Risky Cannabis Use is Associated with Alexithymia, Frontal Lobe Dysfunction, and Impulsivity in Young Adult Cannabis Users

REFERENCES

• Adamson , S.J. and Sellman , J.D. 2003 . A prototype screening instrument for cannabis use disorder: The cannabis use disorders identification test (CUDIT) in an alcohol-dependent clinical sample . Drug & Alcohol Review , 22 : 309 – 315 . &
   PubMed Web of Science ®Google Scholar
• Babor , T.F. , Higgins-Biddle , J.C. , Saunders , J.B. and Monteiro , M.G. 2001 . Alcohol Use Disorders Identification Test: Guidelines for Use in Primary Care , 2nd , Geneva : World Health Organization . &ed
   Google Scholar
• Bagby , R.M. , Parker , J.D.A. and Taylor , G.J. 1994 . The twenty-item Toronto Alexithymia Scale: I. Item selection and cross-validation of the factor structure . Journal of Psychosomatic Research , 38 ( 1 ) : 23 – 32 . &
   PubMed Web of Science ®Google Scholar
• Baron , R.M. and Kenny , D.A. 1986 . The moderator-mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations . Journal of Personality and Social Psychology , 51 ( 6 ) : 1173 – 1182 . &
   PubMed Web of Science ®Google Scholar
• Berthoz , S. and Hill , E.L. 2005 . The validity of using self-reports to assess emotion regulation abilities in adults with autism spectrum disorder . European Psychiatry , 20 ( 3 ) : 291 – 298 . &
   PubMed Web of Science ®Google Scholar
• Bolla , K.I. , Brown , K. , Eldreth , D. , Tate , K. and Cadet , J.L. 2002 . Dose-related neurocognitive effects of marijuana use . Neurology , 59 : 1337 – 1343 . &
   PubMed Web of Science ®Google Scholar
• Caracuel , A. , Verdejo-Garcia , A. , Vilar-Lopez , R. , Perez-Garcia , M. , Salinas , I. , Cuberos , G. , Coin , M.A. , Santiago-Ramajo , S. and Puente , A.E. 2008 . Frontal behavioral and emotional symptoms in Spanish individuals with acquired brain injury and substance use disorders . Archives of Clinical Neuropsychology , 23 : 447 – 454 . &
   PubMed Web of Science ®Google Scholar
• Carrillo de la Pena , M.T. , Otero , J.M. and Romero , E. 1993 . Comparison among various methods of assessment of impulsiveness . Perceptual and Motor Skills , 77 ( 2 ) : 567 – 575 . &
   PubMed Web of Science ®Google Scholar
• Caseras , X. , Avila , C. and Torrubia , R. 2003 . The measurement of individual differences in behavioural inhibition and behavioural activation systems: A comparison of personality scales . Personality and Individual Differences , 34 : 999 – 1013 . &
   Web of Science ®Google Scholar
• Chang , L. , Yakupov , R. , Cloak , C. and Ernst , T. 2006 . Marijuana use is associated with a reorganized visual-attention network and cerebellar hypoactivation . Brain: A Journal of Neurology , 129 ( 5 ) : 1096 – 1112 . &
   PubMed Web of Science ®Google Scholar
• Chen , A.C.H. , Porjesz , B. , Rangaswamy , M. , Kamarajan , C. , Tang , Y. , Jones , K.A. , Chorlian , D.B. , Stimus , A.T. and Begleiter , H. 2007 . Reduced frontal lobe activity in subjects with high impulsivity and alcoholism . Alcoholism: Clinical and Experimental Research , 31 ( 1 ) : 156 – 165 . &
   PubMed Web of Science ®Google Scholar
• Cherek , D.R. , Lane , S.D. and Dougherty , D.M. 2002 . Possible amotivational effects following marijuana smoking under laboratory conditions . Experimental and Clinical Psychopharmacology , 10 ( 1 ) : 26 – 38 . &
   PubMed Web of Science ®Google Scholar
• Clark , L. , Roiser , J.P. , Robbins , T.W. and Sahakian , B.J. 2009 . Disrupted “reflection” impulsivity in cannabis users but not current or former ecstasy users . Journal of Psychopharmacology , 23 ( 1 ) : 14 – 22 . &
   PubMed Web of Science ®Google Scholar
• Corr , P.J. 2004 . Reinforcement sensitivity theory and personality . Neuroscience and Biobehavioral Reviews , 28 : 317 – 332 .
