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Original Articles

Cannabis and Psychosis: What is the Link?

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Pages 131-142 | Published online: 08 Sep 2011

REFERENCES

  • Allebeck , P. , Adamsson , C. , Engstrom , A. and Rydberg , U. 1993 . Cannabis and schizophrenia: A longitudinal study of cases treated in Stockholm County . Acta Psychiatrica Scandinavica , 88 : 21 – 24 .
  • Aloe , L. , lannitelli , A. , Angelucci , F. , Bersani , G. and Fiore , M. 2000 . Studies in animal models and humans suggesting a role of nerve growth factor in schizophrenia-like disorders . Behavioral Pharmacology , 11 : 235 – 42 .
  • Andreasen , N. C. 1987 . The diagnosis of schizophrenia . Schizophrenia Bulletin , 13 : 9 – 22 .
  • Andreasson , S. , Allebeck , P. , Engström , A. and Rydberg , U. 1987 . Cannabis and schizophrenia. A longitudinal study of Swedish conscripts . Lancet , 2 : 1483 – 5 .
  • American Psychiatric Association (APA) . 2000 . Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR), Fourth Edition Revised. Washington, D.C. : American Psychiatric Association. .
  • Arseneault , L. , Cannon , M. , Witton , J. and Murray , R. M. 2004 . Causal association between cannabis and psychosis: Examination of the evidence . British Journal of Psychiatry , 184 : 110 – 17 .
  • Arseneault , L. , Cannon , M. , Poulton , R. , Murray , R. , Caspi , A. and Moffit , T. E. 2002 . Cannabis use in adolescence and risk for adult psychosis: Longitudinal prospective study . British Medical Journal , 325 : 1212 – 13 .
  • Atakan , Z. 2004 . Cannabis and psychosis: How important is the link? . Addiction , 99 : 513 – 15 .
  • Aust , R. , Sharp , C. and Goulden , C. 2002 . Prevalence of Drug Use: Key Findings from the 2001/2002 British Crime Survey, Findings 182. London : Home Office Research, Development and Statistics Directorate. .
  • Bartolucci , G. , Fryer , L. , Perris , C. and Shagass , C. 1969 . Marijuana psychosis: A case report . Canadian Psychiatric Association Journal , 14 : 77 – 79 .
  • Ben Amar , M. 2004 . Pharmacologie du cannabis et synthèse des analyses des principaux comites d'experts . Drogues, Santé et Société , 2 : 9 – 60 .
  • Ben Amar , M. and Leonard , L. 2002 . “ Chapter 16: Cannabis. ” . In Les Psychotropes: Pharmacologie et Toxicomanie. Edited by: Léonard , L. and Ben Amar , M. Montreal : Les Presses de I'Université de Montréal. .
  • Berger , N. 2004 . Cannabis et schizophrénie. De l'euphorie à la psychose . Revue Médicate de Liège , 59 : 98 – 103 .
  • Berk , M. , Brook , S. and Trandafir , A. I. 1999 . A comparison of olanzapine with haloperidol in cannabis-induced psychotic disorder. A double-blind randomized controlled trial . International Clinical Psychopharmacology , 14 : 177 – 80 .
  • Bersani , G. , Orlandi , V. , Kotzalidis , G. D. and Pancheri , P. 2002 . Cannabis and schizophrenia: Impact on onset, course, psychopathology and outcomes . European Archives of Psychiatry and Clinical Neuroscience , 252 : 86 – 92 .
  • Caspi , A. , Moffitt , T. E. , Cannon , M. , McClay , J. , Murray , R. , Harrington , H. L. , Taylor , A. , Arsenault , L. , Williams , B. , Brathwaite , A. , Poulton , R. and Craig , I. W. 2005 . Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction . Biological Psychiatry , 57 : 1117 – 27 .
  • Chaudry , H. R. , Moss , H. B. , Bashir , A. and Suliman , T. 1991 . Cannabis psychosis following bhang ingestion . British Journal of Addiction , 86 : 1075 – 81 .
  • Chopra , G. S. and Smith , J. W. 1974 . Psychotic reactions following cannabis use in East Indians . Archives of General Psychiatry , 30 : 24 – 27 .
  • Compton , M. T. , Furman , A. C. and Kaslow , N. J. 2004 . Lower negative symptom scores among cannabis-dependent patients with schizophrenia-spectrum disorders: Preliminary evidence from an African American first-episode sample . Schizophrenia Research , 71 : 61 – 64 .
  • Davey Smith , G. and Phillips , A. N. 1992 . Confounding in epidemiological studies: Why “independent” effects may not be all they seem . British Medical Journal , 305 : 757 – 59 .
