Laboratory study of bioaerosols: Traditional test systems, modern approaches, and environmental control

References

• Kolberg, D., F. Schubert, N. Lontke, A. Zwigart, and D. M. Spinner. 2011. Development of tunable close match LED solar simulator with extended spectral range to UV and IR. Energy Proc. 8:100–5. doi:10.1016/j.egypro.2011.06.109.
   Google Scholar
• Allegra, S., L. Leclerc, P. A. Massard, F. Girardot, S. Riffard, and J. Pourchez. 2016. Characterization of aerosols containing legionella generated upon nebulization. Sci. Rep. 6:33998. doi:10.1038/srep33998.
   PubMed Web of Science ®Google Scholar
• Antonietti, C. G. 2014. Development of the captive aerosol growth and evolution chamber system. Master's thesis, Texas A&M University. Available electronically from http://hdl.handle.net/1969.1/153855.
   Google Scholar
• Asgharian, B., and O. R. Moss. 1992. Particle suspension in a rotating drum chamber when the influence of gravity and rotation are both significant. Aerosol. Sci. Technol. 17 (4):263–77. doi:10.1080/02786829208959575.
   Web of Science ®Google Scholar
• ASHRAE (American Society of Heating, Refrigerating and Air-Conditioning Engineers, Inc.). (2013). Standard 62.1-2013 ventilation for acceptable indoor air quality. Atlanta, GA: American Society of Heating, Refrigerating and Air-Conditioning Engineers, Inc.
   Google Scholar
• ASTM International. (2012a). Standard tables for reference solar spectral irradiances: Direct normal and hemispherical on 37° tilted surface. ASTM G173-03. West Conshohocken, PA: ASTM International. doi:10.1520/G0173-03R12.
   Google Scholar
• ASTM International. (2012b). Standard tables for reference solar ultraviolet spectral distributions: Hemispherical on 37° tilted surface. ASTM G177-03. West Conshohocken, PA: ASTM International. doi:10.1520/G0177-03R12.
   Google Scholar
• Beebe, J. M., and G. W. Pirsch. 1958. Response of air-borne species of pasteurella to artificial radiation simulating sunlight under different conditions of relative humidity. Appl. Microbiol. 6 (2):127.
   PubMedGoogle Scholar
• Berger, D. S. 1969. Specification and design of solar ultraviolet simulators. J. Invest. Dermatol. 53 (3):192–9. doi:10.1038/jid.1969.133.
   PubMed Web of Science ®Google Scholar
• Blocquet, M., F. Guo, M. Mendez, M. Ward, S. Coudert, S. Batut, C. Hecquet, N. Blond, C. Fittschen, and C. Schoemaecker. 2018. Impact of the spectral and spatial properties of natural light on indoor gas‐phase chemistry: Experimental and modeling study. Indoor Air 28 (3):426–40. doi:10.1111/ina.12450.
   PubMed Web of Science ®Google Scholar
• Bogan, M. J., and G. R. Agnes. 2004. Wall-less sample preparation of mu m-sized sample spots for femtomole detection limits of proteins from liquid based UV-MALDI matrices. J. Am. Soc. Mass Spectrosc. 15 (4):486–95. doi:10.1016/j.jasms.2003.11.012.
   PubMed Web of Science ®Google Scholar
• Brown, A. D. 1954. The survival of airborne microorganisms III. Effects of temperature. Aust. J. Biol. Sci. 7 (4):444–51. doi:10.1071/BI9540444.
   PubMedGoogle Scholar
• Carter, W. P. L., D. R. Cocker, D. R. Fitz, I. L. Malkina, K. Bumiller, C. G. Sauer, J. T. Pisano, C. Bufalino, and C. Song. 2005. A new environmental chamber for evaluation of gas-phase chemical mechanisms and secondary aerosol formation. Atmos. Environ. 39 (40):7768–88. doi:10.1016/j.atmosenv.2005.08.040.
   Web of Science ®Google Scholar
• Christopher, L. G. W., L. T. J. Cieslak, J. A. Pavlin, and E. M. Eitzen. 1997. Biological warfare: A historical perspective. JAMA. 278 (5):412–17. doi:10.1001/jama.278.5.412.
   PubMed Web of Science ®Google Scholar
• Cocker, D. R., R. C. Flagan, and J. H. Seinfeld. 2001. State-of-theart chamber facility for studying atmospheric aerosol chemistry. Environ. Sci. Technol. 35 (12):2594–601. doi:10.1021/es0019169.
   PubMed Web of Science ®Google Scholar
• Codd, D. S., A. Carlson, J. Rees, and A. H. Slocum. 2010. A low cost high flux solar simulator. Solar Energy 84 (12):2202–12. doi:10.1016/j.solener.2010.08.007.
   Web of Science ®Google Scholar
• Cox, C. S. 1987. The aerobiological pathway of microorganisms. Chichester: Wiley.
   Google Scholar
• Cox, C. S., and L. J. Goldberg. 1972. Aerosol survival of Pasteurella tularensis and the influence of relative humidity. Appl. Environ. Microbiol. 23 (1):1–3.
   Google Scholar
• Dark, F. A., and T. Nash. 1970. Comparative toxicity of various ozonized olefins to bacteria suspended in air. J. Hyg. 68 (2):245–52. doi:10.1017/S0022172400028710.
   PubMedGoogle Scholar
• Davies, J. F., A. E. Haddrell, and J. P. Reid. 2012. Time-resolved measurements of the evaporation of volatile components from single aerosol droplets. Aerosol. Sci. Tech. 46 (6):666–77. doi:10.1080/02786826.2011.652750.
   Web of Science ®Google Scholar
• Davis, E. J., M. F. Buehler, and T. L. Ward. 1990. The double-ring electrodynamic balance for microparticle characterization. Rev. Sci. Instrum. 61 (4):1281–8. doi:10.1063/1.1141227.
