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Research Article

Point-of-care CRP matters: normal CRP levels reduce immediate antibiotic prescribing for acutely ill children in primary care: a cluster randomized controlled trial

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References

  • Van de Casteele M. Numbers of reimbursement of antibiotics for children in outpatient care. In: National Institute for Health and Disability Insurance (RIZIV). Consensus meeting June 2th 2016. The rational use of antibiotics for the child in outpatient care. [In Dutch]. Brussels: RIZIV, 2016: 42–53. http://www.riziv.fgov.be/SiteCollectionDocuments/consensus_sprekersbrochure_20160602.pdf (accessed 23 Jan 2018).
  • Cabral C, Lucas PJ, Ingram J, Hay AD, et al. “It's safer to …” parent consulting and clinician antibiotic prescribing decisions for children with respiratory tract infections: an analysis across four qualitative studies. Soc Sci Med. 2015;136-137:156–164.
  • Horwood J, Cabral C, Hay AD, et al. Primary care clinician antibiotic prescribing decisions in consultations for children with RTIs: a qualitative interview study. Br J Gen Pract. 2016;66(644):e207–e213.
  • Mainous AG, 3rd, Hueston WJ, Love MM. Antibiotics for colds in children: who are the high prescribers? Arch Pediatr Adolesc Med. 1998;152(4):349–352.
  • McIsaac WJ, Goel V, To T, Low DE. The validity of a sore throat score in family practice. CMAJ. 2000;163(7):811–815.
  • Murray S, Del Mar C, O'Rourke P. Predictors of an antibiotic prescription by GPs for respiratory tract infections: a pilot. Fam Pract. 2000;17(5):386–388.
  • Chevalier P, Leconte S, De Sutter A. Belgian guide to anti-infectious treatment in the ambulatory care. [In Dutch]. Brussels: BAPCOC, 2012. https://upb-avb.be/assets/antibioticagids-NL-d96b19ad.pdf (accessed 23 Jan 2018).
  • Aabenhus R, Jensen JU, Jorgensen KJ, et al. Biomarkers as point-of-care tests to guide prescription of antibiotics in patients with acute respiratory infections in primary care. Cochrane Database Syst Rev. 2014;11:CD010130.
  • Diederichsen HZ, Skamling M, Diederichsen A, et al. Randomised controlled trial of CRP rapid test as a guide to treatment of respiratory infections in general practice. Scan J Prim Health Care. 2000;18(1):39–43.
  • Lemiengre MB, Verbakel JY, Colman R, et al. Reducing inappropriate antibiotic prescribing for children in primary care: a cluster randomised controlled trial of two interventions. Br J Gen Pract. 2018;68(668):e204–e210.
  • Van den Bruel A, Jones C, Thompson M, et al. C-reactive protein point-of-care testing in acutely ill children: a mixed methods study in primary care. Arch Dis Child. 2016;101(4):382–385.
  • Andreeva E, Melbye H. Usefulness of C-reactive protein testing in acute cough/respiratory tract infection: an open cluster-randomized clinical trial with C-reactive protein testing in the intervention group. BMC Fam Pract. 2014;15:80.
  • Cals JW, Butler CC, Hopstaken RM, et al. Effect of point of care testing for C reactive protein and training in communication skills on antibiotic use in lower respiratory tract infections: cluster randomised trial. BMJ. 2009;338:b1374.
  • Cals JW, Schot MJ, de Jong SA, et al. Point-of-care C-reactive protein testing and antibiotic prescribing for respiratory tract infections: a randomized controlled trial. Ann Fam Med. 2010;8(2):124–33.
  • Little P, Stuart B, Francis N, et al. Effects of internet-based training on antibiotic prescribing rates for acute respiratory-tract infections: a multinational, cluster, randomised, factorial, controlled trial. Lancet. 2013;382(9899):1175–1182.
  • Lemiengre MB, Verbakel JY, De Burghgraeve T, et al. Optimizing antibiotic prescribing for acutely ill children in primary care (ERNIE2 study protocol, part B): a cluster randomized, factorial controlled trial evaluating the effect of a point-of-care C-reactive protein test and a brief intervention combined with written safety net advice. BMC Pediatrics. 2014;14:246.
  • Verbakel JY, Lemiengre MB, De Burghgraeve T, et al. Validating a decision tree for serious infection: diagnostic accuracy in acutely ill children in ambulatory care. BMJ Open. 2015;5(8):e008657.
  • Verbakel JY, Lemiengre MB, De Burghgraeve T, et al. Should all acutely ill children in primary care be tested with point-of-care CRP: a cluster randomised trial. BMC Med. 2016;14(1):131.