  • Davis , K. L. , Kohn , R. S. , Ko , G. and Davidson , M. 1991 . Dopamine in schizophrenia: A review and reconceptualization . American Journal of Psychiatry , 148 : 1474 – 86 .
  • Dean , B. , Sundram , S. , Bradbury , R. , Scarr , E. and Copolov , D. 2001 . Studies on [3H]CP-55940 binding in the human central nervous system: regional specific changes in density of cannabinoid-1 receptors associated with schizophrenia and cannabis use . Neuroscience , 103 : 9 – 15 .
  • Defer , B. 1990 . Cannabis and schizophrenia: Is there a causal association? Commentary in advance in the biosciences. Psychopathology of illicit drugs: cannabis, cocaine, opiates . European Journal of Plychiatry , 80 : 31 – 37 .
  • Degenhardt , L. and Hall , W. 2001 . The association between psychosis and problematic drug use among Australian adults: findings from the National Survey of Mental Health and Well-Being . Psychological Medicine , 31 : 659 – 68 .
  • Degenhardt , L. , Hall , W. and Linskey , M. 2003 . Testing hypotheses about the relationship between cannabis use and psychosis . Drug and Alcohol Dependence , 71 : 37 – 48 .
  • Dervaux , A. , Goldberger , C. , Laqueille , X. and Krebs , M. O. 2004 . Cannabis and psychosis . British Journal of Psychiatry , 185 : 352 – 55 .
  • Dervaux , A. , Laqueille , X. , Bourdel , M. C. , Le Borgne , M. H. , Olié , J. P. , Lôo , H. and Krebs , M. O. 2003 . Cannabis et schizophrénic: données cliniques et socio-démographiques . Encephale , 29 : 11 – 17 .
  • Devane , W. A. , Dysark , F. A. , Johnson , M. R. , Melvin , L. S. and Howlett , A. C. 1988 . Determination and characterization of a cannabinoid receptor in rat brain . Molecular Pharmacology , 34 : 605 – 13 .
  • Dixon , L. , Haas , G. , Wedien , P. J. , Sweeney , J. and Frances , A. J. 1990 . Acute effects of drug abuse in schizophrenic patients: Clinical observations and patients' self reports . Schizophrenia Bulletin , 16 : 69 – 79 .
  • D'Souza , D. C. , Abi-Saab , W. M. , Madonick , S. , Forselius-Bielen , K. , Doersch , A. , Braley , G. , Gueorguieva , R. , Cooper , T. B. and Krystal , J. H. 2005 . Delta-9-tetrahydrocannabinol effects in schizophrenia: Implications for cognition, psychosis and addiction . Biological Psychiatry , 57 : 594 – 608 .
  • D'Souza , D. C. , Perry , E. , MacDougall , L. , Ammerman , Y. , Cooper , T. , Wu , Y. T. , Guerorguieva , R. and Krystal , J. H. 2004 . The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: Implications for psychosis . Neuropsychopharmacology , 29 : 1558 – 72 .
  • Dumas , P. , Saoud , M. , Bouafia , S. , Gutknecht , C. , Ecochard , R. and Daléry , J. 2002 . Cannabis use correlates with schizotypal personality traits in healthy students . Psychiatry Research , 109 : 27 – 35 .
  • Fergusson , D. M. , Horwood , L. J. and Ridder , E. M. 2005 . Tests of causal linkages between cannabis use and psychotic symptoms . Addiction , 100 : 354 – 66 .
  • Fergusson , D. M. 2004 . Cannabis and psychosis: Accumulating evidence . Addiction , 99 : 1351 – 52 .
  • Fergusson , D. M. , Horwood , L. J. and Swain-Campbell , N. R. 2003 . Cannabis dependence and psychotic symptoms in young people . Psychological Medicine , 33 : 15 – 21 .
  • Ferdinand , R. F. , Sondeijker , F. , van der Ende , J. , Selten , J. P. , Huizink , A. and Verhulst , F. C. 2005 . Cannabis use predicts future psychotic symptoms, and vice versa . Addiction , 5 : 612 – 18 .
  • Gardner , E. L. and Lowinson , J. H. 1991 . Marijuana's interaction with brain reward systems: Update . Pharmacology, Biochemistry and Behavior , 40 : 571 – 80 .
  • Georgotas , A. and Zeidenberg , P. 1979 . Observations on the effects of four weeks of heavy marihuana smoking on a group interaction and individual behaviour . Comprehensive Psychiatry , 20 : 427 – 32 .
