1,033
Views
29
CrossRef citations to date
0
Altmetric
Original Articles

Targeted Lung Delivery of Nasally Administered Aerosols

, &
Pages 434-449 | Received 15 Aug 2013, Accepted 07 Jan 2014, Published online: 24 Feb 2014

REFERENCES

  • Allen , M. D. and Raabe , O. G. 1985 . Slip Correction Measurements of Spherical Solid Aerosol Particles in an Improved Millikan Apparatus . Aerosol Sci. Technol. , 4 : 269 – 286 .
  • Ari , A. and Fink , J. B. 2012 . Inhalation Therapy in Patients Receiving Mechanical Ventilation: An Update . J. Aerosol Med. Pulm. Drug Deliv. , 25 ( 6 ) : 319 – 332 .
  • Ari , A. , Harwood , R. , Sheard , M. , Dailey , P. and Fink , J. B. 2011 . In Vitro Comparison of Heliox and Oxygen in Aerosol Delivery Using Pediatric High Flow Nasal Cannula . Pediatr. Pulmonol. , 46 ( 8 ) : 795 – 801 .
  • Bhashyam , A. R. , Wolf , M. T. , Marcinkowski , A. L. , Saville , A. , Thomas , K. Carcillo , J. A. 2008 . Aerosol Delivery Through Nasal Cannulas: An In Vitro Study . J. Aerosol Med. Pulm. Drug Deliv. , 21 ( 2 ) : 181 – 187 .
  • Cheng , Y. S. 2003 . Aerosol Deposition in the Extrathoracic Region . Aerosol Sci. Technol. , 37 : 659 – 671 .
  • Choi , J. , Tawhai , M. , Hoffman , E. A. and Lin , C. L. 2009 . On Intra- and Intersubject Variabilities of Airflow in the Human Lungs . Phys. Fluids , 21 : 101901 – 1 . -17
  • Delvadia , R. , Hindle , M. , Longest , P. W. and Byron , P. R. 2013 . In Vitro Tests for Aerosol Deposition II: IVIVCs for Different Dry Powder Inhalers in Normal Adults . J. Aerosol Med. Pulm. Drug Deliv. , 26 ( 3 ) : 138 – 144 .
  • Delvadia , R. , Longest , P. W. and Byron , P. R. 2012 . In Vitro Tests for Aerosol Deposition. I. Scaling a Physical Model of the Upper Airways to Predict Drug Deposition Variation in Normal Humans . J. Aerosol Med. , 25 ( 1 ) : 32 – 40 .
  • Dhand , R. 2007 . Inhalation Therapy in Invasive and Noninvasive Mechanical Ventilation . Curr. Opin. Crit. Care , 13 ( 1 ) : 27 – 38 .
  • Dhand , R. 2012 . Aerosol Therapy in Patients Receiving Noninvasive Positive Pressure Ventilation . J. Aerosol Med. Pulm. Drug Deliv. , 25 ( 2 ) : 63 – 78 .
  • Ebina , M. , Shimizukawa , M. , Shibata , N. , Kimura , Y. , Suzuki , T. Endo , M. 2004 . Heterogeneous Increase in CD34-positive Alveolar Capillaries in Idiopathic Pulmonary Fibrosis . Am. J. Respir. Crit. Care Med. , 169 ( 11 ) : 1203 – 1208 .
  • Ferron , G. A. 1977 . The Size of Soluble Aerosol Particles as a Function of the Humidity of the Air: Application to the Human Respiratory Tract . J. Aerosol Sci. , 3 : 251 – 267 .
  • Ferron , G. A. , Kreyling , W. G. and Haider , B. 1988 . Inhalation of Salt Aerosol Particles–II. Growth and Deposition in the Human Respiratory Tract . J. Aerosol Sci. , 19 ( 5 ) : 611 – 631 .
  • Finlay , W. H. 1998 . Estimating the Type of Hygroscopic Behavior Exhibited by Aqueous Droplets . J. Aerosol Med. , 11 ( 4 ) : 221 – 229 .
  • Finlay , W. H. 2001 . The Mechanics of Inhaled Pharmaceutical Aerosols , San Diego : Academic Press .
  • Fuchs , N. A. and Sutugin , A. G. 1970 . Highly Dispersed Aerosols , Ann Arbor : Ann Arbor Science Publ. .
  • Garcia , G. J. M. , Tewksbury , E. W. , Wong , B. A. and Kimbell , J. S. 2009 . Interindividual Variability in Nasal Filtration as a Function of Nasal Cavity Geometry . J. Aerosol Med. Pulm. Drug Deliv. , 22 ( 2 ) : 139 – 155 .