   Web of Science ®Google Scholar
• Després, V. R., J. A. Huffman, S. M. Burrows, C. Hoose, A. S. Safatov, G. Buryak, J. Fröhlich-Nowoisky, W. Elbert, M. O. Andreae, et al. 2012. Primary biological aerosol particles in the atmosphere: A review. Tellus B: Chem. Phys. Meteorol. 64 (1):15598. doi:10.3402/tellusb.v64i0.15598.
   Web of Science ®Google Scholar
• Diffey, B. L. 2002. Sources and measurement of ultraviolet radiation. Methods 28 (1):4–13. doi:10.1016/S1046-2023(02)00204-9.
   PubMed Web of Science ®Google Scholar
• Donahue, N. M., K. M. Henry, T. F. Mentel, A. Kiendler-Scharr, C. Spindler, B. Bohn, T. Brauers, H. P. Dorn, H. Fuchs, R. Tillmann, et al. 2012. Aging of biogenic secondary organic aerosol via gas-phase OH radical reactions. Proc. Natl. Acad. Sci. 109 (34):13503–8. doi:10.1073/pnas.1115186109.
   PubMed Web of Science ®Google Scholar
• Donaldson, A. I. 1972. The influence of relative humidity on the aerosol stability of different strains of foot-and-mouth disease virus suspended in saliva. J. Gen. Virol. 15 (1):25–33. doi:10.1099/0022-1317-15-1-25.
   PubMed Web of Science ®Google Scholar
• Druett, H. A. 1971. A safe method of exposing microthreads in the open air. J. Appl. Bacteriol. 34 (3):655–8. doi:10.1111/j.1365-2672.1971.tb02328.x.
   PubMedGoogle Scholar
• Dybwad, M., and G. Skogan. 2017. Aerobiological stabilities of different species of gram-negative bacteria, including well-known biothreat simulants, in single-cell particles and cell clusters of different compositions. Appl. Environ. Microbiol. 83 (18):e00823–17. doi:10.1128/AEM.00823-17.
   PubMed Web of Science ®Google Scholar
• Ehrlich, R., S. Miller, and R. L. Walker. 1970. Relationship between atmospheric temperature and survival of airborne bacteria. Appl. Environ. Microbiol. 19 (2):245–9.
   Web of Science ®Google Scholar
• Emanuel, P. A., P. E. Buckley, T. A. Sutton, J. M. Edmonds, A. M. Bailey, B. A. Rivers, M. H. Kim, W. J. Ginley, C. C. Keiser, R. W. Doherty, et al. 2012. Detection and tracking of a novel genetically tagged biological simulant in the environment. Appl. Environ. Microbiol. 78 (23):8281–8. doi:10.1128/AEM.01827-12.
   PubMed Web of Science ®Google Scholar
• Esen, V., Ş. Sağlam, and B. Oral. 2017. Light sources of solar simulators for photovoltaic devices: A review. Renewable Sustainable Energy Rev. 77:1240–50. doi:10.1016/j.rser.2017.03.062.
   Web of Science ®Google Scholar
• Fan, L., J. Song, P. D. Hildebrand, and C. F. Forney. 2002. Interaction of ozone and negative air ions to control micro-organisms. J. Appl. Microbiol. 93 (1):144–8. doi:10.1046/j.1365-2672.2002.01683.x.
   PubMed Web of Science ®Google Scholar
• Fernandez, M. O., R. J. Thomas, N. J. Garton, A. Hudson, A. Haddrell, and J. P. Reid. 2019. Assessing the airborne survival of bacteria in populations of aerosol droplets with a novel technology. J. R. Soc. Interface 16:20180779.
   PubMed Web of Science ®Google Scholar
• Fernstrom, A., and M. Goldblatt. 2013. Aerobiology and its role in the transmission of infectious diseases. J. Pathog. 2013:1. doi:10.1155/2013/493960.
   Google Scholar
• Frohlich-Nowoisky, J., C. J. Kampf, B. Weber, J. A. Huffman, C. Pohlker, M. O. Andreae, N. Lang-Yona, S. M. Burrows, S. S. Gunthe, W. Elbert, H. Su, P. Hoor, E. Thines, T. Hoffmann, V. R. Despres, and U. Poschl. 2016. Bioaerosols in the earth system: Climate, health, and ecosystem interactions. Atmos. Res. 182:346–76. doi:10.1016/j.atmosres.2016.07.018.
   Web of Science ®Google Scholar
• Fujimori, E. 1985. Changes induced by ozone and ultraviolet light in type I collagen bovine achilles tendon collagen versus rat tail tendon collagen. Eur. J. Biochem. 152 (2):299–306. doi:10.1111/j.1432-1033.1985.tb09198.x.
   PubMedGoogle Scholar
• Gahagan, K. T., and G. A. Swartzlander. 1996. Optical vortex trapping of particles. Opt. Lett. 21 (11):827–9. doi:10.1364/OL.21.000827.
   PubMed Web of Science ®Google Scholar
• Goldberg, L. J., H. M. S. Watkins, E. E. Boerke, and M. A. Chatigny. 1958. The use of a rotating drum for the. Study of aerosols over extended periods of time. Am. J. Hyg. 68 (1):85–93. doi:10.1093/oxfordjournals.aje.a119954.
   PubMed Web of Science ®Google Scholar
• Gong, Z. Y., Y. L. Pan, G. Videen, and C. J. Wang. 2018. Optical trapping-Raman spectroscopy (OT-RS) with embedded microscopy imaging for concurrent characterization and monitoring of physical and chemical properties of single particles. Anal. Chim. Acta 1020:86–94. doi:10.1016/j.aca.2018.02.062.
   PubMed Web of Science ®Google Scholar
• Griffiths, W. D., I. W. Stewart, S. J. Futter, S. L. Upton, and D. Mark. 1997. The development of sampling methods for the assessment of indoor bioaerosols. J. Aerosol. Sci. 28 (3):437–57. doi:10.1016/S0021-8502(96)00446-6.
   Web of Science ®Google Scholar
• Gruel, R. L., C. R. Reid, and R. T. Allemann. 1987. The optimum rate of drum rotation for aerosol aging. J. Aerosol. Sci. 18 (1):17–22. doi:10.1016/0021-8502(87)90004-8.
