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Acta Oncologica Volume 57, 2018 - Issue 4
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ORIGINAL ARTICLES: UROLOGIC ONCOLOGY

Pro-angiogenic gene expression is associated with better outcome on sunitinib in metastatic clear-cell renal cell carcinoma

Benoit BeuselinckInserm, UMR-1162, Génomique fonctionnelle des tumeurs solides, IUH, Paris, France; ;Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; ;Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, KULeuven, Leuven, Belgium; Correspondence[email protected]
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Annelies VerbiestDepartment of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, KULeuven, Leuven, Belgium; View further author information
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Gabrielle CouchyInserm, UMR-1162, Génomique fonctionnelle des tumeurs solides, IUH, Paris, France; ;Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; View further author information
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Sylvie JobProgramme Cartes d’Identité des Tumeurs, Ligue Nationale Contre le Cancer, Paris, France; View further author information
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Aurélien de ReyniesProgramme Cartes d’Identité des Tumeurs, Ligue Nationale Contre le Cancer, Paris, France; View further author information
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Clément MeillerInserm, UMR-1162, Génomique fonctionnelle des tumeurs solides, IUH, Paris, France; ;Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; View further author information
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Maarten AlbersenDepartment of Urology, University Hospitals Leuven, KULeuven, Leuven, Belgium; View further author information
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Virginie VerkarreFaculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; ;Department of Pathology, Assistance Publique-Hôpitaux de Paris, Hôpital Necker-Enfants malades, Paris, France; View further author information
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Evelyne LerutDepartment of Pathology, University Hospitals Leuven, KULeuven, Leuven, Belgium; View further author information
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Arnaud MéjeanFaculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; ;Department of Urology, Hôpital Bicêtre, Le Kremlin-Bicêtre, France; View further author information
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Jean-Jacques PatardDepartment of Urology, Hôpital Bicêtre, Le Kremlin-Bicêtre, France; View further author information
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Brigitte LaguerreDepartment of Medical Oncology, CHU Rennes, Rennes, France; View further author information
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Nathalie Rioux-LeclercqDepartment of Pathology, CHU Rennes, Rennes, France; View further author information
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Patrick SchöffskiDepartment of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, KULeuven, Leuven, Belgium; View further author information
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Stéphane OudardFaculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; ;Department of Oncology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, FranceView further author information
&
Jessica Zucman-RossiInserm, UMR-1162, Génomique fonctionnelle des tumeurs solides, IUH, Paris, France; ;Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; ;Department of Oncology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, FranceView further author information
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Pages 498-508 | Received 14 Jul 2017, Accepted 02 Oct 2017, Published online: 02 Nov 2017

References

  • Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 2007;356:115–124.
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  • Varela I, Tarpey P, Raine K, et al. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature. 2011;469:539–542.
  • Pena-Llopis S, Vega-Rubin-de-Celis S, Liao A, et al. BAP1 loss defines a new class of renal cell carcinoma. Nat Genet. 2012;44:751–759.
  • Messai Y, Gad S, Noman MZ, et al. Renal cell carcinoma programmed death-ligand 1, a new direct target of hypoxia-inducible factor-2 alpha, is regulated by von Hippel-Lindau gene mutation status. Eur Urol. 2015;70:623–632.

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