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ORIGINAL ARTICLE

Malignant ileocaecal serotonin-producing carcinoid tumours: The presence of a solid growth pattern and/or Ki67 index above 1% identifies patients with a poorer prognosis

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Pages 747-756 | Received 28 Jun 2006, Published online: 08 Jul 2009

References

  • Williams ED, Sandler M. The classification of carcinoid tumours. Lancet 1963; i: 238–9
  • Klöppel G, Perren A, Heitz PU. The gastroenteropancreatic neuroendocrine cell system and its tumors: The WHO classification. Ann NY Acad Sci 2004; 1014: 13–27
  • Solcia E, Klöppel G, Sobin LH. Histological typing of endocrine tumours. WHO International Histological Classification of Tumours. 2nd ed. Springer, Berlin 2000
  • Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13,715 carcinoid tumors. Cancer 2003; 97: 934–59
  • Zar N, Garmo H, Holmberg L, Rastad J, Hellman P. Long-term survival of patients with small intestinal carcinoid tumors. World J Surg 2004; 28: 1163–8
  • Janson ET, Holmberg L, Stridsberg M, Eriksson B, Theodorsson E, Wilander E, et al. Carcinoid tumors: Analysis of prognostic factors and survival in 301 patients from a referral center. Ann Oncol 1997; 8: 685–90
  • Gleason DF. Histological grading and clinical staging of prostatic carcinoma. Urologic Pathology: The Prostate, M Tannenbaum. Lea and Febiger, Philadelphia 1977; 171–97
  • Elston CW, Ellis IO. The Breast3rd ed. Churchill Livingstone, Edinburgh 1998
  • Soga J, Tazawa K. Pathologic analysis of carcinoids. Histologic reevaluation of 62 cases. Cancer 1971; 28: 990–8
  • Jones RA, Dawson IM. Morphology and staining patterns of endocrine cell tumours in the gut, pancreas and bronchus and their possible significance. Histopathology 1977; 1: 137–50
  • Johnson LA, Lavin P, Moertel CG, Weiland L, Dayal Y, Doos WG, et al. Carcinoids: The association of histologic growth pattern and survival. Cancer 1983; 51: 882–9
  • Van Eeden S, Quaedvlieg PF, Taal BG, Offerhaus GJ, Lamers CB, Van Velthuysen ML. Classification of low-grade neuroendocrine tumors of midgut and unknown origin. Hum Pathol 2002; 33: 1126–32
  • von Herbay A, Sieg B, Schurmann G, Hofmann WJ, Betzler M, Otto HF. Proliferative activity of neuroendocrine tumours of the gastroenteropancreatic endocrine system: DNA flow cytometric and immunohistological investigations. Gut 1991; 32: 949–53
  • Moyana TN, Xiang J, Senthilselvan A, Kulaga A. The spectrum of neuroendocrine differentiation among gastrointestinal carcinoids: Importance of histologic grading, MIB-1, p53, and bcl-2 immunoreactivity. Arch Pathol Lab Med 2000; 124: 570–6
  • Sokmensuer C, Gedikoglu G, Uzunalimoglu B. Importance of proliferation markers in gastrointestinal carcinoid tumors: A clinicopathologic study. Hepatogastroenterology 2001; 48: 720–3
  • Amarapurkar AD, Davies A, Ramage JK, Stangou AJ, Wight DG, Portmann BC. Proliferation of antigen MIB-1 in metastatic carcinoid tumours removed at liver transplantation: Relevance to prognosis. Eur J Gastroenterol Hepatol 2003; 15: 139–43
  • Kimura N, Miura W, Noshiro T, Miura Y, Ookuma T, Nagura H. Ki67- is an indicator of progression of neuroendocrine tumors. Endocr Pathol 1994; 5: 223–8
  • Van Eeden S, Nederlof PM, Taal BG, Offerhaus GJ, Van Velthuysen ML. A tumour with a neuroendocrine and papillary serous component: Two or a pair?. J Clin Pathol 2002; 55: 710–4
  • Chaudhry A, Öberg K, Wilander E. A study of biological behavior based on the expression of a proliferating antigen in neuroendocrine tumors of the digestive system. Tumour Biol 1992; 13: 27–35
  • Burke AP, Thomas RM, Elsayed AM, Sobin LH. Carcinoids of the jejunum and ileum: An immunohistochemical and clinicopathologic study of 167 cases. Cancer 1997; 79: 1086–93
  • Öberg K, Astrup L, Eriksson B, Falkmer SE, Falkmer UG, Gustafsen J, et al. Guidelines for the management of gastroenteropancreatic neuroendocrine tumours (including bronchopulmonary and thymic neoplasms). Part I-general overview. Acta Oncol 2004; 43: 617–25
  • Canavese G, Azzoni C, Pizzi S, Corleto VD, Pasquali C, Davoli C, et al. p27: A potential main inhibitor of cell proliferation in digestive endocrine tumors but not a marker of benign behavior. Hum Pathol 2001; 32: 1094–101
  • Grimelius L. A silver nitrate stain for alpha-2 cells in human pancreatic islets. Acta Soc Med Ups 1968; 73: 243–70
  • Grimelius L, Wilander E. Silver stains in the study of endocrine cells of the gut and pancreas. Invest Cell Pathol 1980; 3: 3–12
  • Andersson T, Wilander E, Eriksson B, Lindgren PG, Öberg K. Effects of interferon on tumor tissue content in liver metastases of human carcinoid tumors. Cancer Res 1990; 50: 3413–5
  • Öberg K. Diagnosis and treatment of carcinoid tumors. Expert Rev Anticancer Ther 2003; 3: 863–77
  • Öberg K. Management of neuroendocrine tumours. Ann Oncol 2004; 15(Suppl 4)293–8
  • Grimelius L. The argyrophil reaction in islet cells of adult human pancreas studies with a new silver nitrate procedure. Acta Soc Med Ups 1968; 73: 271–94
  • Grimelius L. Silver stains demonstrating neuroendocrine cells. Biotech Histochem 2004; 79: 37–44
  • Lollgen RM, Hessman O, Szabo E, Westin G, Åkerström G. Chromosome 18 deletions are common events in classical midgut carcinoid tumors. Int J Cancer 2001; 92: 812–5
  • D'Adda T, Pizzi S, Azzoni C, Bottarelli L, Crafa P, Pasquali C, et al. Different patterns of 11q allelic losses in digestive endocrine tumors. Hum Pathol 2002; 33: 322–9
  • Kytola S, Hoog A, Nord B, Cedermark B, Frisk T, Larsson C, et al. Comparative genomic hybridization identifies loss of 18q22-qter as an early and specific event in tumorigenesis of midgut carcinoids. Am J Pathol 2001; 158: 1803–8
  • Duerr E, Mizukami Y, Warshaw A, Kulke M, Chung C. Gene expression profiles of pancreatic neuroendocrine tumors and gastrointestinal carcinoids. Gastroenterology 2006; 130(Suppl 2)S1887
  • Rorstad O. Prognostic indicators for carcinoid neuroendocrine tumors of the gastrointestinal tract. J Surg Oncol 2005; 89: 151–60

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