  • Giuffrida , A. , Leweke , F. M. , Gerth , C. W. , Schreiber , D. , Koethe , D. , Faulhaber , J. , Klosterkotter , J. and Piomelli , D. 2004 . Cerebrospinal anandamide levels are elevated in acute schizophrenia and are inversely correlated with psychotic symptoms . Neuropsychopharmacology , 29 : 2108 – 14 .
  • Gorriti , M. A. , Rodriguez de Fonseca , F. , Navarro , M. and Palomo , T. 1999 . Chronic Δ9 tetrahydrocannabinol treatment induces sensitization to the psychomotor effects of amphetamine in rats . European Journal of Pharmacology , 365 : 133 – 42 .
  • Hall , W. and Degenhardt , L. 2000 . Cannabis use and psychosis: A review of clinical and epidemiological evidence . Australian and New Zealand Journal of Psychiatry , 34 : 26 – 34 .
  • Hambrecht , M. and Häfner , H. 2000 . Cannabis, vulnerability, and the onset of schizophrenia: An epidemiological perspective . Australian and New Zealand Journal of Psychiatry , 34 : 468 – 75 .
  • Hanak , C. , Tecco , J. , Verbanck , P. and Pelc , I. 2002 . “ Chapter 4: Cannabis, mental health and dependence. Part A. Psychosis. ” . In Cannabis 2002 Report. A Joint International Effort at the Initiative of the Ministers of Public Health of Belgium, France, Germany, The Netherlands, Switzerland. Technical Report of the International Scientific Conference. Edited by: Spruit , I. Brussels : Ministry of Public Health of Belgium. . Brussels, Belgium, 2/25/2002
  • Henquet , C. , Krabbendam , L. , Spauwen , J. , Kaplan , C. , Lieb , R. , Wittchen , H. U. and van Os , J. 2005 . Prospective cohort study of cannabis use, predisposition for psychosis, and psychotic symptoms in young people . British Medical Journal , 330 : 11 – 5 .
  • Institut National de Ia Santé et de la Recherche Médicale (INSERM) . 2001 . Cannabis. Quels Effets sur le Comportement el la Santé? Paris : Éditions Inserm . .
  • Isbell , H. , Gorodetzsky , C. W. , Jasinski , D. , Claussen , U. , Spulak , F. V. and Karte , F. 1967 . Effects of Δ9 tetrahydrocannabinol in man . Psychopharmacologia , I1 : 184 – 8 .
  • Jablensky , A. 2000 . Epidemiology of schizophrenia: The global burden of disease and disability . European Archives of Psychiatry and Clinical Neuroscience , 250 : 274 – 85 .
  • Jablensky , A. , Sartorius , N. , Ernberg , G. , Anker , M. , Karten , A. , Cooper , J. E. , Day , R. and Bertelsen , A. 1992 . Schizophrenia: Manifestations, incidence and course in different cultures . Psychological Medicine Monograph , Supplement 20
  • Jockers-Scherübl , M. C. , Danker-Hopfe , H. , Mahlberg , R. , Selig , F. , Rentzsch , J. , Schürer , F. , Lang , Lang , U. E. and Hellweg , R. 2004 . Brain-derived neurotrophic factor serum concentrations in drug-naïve schizophrenic patients with chronic cannabis abuse and multiple substance abuse . Neuroscience Leiters , 371 : 79 – 83 .
  • Jockers-Scherübl , M. C. , Matthies , U. , Danker-Hopfe , H. , Lang , U. E. , Mahlberg , R. and Hellweg , R. 2003 . Chronic cannabis abuse raises nerve growth factor serum concentrations in drug-naïve schizophrenic patients . Journal of Psychopharmacology , 17 : 439 – 45 .
  • Johns , A. 2001 . Psychiatric effects of cannabis . British Journal of Psychiatry , 178 : 116 – 22 .
  • Johns , L. C. , Cannon , M. , Singleton , N. , Murray , R. M. , Farrell , M. , Brugha , T. , Bebbington , P. , Jenkins , R. and Meltzer , H. 2004 . Prevalence and correlates of self-reported psychotic symptoms in the British population . British Journal of Psychiatry , 185 : 298 – 305 .
  • Kaplan , H. S. 1971 . Psychosis associated with marijuana . New York State Journal of Medicine , 71 : 433 – 35 .
  • Kay , S. R. , Fiszbein , A. and Opler , L. A. 1987 . The positive and negative syndrome scale (PANSS) for schizophrenia . Schizophrenia Bulletin , 13 : 261 – 76 .
  • Kroll , P. 1975 . Psychoses associated with marijuana use in Thailand . Journal of Nervous and Mental Disease , 161 : 149 – 56 .