   Web of Science ®Google Scholar
• Guedes, A., H. Ribeiro, M. Fernandez-Gonzalez, M. J. Aira, and I. Abreu. 2014. Pollen raman spectra database: Application to the identification of airborne pollen. Talanta 119:473–8. doi:10.1016/j.talanta.2013.11.046.
   PubMed Web of Science ®Google Scholar
• Haddrell, A. E., and R. J. Thomas. 2017. Aerobiology: Experimental considerations, observations, and future tools. Appl. Environ. Microbiol. 83 (17):e00809–17. doi:10.1128/AEM.00809-17.
   PubMed Web of Science ®Google Scholar
• Haddrell, A. E., G. Hargreaves, J. F. Davies, and J. P. Reid. 2013. Control over hygroscopic growth of saline aqueous aerosol using pluronic polymer additives. Int. J. Pharm. 443 (1–2):183–92. doi:10.1016/j.ijpharm.2012.12.039.
   PubMed Web of Science ®Google Scholar
• Haddrell, A. E., J. F. Davies, R. E. H. Miles, J. P. Reid, L. A. Dailey, and D. Murnane. 2014. Dynamics of aerosol size during inhalation: Hygroscopic growth of commercial nebulizer formulations. Int. J. Pharm. 463 (1):50–61. doi:10.1016/j.ijpharm.2013.12.048.
   PubMed Web of Science ®Google Scholar
• Haddrell, A. E., R. E. Miles, B. R. Bzdek, J. P. Reid, R. J. Hopkins, and J. S. Walker. 2017. Coalescence sampling and analysis of aerosols using aerosol optical tweezers. Anal. Chem. 89 (4):2345–52. doi:10.1021/acs.analchem.6b03979.
   PubMed Web of Science ®Google Scholar
• Hairston, P. P., J. Ho, and F. R. Quant. 1997. Design of an instrument for real-time detection of bioaerosols using simultaneous measurement of particle aerodynamic size and intrinsic fluorescence. J. Aerosol. Sci. 28 (3):471–82. doi:10.1016/S0021-8502(96)00448-X.
   PubMed Web of Science ®Google Scholar
• Hambleton, P., M. G. Broster, P. J. Dennis, R. Henstridge, R. Fitzgeorge, and J. W. Conlan. 1983. Survival of virulent Legionella pneumophila in aerosols. Epidemiol. Infect. 90 (3):451–60. doi:10.1017/S0022172400029090.
   Web of Science ®Google Scholar
• Handley, B. A., and J. M. Roe. 1994. An alternative microthread for the study of airborne survival of bacteria outdoors. J. Appl. Bacteriol. 77 (5):504–8. doi:10.1111/j.1365-2672.1994.tb04394.x.
   Google Scholar
• Hatch, M. T., and R. L. Dimmick. 1966. Physiological responses of airborne bacteria to shifts in relative humidity. Bacteriol. Rev. 30 (3):597.
   PubMedGoogle Scholar
• Healy, D. A., D. J. O'Connor, A. M. Burke, and J. R. Sodeau. 2012. A laboratory assessment of the waveband integrated bioaerosol sensor (WIBS-4) using individual samples of pollen and fungal spore material. Atmos. Environ. 60:534–43. doi:10.1016/j.atmosenv.2012.06.052.
   Web of Science ®Google Scholar
• Hermann, J., S. Hoff, C. Muñoz-Zanzi, K. J. Yoon, M. Roof, A. Burkhardt, and J. Zimmerman. 2007. Effect of temperature and relative humidity on the stability of infectious porcine reproductive and respiratory syndrome virus in aerosols. Vet. Res. 38 (1):81–93. doi:10.1051/vetres:2006044.
   PubMed Web of Science ®Google Scholar
• Hinds, W. C. 1999. Aerosol technology: Properties, behavior, and measurement of airborne particles. New York: John Wiley & Sons.
   Google Scholar
• Hopkins, R. J., L. Mitchem, A. D. Ward, and J. P. Reid. 2004. Control and characterisation of a single aerosol droplet in a single-beam gradient-force optical trap. Phys. Chem. Chem. Phys. 6 (21):4924–27. doi:10.1039/b414459g.
   Web of Science ®Google Scholar
• Huffman, J. A., and J. Santarpia. 2017. Online techniques for quantification and characterization of biological aerosols. In Microbiology of aerosols, ed. Anne-Marie Delort and Pierre Amato, New York: John Wiley & Sons, Inc.
   Google Scholar
• Humphreys, M. A. 1981. The dependence of comfortable temperatures upon indoor and outdoor climates. In Studies in environmental science. ed. K. Cena and J. A. Clark, Vol. 10, 229–50. Elsevier.
   Google Scholar
• Ignatenko, A. V. 1988. Use of the method of tryptophan fluorescence to characterize disruptions of the structure of ozonized proteins. J. Appl. Spectrosc. 49 (1):691–5. doi:10.1007/BF00662905.
   Google Scholar
• Ignatenko, A. V., B. A. Tatarinov, N. N. Khovratovich, V. P. Khrapovitskii, and S. N. Cherenkevich. 1982. Spectral-fluorescent investigation of the action of ozone on aromatic amino acids. J. Appl. Spectrosc. 37 (1):781–4. doi:10.1007/BF00663829.
   Google Scholar
• Ijaz, M. K., S. A. Sattar, C. M. Johnson-Lussenburg, V. S. Springthorpe, and R. C. Nair. 1985. Effect of relative humidity, atmospheric temperature, and suspending medium on the airborne survival of human rotavirus. Can. J. Microbiol. 31 (8):681–5. doi:10.1139/m85-129.
   PubMed Web of Science ®Google Scholar
• IPCC. 2013. Climate change 2013: The physical science basis. Contribution of working group I to the fifth assessment report of the intergovernmental panel on climate change. Cambridge University Press, Cambridge, UK.
   Google Scholar
• Johnson, D. L. 1999. The effect of phosphate buffer on aerosol size distribution of nebulized Bacillus subtilis and Pseudomonas fluorescens bacteria. Aerosol Sci. Technol. 30 (2):202–10. doi:10.1080/027868299304787.
