Effect of adjuvant systemic treatment on cosmetic outcome and late normal-tissue reactions after breast conservation

References

• Overgaard M, Hansen PS, Overgaard J, Rose C, Andersson M, Bach F, et al. Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. N Engl J Med 1997; 337: 949–55
   PubMed Web of Science ®Google Scholar
• Overgaard M, Jensen MB, Overgaard J, Hansen PS, Rose C, Andersson M, et al. Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial. Lancet 1999; 353: 1641–8
   PubMed Web of Science ®Google Scholar
• Early Breast Cancer Trialists’ Collaborative Group. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials. Lancet 2005;365:1687–717.
   PubMed Web of Science ®Google Scholar
• van der Hage JA, Putter H, Bonnema J, Bartelink H, Therasse P, van de Velde CJ. Impact of locoregional treatment on the early-stage breast cancer patients: A retrospective analysis. Eur J Cancer 2003; 39: 2192–9
   PubMedGoogle Scholar
• Huang EH, Tucker SL, Strom EA, McNeese MD, Kuerer HM, Buzdar AU, et al. Postmastectomy radiation improves local-regional control and survival for selected patients with locally advanced breast cancer treated with neoadjuvant chemotherapy and mastectomy. J Clin Oncol 2004; 22: 4691–9
   PubMed Web of Science ®Google Scholar
• Ragaz J, Olivotto IA, Spinelli JJ, Phillips N, Jackson SM, Wilson KS, et al. Locoregional radiation therapy in patients with high-risk breast cancer receiving adjuvant chemotherapy: 20-year results of the British Columbia randomized trial. J Natl Cancer Inst 2005; 97: 116–26
   PubMedGoogle Scholar
• Whelan TJ, Julian J, Wright J, Jadad AR, Levine ML. Does locoregional radiation therapy improve survival in breast cancer? A meta-analysis. J Clin Oncol 2000; 18: 1220–9
   PubMed Web of Science ®Google Scholar
• Bentzen SM, Overgaard M, Thames HD, Christensen JJ, Overgaard J. Early and late normal-tissue injury after postmastectomy radiotherapy alone or combined with chemotherapy. Int J Radiat Biol 1989; 56: 711–5
   PubMed Web of Science ®Google Scholar
• Bentzen SM, Skoczylas JZ, Overgaard M, Overgaard J. Radiotherapy-related lung fibrosis enhanced by tamoxifen. J Natl Cancer Inst 1996; 88: 918–22
   PubMedGoogle Scholar
• Canney PA, Dean S. Transforming growth factor beta: A promotor of late connective tissue injury following radiotherapy?. Br J Radiol 1990; 63: 620–3
   PubMed Web of Science ®Google Scholar
• Border WA, Noble NA. Transforming growth factor beta in tissue fibrosis. N Engl J Med 1994; 331: 1286–92
   PubMed Web of Science ®Google Scholar
• Johansen J, Overgaard J, Rose C, Engelholm SA, Gadeberg CC, Kjær M, et al. Cosmetic outcome and breast morbidity in breast-conserving treatment. Results from the Danish DBCG-82TM national randomized trial in breast cancer. Acta Oncol 2002; 41: 369–80
   PubMed Web of Science ®Google Scholar
• Blichert-Toft M, Rose C, Andersen JA, Overgaard M, Axelsson CK, Andersen KW, et al. Danish randomized trial comparing breast conservation therapy with mastectomy: Six years of life-table analysis. Monogr Natl Cancer Inst 1992; 11: 19–25
   PubMedGoogle Scholar
• Voogd AC, Nielsen M, Peterse JL, Blichert-Toft M, Bartelink H, Overgaard M, et al. Differences in risk factors for local and distant recurrence after breast-conserving therapy or mastectomy for stage I and II breast cancer: Pooled results of two large European randomized trials. J Clin Oncol 2001; 19: 1688–97
   PubMed Web of Science ®Google Scholar
• Turesson I, Nyman J, Holmberg E, Odén A. Prognostic factors for acute and late skin reactions in radiotherapy patients. Int J Radiat Oncol Biol Phys 1996; 36: 1065–75
   PubMed Web of Science ®Google Scholar
• Safwat A, Bentzen SM, Turesson I, Hendry JH. Deterministic rather than stochastic factors explain most of the variation in the expression of skin telangiectasia after radiotherapy. Int J Radiat Oncol Biol Phys 2002; 52: 198–204
