In Vitro Assessment of Dose Delivery Performance of Dry Powders for Inhalation

REFERENCES

• Al-Ahowair, R. A. M., Tarsin, W. Y., Assi, K. H., Pearson, S. B., and Chrystyn, H. (2007). Can All Patients with COPD Use the Correct Inhalation Flow with all Inhalers and Does Training Help? Resp. Med., 101:2395–2401.
   PubMed Web of Science ®Google Scholar
• Asmanex® Twisthaler®, Package Insert for Use.
   Google Scholar
• Cardwell, N. D., Zee, J., Kadrichu, N. P., Rao, N. P., and Clark, A. R. (2014). Flow Field Characterization of Three Dry Powder Inhalers. Respir. Drug Deliv., 501–505.
   Google Scholar
• Chodosh, S., Flanders, J. S., Kesten, S., Serby, C. W., Hochrainer, D., and Witek, T. J. (2001). Effective Delivery of Particles with the HandiHaler Dry Powder Inhalation System over a Range of Chronic Obstructive Pulmonary Disease Severity. J. Aerosol Med., 14(3):309–315.
   PubMedGoogle Scholar
• Clark, A. R., and Hollingworth, A. M. (1993). The Relationship Between Powder Inhaler Resistance and Peak Inspiratory Conditions in Healthy Volunteers—Implications for In Vitro Testing. J. Aerosol Med., 6(2):99–110.
   PubMedGoogle Scholar
• Copley, M., Smurthwaite, M., Roberts, D. L., and Mitchell, J. P. (2005). Revised Internal Volumes of Cascade Impactors for Those Provided by Mitchell and Nagel. J. Aerosol Med., 18(3):364–366.
   PubMedGoogle Scholar
• DeHaan, W. H., and Finlay, W. H. (2001). In Vitro Monodisperse Aerosol Deposition in a Mouth and Throat with Six Different Inhalation Devices. J. Aerosol Med., 14:361–367.
   PubMedGoogle Scholar
• DeHaan, W. H., and Finlay, W. H. (2004). Predicting Extrathoracic Deposition from Dry Powder Inhalers. Aerosol Sci., 35:309–331.
   Web of Science ®Google Scholar
• Delvadia, R. R., Longest, P. W., and Byron, P. R. (2012). In Vitro Tests for Aerosol Deposition. I: Scaling a Physical Model of the Upper Airways to Predict Drug Deposition Validation in Normal Humans. J Aerosol Med., 25(1):32–40.
   Google Scholar
• Duddu, S. P., Sisk, S. A., Walter, Y. H., Tarara, T. E., Trimble, K. R., Clark, A. R., et al. (2002). Improved Lung Delivery from a Passive Dry Powder Inhaler Using an Engineered PulmoSphere® Powder. Pharmaceut. Res., 19:689–695.
   PubMed Web of Science ®Google Scholar
• Finlay, W. H., DeHaan, W., Grgic, B., Heenan, A., Matida, E. A., Hoskinson, M., et al. (2002). Fluid Mechanicals and Particle Deposition in the Oropharynx: The Factors that Really Matter. Respir. Drug Deliv. VIII, 171–177.
   Google Scholar
• Golshahi, L., Noga, M. L., Vehring, R., and Finlay, W. H. (2013). An In Vitro Study on the Deposition of Micrometer-Sized Particles in the Extrathoracic Airways of Adults During Tidal Oral Breathing. Ann. Biomed. Eng., 41(5):979–989.
   PubMed Web of Science ®Google Scholar
• Grgic, B., Finlay, W. H., and Heenan, A. F. (2004). Regional Aerosol Deposition and Flow Measurements in an Idealized Mouth and Throat. J. Aerosol Sci., 35:21–32.
   Web of Science ®Google Scholar
• Hirst, P. H., Pitcairn, G. R., Weers, J. G., Tarara, T. E., Clark, A. R., Dellamary, L. A., et al. (2002). In Vitro Lung Deposition of Hollow Porous Particles from a Pressurized Metered Dose Inhaler. Pharmaceut. Res., 19:258–264.
   PubMed Web of Science ®Google Scholar
• Longest, P. W., Hindle, M., Choudhuri, S. D., and Xi, J. (2008). Comparison of Ambient and Spray Aerosol Deposition in a Standard Induction Port and More Realistic Mouth—Throat Geometry. J. Aerosol Sci., 39(7):572–591.
   Web of Science ®Google Scholar
• Marple, V. A., Olson, B. A., Santhanakrishnan, K., Mitchell, J. P., Murray, S. C., and Hudson-Curtis, B. L. (2003). Next Generation Pharmaceutical Impactor (A New Impactor for Pharmaceutical Inhaler Testing). Part II: Archival Calibration. J. Aerosol Med., 16(3):301–324.
