilla , D. J. , Garcia-Contreras , L. , Verberkmoes , J. L. , Durbin , D. , Peloquin , C. A. , Elbert , K. J. , Hickey , A. J. and Edwards , D. A. 2009 . Formulation and Pharmacokinetics of Self-Assembled Rifampicin Nanoparticle Systems for Pulmonary Delivery . Pharm. Res. , 26 ( 8 ) : 1847 – 1855 .
  • Teague , S. V. , Veranth , J. M. , Aust , A. E. and Pinkerton , K. E. 2005 . Dust Generator for Inhalation Studies with Limited Amounts of Archived Particulate Matter . Aerosol Sci. Technol. , 39 : 85 – 91 .
  • Tian , F. , Cui , D. , Schwarz , H. , Estrada , G. G. and Kobayashi , H. 2006 . Cytotoxicity of Single-Wall Carbon Nanotubes on Human Fibroblasts . Toxicol. In Vitro , 20 ( 7 ) : 1202 – 1212 .
  • Tong , H. , McGee , J. K. , Saxena , R. K. , Kodavanti , U. P. , Devlin , R. B. and Gilmour , M. I. 2009 . Influence of Acid Functionalization on the Cardiopulmonary Toxicity of Carbon Nanotubes and Carbon Black Particles in Mice . Toxicol. Appl. Pharmacol. , 239 ( 3 ) : 224 – 232 .
  • US Environmental Protection Agency . 1999 . Compendium of Methods for the Determination of Inorganic Compounds in Ambient Air. Compendium Method IO-3.4. Determination of Metals in Ambient Particulate Matter Using Inductively Coupled Plasma (ICP) Spectroscopy. , Cincinnati, OH : Center for Environmental Research Information, Office of Research and Development, US Environmental Protection Agency (US EPA) .
  • Usui , Y. , Aoki , K. , Narita , N. , Murakami , N. , Nakamura , I. , Nakamura , K. , Ishigaki , N. , Yamazaki , H. , Horiuchi , H. , Kato , H. , Taruta , S. , Kim , Y. A. , Endo , M. and Saito , N. 2008 . Carbon Nanotubes with High Bone-Tissue Compatibility and Bone-Formation Acceleration Effects . Small , 4 ( 2 ) : 240 – 246 .
  • Wang , Y. , Shan , H. , Hauge , R. H. , Pasquali , M. and Smalley , R. E. 2007 . A Highly Selective, One-Pot Purification Method for Single-Walled Carbon Nanotubes . J. Phys. Chem. B , 111 ( 6 ) : 1249 – 1252 .
  • West , J. L. and Halas , N. J. 2003 . Engineered Nanomaterials for Biophotonics Applications: Improving Sensing, Imaging, and Therapeutics . Ann. Rev. Biomed. Eng. , 5 : 285 – 292 .
  • Yang , G.-S. , Teague , S. , Pinkerton , K. and Kennedy , I. M. 2001 . Synthesis of an Ultrafine Iron and Soot Aerosol for the Evaluation of Particle Toxicity . Aerosol Sci. Technol. , 35 : 759 – 766 .
  • Zavaleta , C. , de la Zerda , A. , Liu , Z. , Keren , S. , Cheng , Z. , Schipper , M. , Chen , X. , Dai , H. and Gambhir , S. S. 2008 . Noninvasive Raman Spectroscopy in Living Mice for Evaluation of Tumor Targeting with Carbon Nanotubes . Nano Lett , 8 ( 9 ) : 2800 – 2805 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.