   PubMed Web of Science ®Google Scholar
• Johansen J, Bentzen SM, Overgaard J, Overgaard M. Relationship between the in vitro radiosensitivity of skin fibroblasts and the expression of subcutaneous fibrosis, telangiectasia, and skin erythema after radiotherapy. Radiother Oncol 1996; 40: 101–9
   PubMed Web of Science ®Google Scholar
• Russell NS, Begg AC. Editorial radiotherapy and oncology : Predictive assays for normal tissue damage. Radiother Oncol 2002; 64: 125–9
   PubMed Web of Science ®Google Scholar
• Andreassen CN, Alsner J, Overgaard M, Overgaard J. Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes. Radiother Oncol 2003; 69: 127–35
   PubMed Web of Science ®Google Scholar
• Martin M, Lefaix JL, Pinton P, Crechet F, Daburon F. Temporal modulation of TGF-β1 and β-actin gene expression in pig skin and muscular fibrosis after ionizing radiation. Radiat Res 1993; 134: 63–70
   PubMed Web of Science ®Google Scholar
• Illsley MC, Peacock JH, McAnulty RJ, Yarnold JR. Increased collagen production in fibroblasts cultured from irradiated skin and effect of TGF beta1-clinical study. Br J Cancer 2000; 83: 650–4
   PubMedGoogle Scholar
• Andreassen CN, Alsner J, Overgaard J, Herskind C, Haviland J, Owen R, et al. TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer. Radiother Oncol 2005; 75: 18–21
   PubMed Web of Science ®Google Scholar
• Barcellos-Hoff MH. Radiation-induced transforming growth factor β and subsequent extracellular matrix reorganization in murine mammary gland. Cancer Res 1993; 53: 3880–6
   PubMed Web of Science ®Google Scholar
• Butta A, MacLennan K, Flanders KC, Sacks NPM, Smith I, McKinna A, et al. Induction of transforming growth factor β1 in human breast cancer in vivo following tamoxifen treatment. Cancer Res 1992; 52: 4261–4
   PubMed Web of Science ®Google Scholar
• Wazer DE, DiPetrillo T, Schmidt-Ullrich R, Weld L, Smith TJ, Marchant DJ, et al. Factors influencing cosmetic outcome and complication risk after conservative surgery and radiotherapy for early-stage breast carcinoma. J Clin Oncol 1992; 10: 356–63
   PubMed Web of Science ®Google Scholar
• Olivotto IA, Rose MA, Osteen RT, Love S, Cady B, Silver B, et al. Late cosmetic outcome after conservative surgery and radiotherapy: analysis of causes of cosmetic failure. Int J Radiat Oncol Biol Phys 1989; 17: 747–53
   PubMed Web of Science ®Google Scholar
• Taylor ME, Perez CA, Halverson KJ, Kuske RR, Philpott GW, Garcia DM, et al. Factors influencing cosmetic results after conservation therapy for breast cancer. Int J Radiat Oncol Biol Phys 1995; 31: 753–64
   PubMed Web of Science ®Google Scholar
• Vass S, Bairati I. A cosmetic evaluation of breast cancer treatment: A randomized study of radiotherapy boost technique. Int J Radiat Oncol Biol Phys 2005; 62: 1274–82
   PubMedGoogle Scholar
• Huang E-Y, Wang CJ, Chen HC, Sun LM, Fang FM, Yeh SA, et al. Multivariate analysis of pulmonary fibrosis after electron beam irradiation for postmastectomy chest wall and regional lymphatics: evidence for non-dosimetric factors. Radiother Oncol 2000; 57: 91–6
   PubMed Web of Science ®Google Scholar
• Koc M, Polat P, Suma S. Effects of tamoxifen on pulmonary fibrosis after cobalt-60 radiotherapy in breast cancer patients. Radiother Oncol 2002; 64: 171–5
   PubMedGoogle Scholar
• Lingos TI, Recht A, Vicini F, Abner A, Silver B, Harris JR. Radiation pneumonitis in breast cancer patients treated with conservative surgery and radiation therapy. Int J Radiat Oncol Biol Phys 1991; 21: 355–60
   PubMed Web of Science ®Google Scholar
• Fu XL, Huang H, Bentel G, Clough R, Jirtle RL, Kong FM, et al. Predicting the risk of symptomatic radiation-induced lung injury using both the physical and biologic parameters V(30) and transforming growth factor beta. Int J Radiat Oncol Biol Phys 2001; 50: 899–908