  • Golshahi , L. , Noga , M. L. , Thompson , R. B. and Finlay , W. H. 2011 . In Vitro Deposition Measurement of Inhaled Micrometer-Sized Particle in Extrathoracic Airways of Children and Adolescents During Nose Breathing . J. Aerosol Sci. , 42 : 474 – 488 .
  • Golshahi , L. , Tian , G. , Azimi , M. , Son , Y.-J. , Walenga , R. L. Longest , P. W. 2013 . The Use of Condensational Growth Methods for Efficient Drug Delivery to the Lungs During Noninvasive Ventilation High Flow Therapy . Pharmaceutical Res. , 30 : 2917 – 2930 .
  • Green , D. W. 1997 . Perry's Chemical Engineers’ Handbook , New York : McGraw-Hill .
  • Guilmette , R. A. , Wicks , J. D. and Wolff , R. K. 1989 . Morphometry of Human Nasal Airways In Vivo Using Magnetic Resonance Imaging . J. Aerosol Med. , 2 ( 4 ) : 365 – 377 .
  • Hess , D. R. 2007 . The Mask of Noninvasive Ventilation: Principles of Design and Effects on Aerosol Delivery . J. Aerosol Med. , 20 : S85 – S99 .
  • Hindle , M. and Longest , P. W. 2010 . Evaluation of Enhanced Condensational Growth (ECG) for Controlled Respiratory Drug Delivery in a Mouth-Throat and Upper Tracheobronchial Model . Pharmaceutical Res. , 27 ( 9 ) : 1800 – 1811 .
  • Hindle , M. and Longest , P. W. 2012 . Condensational Growth of Combination Drug-Excipient Submicrometer Particles for Targeted High Efficiency Pulmonary Delivery: Evaluation of Formulation and Delivery Device . J. Pharm. Pharmacol. , 64 ( 9 ) : 1254 – 1263 .
  • Hinds , W. C. 1999 . Aerosol Technology: Properties, Behavior, and Measurement of Airborne Particles , New York : John Wiley and Sons .
  • Jayaraju , S. T. , Brouns , M. , Lacor , C. , Belkassem , B. and Verbanck , S. 2008 . Large Eddy and Detached Eddy Simulations of Fluid Flow and Particle Deposition in a Human Mouth-Throat . Aerosol Sci. , 39 : 862 – 875 .
  • Keck , T. , Leiacker , R. , Riechelmann , H. and Rettinger , G. 2000 . Temperature Profile in the Nasal Cavity . Laryngoscope , 110 ( 4 ) : 651 – 654 .
  • Kelly , J. T. , Asgharian , B. , Kimbell , J. S. and Wong , B. 2004a . Particle Deposition in Human Nasal Airway Replicas Manufactured by Different Methods. Part I: Inertial Regime Particles . Aerosol Sci. Technol. , 38 : 1063 – 1071 .
  • Kelly , J. T. , Asgharian , B. , Kimbell , J. S. and Wong , B. 2004b . Particle Deposition in Human Nasal Airway Replicas Manufactured by Different Methods. Part II: Ultrafine Particles . Aerosol Sci. Technol. , 38 : 1072 – 1079 .
  • Kimbell , J. S. , Segal , R. A. , Asgharian , B. , Wong , B. A. Schroeter , J. D. 2007 . Characterization of Deposition from Nasal Spray Devices Using a Computational Fluid Dynamics Model of the Human Nasal Passages . J. Aerosol Med. , 20 ( 1 ) : 59 – 74 .
  • Kotaru , C. , Coreno , A. , Skowronski , M. , Muswick , G. , Gilkeson , R. C. and McFadden , E. R. 2005 . Morphometric Changes after Thermal and Methacholine Bronchoprovocations . J. Appl. Physiol. , 98 ( 3 ) : 1028 – 1036 .
  • Lahaije , A. , Heijdra , Y. F. , Willems , L. M. , van Helvoort , H. A. C. and Dekhuijzen , P. N. R. 2012 . COPD Anno 2011: Emphasis on Bronch(iol)odilation . J. Aerosol Med. Pulm. Drug Deliv. , 25 ( 3 ) : 148 – 153 .
  • Li , W. and Hopke , P. K. 1993 . Initial Size Distributions and Hygroscopicity of Indoor Combustion Aerosol Particles . Aerosol Sci. Technol. , 19 : 305 – 316 .
  • Li , Z. , Kleinstreuer , C. and Zhang , Z. 2007 . Particle Deposition in the Human Tracheobronchial Airways Due to Transient Inspiratory Flow Patterns . Aerosol Sci. , 38 : 625 – 644 .