  • Leroy , S. , Griffon , N. , Bourdel , M. C. , Olié , J. P. , Poirier , M. F. and Krebs , M. O. 2001 . Schizophrenia and the cannabinoid receptor type I (CBI): Association study using a single-base polymorphism in coding exon I . American Journal of Medical Genetics (Neuropsychiatric Genetics) , 105 : 749 – 52 .
  • Leweke , F. M. , Gerth , C. W. and Klosterkötter , J. 2004 . Cannabis-associated psychosis. Current status of research . CNS Drugs , 18 : 895 – 910 .
  • Leweke , F. M. , Giuffrida , A. , Wurster , U. , Emrich , H. M. and Piomelli , D. 1999 . Elevated endogenous cannabinoids in schizophrenia . Neuroreport , 10 : 1665 – 9 .
  • Linszen , D. H. , Dingemans , P. M. and Lenior , M. E. 1994 . Cannabis abuse and the course of recent-onset schizophrenic disorders . Archives of General Psychiatry , 51 : 273 – 39 .
  • Lishman , W. A. 1998 . Organic Psychiatry: The Psychological Consequences of Cerebral Disorder. , Third Edition Oxford : Blackwell. .
  • Macleod , J. , Oakes , R. , Copello , A. , Crome , I. , Egger , M. , Hickman , M. , Oppenkowski , T. , Stokes-Lampard , H. and Davey Smith , G. 2004 . Psychological and social sequelae of cannabis and other illicit drug use by young people: A systematic review of longitudinal, general population studies . Lancet , 363 : 1579 – 88 .
  • Marken , P. A. and Stanislav , S. W. 2001 . “ Chapter 76: Schizophrenia. ” . In Applied Therapeutics. The Clinical Use of Drugs, Seventh Edition. Edited by: Koda-Kimble , M. A. , Young LY , L. Y. , Kradjan , W. A. and Guglielmo , B. J. Philadelphia : Lippincott Williams & Wilkins. .
  • Martinez-Arevalo , M. J. , Calcedo-Ordoñez , A. and Varo-Prieto , J. R. 1994 . Cannabis consumption as a prognostic factor in schizophrenia . British Journal of Psychiatry , 164 : 679 – 81 .
  • McGuire , P. , Jones , R. , Harvey , I. , Williams , M. , McGuffin , P. and Murray , R. 1995 . Morbid risk of schizophrenia for relatives of patients with cannabis associated psychosis . Schizophrenia Research , 15 : 277 – 81 .
  • McKenna , P. J. 1987 . Pathology, phenomenology and the dopamine hypothesis of schizophrenia . British Journal of Psychiatry , 151 : 288 – 301 .
  • Moreau de Tours , J. J. 1845 . Du Hachish et de L'aliénation Mentale. Études Psychologiques. Paris : Masson. .
  • Munro , S. , Thomas , K. L. and Abu-Shaar , M. 1993 . Molecular characterization of a peripheral receptor for cannabinoids . Nature , 365 : 61 – 5 .
  • Negrete , J. C. , Knapp , W. P. , Douglas , D. E. and Smith , W. B. 1986 . Cannabis affects the severity of schizophrenic symptoms: Results of a clinical survey . Psychological Medicine , 16 : 515 – 20 .
  • Peralta , V. and Cuesta , M. J. 1992 . Influence of cannabis abuse on schizophrenic psychopathology . Acta Psychiatrica Scandinavica , 85 : 127 – 30 .
  • Phillips , L. J. , Curry , C. , Yung , A. R. , Yuen , H. P. , Adlard , S. and McGorry , P. D. 2002 . Cannabis use is not associated with the development of psychosis in an ‘ultra’ high-risk group . Australian and New Zealand Journal of Psychiatry , 36 : 800 – 06 .
  • Potvin , S. , Stip , E. and Roy , J. Y. 2004 . Schizophrénie et cannabinoïdes: Données cliniques, expérimentales et biologiques . Drogues, Santé et Sociétié , 2 : 61 – 97 .
  • Regier , D. A. , Farmer , M. E. , Rae , D. S. , Locke , B. Z. , Keith , S. J. , Judd , L. L. and Goodwin , F. K. 1990 . Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study . Journal of the American Medical Association , 264 : 2511 – 8 .
  • Rey , J. M. , Martin , A. and Krabman , P. 2004 . Is the party over? Cannabis and juvenile psychiatric disorder: The past 10 years . Journal of the American Academy of Child Adolescent Psychiatry , 43 : 1194 – 1205 .
  • Salyers , M. P. and Mueser , K. T. 2001 . Social functioning, psychopathology, and medication side effects in relation to substance use and abuse in schizophrenia . Schizophrenia Research , 48 : 109 – 23 .