   Web of Science ®Google Scholar
• Jonsson, P., G. R Olofsson, and T. R Tjärnhage. 2014. Bioaerosol detection technologies. New York: Springer.
   Google Scholar
• Kesavan, J., and E. Stuebing. 2009. Aerosol sampling efficiency evaluation methods at the US Army Edgewood chemical biological center. In Atmospheric and biological environmental monitoring, 83–103. Dordrecht: Springer.
   Google Scholar
• Kesavan, J., D. Schepers, J. Bottiger, and J. Edmonds. 2014. UV-C decontamination of aerosolized and surface-bound single spores and bioclusters. Aerosol Sci. Technol. 48 (4):450–7. doi:10.1080/02786826.2014.889276.
   Web of Science ®Google Scholar
• Kim, J. G., and A. E. Yousef. 2000. Inactivation kinetics of foodborne spoilage and pathogenic bacteria by ozone. J. Food Sci. 65 (3):521–8. doi:10.1111/j.1365-2621.2000.tb16040.x.
   Web of Science ®Google Scholar
• Kim, K. H., E. Kabir, and S. A. Jahan. 2018. Airborne bioaerosols and their impact on human health. J. Environ. Sci. 67:23–35. doi:10.1016/j.jes.2017.08.027.
   Web of Science ®Google Scholar
• Kinahan, S. M., M. S. Tezak, C. M. Siegrist, G. Lucero, B. L. Servantes, J. L. Santarpia, … Y. L. Pan. 2019. Changes of fluorescence spectra and viability from aging aerosolized E. coli cells under various laboratory-controlled conditions in an advanced rotating drum. Aerosol. Sci. Technol. 53:1–16. doi:10.1080/02786826.2019.1653446.
   Web of Science ®Google Scholar
• King, M. D., and A. R. McFarland. 2012a. Bioaerosol sampling with a wetted wall cyclone: Cell culturability and DNA integrity of Escherichia coli bacteria. Aerosol Sci. Technol. 46 (1):82–93. doi:10.1080/02786826.2011.605400.
   Web of Science ®Google Scholar
• King, M. D., and A. R. McFarland. 2012b. Use of an andersen bioaerosol sampler to simultaneously provide culturable particle and culturable organism size distributions. Aerosol. Sci. Technol. 46 (8):852–61. doi:10.1080/02786826.2012.669507.
   Web of Science ®Google Scholar
• Ko, G., M. W. First, and H. A. Burge. 2000. Influence of relative humidity on particle size and UV sensitivity of Serratia marcescens and Mycobacterium bovis BCG aerosols. Tubercle Lung Dis. 80 (4–5):217–28. doi:10.1054/tuld.2000.0249.
   PubMedGoogle Scholar
• Kotiaho, T., M. N. Eberlin, P. Vainiotalo, and R. Kostiainen. 2000. Electrospray mass and tandem mass spectrometry identification of ozone oxidation products of amino acids and small peptides. J. Am. Soc. Mass Spectrom. 11 (6):526–35. doi:10.1016/S1044-0305(00)00116-1.
   PubMed Web of Science ®Google Scholar
• Kowal, S. F., S. R. Allen, and T. F. Kahan. 2017. Wavelength-Resolved photon fluxes of indoor light sources: Implications for HO x production. Environ. Sci. Technol. 51 (18):10423–30. doi:10.1021/acs.est.7b02015.
   PubMed Web of Science ®Google Scholar
• Krumins, V., E.-K. Son, G. Mainelis, and D. E. Fennell. 2008. Retention of inactivated bioaerosols and ethene in a rotating gioreactor constructed for bioaerosol activity studies. Clean 36 (7):593–600. doi:10.1002/clen.200800004.
   Web of Science ®Google Scholar
• Laucks, M. L., G. Roll, G. Schweiger, and E. J. Davis. 2000. Physical and chemical (raman) characterization of bioaerosols - Pollen. J. Aerosol. Sci. 31 (3):307–19. doi:10.1016/S0021-8502(99)00058-0.
   Web of Science ®Google Scholar
• Lee, B. U., S. H. Kim, and S. S. Kim. 2002. Hygroscopic growth of E. coli and B. subtilis bioaerosols. J. Aerosol. Sci. 33 (12):1721–3. doi:10.1016/S0021-8502(02)00114-3.
   Web of Science ®Google Scholar
• Li, R., D. Dhankhar, J. Chen, A. Krishnamoorthi, T. C. Cesario, and P. M. Rentzepis. 2019. Identification of live and dead bacteria: A Raman spectroscopic study. IEEE Access 7:23549–59.
   Web of Science ®Google Scholar
• Lighthart, B., and A. J. Mohr. 2012. Atmospheric microbial aerosols: Theory and applications. New York: Springer Science & Business Media.
   Google Scholar
• Liu, F. R., Z. G. Zhang, S. H. Fu, Y. F. Wei, T. Cheng, Q. C. Zhang, and X. P. Wu. 2014. Manipulation of aerosols revolving in taper-ring optical traps. Opt. Lett. 39 (1):100–3. doi:10.1364/OL.39.000100.
   PubMed Web of Science ®Google Scholar
• Liu, F. R., Z. G. Zhang, Y. F. Wei, Q. C. Zhang, T. Cheng, and X. P. Wu. 2014. Photophoretic trapping of multiple particles in tapered-ring optical field. Opt. Express 22 (19):23716–23. doi:10.1364/OE.22.023716.
   PubMed Web of Science ®Google Scholar
• Marr, L. C., J. W. Tang, J. Van Mullekom, and S. S. Lakdawala. 2019. Mechanistic insights into the effect of humidity on airborne influenza virus survival, transmission and incidence. J. Roy. Soc. Interface 16 (150):20180298. doi:10.1098/rsif.2018.0298.
   PubMed Web of Science ®Google Scholar
• Marsh, A., G. Rovelli, R. E. Miles, and J. P. Reid. 2019. Complexity of measuring and representing the hygroscopicity of mixed component aerosol. J. Phys. Chem. A 123 (8):1648–60. doi:10.1021/acs.jpca.8b11623.