  • Longest , P. W. , Golshahi , L. and Hindle , M. 2013a . Improving Pharmaceutical Aerosol Delivery During Noninvasive Ventilation: Effects of Streamlined Components . Ann. Biomed. Eng. , 41 ( 6 ) : 1217 – 1232 .
  • Longest , P. W. and Hindle , M. 2010 . CFD Simulations of Enhanced Condensational Growth (ECG) Applied to Respiratory Drug Delivery with Comparisons to In Vitro Data . J. Aerosol Sci. , 41 : 805 – 820 .
  • Longest , P. W. and Hindle , M. 2011 . Numerical Model to Characterize the Size Increase of Combination Drug and Hygroscopic Excipient Nanoparticle Aerosols . Aerosol Sci. Technol. , 45 : 884 – 899 .
  • Longest , P. W. and Hindle , M. 2012 . Condensational Growth of Combination Drug-excipient Submicrometer Particles: Comparison of CFD Predictions with Experimental Results . Pharmaceutical Res. , 29 ( 3 ) : 707 – 721 .
  • Longest , P. W. , Hindle , M. , Das Choudhuri , S. and Byron , P. R. 2007 . Numerical Simulations of Capillary Aerosol Generation: CFD Model Development and Comparisons with Experimental Data . Aerosol Sci. Technol. , 41 ( 10 ) : 952 – 973 .
  • Longest , P. W. , Hindle , M. , Das Choudhuri , S. and Xi , J. 2008 . Comparison of Ambient and Spray Aerosol Deposition in a Standard Induction Port and More Realistic Mouth-Throat Geometry . J. Aerosol Sci. , 39 ( 7 ) : 572 – 591 .
  • Longest , P. W. and Holbrook , L. T. 2012 . In Silico Models of Aerosol Delivery to the Respiratory Tract—Development and Applications . Adv. Drug Deliver. Rev. , 64 : 296 – 311 .
  • Longest , P. W. and Kleinstreuer , C. 2005 . Computational Models for Simulating Multicomponent Aerosol Evaporation in the Upper Respiratory Airways . Aerosol Sci. Technol. , 39 : 124 – 138 .
  • Longest , P. W. , Kleinstreuer , C. and Buchanan , J. R. 2004 . Efficient Computation of Micro-Particle Dynamics Including Wall Effects . Comput. Fluids , 33 ( 4 ) : 577 – 601 .
  • Longest , P. W. , McLeskey , J. T. and Hindle , M. 2010 . Characterization of Nanoaerosol Size Change During Enhanced Condensational Growth . Aerosol Sci. Technol. , 44 : 473 – 483 .
  • Longest , P. W. , Tian , G. , Delvadia , R. and Hindle , M. 2012a . Development of a Stochastic Individual Path (SIP) Model for Predicting the Deposition of Pharmaceutical Aerosols: Effects of Turbulence, Polydisperse Aerosol Size, and Evaluation of Multiple Lung Lobes . Aerosol Sci. Technol. , 46 ( 12 ) : 1271 – 1285 .
  • Longest , P. W. , Tian , G. and Hindle , M. 2011 . Improving the Lung Delivery of Nasally Administered Aerosols During Noninvasive Ventilation—An Application of Enhanced Condensational Growth (ECG) . J. Aerosol Med. Pulm. Drug Deliv. , 24 ( 2 ) : 103 – 118 . doi: 10.1089/jamp.2010.0849
  • Longest , P. W. , Tian , G. , Li , X. , Son , Y.-J. and Hindle , M. 2012b . Performance of Combination Drug and Hygroscopic Excipient Submicrometer Particles from a Softmist Inhaler in a Characteristic Model of the Airways . Ann. Biomed. Eng. , 40 ( 12 ) : 2596 – 2610 .
  • Longest , P. W. , Tian , G. , Walenga , R. L. and Hindle , M. 2012c . Comparing MDI and DPI Aerosol Deposition Using In Vitro Experiments and a New Stochastic Individual Path (SIP) Model of the Conducting Airways . Pharmaceutical Res. , 29 : 1670 – 1688 .
  • Longest , P. W. and Vinchurkar , S. 2007 . Validating CFD Predictions of Respiratory Aerosol Deposition: Effects of Upstream Transition and Turbulence . J. Biomech. , 40 ( 2 ) : 305 – 316 .