  • Verbakel JY, Lemiengre MB, De Burghgraeve T, et al. Diagnosing serious infections in acutely ill children in ambulatory care (ERNIE 2 study protocol part A): diagnostic accuracy of a Clinical Decision Tree and added value of a Point-of-Care C-reactive protein Test and Oxygen Saturation. BMC Pediatrics. 2014;14:207.
  • Van den Bruel A, Aertgeerts B, Bruyninckx R, et al. Signs and symptoms for diagnosis of serious infections in children: a prospective study in primary care. Br J Gen Pract. 2007;57(540):538–546.
  • Verbakel JY, Aertgeerts B, Lemiengre M, et al. Analytical accuracy and user-friendliness of the Afinion point-of-care CRP test. J Clin Pathol 2014;67(1):83–86.
  • Pocock SJ. Clinical trials. A practical approach. Chichester: J Wiley & Sons; 1983.
  • IBM Corp. Released 2016. IBM SPSS Statistics for Windows, Version 24.0. Amonk, NY: IBM Corp.
  • Grol R, Whitfield M, De Maeseneer J, et al. Attitudes to risk taking in medical decision making among British, Dutch and Belgian general practitioners. British J Gen Pract J R College Gen Practitioners. 1990;40(333):134–136.
  • Heiskanen-Kosma T, Korppi M. Serum C-reactive protein cannot differentiate bacterial and viral aetiology of community-acquired pneumonia in children in primary healthcare settings. Scand J Infect Dis. 2000;32(4):399–402.
  • Sanders S, Barnett A, Correa-Velez I, et al. Systematic review of the diagnostic accuracy of C-reactive protein to detect bacterial infection in nonhospitalized infants and children with fever. J Pediatr. 2008;153(4):570–574.
  • Van den Bruel A, Thompson MJ, Haj-Hassan T, et al. Diagnostic value of laboratory tests in identifying serious infections in febrile children: systematic review. BMJ. 2011;342:d3082.
  • Truyers C, Goderis G, Dewitte H, et al. The Intego database: background, methods and basic results of a Flemish general practice-based continuous morbidity registration project. BMC Med Inform Decis Mak. 2014;14(1):48.
  • Mangione-Smith R, Elliott MN, McDonald L, et al. An observational study of antibiotic prescribing behavior and the Hawthorne effect. Health Serv Res. 2002;37(6):1603–1623.
  • Lieberthal AS. Acute otitis media guidelines: review and update. Curr Allergy Asthma Rep. 2006;6(4):334–341.
  • Shulman ST, Bisno AL, Clegg HW, et al. Clinical practice guideline for the diagnosis and management of group A streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America. Clin Infect Dis. 2012;55(10):e86–e102.
  • Britten N, Ukoumunne O. The influence of patients' hopes of receiving a prescription on doctors' perceptions and the decision to prescribe: a questionnaire survey. BMJ. 1997;315(7121):1506–1510.
  • Cockburn J, Pit S. Prescribing behaviour in clinical practice: patients' expectations and doctors' perceptions of patients' expectations–a questionnaire study. BMJ. 1997;315(7107):520–523.
  • Coenen S, Van Royen P, Vermeire E, et al. Antibiotics for coughing in general practice: a qualitative decision analysis. Fam Pract. 2000;17(5):380–385.
  • Macfarlane J, Holmes W, Macfarlane R, et al. Influence of patients' expectations on antibiotic management of acute lower respiratory tract illness in general practice: questionnaire study. BMJ. 1997;315(7117):1211–1214.
  • Ayyad S, Al-Owaisheer A, Al-Banwan F, et al. Evidence-based practice in the use of antibiotics for respiratory tract infections in primary health centers in Kuwait. Med Princ Pract. 2010;19(5):339–343.
  • Boonstra E, Lindbaek M, Ngome E. Adherence to management guidelines in acute respiratory infections and diarrhoea in children under 5 years old in primary health care in Botswana. Int J Qual Health Care. 2005;17(3):221–227.
  • Ivanovska V, Hek K, Mantel Teeuwisse AK, et al. Antibiotic prescribing for children in primary care and adherence to treatment guidelines. J Antimicrob Chemother. 2016;71(6):1707–1714.
  • Ivanovska V, Hek K, Mantel-Teeuwisse AK, et al. Age-specific antibiotic prescribing and adherence to guidelines in pediatric patients in primary care. Pediatr Infect Dis J. 2018 ;37(3):218–223.
  • Reuveni H, Asher E, Greenberg D, et al. Adherence to therapeutic guidelines for acute otitis media in children younger than 2 years. Int J Pediatr Otorhinolaryngol. 2006;70(2):267–273.
  • Dekker AR, Verheij TJ, van der Velden AW. Inappropriate antibiotic prescription for respiratory tract indications: most prominent in adult patients. Fam Pract. 2015;32(4):401–407.