   PubMedGoogle Scholar
• Li C, Wilson PB, Levine E, Barber J, Stewart AL, Kumar S. TGF-beta1 levels in pre-treatment plasma identify breast cancer patients at risk of developing post-radiotherapy fibrosis. Int J Cancer 1999; 84: 155–9
   PubMed Web of Science ®Google Scholar
• Azria D, Gourgou S, Sozzi WJ, Zouhair A, Mirimanoff RO, Kramar A, et al. Concomitant use of tamoxifen with radiotherapy enhances subcutaneous breast fibrosis in hypersensitive patients. Br J Cancer 2004; 91: 1251–60
   PubMedGoogle Scholar
• Fowble B, Fein DA, Hanlon AL, Eisenberg BL, Hoffman JP, Sigurdson ER, et al. The impact of tamoxifen on breast recurrence, cosmesis, complications, and survival in estrogen receptor-positive early-stage breast cancer. Int J Radiat Oncol Biol Phys 1996; 35: 669–77
   PubMed Web of Science ®Google Scholar
• Wazer DE, Morr J, Erban JK, Schmid CH, Ruthazer R, Schmidt-Ullrich RK. The effects of postradiation treatment with tamoxifen on local control and cosmetic outcome in the conservatively treated breast. Cancer 1997; 80: 732–40
   PubMed Web of Science ®Google Scholar
• Harris EE, Christensen VJ, Hwang WT, Fox K, Solin LJ. Impact of concurrent versus sequential tamoxifen with radiation therapy in early-stage breast cancer patients undergoing breast conservation treatment. J Clin Oncol 2005; 23: 11–6
   PubMed Web of Science ®Google Scholar
• Markiewicz DA, Schultz DJ, Haas JA, Harris EE, Fox KR, Glick JH, et al. The effects of sequence and type of chemotherapy and radiation therapy on cosmesis and complications after breast conservation therapy. Int J Radiat Oncol Biol Phys 1996; 35: 661–8
   PubMedGoogle Scholar
• Ray GR, Fish VJ, Marmor JB, Rogoway W, Kushlan P, Arnold C, et al. Impact of adjuvant chemotherapy on cosmesis and complications in stages I and II carcinoma of the breast treated by biopsy and radiation therapy. Int J Radiat Oncol Biol Phys 1984; 10: 837–41
   PubMedGoogle Scholar
• de la Rochefordiere A, Abner AL, Silver B, Vicini F, Recht A, Harris JR. Are cosmetic results following conservative surgery and radiation therapy for early breast cancer dependent on technique?. Int J Radiat Oncol Biol Phys 1992; 23: 925–31
   PubMedGoogle Scholar
• Moro G, Stasi M, Borca VC. Does concomitant chemoradiotherapy influence cosmetic outcome in conservative treatment of breast cancer?. Tumori 1997; 83: 743–7
   PubMedGoogle Scholar
• Borger JH, Keijser AH. Conservative breast cancer treatment: Analysis of cosmetic results and the role of concomitant adjuvant chemotherapy. Int J Radiat Oncol Biol Phys 1987; 13: 1173–7
   PubMed Web of Science ®Google Scholar
• Abner AL, Recht A, Vicini FA, Silver B, Hayes D, Come S, et al. Cosmetic results after surgery, chemotherapy, and radiation therapy for early breast cancer. Int J Radiat Oncol Biol Phys 1991; 21: 331–8
   PubMed Web of Science ®Google Scholar
• Fehlauer F, Tribius S, Holler U, Rades D, Kuhlmey A, Bajrovic A, et al. Long-term radiation sequelae after breast-conserving therapy in women with early-stage breast cancer: An observational study using the LENT-SOMA scoring system. Int J Radiat Oncol Biol Phys 2003; 55: 651–8
   PubMedGoogle Scholar
• Whelan T, Levine M. Radiation therapy and tamoxifen: Concurrent or sequential? That is the question. J Clin Oncol 2005; 23: 1–4
   PubMedGoogle Scholar
• Toledano A, Garaud P, Serin D, Fourquet A, Bosset JF, Breteau N, et al. Concurrent administration of adjuvant chemotherapy and radiotherapy after breast-conserving surgery enhances late toxicities: Long-term results of the ARCOSEIN multicenter randomized study. Int J Radiat Oncol Biol Phys 2006; 65: 324–32
   PubMedGoogle Scholar
• Recht A. Integration of systemic therapy and radiation therapy for patients with early-stage breast cancer treated with conservative surgery. Clin Breast Cancer 2003; 4: 104–13
   PubMedGoogle Scholar