   PubMed Web of Science ®Google Scholar
• Martín-Reviejo, M., and K. Wirtz. 2005. Is benzene a precursor for secondary organic aerosol? Environ. Sci. Technol. 39 (4):1045–54. doi:10.1021/es049802a,.
   PubMed Web of Science ®Google Scholar
• May, K. R., and H. A. Druett. 1968. A microthread technique for studying the viability of microbes in a simulated airborne state. Microbiology 51 (3):353–66. doi:10.1099/00221287-51-3-353.
   Web of Science ®Google Scholar
• McDevitt, J. J., K. M. Lai, S. N. Rudnick, E. A. Houseman, M. W. First, and D. K. Milton. 2007. Characterization of UVC light sensitivity of vaccinia virus. Appl. Environ. Microbiol. 73 (18):5760–6. doi:10.1128/AEM.00110-07.
   PubMed Web of Science ®Google Scholar
• McDevitt, J. J., S. N. Rudnick, and L. J. Radonovich. 2012. Aerosol susceptibility of influenza virus to UV-C light. Appl. Environ. Microbiol. 78 (6):1666–9. doi:10.1128/AEM.06960-11.
   PubMed Web of Science ®Google Scholar
• McFarland, A. R., J. S. Haglund, M. D. King, S. Hu, M. S. Phull, B. W. Moncla, and Y. Seo. 2010. Wetted wall cyclones for bioaerosol sampling. Aerosol. Sci. Technol. 44 (4):241–52. doi:10.1080/02786820903555552.
   Web of Science ®Google Scholar
• Mikhailov, E., S. Vlasenko, R. Niessner, and U. Pöschl. 2004. Interaction of aerosol particles composed of protein and salts zwith water vapor: Hygroscopic growth and microstructural rearrangement. Atmos. Chem. Phys. 4 (2):323–50.
   Web of Science ®Google Scholar
• Mohr, A. J. 2007. Fate and transport of microorganisms in air. In Manual of environmental microbiology. ed. Ronald L. Crawford, Jay L. Garland, Christon J. Hurst, Aaron L. Mills, and David A. Lipson, 961–71. 3rd ed. American Society of Microbiology.
   Google Scholar
• Montgomery, T. L., and M. Corn. 1970. Aerosol deposition in a pipe with turbulent airflow. j. Aerosol Sci. 1 (3):185–213. doi:10.1016/0021-8502(70)90034-0.
   Google Scholar
• Mudd, J. B., R. Leavitt, A. Ongun, and T. T. McManus. 1969. Reaction of ozone with amino acids and proteins. Atmos. Instrum. 3:669–82. doi:10.1016/0004-6981(69)90024-9.
   Web of Science ®Google Scholar
• National Research Council. 2005. Review of testing and evaluation methodology for biological point detectors: Abbreviated summary. Washington, DC: National Academies Press.
   Google Scholar
• Nguyen, J. L., J. Schwartz, and D. W. Dockery. 2014. The relationship between indoor and outdoor temperature, apparent temperature, relative humidity, and absolute humidity. Indoor Air 24 (1):103–12. doi:10.1111/ina.12052.
   PubMed Web of Science ®Google Scholar
• Noti, J. D., F. M. Blachere, C. M. McMillen, W. G. Lindsley, M. L. Kashon, D. R. Slaughter, and D. H. Beezhold. 2013. High humidity leads to loss of infectious influenza virus from simulated coughs. PloS One 8 (2):e57485. doi:10.1371/journal.pone.0057485.
   PubMed Web of Science ®Google Scholar
• Otero-Fernandez, M., R. Thomas, N. Garton, A. Hudson, A. Haddrell, and J. Reid. 2019. Assessing the airborne survival of bacteria in populations of aerosol droplets with a novel technology. J. Roy. Soc. Interface 16 (150):20180779. 2018.0779. doi:10.1098/rsif.
   PubMed Web of Science ®Google Scholar
• Paez-Rubio, T., and J. Peccia. 2005. Estimating solar and nonsolar inactivation rates of airborne bacteria. J. Environ. Eng. 131 (4):512–17. doi:10.1061/(ASCE)0733-9372(2005)131:4(512).
   Web of Science ®Google Scholar
• Pan, Y. L., S. C. Hill, and M. Coleman. 2012. Photophoretic trapping of absorbing particles in air and measurement of their single-particle Raman spectra. Opt. Express 20 (5):5325–34. doi:10.1364/OE.20.005325.
   PubMed Web of Science ®Google Scholar
• Pan, Y.-L., J. L. Santarpia, S. Ratnesar-Shumate, E. Corson, J. Eshbaugh, S. C. Hill, C. C. Williamson, M. Coleman, C. Bare, and S. Kinahan. 2014. Effects of ozone and relative humidity on fluorescence spectra of octapeptide bioaerosol particles. J. Quant. Spectrosc. Radiat. Transfer 133:538–50. doi:10.1016/j.jqsrt.2013.09.017.
   Web of Science ®Google Scholar
• Pan, Y.-L., S. C. Hill, J. L. Santarpia, K. Brinkley, T. Sickler, M. Coleman, C. Williamson, K. Gurton, M. Felton, R. G. Pinnick, N. Baker, J. Eshbaugh, J. Hahn, E. Smith, B. Alvarez, A. Prugh, and W. Gardner. 2014. Spectrally-resolved fluorescence cross sections of aerosolized biological live agents and simulants using five excitation wavelengths in a BSL-3 laboratory. Opt. Express 22 (7):8165–89. doi:10.1364/OE.22.008165.
   PubMed Web of Science ®Google Scholar
• Park, C. W., K. Y. Yoon, Y. Do Kim, J. H. Park, and J. Hwang. 2011. Effects of condensational growth on culturability of airborne bacteria: Implications for sampling and control of bioaerosols. J. Aerosol. Sci. 42 (4):213–23. doi:10.1016/j.jaerosci.2011.01.006.
