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Articles

Transient aerodynamic atomization model to predict aerosol droplet size of pressurized metered dose inhalers (pMDI)

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Pages 998-1008 | Received 25 Jan 2017, Accepted 28 Apr 2017, Published online: 24 May 2017

References

  • Bailey, A. G., Balachandran, W., and Williams, T. J. (1983). The Rosin—Rammler Size Distribution for Liquid Droplet Ensembles. J. Aerosol Sci., 14(1):39–46.
  • Brambilla, G., Ganderton, D., Garzia, R., Lewis, D., Meakin, B., and Ventura, P. (1999). Modulation of Aerosol Clouds Produced by Pressurised Inhalation Aerosols. Int. J. Pharm., 186(1):53–61.
  • Clark, A. R. (1991). Metered Atomisation for Respiratory Drug Delivery. PhD Thesis. Loughborough University of Technology, Loughborough, UK.
  • Dombrowski, N., and Hooper, P. C. (1962). The Effect of Ambient Density on Drop Formation in Sprays. Chem. Eng. Sci., 17(4):291–305.
  • Dombrowski, N., and Johns, W. (1963). The Aerodynamic Instability and Disintegration of Viscous Liquid Sheets. Chem. Eng. Sci., 18(3):203–214.
  • Dumouchel, C. (2008). On the Experimental Investigation on Primary Atomization of Liquid Streams. Exp. Fluids, 45(3):371–422.
  • Dumouchel, C., and Ledoux, M. (1991). Atomization of Flat and Annular Liquid Sheets. Practical Use of Linear Theories, in Proceedings of ICLASS, 91, Gaithersburg, MD, USA, pp. 157–164.
  • Dunbar, C. A. (1997). Atomization Mechanisms of the Pressurized Metered Dose Inhaler. Part. Sci. Technol., 15(3–4):253–271.
  • Dunbar, C. A., and Miller, J. F. (1997). Theoretical Investigation of the Spray from a Pressurized Metered-Dose Inhaler. Atom. Sprays, 7(4):417–436.
  • Dunbar, C. A., Watkins, A. P., and Miller, J. F. (1997). An Experimental Investigation of the Spray Issued from a pMDI Using Laser Diagnostic Techniques. J. Aerosol Med., 10(4):351–368.
  • FDA Draft Guidance. (1998). Guidance for Industry (Draft). Metered Dose Inhaler (MDI) and Dry Powder Inhaler (DPI) Drug Products: Chemistry, Manufacturing, and Controls Documentation. US Food and Drug Administration, Center for Drug Evaluation and Research.
  • Finlay, W. H. (2001). The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction. 6th ed. Academic Press, London.
  • Fletcher, G. E. (1975). Factors Affecting the Atomisation of Saturated Liquids. PhD Thesis, Loughborough University of Technology, Loughborough, UK.
  • Gavtash, B., Versteeg, H. K., Hargrave, G. K., Lewis, D., Church, T., and Brambilla, G. (2014). Linear Instability Sheet Atomisation (LISA) Model to Predict Droplet Size Issued from a pMDI, in Proceedings Of The ILASS – Europe 2014, 26th Annual Conference on Liquid Atomization and Spray Systems, Bremen, September, pp. 283–285.
  • Gavtash, B., Versteeg, H. K., Hargrave, G., Myatt, B., Lewis, D., Church, T., and Brambilla, G. (2017). Transient Flashing Propellant Flow Models to Predict Internal Flow Characteristics, Spray Velocity, and Aerosol Droplet Size of a pMDI. Aerosol Sci. Technol., 51(5):564–575.
  • Ghose, P., Patra, J., Datta, A., and Mukhopadhyay, A. (2014). Effect of Air Flow Distribution on Soot Formation and Radiative Heat Transfer in a Model Liquid Fuel Spray Combustor Firing Kerosene. Int. J. Heat Mass Transf., 74:143–155.
  • Honnery, D., Mason-Smith, N., Duke, D. J., Kastengren, A. L., Chen, Y., Young, P., Traini, D., Lewis, D., and Edgington-Mitchell, D. (2016). New Insights into pMDI Operation using Synchrotron X-Ray Techniques, in Proceedings of Respiratory Drug Delivery Asia (RDD Asia), Goa, India, November 8–11, pp. 209–218.
  • Hsiang, L. P., and Faeth, G. M. (1995). Drop Deformation and Breakup due to Shock Wave and Steady Disturbances. Int. J. Multiphase Flow, 21(4):545–560.
  • Hutcheson, P. S., Chew, J. W., Thorpe, R. B., and Young, C. (2008). Assessment of Models for Liquid Jet Breakup, in ASME Turbo Expo 2008: Power for Land, Sea, and Air. American Society of Mechanical Engineers, pp. 1517–1529.
  • Ivey, J. W., Lewis, D., Church, T., Finlay, W. H., and Vehring, R. (2014). A Correlation Equation for the Mass Median Aerodynamic Diameter of the Aerosol Emitted by Solution Metered Dose Inhalers. Int. J. Pharm., 465(1):18–24.
