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Research Article

Interstitial Fluid Pressure, Fraction of Necrotic Tumor Tissue, and Tumor Cell Density in Human Melanoma Xenografts

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Pages 291-297 | Published online: 08 Jul 2009

References

  • Jain RK. Transport of molecules in the tumor interstitium: a review. Cancer Res 1987; 47: 3039–51.
  • Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 1989; 49: 6449–65.
  • Taginawa N, Kanazawa T, Satomura K, Hikasa Y, Hashida M, Muranishi S, Sezaki H. Experimental study on lymphatic vascular changes in the development of cancer. Lymphology 1981; 14: 149–54.
  • Jain RK, Baxter LT. Mechanisms of heterogeneous distribu-tion of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure. Cancer Res 1988; 48: 7022–32.
  • Boucher Y, Baxter LT, Jain RK. Interstitial pressure gradi-ents in tissue-isolated and subcutaneous tumors: implications for therapy. Cancer Res 1990; 50: 4478–84.
  • Boucher Y, Jain RK. Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse. Cancer Res 1992; 52: 5110–4.
  • Gerlowski LE, Jain RK. Microvascular permeability of nor-mal and neoplastic tissues. Microvasc Res 1986; 31: 288–305.
  • Jain RK. Determinants of tumor blood flow: a review. Cancer Res 1988; 48: 2641–58.
  • Netti PA, Roberge S, Boucher Y, Baxter LT, Jain RK. Effect of transvascular fluid exchange on pressure-flow relationship in tumors: a proposed mechanism for tumor blood flow heterogeneity. Microvasc Res 1996; 52: 27–46.
  • Znati CA, Rosenstein M, Boucher Y, Epperly MW, Bloomer WD, Jain RK. Effect of radiation on interstitial fluid pressure and oxygenation in a human tumor xenograft. Cancer Res 1996; 56: 964–8.
  • Boucher Y, Kirkwood JM, Opacic D, Desantis M, Jain RK. Interstitial hypertension in superficial metastatic melanomas in humans. Cancer Res 1991; 51: 6691–4.
  • Tufto I, Rofstad EK. Interstitial fluid pressure in human melanoma xenografts. Relationship to fractional tumor water content, tumor size, and tumor volume-doubling time. Acta Oncol 1995; 34: 361–5.
  • Less JR, Posner MC, Boucher Y, Borochovitz D, Wolmark N, Jain RK. Interstitial hypertension in human breast and colorectal tumors. Cancer Res 1992; 52: 6371–4.
  • Curti BD, Urba WJ, Alvord WG, et al. Interstitial pressure of subcutaneous nodules in melanoma and lymphoma patients: changes during treatment. Cancer Res 1993; 53: 2204–7.
  • Sevick EM, Jain RK. Geometric resistance to blood flow in solid tumors perfused ex vivo: effects of tumor size and perfusion pressure. Cancer Res 1989; 49: 3506–12.
  • Sevick EM, Jain RK. Viscous resistance to blood flow in solid tumors: effect of hematocrit on intratumor blood viscosity. Cancer Res 1989; 49: 3513–9.
  • Jain RK. Transport of molecules across tumor vasculature. Cancer Metastasis Rev 1987; 6: 559–93.
  • Cobb LM. Intratumour factors influencing the access of antibody to tumour cells. Cancer Immunol Immunother 1989; 28: 235–40.
  • Boucher Y, Salehi H, Witwer B, Harsh W GR, Jain RK. Interstitial fluid pressure in intracranial tumours in patients and in rodents. Br J Cancer 1997; 75: 829–36.
  • Jain RK. Vascular and interstitial barriers to delivery of therapeutic agents in tumors. Cancer Metastasis Rev 1990; 9: 253–66.
  • Rofstad EK. Orthotopic human melanoma xenograft model systems for studies of tumour angiogenesis, pathophysiology,treatment sensitivity and metastatic pattern. Br J Cancer 1994; 70: 804–12.
  • Fadnes HO, Reed RK, Aukland K. Interstitial fluid pressure in rats measured with a modified wick technique. Microvasc Res 1977; 14: 27–36.
  • Weibel ER. Stereological methods. London: Academic Press, 1979.
  • Solesvik OV, Rofstad EK, Brustad T. Vascular structure of five human malignant melanomas grown in athymic nude mice. Br J Cancer 1982; 46: 557–67.
  • Brammer I, Jung H. Morphometry of irradiated tumors. In: Kallmann RF, ed. Rodent tumor models in experimental cancer therapy. Elmsford: Pergamon Press, 1987: 97–100.
  • Lee I, Boucher Y, Jain RK. Nicotinamide can lower tumor interstitial fluid pressure: mechanistic and therapeutic implica-tions. Cancer Res 1992; 52: 3237–40.
  • Roh HD, Boucher Y, Kalnicki S, Buchsbaum R, Bloomer WD, Jain RK. Interstitial hypertension in carcinoma of uter-ine cervix in patients: possible correlation with tumor oxy-genation and radiation response. Cancer Res 1991; 51: 6695–8.
  • Hon i K, Suzuki M, Abe I, Saito S. Increased tumor tissue pressure in association with the growth of rat tumors. Jpn J Cancer Res 1986; 77: 65–73.
  • Jain RK, Wei J. Dynamics of drug transport in solid tumors: distributed parameter model. J Bioeng 1977; 1: 313–29.
  • Iozza RV. Proteoglycans and the intercellular tumor matrix. Curr Topics Pathol 1987; 77: 207–21.

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