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Original Articles

Ritualistic Use of Ayahuasca versus Street Use of Similar Substances Seized by the Police: A Key Factor Involved in the Potential for Intoxications and Overdose?

, M.Sc., , B.Sc., , M.Sc., , Ph.D., , Ph.D., , Ph.D. & , Ph.D. show all

REFERENCES

  • Ables, A.Z. & Nagubilli, R. 2010. Prevention, diagnosis, and management of serotonin syndrome. American Family Physician 81 (9): 1139–42.
  • Balíková, M. 2002. Collective poisoning with hallucinogenous [sic] herbal tea. Forensic Science International 128 (1–2): 50–2.
  • Barbosa, P.C.; Mizumoto, S.; Bogenschutz, M.P. & Strassman, R.J. 2012. Health status of ayahuasca users. Drug Test Analysis 4 (7–8): 601–9.
  • Björnstad, K.; Hultén, P.; Beck, O. & Helander, A. 2009. Bioanalytical and clinical evaluation of 103 suspected cases of intoxications with psychoactive plant materials. Clinical Toxicology 47 (6): 566–72.
  • Bouso, J.C.; González, D.; Fondevila, S.; Cutchet, M.; Fernández, X.; Barbosa, P.C.R.; Alcázar-Córcoles, M.Á.; Araújo, W.S.; Barbanoj, M.J.; Fábregas, J.M. & Riba, J. 2012. Personality, psychopathology, life attitudes and neuropsychological performance among ritual users of ayahuasca: A longitudinal study. PLoS ONE 7 (8): e42421.
  • Brierley, D.I. & Davidson, C. 2012. Developments in harmine pharmacology: Implications for ayahuasca use and drug-dependence treatment. Progress in Neuropsychopharmacology & Biological Psychiatry 39 (2): 263–72.
  • Brush, D.E.; Bird, S.B. & Boyer, E.W. 2004. Monoamine oxidase inhibitor poisoning resulting from internet misinformation on illicit substances. Journal of Toxicology Clinical Toxicology 42 (2): 191–5.
  • Cakic, V.; Potkonyak, J. & Marshall, A. 2010. Dimethyltryptamine (DMT): Subjective effects and patterns of use among Australian recreational users. Drug and Alcohol Dependence 111 (1–2): 30–7.
  • Callaway, J.C. & Grob, C.S. 1998. Ayahuasca preparations and serotonin reuptake inhibitors: A potential combination for severe adverse interactions. Journal of Psychoactive Drugs 30 (4): 367–9.
  • Callaway, J.C.; Grob, C.S.; McKenna, D.J.; Nichols, D.E.; Shulgin, A. & Tupper, K.W. 2006. A demand for clarity regarding a case report on the ingestion of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in an Ayahuasca preparation. Journal of Analytical Toxicology 29 (8): 406–7.
  • Callaway, J.C.; McKenna, D.J.; Grob, C.S.; Brito, G.S.; Raymon, L.P.; Poland, R.E.; Andrade, E.N.; Andrade, E.O. & Mash, D.C. 1999. Pharmacokinetics of Hoasca alkaloids in healthy humans. Journal Ethnopharmacology 65 (3): 243–56.
  • Callaway, J.C.; Raymon, L.P.; Hearn, W.L.; McKenna, D.J.; Grob, C.S. & Brito, G.S. 1996. Quantitation of N,N-dimethyltryptamine and harmala alkaloids in human plasma after oral dosing with Ayahuasca. Journal of Analytical Toxicology 20 (6): 492–7.
  • Collins, D. (Ed.) 1990. Plants for Medicines: A Chemical and Pharmacological Survey of Plants in the Australia Region. East Melbourne: CSIRO Australia.
  • Conselho Nacional de Políticas sobre Drogas (CONAD). Resolução no. 5 (Resolution no. 5). 2004. ( Nov. 4). Diário Oficial da União. Brasília (DF).
  • Conselho Nacional de Políticas sobre Drogas (CONAD). Resolução no. 1 (Resolution no. 1). 2010. (Jan. 25). Diário Oficial da União. Brasília (DF).
  • Deliganis, A.; Pierce, P. & Peroutka, S. 1991. Differential interactions of dimethyltryptamine (DMT) with 5-HT1A and 5-HT2 receptors. Biochemical Pharmacology 41 (11): 1739–44.
  • Deluca, P.; Davey, Z.; Corazza, O.; Di Furia, L.; Farre, M.; Flesland, L.H.; Mannonen, M.; Majava, A.; Peltoniemi, T.; Pasinetti, M.; Pezzolesi, C.; Scherbaum, N.; Siemann, H.; Skutle, A.; Torrens, M.; van der Kreeft, P.; Iversen, E. & Schifano, F. 2012. Identifying emerging trends in recreational drug use: Outcomes from the Psychonaut Web Mapping Project. Progress in Neuropsychopharmacology Biological & Psychiatry 39 (2): 221–6.