  • Semple , D. M. , McIntosh , A. M. and Lawrie , S. M. 2005 . Cannabis as a risk factor for psychosis: systematic review . Journal of Psychopharmacology , 19 : 187 – 94 .
  • Sim , M. G. , Khong , E. and Hulse , G. 2004 . Cannabis and psychosis . Australian Family Physician , 33 : 229 – 32 .
  • Smit , F. , Bolier , L. and Cujpers , P. 2004 . Cannabis use and the risk of later schizophrenia: A review . Addiction , 99 : 425 – 30 .
  • Talbott , J. A. and Teague , J. W. 1969 . Marihuana psychosis: Acute toxic psychosis associated with the use of cannabis derivatives . Journal of the American Medical Association , 210 : 299 – 302 .
  • Tanda , G. , Pontieri , F. E. and Di Chiara , G. 1997 . Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common u1 opioid receptor mechanism . Science , 276 : 2048 – 50 .
  • Teesson , M. 2004 . Cannabis and psychosis: extending the debate . Addiction , 99 : 1352 – 53 .
  • Tennant , F. S. and Groesbeck , C. J. 1972 . Psychiatric effects of hashish . Archives of General Psychiatry , 27 : 133 – 36 .
  • Thacore , V. R. and Shukla , S. R.P. 1976 . Cannabis psychosis and paranoi schizophrenia . Archives of General Psychiatry , 33 : 383 – 6 .
  • Thomas , H. 1996 . A community survey of adverse effects of cannabis use . Drug and Alcohol Dependence , 42 : 201 – 07 .
  • Tsapakis , E. M. , Guillin , O. and Murray , R. M. 2003 . Does dopamine sensitizaton underlie the association between schizophrenia and drug abuse? . Current Opinion in Psychiatry , 16 : S45 – S52 .
  • Ujike , H. 2002 . Stimulant-induced psychosis and schizophrenia: The role of sensitization . Current Psychiatry Reports , 4 : 177 – 84 .
  • Ujike , H. , Takaki , M. , Nakata , K. , Tanaka , Y. , Takeda , T. , Kodama , M. , Fujiwara , Y. , Sakai , A. and Kuroda , S. 2002 . CNR I, central cannabinoid receptor gene, associated with susceptibility to hebephreni schizophrenia . Molecular Psychiatry , 7 : 515 – 18 .
  • United Nations Office on Drugs and Crime (UNODC) . 2003 . Global Illicit Drug Trends 2003. New York : United Nations Office on Drugs and Crime. .
  • Van Os , J. , Bak , M. , Hanssen , M. , Bijl , R. V. , de Graaf , R. and Verdoux , H. 2002 . Cannabis use and psychosis: A longitudinal population-base study . American Journal of Epidemiology , 156 : 319 – 27 .
  • Veen , N. D. , Selten , J. P. , van der Tweel , I. , Feller , W. G. , Hoek , H. W. and Kahn , R. S. 2004 . Cannabis use and age at onset of schizophrenia . American Journal of Psychiatry , 161 : 501 – 06 .
  • Verdoux , H. and Toumier , M. 2004 . Cannabis et troubles psychotiques, quel lien étiologique ? . Presse Médicate , 33 : 551 – 4 .
  • Verdoux , H. , Gindre , C. , Sorbara , F. , Tournier , M. and Swendsen , J. D. 2003 . Effects of cannabis and psychosis vulnerability in daily life: An experience sampling test study . Psychological Medicine , 33 : 23 – 32 .
  • Voruganti , L. N.P. , Slomka , P. , Zabel , P. , Matter , A. and Awad , A. G. 2001 . Cannabis induced dopamine release: An in-vivo SPECT study . Psychiatry Research Neuroimaging Section , 107 : 173 – 77 .
  • Zmmit , S. and Lewis , G. 2004 . Exploring the relationship between cannabis use and psychosis . Addiction , 99 : 1351 – 58 .
  • Zammit , S. , Allebeck , P. , Andreasson , S. , Lundberg , I. and Lewis , G. 2002 . Self reported cannabis use as a risk factor for schizophrenia in Swedish conscripts of 1969: historical cohort study . British Medical Journal , 325 : 1199 – 1201 .
  • Zavitsanou , K. , Garrick , T. and Huang , X. F. 2004 . Selective antagonist 3H SR141716A binding to CBI receptors is increased in the anterior cingulate cortex in schizophrenia . Progress in Neuropsychopharmacology & Biological Psychiatry , 28 ( 2 ) : 355 – 60 .

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