   Web of Science ®Google Scholar
• Paul, W., and H. Steinwedel. 1953. *Ein neues massenspektrometer ohne magnetfeld. Z Naturforsch A 8:448–50.
   Google Scholar
• Paulsen, D., J. Dommen, M. Kalberer, A. S. H. Prévôt, R. Richter, M. Sax, M. Steinbacher, E. Weingartner, and U. Baltensperger. 2005. Secondary organic aerosol formation by irradiation of 1,3,5- Trimethylbenzene – NOx-H2O in a new reaction chamber for atmospheric chemistry and physics. Environ. Sci. Technol. 39 (8):2668–78. doi:10.1021/es0489137.
   PubMed Web of Science ®Google Scholar
• Peccia, J., H. M. Werth, S. Miller, and M. Hernandez. 2001. Effects of relative humidity on the ultraviolet induced inactivation of airborne bacteria. Aerosol. Sci. Technol. 35 (3):728–40. doi:10.1080/02786820152546770.
   Web of Science ®Google Scholar
• Peng, J., M. Hu, S. Guo, Z. Du, J. Zheng, D. Shang, M. Levy Zamora, L. Zeng, M. Shao, Y.-S. Wu, J. Zheng, Y. Wang, C. R. Glen, D. R. Collins, M. J. Molina, and R. Zhang. 2016. Markedly enhanced absorption and direct radiative forcing of black carbon under polluted urban environments. Proc. Nat. Acad. Sci. 113 (16):4266–71. doi:10.1073/pnas.1602310113.
   PubMed Web of Science ®Google Scholar
• Piercy, T. J., S. J. Smither, J. A. Steward, L. Eastaugh, and M. S. Lever. 2010. The survival of filoviruses in liquids, on solid substrates and in a dynamic aerosol. J. Appl. Microbiol. 109 (5):1531–9. doi:10.1111/j.1365-2672.2010.04778.x.
   PubMed Web of Science ®Google Scholar
• Pope, F. D. 2010. Pollen grains are efficient cloud condensation nuclei. Environ. Res. Lett. 5:044015.
   Web of Science ®Google Scholar
• Ratnesar-Shumate, S., M. L. Wagner, C. Kerechanin, G. House, K. M. Brinkley, C. Bare, N. A. Baker, R. Quizon, J. Quizon, A. Proescher, E. Van Gieson, and J. L. Santarpia. 2011. Improved method for the evaluation of real-time biological aerosol detection technologies. Aerosol. Sci. Technol. 45 (5):635–44. doi:10.1080/02786826.2010.551144.
   Web of Science ®Google Scholar
• Ratnesar-Shumate, S., Y. L. Pan, S. C. Hill, S. Kinahan, E. Corson, J. Eshbaugh, and J. L. Santarpia. 2015. Fluorescence spectra and biological activity of aerosolized bacillus spores and MS2 bacteriophage exposed to ozone at different relative humidities in a rotating drum. J. Quant. Spectrosc. Radiat. Transfer 153:13–28. doi:10.1016/j.jqsrt.2014.10.003.
   Web of Science ®Google Scholar
• Redding, B., and Y. L. Pan. 2015. Optical trap for both transparent and absorbing particles in air using a single shaped laser beam. Opt. Lett. 40 (12):2798–801. doi:10.1364/OL.40.002798.
   PubMed Web of Science ®Google Scholar
• Redding, B., S. C. Hill, D. Alexson, C. J. Wang, and Y. L. Pan. 2015. Photophoretic trapping of airborne particles using ultraviolet illumination. Opt. Express 23 (3):3630–9. doi:10.1364/OE.23.003630.
   PubMed Web of Science ®Google Scholar
• Reed, D. S., A. Nalca, and C. J. Roy. 2018. Aerobiology: History, development, and programs. In Medical Aspects of Biological Warfare, ed. J. Bozue, C. K. Cote and P. J. Glass, Fort Sam Houston, Texas: Office of The Surgeon General, Borden Institute, US Army Medical Department Center and School, Health Readiness Center of Excellence.
   Google Scholar
• Reid, J. P., and L. Mitchem. 2006. Laser probing of single-aerosoldroplet dynamics. Annu. Rev. Phys. Chem. 57 (1):245–71. doi:10.1146/annurev.physchem.57.032905.104621.
   PubMed Web of Science ®Google Scholar
• Reid, J. P., H. Meresman, L. Mitchem, and R. Symes. 2007. Spectroscopic studies of the size and composition of single aerosol droplets. Int. Rev. Phys. Chem. 26 (1):139–92. doi:10.1080/01442350601081899.
   Web of Science ®Google Scholar
• Reponen, T., K. Willeke, V. Ulevicius, A. Reponen, and S. A. Grinshpun. 1996. Effect of relative humidity on the aerodynamic diameter and respiratory deposition of fungal spores. Atmos. Environ. 30 (23):3967–74. doi:10.1016/1352-2310(96)00128-8.
   Web of Science ®Google Scholar
• Rollins, A. W., A. Kiendler-Scharr, J. L. Fry, T. Brauers, S. S. Brown, H.-P. Dorn, W. P. Dubé, H. Fuchs, A. Mensah, T. F. Mentel, F. Rohrer, R. Tillmann, R. Wegener, P. J. Wooldridge, and R. C. Cohen. 2009. Isoprene oxidation by nitrate radical: Alkyl nitrate and secondary organic aerosol yields. Atmos. Chem. Phys. 9 (18):6685–703. doi:10.5194/acp-9-6685-2009.
   Web of Science ®Google Scholar
• Ruoff, K. L. 1998. Biological warfare. Clin. Microbiol. Newslett. 20 (21):173–6. doi:10.1016/S0196-4399(00)88655-9.
   Google Scholar
• Santarpia, J. L. 2016. Bioaerosols in the environment: Populations, measurement and processes, In Aerobiology: The Toxicology of Airborne Pathogens and Toxins, ed. H. Salem and S. A. Katz, Cambridge: Royal Society of Chemistry.