  • Fábregas, J.M.; González, D.; Fondevila, S.; Cutchet, M.; Fernández, X.; Barbosa, P.C.; Alcázar-Córcoles, M.A.; Barbanoj, M.J.; Riba, J. & Bouso, J.C. 2010. Assessment of addiction severity among ritual users of ayahuasca. Drug and Alcohol Dependence 111 (3): 257–61
  • Fantegrossi, W.E.; Harrington, A.W.; Kiessel, C.L.; Eckler, J.R.; Rabin, R.A.; Winter, J.C.; Coop, A.; Rice, K.C. & Woods, J.H. 2006. Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats. Pharmacology Biochemistry Behavior 83 (1): 122–9.
  • Gable, R.S. 2007. Risk assessment of ritual use of oral dimethyltryptamine (DMT) and harmala alkaloids. Addiction 102 (1): 24–34.
  • Giumanini, A.G.; Chiavari, G.; Musiani, M.M. & Rossi, P. 1980. N-Permethylation of primary and secondary aromatic-amines. Synthesis-Stuttgart 9: 743–6.
  • Gordon, S.M.; Forman, R.F. & Siatkowski, C. 2006. Knowledge and use of the internet as a source of controlled substances. Journal of Substance Abuse Treatment 30 (3): 271–4.
  • Goulart, S.L. 2011. The notion of cure in the Brazilian ayahuasca religions. In: R.G. Santos (Ed.) The Ethnopharmacology of Ayahuasca, pp. 23–53. Kerala, India: Transworld Research Network.
  • Grob, C.S.; McKenna, D.J.; Callaway, J.C.; Brito, G.S.; Neves, E.S.; Oberlaender, G.; Saide, O.L.; Labigalini, E.; Tacla, C.; Miranda, C.T.; Strassman, R.J. & Boone, K.B. 1996. Human psychopharmacology of hoasca, a plant hallucinogen used in ritual context in Brazil. Journal of Nervous and Mental Disease 184 (2): 86–94.
  • Halpern, J.H. 2004. Hallucinogens and dissociative agents naturally growing in the United States. Pharmacology Therapeutics 102 (2): 131–8.
  • Haroz, R. & Greenberg, M.I. 2005. Emerging drugs of abuse. Medical Clinical of North America 89 (6): 1259–76.
  • Harris, R. & Gurel, L. 2012. A study of ayahuasca use in North America. Journal of Psychoactive Drugs 44 (3): 209–15.
  • Labate, B.C. 2004. A literatura brasileira sobre as religiões ayahuasqueiras. In: B.C. Labate (Ed.) O Uso Ritual da Ayahuasca, pp. 231–273. Campinas: Mercado de Letras Edições e Livraria.
  • Labate, B.C. & Cavnar, C. (Eds.). 2014. The Therapeutic Use of Ayahuasca. Berlin: Springer.
  • Labate, B.C. & Feeney, K. 2012. Ayahuasca and the process of regulation in Brazil and internationally: Implications and challenges. International Journal of Drug Policy 23 (2): 154–61.
  • Liester, M.B. & Prickett, J.I. 2012. Hypotheses regarding the mechanisms of ayahuasca in the treatment of addictions. Journal of Psychoactive Drugs 44 (3): 200–8.
  • Loizaga-Velder, A. & Verres, R. 2014. Therapeutic effects of ritual ayahuasca use in the treatment of substance dependence: Qualitative results. Journal of Psychoactive Drugs 46 (1): 63–72.
  • Luna, L.E. 2011. Indigenous and mestizo use of ayahuasca: An overview. In: R.G. Santos (Ed.) The Ethnopharmacology of Ayahuasca, pp. 1–21. Kerala, India: Transworld Research Network.
  • McKenna, D.J. 2004. Clinical investigations of the therapeutic potential of ayahuasca: Rationale and regulatory challenges. Pharmacology Therapeutics 102 (2): 111–9.
  • McKenna, D.J. & Towers, G.H.N. 1984. Biochemistry and pharmacology of tryptamine and β-carboline derivatives: A mini review. Journal of Psychoactive Drugs 16 (4): 347–58.
  • McKenna, D.J.; Towers, G.H.N. & Abbott, F.S. 1984. Monoamine oxidase inhibitors in South American hallucinogenic plants: Tryptamine and β-carboline constituents of ayahuasca. Journal of Ethnopharmacology 10 (2): 195–223.
  • Montagne, M. 2008. Drugs on the internet. I: Introduction and web sites on psychedelic drugs. Substance Use and Misuse 43 (1): 17–25.
  • Nichols, D.E.; Oberlender, R. & McKenna, D.J. 1991. Stereochemical aspects of allucinogenesis. In: R.R. Watson (Ed.) Biochemistry and Physiology of Substance Abuse. Boca Raton, FL: CRC Press.
