An Idealized Child Throat that Mimics Average Pediatric Oropharyngeal Deposition

REFERENCES

• Borgstrom , L. , Olsson , B. and Thorsson , L. 2006 . Degree of Throat Deposition can Explain the Variability in Lung Deposition of Inhaled Drugs . J Aerosol Med., , 19 : 473 – 483 .
   PubMedGoogle Scholar
• Corcoran , T. E. , Shortall , B. P. , Kim , I. K. , Meza , M. P. and Chigier , N. 2003 . Aerosol Drug Delivery Using Heliox and Nebulizer Reservoirs: Results from an MRI-Based Pediatric Model . J Aerosol Med., , 16 : 365 – 271 .
   Google Scholar
• DeHaan , W. H. and Finlay , W. H. 2004 . Predicting Extrathoracic Deposition From Dry Powder Inhalers . J Aerosol Sci., , 35 : 309 – 331 .
   Web of Science ®Google Scholar
• Delvadia , R. R. , Longest , P. W. and Byron , P. R. 2011 . In vitro Tests for Aerosol Deposition. I: Scaling a Physical Model of the Upper Airways To Predict Drug Deposition Variation in Normal Humans . J Aerosol Med., , 25 ( 1 ) : 32 – 40 .
   Google Scholar
• Ehtezazi , T. , Southern , K. W. , Allanson , D. , Jenkinson , I. and O’Callaghan , C. 2005 . Suitability of the Upper Airway Models Obtained from MRI Studies in Simulating Drug Lung Deposition From Inhalers . Pharm Res., , 22 : 166 – 170 .
   PubMed Web of Science ®Google Scholar
• Finlay , W. H. and Martin , A. R. 2008 . Recent Advances in Predictive Understanding of Respiratory Tract Deposition . J Aerosol Med., , 21 : 189 – 205 .
   Google Scholar
• Golshahi , L. , Noga , M. L. , Thompson , R. B. and Finlay , W. H. 2011a . In Vitro Deposition Measurement of Inhaled Micrometer-Sized Particles in Nasal Airways Of Children and Adolescents During Nose Breathing . J Aerosol Sci., , 42 : 447 – 488 .
   Web of Science ®Google Scholar
• Golshahi , L. , Noga , M. L. and Finlay , W. H. 2011b . Deposition of Inhaled Micrometer-Sized Particles in Oropharyngeal Airway Replicas of Children at Constant Flow Rates . Submitted J Aerosol Sci ,
   Google Scholar
• Grgic , B. , Heenan , A. F. , Burnell , P. K. P. and Finlay , W. H. 2004a . In vitro Intersubject and Intrasubject Deposition Measurements in Realistic Mouth-Throat Geometries . J Aerosol Sci. , 35 : 1025 – 1040 .
   Web of Science ®Google Scholar
• Grgic , B. , Finlay , W. H. and Heenan , A. F. 2004b . Regional Aerosol Deposition and Flow Measurements in an Idealized Mouth and Throat . J Aerosol Sci. , 35 : 21 – 32 .
   Web of Science ®Google Scholar
• Janssens , H. M. , De Jongste , J. C. , Fokkens , W. J. , Robben , S. G. F. , Wouters , K. and Tiddens , H. A. W. M. 2001 . The Sophia Anatomical Infant Nose-Throat (Saint) Model:A Valuable Tool to Study Aerosol Deposition in Infants . J Aerosol Med. , 14 : 433 – 441 .
   PubMedGoogle Scholar
• Laube , B. L. , Sharpless , G. , Shermer , C. , Nasir , O. , Sullivan , V. and Powell , K. 2010 . Deposition of Albuterol Aerosol Generated by Pneumatic Nebulizer in The Sophia Anatomical Infant Nose-Throat (Saint) Model . Pharm Res. , 27 : 1722 – 1729 .
   PubMed Web of Science ®Google Scholar
• Minocchieri , S. , Burren , J. M. , Bachmann , M. A. , Stern , G. , Wildhaber , J. Buob , S. 2008 . Development of the Premature Infant Nose Throat-Model (PrINT-Model)–An Upper Airway Replica of a Premature Neonate for the Study of Aerosol Delivery . Ped Res., , 64 : 141 – 146 .
   PubMed Web of Science ®Google Scholar
• Newhouse , M. T. , Dobranowski , J. A. , Chambers , C. , Dobranowski , J. and Dobranowski , M. 1998 . “ Development and Preliminary Validation Studies with an ex-vivo Oropharyngeal Model ” . In Respiratory Drug Delivery VI , Edited by: Byron , P. R. , Dalby , R. N. and Farr , S. J. 389 – 391 . Buffalo Grove, Illinoise : Interpharm Press Inc. .
   Google Scholar
• Srichana , T. , Martin , G. and Marriott , C. 2000 . A Human Oral-Throat Cast Integrated with A Twin-Stage Impinger For Evaluation of Dry Powder Inhalers . J Pharm Pharmacol., , 52 : 771 – 778 .
   PubMed Web of Science ®Google Scholar
• Stapleton , K. W. , Guentsch , E. , Hoskinson , M. K. and Finlay , W. H. 2000 . On The Suitability of The K-E Turbulence Model for Aerosol Deposition in The Mouth And Throat: A Comparison with Experiments . J Aerosol Sci., , 31 : 739 – 749 .
   Web of Science ®Google Scholar
• Stahlhofen , W. , Rudolf , G. and James , A. C. 1989 . Intercomparison Of Experimental Regional Aerosol Deposition Data . J Aerosol Med., , 2 : 285 – 308 .
   Google Scholar
• Storey-Bishoff , J. , Noga , M. and Finlay , W. H. 2008 . Deposition of Micrometer-Sized Aerosol Particles in Infant Nasal Airway Replicas . J Aerosol Sci., , 39 : 1055 – 1065 .
   Web of Science ®Google Scholar
• Wachtel , H. , Bickmann , D. , Breitkreutz , J. and Langguth , P. 2010 . “ Can pediatric throat models and air flow profiles improve our dose finding strategy ” . In Respiratory Drug Delivery 2010 , Edited by: Dalby , R. N. , Byron , P. R. , Peart , J. , Suman , J. D. , Farr , S. J. and Young , P. M. 195 – 204 . Rivergrove, Illinois : Davis Healthcare .
   Google Scholar
• Zhang , Y. , Gilbertson , K. and Finlay , W. H. 2007 . In Vivo-in Vitro Comparison of Deposition in Three Mouth-Throat Models with Qvar and Turbuhaler Inhalers . J Aerosol Med., , 20 : 227 – 235 .
   PubMedGoogle Scholar
• Zhou , Y. , Sun , J. and Cheng , Y. S. 2011 . Comparison of Deposition in The Usp and Physical Mouth-Throat Models with Solid and Liquid Particles . J Aerosol Med., , 24 ( 6 ) : 277 – 284 .
   Google Scholar