   PubMed Web of Science ®Google Scholar
• Croft , R.J. , Mackay , A.J. , Mills , A.T.D. and Gruzelier , J.G.H. 2001 . The relative contribution of ecstasy and cannabis to cognitive impairment . Psychopharmacology , 153 : 373 – 379 . &
   PubMed Web of Science ®Google Scholar
• Dafters , R.I. , Hoshi , R. and Talbot , A.C. 2004 . Contribution of cannabis and MDMA (“ecstasy”) to cognitive changes in long-term polydrug users . Psychopharmacology (Berlin) , 173 : 405 – 410 . &
   PubMedGoogle Scholar
• Daumann , J. , Pelz , S. , Becker , S. , Tuchtenhagen , F. and Gouzoulis-Mayfrank , E. 2001 . Psychological profile of abstinent recreational Ecstasy (MDMA) users and significance of concomitant cannabis use . Human Psychopharmacolog: Clinical and Experimental , 16 : 627 – 633 . &
   PubMed Web of Science ®Google Scholar
• Dawe , S. , Gullo , M.J. and Loxton , N.J. 2004 . Reward drive and rash impulsiveness as dimensions of impulsivity: Implications for substance misuse . Addictive Behaviors , 29 ( 7 ) : 1389 – 1405 . &
   PubMed Web of Science ®Google Scholar
• Dorard , G. , Berthoz , S. , Haviland , M.G. , Phan , O. , Corcos , M. and Bungener , C. 2008 . Multimethod alexithymia assessment in adolescents and young adults with a cannabis use disorder . Comprehensive Psychiatry , 49 ( 6 ) : 585 – 592 . &
   PubMed Web of Science ®Google Scholar
• D'Souza , D.C. , Sewell , R.A. and Ranganathan , M. 2009 . Cannabis and psychosis/ schizophrenia: Human studies . European Archives of Psychiatry and Clinical Neuroscience , 259 ( 7 ) : 413 – 431 . &
   PubMed Web of Science ®Google Scholar
• Fleming , M.F. , Mihic , S.J. and Harris , R.A. 2001 . “ Ethanol ” . In Goodman & Gilman's the Pharmacological Basis of Therapeutics , 10th , Edited by: Hardman , J.G. and Limbird , L.E. 429 – 445 . New York : McGraw-Hill . &In&Eds.ed., pp
   Google Scholar
• Fletcher , J.M. , Page , J.B. , Francis , D.J. , Copeland , K. , Naus , M.J. , Davis , C.M. , Morris , R. , Krauskopf , D. and Satz , P. 1996 . Cognitive correlates of long-term cannabis use in Costa Rican men . Archives of General Psychiatry , 53 : 1051 – 1057 . &
   PubMed Web of Science ®Google Scholar
• Fontes , M.A. , Bolla , K.I. , Cunha , P.J. , Almeida , P.P. , Jungerman , F. , Laranjeira , R.R. , Bressan , R.A. and Lacerda , A.L.T. 2011 . Frontal Assessment Battery (FAB) is a simple tool for detecting executive deficits in chronic cannabis users . Journal of Clinical and Experimental Neuropsychology , 33 ( 5 ) : 523 – 531 . &
   PubMed Web of Science ®Google Scholar
• Gardner , E.L. 2005 . Endocannabinoid signalling system and brain reward: Emphasis on dopamine . Pharmacology, Biochemistry and Behavior , 81 ( 2 ) : 263 – 284 .
   PubMed Web of Science ®Google Scholar
• Grace , J. and Malloy , P.F. 2001 . Frontal Systems Behavioral Scale (FrSBe): Professional Manual , Lutz , FL : Psychological Assessment Resources . &
   Google Scholar
• Gray , J.A. 1987 . The Psychology of Fear and Stress , Cambridge : Cambridge University Press .