   PubMedGoogle Scholar
• Marple, V. A., Olson, B. A., Santhanakrishnan, K., Roberts, D. L., Mitchell, J. P., and Hudson-Curtis, B. L. (2004). Next Generation Pharmaceutical Impactor: A New Impactor for Pharmaceutical Inhaler Testing. Part III. Extension of Archival Calibration to 15 L/min. J. Aerosol Med., 17(4): 335–343.
   PubMedGoogle Scholar
• Martin, A. R., and Warran, F. H. (2008). An Online Calculator for Predicting Respiratory Deposition of Inhaled Aerosols. Respir. Drug Deliv., Book 2, 801–805. www.mece.ualberta.ca/arla/aerosoldepositioncalculator_adult.html
   Google Scholar
• McRobbie, D. W., and Pritchard, S. (2005). Studies of Human Oropharygneal Airspaces Using Magnetic Resonance Imaging. II. The Effects of Device Resistance with Forced Maneuver and Tidal Breathing on Upper Airway Geometry. J. Aerosol Med., 18:325–336.
   PubMedGoogle Scholar
• McRobbie, D. W., Pritchard, S., and Quest, R. A. (2003). Studies of Human Oropharyngeal Airspaces Using Magnetic Resonance Imaging. I. Validation of a Three-Dimensional MRI Method for Producing Ex Vivo Virtual and Physical Casts of the Oropharyngeal Airways During Inspiration. J. Aerosol Med., 16:401–415.
   PubMedGoogle Scholar
• Newhouse, M. T., Hirst, P. H., Duddu, S. P., Walter, Y. H., Tarara, T. E., Clark, A. R., et al. (2003). Inhalation of a Dry Powder Tobramycin PulmoSphere Formulation in Healthy Volunteers. Chest., 124:360–366.
   PubMed Web of Science ®Google Scholar
• Olsson, B., Borgström, L., Lundbäck, H., and Svensson, M. (2013). Validation of a General In Vitro Approach for Prediction of Total Lung Deposition in Healthy Adults for Pharmaceutical Inhalation Products. J. Aerosol Med., 26:1–15.
   Google Scholar
• Olsson, B., Borgstrom, L., Svensson, M., and Lundback, H. (2008). Modeling Oropharyngeal Cast Deposition to Predict Lung Delivery from Powder Inhalers. Respir. Drug Deliv., 197–205.
   Google Scholar
• Podczeck, F. (1998). The Relationship Between Physical Properties of Lactose Monohydrate and the Aerodynamic Behavior of Adhered Drug Particles. Int. J. Pharmaceut., 160:119–130.
   Web of Science ®Google Scholar
• Pritchard, S., and McRobbie, D. W. (2004). Studies of Human Oropharyngeal Airspaces using Magnetic Resonance Imaging. II. The Use of Three-Dimensional Gated MRI to Determine the Influence of Mouthpiece Diameter and Resistance of Inhalation Devices on the Oropharyngeal Airways Geometry. J. Aerosol Med., 17:310–324.
   PubMedGoogle Scholar
• Spiriva® HandiHaler®, Package Insert for Use.
   Google Scholar
• Stahlhofen, W., Rudof, G., and James, A. C. (1989). Intercomparison of Experimental Regional Aerosol Deposition Data. J. Aerosol Med., 2:285–308.
   Google Scholar
• Stapleton, K. W., Guentsch, E. Hoskinson, M. K., and Finlay, W. H. (2000). On The Suitability of k-e Turbulence Modeling for Aerosol Deposition in the Mouth and Throat: A Comparison with Experiment. J. Aerosol Sci., 31:739–749.
   Web of Science ®Google Scholar
• Weers, J. G. (2001). Dispersible Powders for Inhalation Applications. Innov. Pharmaceut. Technol., 111–116.
   Google Scholar
• Weers, J. G., Maltz, D. S., Ung, K., Chan, L., Glusker, M., Ament, B., et al.. (2012). Minimizing Human Factors Effects through Inhaler Design. Respir. Drug Deliv., 217–226.
   Google Scholar
• Weers, J. G., Tarara, T. E., and Clark, A. R. (2007). Design of Fine Particles for Pulmonary Drug Delivery. Expert Opin. Drug Deliv., 4:297–313.
   PubMed Web of Science ®Google Scholar
• Weers, J. G., Ung, K., Le, J., Rao, N., Ament, B., Axford, G., et al. (2013). Dose Emission Characteristics of Placebo PulmoSphere® Particles Are Unaffected by a Subject's Inhalation Maneuver. J. Aerosol Med., 26(1):56–68.
   Google Scholar
• Yang, T. T., Li, S., Wyka, B., and Kenyon, D. (2001). Drug Delivery Performance of the Mometasone Furoate Dry Powder Inhaler. J. Aerosol Med., 14:487–494.
   PubMedGoogle Scholar
• Zhou, Y., Sun, J., and Cheng, Y. (2011). Comparison of Deposition in the USP and Physical Mouth-Throat Models with Solid and Liquid Particles. J, Aerosol Med Pulm Drug Deliv., 24(3):277–284.
   PubMed Web of Science ®Google Scholar