   Google Scholar
• Santarpia, J. L., S. Ratnesar-Shumate, J. U. Gilberry, and J. J. Quizon. 2013. Relationship between biologically fluorescent aerosol and local meteorological conditions. Aerosol. Sci. Technol. 47 (6):655–61. doi:10.1080/02786826.2013.781263.
   Web of Science ®Google Scholar
• Santarpia, J. L., Y.-L. Pan, S. C. Hill, N. Baker, B. Cottrell, L. McKee, S. Ratnesar-Shumate, and R. G. Pinnick. 2012. Changes in fluorescence spectra of bioaerosols exposed to ozone in a laboratory reaction chamber to simulate atmospheric aging. Opt. Express 20 (28):29867–81. doi:10.1364/OE.20.029867.
   PubMed Web of Science ®Google Scholar
• Sattler, B., H. Puxbaum, and R. Psenner. 2001. Bacterial growth in supercooled cloud droplets. Geophys. Res. Lett. 28 (2):239–42. doi:10.1029/2000GL011684.
   Web of Science ®Google Scholar
• Sawyer, W. D., J. V. Jemski, A. L. Hogge, Jr., H. T. Eigelsbach, E. K. Wolfe, H. G. Dangerfield, W. S. Gochenour, Jr., and D. Crozier. 1966. Effect of aerosol age on the infectivity of airborne Pasteurella tularensis for Macaca mulatta and man. J. Bacteriol. 91 (6):2180–4.
   PubMed Web of Science ®Google Scholar
• Seinfeld, J. H., and S. N. Pandis. 2016. Atmospheric chemistry and physics: From air pollution to climate change. New York: John Wiley & Sons.
   Google Scholar
• Selma, M. V., A. M. Ibanez, M. Cantwell, and T. Suslow. 2008. Reduction by gaseous ozone of salmonella and microbial flora associated with fresh-cut cantaloupe. Food Microbiol. 25 (4):558–65. doi:10.1016/j.fm.2008.02.006.
   PubMed Web of Science ®Google Scholar
• Shaman, J., and M. Kohn. 2009. Absolute humidity modulates influenza survival, transmission, and seasonality. Proc. Nat. Acad. Sci. 106 (9):3243–8. doi:10.1073/pnas.0806852106.
   PubMed Web of Science ®Google Scholar
• Sivaprakasam, V., A. Huston, H. B. Lin, J. Eversole, P. Falkenstein, and A. Schultz. (2007, May). Field test results and ambient aerosol measurements using dual wavelength fluorescence excitation and elastic scatter for bio-aerosols. In Chemical and biological sensing VIII, ed. W. Augustus and Fountain III, Vol. 6554, 65540R. Bellingham, Washington: International Society for Optics and Photonics.
   Google Scholar
• Smets, W., S. Moretti, S. Denys, and S. Lebeer. 2016. Airborne bacteria in the atmosphere: Presence, purpose, and potential. Atmos. Environ. 139:214–21. doi:10.1016/j.atmosenv.2016.05.038.
   Web of Science ®Google Scholar
• Smither, S. J., T. J. Piercy, L. Eastaugh, J. A. Steward, and M. S. Lever. 2011. An alternative method of measuring aerosol survival using spiders’ webs and its use for the filoviruses. J. Virol. Methods 177 (1):123–7. doi:10.1016/j.jviromet.2011.06.021.
   PubMed Web of Science ®Google Scholar
• Songer, J. R. 1967. Influence of relative humidity on the survival of some airborne viruses. Appl. Environ. Microbiol. 15 (1):35–42.
   Web of Science ®Google Scholar
• Su, W. C., A. D. Tolchinsky, B. T. Chen, V. I. Sigaev, and Y. S. Cheng. 2012. Evaluation of physical sampling efficiency for cyclone-based personal bioaerosol samplers in moving air environments. J. Environ. Monitor. 14 (9):2430–7. doi:10.1039/c2em30299c.
   PubMedGoogle Scholar
• Svenningsson, B., J. Rissler, E. Swietlicki, M. Mircea, M. Bilde, M. C. Facchini, S. Decesari, S. Fuzzi, J. Zhou, J. Monster, and T. Rosenorn. 2006. Hygroscopic growth and critical supersaturations for mixed aerosol particles of inorganic and organic compounds of atmospheric relevance. Atmos. Chem. Phys. 6 (7):1937–52. doi:10.5194/acp-6-1937-2006.
   Web of Science ®Google Scholar
• Tang, J. W. 2009. The effect of environmental parameters on the survival of airborne infectious agents. J. Roy. Soc. Interf. 6 (suppl_6):S737–S46. doi:10.1098/rsif.2009.0227.focus.
   PubMed Web of Science ®Google Scholar
• Tellier, R., Y. Li, B. J. Cowling, and J. W. Tang. 2019. Recognition of aerosol transmission of infectious agents: A commentary. BMC Infect. Dis. 19 (1):101. doi:10.1186/s12879-019-3707-y.
   PubMed Web of Science ®Google Scholar
• Theunissen, H. J., N. A. Lemmens-den Toom, A. Burggraaf, E. Stolz, and M. F. Michel. 1993. Influence of temperature and relative humidity on the survival of Chlamydia pneumoniae in aerosols. Appl. Environ. Microbiol. 59 (8):2589–93.
   PubMed Web of Science ®Google Scholar
• Thompson, K.-A., A. M. Bennett, and J. T. Walker. 2011. Aerosol survival of Staphylococcus epidermidis. J. Hosp. Infect. 78 (3):216–20. doi:10.1016/j.jhin.2010.12.009.
   PubMed Web of Science ®Google Scholar
• Tong, Y., and B. Lighthart. 1998. Effect of simulated solar radiation on mixed outdoor atmospheric bacterial populations. FEMS Microbiol. Ecol. 26 (4):311–16. doi:10.1111/j.1574-6941.1998.tb00515.x.
   Web of Science ®Google Scholar
• Toprak, E., and M. Schnaiter. 2013. Fluorescent biological aerosol particles measured with the waveband integrated bioaerosol sensor WIBS-4: Laboratory tests combined with a one year field study. Atmos. Chem. Phys. 13 (1):225–43. doi:10.5194/acp-13-225-2013.