   Google Scholar
• Hall , W. and Solowij , N. 1998 . Adverse effects of cannabis . Lancet , 352 : 1611 – 1616 . &
   PubMed Web of Science ®Google Scholar
• Haviland , M.G. , Hendryx , M.S. , Shaw , D.G. and Henry , J.P. 1994 . Alexithymia in women and men hospitalized for psychoactive substance dependence . Comprehensive Psychiatry , 35 ( 2 ) : 124 – 128 . &
   PubMed Web of Science ®Google Scholar
• Honkalampi , K. , Hintikka , J. , Saarinen , P. , Lehtonen , J. and Vilnamaki , H. 2000 . Is alexithymia a permanent feature in depressed patients? Results from a 6-month follow-up study . Psychotherapy & Psychosomatics , 69 ( 6 ) : 303 – 308 . &
   PubMed Web of Science ®Google Scholar
• Hoptman , M.J. , Volavka , J. , Johnson , G. , Weiss , E. , Bilder , R.M. and Lim , K.O. 2002 . Frontal white matter microstructure, aggression, and impulsivity in men with schizophrenia: A preliminary study . Biological Psychiatry , 52 ( 1 ) : 9 – 14 . &
   PubMed Web of Science ®Google Scholar
• Iacono , W.G. , Carlson , S.R. , Taylor Elkins , I.J. and Mcgue , M. 1999 . Behavioral disinhibition and the development of substance-use disorders: Findings from the Minnesota Twin Family Study . Development and Psychopathology , 11 ( 4 ) : 869 – 900 . &
   PubMed Web of Science ®Google Scholar
• Justinova , Z. , Tanda , G. , Redhi , G. and Goldberg , S.R. 2003 . Self-administration of delta 9-tetrahydrocannabinol (THC) by drug naive squirrel monkeys . Psychopharmacology , 169 : 135 – 140 . &
   PubMed Web of Science ®Google Scholar
• Karschner , E.L. , Schwilke , E.W. , Lowe , R.H. , Darwin , W.D. , Pope , H.G. , Herning , R. , Cadet , J.L. and Huestis , M.A. 2009 . Do delta 9-tetrahydrocannabinol concentrations indicate recent use in chronic cannabis users? . Addiction , 104 ( 12 ) : 2041 – 2048 . &
   PubMed Web of Science ®Google Scholar
• Kauhanen , J. , Julkunen , J. and Salonen , J.T. 1992 . Coping with inner feelings and stress: Heavy alcohol use in the context of alexithymia . Behavioral Medicine , 18 ( 3 ) : 121 – 126 . &
   PubMed Web of Science ®Google Scholar
• Lee , W.E. , Wadsworth , M.E. and Hotopf , M. 2006 . The protective role of trait anxiety: A longitudinal cohort study . Psychological Medicine , 36 : 345 – 351 . &
   PubMed Web of Science ®Google Scholar
• Liraud , F. and Verdoux , H. 2000 . Bottom of Form Which temperamental characteristics are associated with substance use in subjects with psychotic and mood disorders? . Psychiatry Research , 93 ( 1 ) : 63 – 72 . &
   PubMed Web of Science ®Google Scholar
• Loxton , N.J. and Dawe , S. 2001 . Alcohol abuse and dysfunctional eating in adolescent girls: The influence of individual differences in sensitivity to reward and punishment . International Journal of Eating Disorders , 29 : 455 – 462 . &
   PubMed Web of Science ®Google Scholar
• Lyvers , M. 2000 . “Loss of control” in alcoholism and drug addiction: A neuroscientific interpretation . Experimental and Clinical Psychopharmacology , 8 : 225 – 249 .