  • Longest , P. W. , Walenga , R. L. , Son , Y.-J. and Hindle , M. 2013b . High Efficiency Generation and Delivery of Aerosols Through Nasal Cannula During Noninvasive Ventilation . J. Aerosol Med. Pulm. Drug Deliv. , 26 ( 5 ) : 266 – 279 .
  • Longest , P. W. and Xi , J. 2007 . Effectiveness of Direct Lagrangian Tracking Models for Simulating Nanoparticle Deposition in the Upper Airways . Aerosol Sci. Technol. , 41 ( 4 ) : 380 – 397 .
  • Longest , P. W. and Xi , J. 2008 . Condensational Growth May Contribute to the Enhanced Deposition of Cigarette Smoke Particles in the Upper Respiratory Tract . Aerosol Sci. Technol. , 42 : 579 – 602 .
  • Matida , E. A. , Finlay , W. H. , Breuer , M. and Lange , C. F. 2006 . Improving Prediction of Aerosol Deposition in an Idealized Mouth Using Large-Eddy Simulation . J. Aerosol Med. , 19 ( 3 ) : 290 – 300 .
  • Matida , E. A. , Finlay , W. H. and Grgic , L. B. 2004 . Improved Numerical Simulation of Aerosol Deposition in an Idealized Mouth-Throat . J. Aerosol Sci. , 35 : 1 – 19 .
  • Morsi , S. A. and Alexander , A. J. 1972 . An Investigation of Particle Trajectories in Two-Phase Flow Systems . J. Fluid Mech. , 55 ( 2 ) : 193 – 208 .
  • Nasr , H. , Ahmadi , G. and McLaughlin , J. B. 2009 . A DNS Study of Effects of Particle-Particle Collisions and Two-Way Coupling on Particle Deposition and Phasic Fluctuations . J. Fluid Mech. , 640 : 507 – 536 .
  • Newman , S. 2009 . Respiratory Drug Delivery: Essential Theory and Practice , Richmond : RDD Online .
  • Patton , J. S. , Brain , J. D. , Davies , L. A. , Fiegel , J. , Gumbleton , M. Kim , K. J. 2010 . The Particle has Landed-Characterizing the Fate of Inhaled Pharmaceuticals . J. Aerosol Med. Pulm. Drug Deliv. , 23 : S71 – S87 .
  • Patton , J. S. and Byron , P. R. 2007 . Inhaling Medicines: Delivering Drugs to the Body Through the Lungs . Nat. Rev. Drug Discov. , 6 : 67 – 74 .
  • Postma , D. S. and van den Berge , M. 2013 . Small Airway Dysfunction in Asthma and COPD: Consequences for Therapy and the Future . Respiratory Drug Delivery Europe 2013 , 1 : 1 – 12 .
  • Robinson , R. and Yu , C. P. 1998 . Theoretical Analysis of Hygroscopic Growth Rate of Mainstream and Sidestream Cigarette Smoke Particles in the Human Respiratory Tract . Aerosol Sci. Technol. , 28 : 21 – 32 .
  • Rubin , B. K. 2011 . Pediatric Aerosol Therapy: New Devices and New Drugs . Respiratory Care , 56 ( 9 ) : 1411 – 1421 .
  • Schroeter , J. D. , Garcia , G. J. M. and Kimbell , J. S. 2011 . Effects of Surface Smoothness on Inertial Particle Deposition in Human Nasal Models . J. Aerosol Sci. , 42 : 52 – 63 .
  • Schroeter , J. D. , Kimbell , J. S. and Asgharian , B. 2006 . Analysis of Particle Deposition in the Turbinate and Olfactory Regions Using a Human Nasal Computational Fluid Dynamics Model . J. Aerosol Med. , 19 ( 3 ) : 301 – 313 .
  • Schroeter , J. D. , Musante , C. J. , Hwang , D. M. , Burton , R. , Guilmette , R. and Martonen , T. B. 2001 . Hygroscopic Growth and Deposition of Inhaled Secondary Cigarette Smoke in Human Nasal Pathways . Aerosol Sci. Technol. , 34 ( 1 ) : 137 – 143 .
  • Son , Y.-J. , Longest , P. W. and Hindle , M. 2013 . Aerosolization Characteristics of Dry Powder Inhaler Formulations for the Excipient Enhanced Growth (EEG) Application: Effect of Spray Drying Process Conditions on Aerosol Performance . Int. J. Pharm. , 443 : 137 – 145 .
  • Sosnowski , T. R. , Moskal , A. and Gradon , L. 2006 . Dynamics of Oropharyngeal Aerosol Transport and Deposition with the Realistic Flow Pattern . Inhalation Toxicol. , 18 ( 10 ) : 773 – 780 .