   Web of Science ®Google Scholar
• Upton, S. L., D. Mark, E. J. Douglass, D. J. Hall, and W. D. Griffiths. 1994. A wind tunnel evaluation of the physical sampling efficiencies of three bioaerosol samplers. J. Aerosol. Sci. 25 (8):1493–501. doi:10.1016/0021-8502(94)90220-8.
   Web of Science ®Google Scholar
• Vejerano, E. P., and L. C. Marr. 2018. Physico-chemical characteristics of evaporating respiratory fluid droplets. J. Roy. Soc. Interface 15 (139):20170939. doi:10.1098/rsif.2017.0939.
   PubMed Web of Science ®Google Scholar
• Verreault, D., C. Duchaine, M. Marcoux-Voiselle, N. Turgeon, and C. J. Roy. 2014. Design of an environmentally controlled rotating chamber for bioaerosol aging studies. Inhalation Toxicol. 26 (9):554–8. doi:10.3109/08958378.2014.928763.
   PubMed Web of Science ®Google Scholar
• Walikewitz, N., B. Jänicke, M. Langner, F. Meier, and W. Endlicher. 2015. The difference between the mean radiant temperature and the air temperature within indoor environments: A case study during summer conditions. Build. Environ. 84:151–61. doi:10.1016/j.buildenv.2014.11.004.
   Web of Science ®Google Scholar
• Walker, C. M., and G. Ko. 2007. Effect of ultraviolet germicidal irradiation on viral aerosols. Environ. Sci. Technol. 41 (15):5460–65. doi:10.1021/es070056u.
   PubMed Web of Science ®Google Scholar
• Wang, C. J., Y. L. Pan, S. C. Hill, and B. Redding. 2015. Photophoretic trapping-Raman spectroscopy for single pollen grains and fungal spores trapped in air. J. Quant. Spectrosc Radiat. Transf. 153:4–12. doi:10.1016/j.jqsrt.2014.11.004.
   Web of Science ®Google Scholar
• Wang, X., T. Liu, F. Bernard, X. Ding, S. Wen, Y. Zhang, Z. Zhang, Q. He, S. Lü, J. Chen, S. Saunders, and J. Yu. 2014. Design and characterization of a smog chamber for studying gas-phase chemical mechanisms and aerosol formation. Atmos. Meas. Tech. 7 (1):301–13. doi:10.5194/amt-7-301-2014.
   Web of Science ®Google Scholar
• Wathes, C. M., K. Howard, and A. J. F. Webster. 1986. The survival of Escherichia coli in an aerosol at air temperatures of 15 and 30 C and a range of humidities. Epidemiol. Infect. 97 (3):489–96. doi:10.1017/S0022172400063671.
   Web of Science ®Google Scholar
• Webb, S. J. 1961. Factors affecting the viability of air-borne bacteria: IV. The inactivation and reactivation of air-borne Serratia marcescens by ultraviolet and visible light. Can. J. Microbiol. 7 (4):607–19. doi:10.1139/m61-070.
   PubMed Web of Science ®Google Scholar
• Whitney, E. A. S., M. E. Beatty, T. H. Taylor, Jr, R. Weyant, J. Sobel, M. J. Arduino, and D. A. Ashford. 2003. Inactivation of Bacillus anthracis spores. Emerging Infect. Dis. 9 (6):623. doi:10.3201/eid0906.020377.
   PubMed Web of Science ®Google Scholar
• Wright, D. N., and G. D. Batley. 1969. Effect of relative humidity on the stability of Mycoplasma pneumoniae exposed to simulated solar ultraviolet and to visible radiation. Can. J. Microbiol. 15 (12):1449–52. doi:10.1139/m69-258.
   PubMed Web of Science ®Google Scholar
• Wuerker, R. F., H. Shelton, and R. V. Langmuir. 1959. Electrodynamic containment of charged particles. J. Appl. Phys. 30 (3):342–9. doi:10.1063/1.1735165.
   Web of Science ®Google Scholar
• Xie, C. G., M. A. Dinno, and Y. Q. Li. 2002. Near-infrared Raman spectroscopy of single optically trapped biological cells. Opt. Lett. 27 (4):249–51. doi:10.1364/OL.27.000249.
   PubMed Web of Science ®Google Scholar
• Xie, C. G., Y. Q. Li, W. Tang, and R. J. Newton. 2003. Study of dynamical process of heat denaturation in optically trapped single microorganisms by near-infrared Raman spectroscopy. J. Appl. Phys. 94 (9):6138–42. doi:10.1063/1.1617359.
   Web of Science ®Google Scholar
• Yang, W., and L. C. Marr. 2012. Mechanisms by which ambient humidity may affect viruses in aerosols. Appl. Environ. Microbiol. 78 (19):6781–8. doi:10.1128/AEM.01658-12.
   PubMed Web of Science ®Google Scholar
• Zhang, P., J. Prakash, Z. Zhang, M. S. Mills, N. K. Efremidis, D. N. Christodoulides, and Z. G. Chen. 2011. Trapping and guiding microparticles with morphing autofocusing airy beams. Opt. Lett. 36 (15):2883–5. doi:10.1364/OL.36.002883.
   PubMed Web of Science ®Google Scholar
• Zhang, Y., H. Yang, and U. Poschl. 2011. Analysis of nitrated proteins and tryptic peptides by HPLC-chip-MS/MS site-specific quantification, nitration degree and reactivity of tyrosine residues. Anal. Bioanal. Chem. 399:459–71.
   PubMed Web of Science ®Google Scholar
• Zhao, Y., A. J. Aarnink, R. Dijkman, T. Fabri, M. C. de Jong, and P. W. G. Koerkamp. 2012. Effects of temperature, relative humidity, absolute humidity, and evaporation potential on survival of airborne gumboro vaccine virus. Appl. Environ. Microbiol. 78 (4):1048–54. doi:10.1128/AEM.06477-11.
   PubMed Web of Science ®Google Scholar