   PubMed Web of Science ®Google Scholar
• Lyvers , M. , Czerczyk , C. , Follent , A. and Lodge , P. 2009 . Disinhibition and reward sensitivity in relation to alcohol consumption by university students . Addiction Research & Theory , 17 ( 6 ) : 668 – 677 . &
   Web of Science ®Google Scholar
• Lyvers , M. , Duff , H. and Hasking , P. 2011 . Risky alcohol use and age at onset of regular alcohol consumption in relation to frontal lobe indices, reward sensitivity and rash impulsiveness . Addiction Research & Theory , 19 : 251 – 259 . &
   Web of Science ®Google Scholar
• Lyvers , M. , Onuoha , R. , Thorberg , F.A. and Samios , C. 2012 . Alexithymia in relation to parental alcoholism, everyday frontal lobe functioning and alcohol consumption in a non-clinical sample . Addictive Behaviors , 37 : 205 – 210 . &
   PubMed Web of Science ®Google Scholar
• Lyvers , M. , Thorberg , F.A. , Ellul , A. , Turner , J. and Bahr , M. 2010 . Negative mood regulation expectancies, frontal lobe related behaviors and alcohol use . Personality and Individual Differences , 48 : 332 – 337 . &
   Web of Science ®Google Scholar
• Martin-Santos , R. , Fagundo , A.B. , Crippa , J.A. , Atakan , Z. , Bhattacharyya , S. , Allen , P. , Fusar-Poli , P. , Borgwardt , S. , Seal , M. , Busatto , G. F. and McGuire , P. 2010 . Neuroimaging in cannabis use: A systematic review of the literature . Psychological Medicine , 40 ( 3 ) : 383 – 398 . &
   PubMed Web of Science ®Google Scholar
• National Drug Strategy 2010-2015. 2011. Canberra: Commonwealth of Australia. Available at http://www.nationaldrugstrategy.gov.au/internet/drugstrategy/publishing.nsf/Content/DB4076D49F13309FCA257854007BAF30/$File/nds2015.pdf (http://www.nationaldrugstrategy.gov.au/internet/drugstrategy/publishing.nsf/Content/DB4076D49F13309FCA257854007BAF30/$File/nds2015.pdf)
   Google Scholar
• Noel , X. , Paternot , J. , Van Der Linden , M. , Sferrazza , R. , Verhas , M. , Hanak , C. , Kornreich , C. , Martin , P. , Del Mol , J. Pelc , I. 2001 . Correlation between inhibition, working memory and delimited frontal area blood flow measured by Tc-Bicisate SPECT in alcohol-dependent patients . Alcohol & Alcoholism , 36 ( 6 ) : 556 – 563 .
   PubMed Web of Science ®Google Scholar
• Olive , M.F. and Griffin , W.C. 2008 . Ethanol increases extracellular glutamate levels in the ventral tegmental area via D1 receptor activation. Presented at the Annual Scientific Meeting of the College on Problems of Drug Dependence San Juan , Puerto Rico. &June 14-19
   Google Scholar
• Oscar-Berman , M. and Marinkovic , K. 2007 . Alcohol: Effects on neurobehavioral functions and the brain . Neuropsychological Review , 17 : 239 – 257 . &
   PubMed Web of Science ®Google Scholar
• Parker , J.D.A. , Taylor , G.J. and Bagby , R.M. 2003 . The 20-item Toronto Alexithymia Scale—III: Reliability and factorial validity in a community population . Journal of Psychosomatic Research , 55 ( 3 ) : 269 – 275 . &
   PubMed Web of Science ®Google Scholar
• Patton , J.H. , Stanford , M.S. and Barratt , E.S. 1995 . Factor structure of the Barratt impulsiveness scale . Journal of Clinical Psychology , 51 : 768 – 774 . &
   PubMed Web of Science ®Google Scholar
• Pinard , L. , Negrete , J.C. , Annable , L. and Audet , N. 1996 . Alexithymia in substance abusers: Persistence and correlates of variance . American Journal on Addictions , 5 ( 1 ) : 32 – 39 . &
   Web of Science ®Google Scholar
• Piontek , D. , Kraus , L. and Klempova , D. 2008 . Short scales to assess cannabis-related problems: A review of psychometric properties . Substance Abuse Treatment, Prevention, and Policy , 3 : 25 &
   PubMed Web of Science ®Google Scholar
• Pope , H.G., Jr and Yurgelun-Todd , D. 2004 . “ Residual cognitive effects of long-term cannabis use ” . In Marijuana and Madness: Psychiatry and Neurobiology , Edited by: Castle , D. and Murray , R. 198 – 210 . New York : Cambridge University Press . &In&Eds.pp
   Google Scholar
• Reinert , D.F. and Allen , J.P. 2007 . The Alcohol Use Disorders Identification Test: An update of research findings . Alcoholism: Clinical and Experimental Research , 31 : 185 – 199 . &
   PubMed Web of Science ®Google Scholar
• Rohsenow , D.J. , Howland , J. , Arnedt , J.T. , Almeida , A.B. , Greece , J. , Minsky , S. , Kempler , C. S. and Sales , S. 2010 . Intoxication with bourbon versus vodka: Effects on hangover, sleep, and next-day neurocognitive performance in young adults . Alcoholism: Clinical and Experimental Research , 34 ( 3 ) : 509 – 518 . &
   PubMed Web of Science ®Google Scholar
• Rubino , T. , Sala , M. , Viganò , D. , Braida , D. , Castiglioni , C. , Limonta , V. , Guidali , C. , Realini , N. and Parolaro , D. 2007 . Cellular mechanisms underlying the anxiolytic effect of low doses of peripheral Δ 9-tetrahydrocannabinol in rats . Neuropsychopharmacology , 32 : 2036 – 2045 . &
   PubMed Web of Science ®Google Scholar
• Sifneos , P. 1973 . The prevalance of “alexithymic” characteristics in psychosomatic patients . Psychotherapy and Psychosomatics , 22 ( 2 ) : 255 – 262 .