  • Osório, F.L.; Macedo, L.R.H.; Sousa, J.P.M.; Pinto, J.P.; Quevedo, J.; Crippa, J.A.S. & Hallak, J.E.C. 2011. The therapeutic potential of harmine and ayahuasca in depression: evidence from exploratory animal and human studies. In: R.G. Santos (Ed.) The Ethnopharmacology of Ayahuasca, pp. 75–85. Kerala, India: Transworld Research Network.
  • Pierce, P. & Peroutka, S. 1989. Hallucinogenic drug interactions with neurotransmitter receptor binding sites in human cortex. Psychopharmacology 97 (1): 118–22.
  • Pires, A.P.S.; De Oliveira, C.D.R.; Moura, S.; Dorr, F.A.; Silva, W.A.E. & Yonamine, M. 2009. Gas chromatographic analysis of dimethyltryptamine and beta-carboline alkaloids in ayahuasca, an Amazonian psychoactive plant beverage. Phytochemical Analysis 20 (2): 149–53.
  • Riba, J.; Rodríguez-Fornells, A.; Urbano, G.; Morte, A.; Antonijoan, R.; Montero, M.; Callaway, J.C. & Barbanoj, M.J. 2001. Subjective effects and tolerability of the South American psychoactive beverage Ayahuasca in healthy volunteers. Psychopharmacology (Berl) 154 (1): 85–95.
  • Santos, R.G.; Landeira-Fernandez, J.; Strassman, R.J.; Motta, V. & Cruz, A.P.J. 2007. Effects of ayahuasca on psychometric measures of anxiety, panic-like and hopelessness in Santo Daime members. Journal of Ethnopharmacology 112 (3): 507–13.
  • Sklerov, J.; Levine, B.; Moore, K.A.; King, T. & Fowler, D. 2005. A fatal intoxication following the ingestion of 5-methoxy-N,N-dimethyltryptamine in an ayahuasca preparation. Journal of Analytical Toxicology 29 (8): 838–41.
  • Smith, R.L.; Canton, H.; Barrett, R.J. & Sanders-Bush, E. 1998. Agonist properties of N,N-dimethyltryptamine at serotonin 5-HT2A and 5-HT2C receptors. Pharmacology Biochemistry Behavior 61 (3): 323–30.
  • Strassman, R.J.; Qualls, C.R. & Berg, L. 1996. Differential tolerance to biological and subjective effects of four closely spaced doses of N,N-dimethyltryptamine in humans. Biological Psychiatry 39 (9): 784–95.
  • Strassman, R.J.; Qualls, C.R.; Uhlenhuth, E.H. & Kellner, R. 1994. Dose-response study of N,N-dimethyltryptamine in humans. II. Subjective effects and preliminary results of a new rating scale. Archives of General Psychiatry 51 (2): 98–108.
  • SWGDRUG. Scientific Working Group for the Analysis of Seized Drugs Recommendations. Available at http://www.swgdrug.org/Documents/SWGDRUGRecommendations6.pdf. Accessed April 26, 2013.
  • Thomas, G.; Lucas, P.; Capler, N.R.; Tupper, K.W. & Martin, G. 2013. Ayahuasca-assisted therapy for addiction: Results from a preliminary observational study in Canada. Current Drug Abuse Reviews 6 (1): 30–42.
  • Tupper, K.W. 2008. The globalization of ayahuasca: Harm reduction or benefit maximization? International Journal of Drug Policy 19 (4): 297–303.
  • UNODC. Guidance for the validation of analytical methodology and calibration of equipment used for testing of illicit drugs in seized materials and biological specimens. Available at http://www.unodc.org/documents/scientific/validation_E.pdf. Accessed April 26, 2013.
  • Volpi-Abadie, J.; Kaye, A.M. & Kaye, A.D. 2013. Serotonin syndrome. The Ochsner Journal 13 (4): 533–40.
  • Warren, R.J. 2004. Fatal intoxication resulting from the ingestion of ayahuasca. Journal of Analytical Toxicology 28 (4): 287 (abstract).
  • Warren, J.M.; Dham-Nayyar, P. & Alexander, J. 2013. Recreational use of naturally occurring dimethyltryptmine contributing to psychosis? Australian & New Zealand Journal of Psychiatry 47 (4): 398–9.
  • Winstock, A.; Kaar, S. & Borschmann, R. 2014. Dimethyltryptamine (DMT): Prevalence, user characteristics and abuse liability in a large global sample. Journal of Psychopharmacology 28 (1): 49–54.
  • Yritia, M.; Riba, J.; Ortuño, J.; Ramirez, A.; Castillo, A.; Alfaro, Y.; de la Torre, R. & Barbanoj, M.J. 2002. Determination of N,N-dimethyltryptamine and beta-carboline alkaloids in human plasma following oral administration of Ayahuasca. Journal of Chromatography B 779 (2): 271–81.

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