  • Souza , C. A. , Muller , N. L. , Flint , J. , Wright , J. L. and Churg , A. 2005 . Idiopathic Pulmonary Fibrosis: Spectrum of High-Resolution CT Findings . Am. J. Roentgenol. , 185 ( 6 ) : 1531 – 1539 .
  • Stahlhofen , W. , Kobrich , R. , Rudolf , G. and Scheuch , G. 1990 . Short-Term and Long-Term Clearance of Particles form the Upper Human Respiratory Tract as a Function of Particle Size . J. Aerosol Sci. , 21 ( Suppl. 1 ) : S407 – S410 .
  • Storey-Bishoff , J. , Noga , M. and Finlay , W. H. 2008 . Deposition of Micrometer-Sized Aerosol Particles in Infant Nasal Airway Replicas . Aerosol Sci. , 39 : 1055 – 1065 .
  • Tgavalekos , N. T. , Tawhai , M. , Harris , R. S. , Mush , G. , Vidal-Melo , M. Venegas , J. G. 2005 . Identifying Airways Responsible for Heterogeneous Ventilation and Mechanical Dysfunction in Asthma: An Image Functional Modeling Approach . J. Appl. Physiol. , 99 ( 6 ) : 2388 – 2397 .
  • Tian , G. , Longest , P. W. , Li , X. and Hindle , M. 2013 . Targeting Aerosol Deposition to and Within the Lung Airways Using Excipient Enhanced Growth . J. Aerosol Med. Pulm. Drug Deliv. , 26 ( 5 ) : 248 – 265 .
  • Tian , G. , Longest , P. W. , Su , G. and Hindle , M. 2011a . Characterization of Respiratory Drug Delivery with Enhanced Condensational Growth (ECG) Using an Individual Path Model of the Entire Tracheobronchial Airways . Ann. Biomed. Eng. , 39 ( 3 ) : 1136 – 1153 .
  • Tian , G. , Longest , P. W. , Su , G. , Walenga , R. L. and Hindle , M. 2011b . Development of a Stochastic Individual Path (SIP) Model for Predicting the Tracheobronchial Deposition of Pharmaceutical Aerosols: Effects of Transient Inhalation and Sampling the Airways . J. Aerosol Sci. , 42 : 781 – 799 .
  • Vinchurkar , S. , Longest , P. W. and Peart , J. 2009 . CFD Simulations of the Andersen Cascade Impactor: Model Development and Effects of Aerosol Charge . J. Aerosol Sci. , 40 : 807 – 822 .
  • Walenga , R. L. , Tian , G. and Longest , P. W. 2013 . Development of Characteristic Upper Tracheobronchial Airway Models for Testing Pharmaceutical Aerosol Delivery . ASME J. Biomech. Eng. , 135 ( 9 ) : 091010
  • Wang , Y. and James , P. W. 1999 . On the Effect of Anisotropy on the Turbulent Dispersion and Deposition of Small Particles . Int. J. Multiphase Flow , 22 : 551 – 558 .
  • Wilcox , D. C. 1998 . Turbulence Modeling for CFD (2nd ed.) , California : DCW Industries, Inc. .
  • Xi , J. and Longest , P. W. 2007 . Transport and Deposition of Micro-Aerosols in Realistic and Simplified Models of the Oral Airway . Ann. Biomed. Eng. , 35 ( 4 ) : 560 – 581 .
  • Xi , J. and Longest , P. W. 2008a . Effects of Oral Airway Geometry Characteristics on the Diffusional Deposition of Inhaled Nanoparticles . ASME J. Biomech. Eng. , 130 : 011008
  • Xi , J. and Longest , P. W. 2008b . Numerical Predictions of Submicrometer Aerosol Deposition in the Nasal Cavity Using a Novel Drift Flux Approach . Int. J. Heat Mass Transfer , 51 : 5562 – 5577 .
  • Xi , J. and Longest , P. W. 2009 . Characterization of Submicrometer Aerosol Deposition in Extrathoracic Airways During Nasal Exhalation . Aerosol Sci. Technol. , 43 : 808 – 827 .
  • Xi , J. , Longest , P. W. and Martonen , T. B. 2008 . Effects of the Laryngeal Jet on Nano- and Microparticle Transport and Deposition in an Approximate Model of the Upper Tracheobronchial Airways . J. Appl. Physiol. , 104 ( 6 ) : 1761 – 1777 .
  • Yeh , H. C. and Schum , G. M. 1980 . Models of Human Lung Airways and Their Application to Inhaled Particle Deposition . Bull. Math. Biol. , 42 : 461 – 480 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.