   PubMed Web of Science ®Google Scholar
• Spinella , M. 2003 . Relationship between drug use and prefrontal associated traits . Addiction Biology , 8 : 67 – 74 .
   PubMed Web of Science ®Google Scholar
• Stout , J.C. , Ready , R.E. , Grace , J. , Malloy , P.F. and Paulsen , J.S. 2003 . Factor analysis of the Frontal Systems Behavior Scale (FrSBe) . Assessment , 10 : 79 – 85 . &
   PubMed Web of Science ®Google Scholar
• Swann , A.C. , Andersen , J.C. , Dougherty , D.M. and Moeller , F.G. 2001 . Measurement ofinterepisode impulsivity in bipolar disorder . Psychiatry Research , 101 ( 2 ) : 195 – 197 . &
   PubMed Web of Science ®Google Scholar
• Thorberg , F.A. , Young , R. , Sullivan , K.A. and Lyvers , M. 2009 . Alexithymia and alcohol use disorders: A critical review . Addictive Behaviors , 34 : 237 – 245 . &
   PubMed Web of Science ®Google Scholar
• Thorberg , F. , Young , R. , Sullivan , K. , Lyvers , M. , Connor , J. and Feeney , G. 2010a . A psychometric comparison of the Toronto Alexithymia Scale (TAS-20) and the Observer Alexithymia Scale (OAS) in an alcohol-dependent sample . Personality and Individual Differences , 49 ( 2 ) : 119 – 123 . &
   Web of Science ®Google Scholar
• Thorberg , F.A. , Young , R.M. , Sullivan , K.A. , Lyvers , M. , Hurst , C. , Connor , J.P. and Feeney , G.F.X. 2010b . A confirmatory factor analysis of the Toronto alexithymia scale (TAS-20) in an alcohol dependent sample . Psychiatry Research , 178 ( 3 ) : 565 – 567 . &
   PubMed Web of Science ®Google Scholar
• Thorberg , F.A. , Young , R.M. , Sullivan , K.A. , Lyvers , M. , Connor , J.P. and Feeney , G.F.X. 2011a . Alexithymia, craving and attachment in a heavy drinking population . Addictive Behaviors , 36 : 427 – 430 . &
   PubMed Web of Science ®Google Scholar
• Thorberg , F.A. , Young , R.M. , Sullivan , K.A. , Lyvers , M. , Hurst , C. , Connor , J.P. and Feeney , G.F.X. 2011b . Alexithymia in alcohol dependent patients is partially mediated by alcohol expectancy . Drug and Alcohol Dependence , 116 : 238 – 241 . &
   PubMed Web of Science ®Google Scholar
• Torrubia , R. , Avila , C. , Molto , J. and Caseras , X. 2001 . The Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ) as a measure of Gray's anxiety and impulsivity dimensions . Personality and Individual Differences , 31 : 837 – 862 . &
   Web of Science ®Google Scholar
• Troisi , A. , Pasini , A. , Saracco , M. and Spalletta , G. 1998 . Psychiatric symptoms in male cannabis users not using other illicit drugs . Addiction , 93 ( 4 ) : 487 – 492 . &
   PubMed Web of Science ®Google Scholar
• Verdejo-García , A. , Bechara , A. , Recknor , E.C. and Pérez-García , M. 2006 . Executive dysfunction in substance dependent individuals during drug use and abstinence: An examination of the behavioral, cognitive and emotional correlates of addiction . Journal of the International Neuropsychological Society , 12 : 405 – 415 . &
   PubMed Web of Science ®Google Scholar
• Whitlow , C.T. , Liguori , A. , Livengood , L.B. , Hart , S.L. , Mussat-Whiltlow , B.J. , Lamborn , C.M. , Laurienti , P.J. and Porrino , L.J. 2004 . Long-term heavy marijuana users make costly decisions on a gambling task . Drug and Alcohol Dependence , 76 : 107 – 111 . &
   PubMed Web of Science ®Google Scholar