  • Jeandel, X., and Dumouchel, C. (1999). Influence of the Viscosity on the Linear Stability of an Annular Liquid Sheet. Int. J. Heat Fluid Flow, 20(5):499–506.
  • Ju, D., Shrimpton, J., and Hearn, A. (2010). The Effect of Reduction of Propellant Mass Fraction on the Injection Profile of Metered Dose Inhalers. Int. J. Pharm., 391(1):221–229.
  • Larmi, M., and Tiainen, J. (2003). Diesel Spray Simulation and KH-RT Wave Model. SAE Technical Paper 2003-01-3231.
  • Lefebvre, A. (1989). Atomization and Sprays. CRC Press, Boca Raton, FL.
  • Liu, A. B., Mather, D., and Reitz, R. D. (1993). Modeling the Effects of Drop Drag and Breakup on Fuel Sprays. SAE Technical Paper 930072.
  • Myatt, B., Lewis, D., Church, T., Brambilla, G., Hargrave, G., Versteeg, H., Long, E., and Gavtash, B. (2015a). PDA Analysis of HFA/Ethanol pMDI Aerosols: An Improved Test Protocol and New Findings, in Proceedings of ICLASS 2015, 13th Triennial International Conference on Liquid Atomization and Spray Systems, Thailand, August, pp. 11.
  • Myatt, B., Newton, R., Lewis, D., Church, T., Brambilla, G., Hargrave, G., Versteeg, H., Gavtash, B., and Long, E., (2015b). PDA and High Speed Image Analysis of HFA/Ethanol pMDI Aerosols: New Findings, in DDL 26, Edinburgh, December, pp. 73–77.
  • Myrdal, P. B., Karlage, K. L., Stein, S. W., Brown, B. A., and Haynes, A. (2004). Optimized Dose Delivery of the Peptide Cyclosporine using Hydrofluoroalkane based Metered Dose Inhalers. J. Pharm. Sci., 93(4):1054–1061.
  • Park, S. H., Kim, H. J., Suh, H. K., and Lee, C. S. (2009). Experimental and Numerical Analysis of Spray-Atomization Characteristics of Biodiesel Fuel in Various Fuel and Ambient Temperatures Conditions. Int. J. Heat Fluid Flow, 30(5):960–970.
  • Patterson, M. A., and Reitz, R. D. (1998). Modeling the Effects of Fuel Spray Characteristics on Diesel Engine Combustion and Emission. SAE Technical Paper 980131.
  • Polli, G. P., Grim, W. M., Bacher, F. A., and Yunker, M. H. (1969). Influence of Formulation on Aerosol Particle Size. J. Pharm. Sci., 58(4):484–486.
  • Razzaghi, M. (1989). Droplet Size Estimation of Two-Phase Flashing Jets. Nucl. Eng. Des., 114(1):115–124.
  • Reitz, R. D. (1987). Modeling Atomization Processes in High-Pressure Vaporizing Sprays. Atom. Spray Technol., 3:309–337.
  • Reitz, R. D., and Bracco, F. V. (1986). Mechanisms of Breakup of Round Liquid Jets, in The Encyclopedia of Fluid Mechanics. Vol. 3. N. Cheremisnoff, ed., Gulf Publishing, Houston, TX, pp. 233–249.
  • Schmidt, D. P., Nouar, I., Senecal, P., Rutland, C., Martin, J., Reitz, R., and Hoffman, J. A. (1999). Pressure-Swirl Atomization in the Near Field. SAE Trans., 108(3):471–484.
  • Senecal, P., Schmidt, D. P., Nouar, I., Rutland, C. J., Reitz, R. D., and Corradini, M. (1999). Modeling High-Speed Viscous Liquid Sheet Atomization. Int. J. Multiphase Flow, 25(6):1073–1097.
  • Smyth, H. D. C. (2003). The Influence of Formulation Variables on the Performance of Alternative Propellant-Driven Metered Dose Inhalers. Adv. Drug Deliv. Rev., 55(7):807–828.
  • Squire, H. (1953). Investigation of the Instability of a Moving Liquid Film. Br. J. Appl. Phys., 4(6):167–169.
  • Stein, S. W., and Myrdal, P. B. (2004). A Theoretical and Experimental Analysis of Formulation and Device Parameters Affecting Solution MDI Size Distributions. J. Pharm. Sci., 93(8):2158–2175.
  • Versteeg, H., Hargrave, G., and Kirby, M. (2006). Internal Flow and Near-Orifice Spray Visualisations of a Model Pharmaceutical Pressurised Metered Dose Inhaler. J. Phys.: Conf. Series 45:207–217.
  • Whalley, P. B. (1987). Boiling, Condensation, and Gas-Liquid Flow. Clarendon Press, Oxford.
  • Wigley, G., Versteeg, H. K., and Hodson, D. (2002). Near-Orifice PDA Measurements and Atomisation Mechanism of a Pharmaceutical Pressurised Metered Dose Inhaler, in Proceedings of the 18th Annual Conference on Liquid Atomization and Spray Systems, Ilass-Europe 2002, Zaragoza, Spain, September, 165–170.
  • York, J., Stubbs, H., and Tek, M. (1953). The Mechanism of Disintegration of Liquid Sheets. Trans. ASME, 75(7):1279–1286.