Non-linear conversion of HX4 uptake for automatic segmentation of hypoxic volumes and dose prescription

References

• Overgaard J. Hypoxic radiosensitization: adored and ignored. J Clin Oncol. 2007;25:4066–4074.
   PubMed Web of Science ®Google Scholar
• Toma-Dasu I, Dasu A. Towards multidimensional radiotherapy: key challenges for treatment individualisation. Comput Math Methods Med. 2015;2015:934380.
   PubMedGoogle Scholar
• Toma-Dasu I, Dasu A, Brahme A. Quantifying tumour hypoxia by PET imaging—a theoretical analysis. Adv Exp Med Biol. 2009;645:267–272.
   PubMed Web of Science ®Google Scholar
• Bentzen SM, Gregoire V. Molecular imaging-based dose painting: a novel paradigm for radiation therapy prescription. Semin Radiat Oncol. 2011;21:101–110.
   PubMed Web of Science ®Google Scholar
• Rajendran JG, Krohn KA. F-18 fluoromisonidazole for imaging tumor hypoxia: imaging the microenvironment for personalized cancer therapy. Semin Nucl Med. 2015;45:151–162.
   PubMed Web of Science ®Google Scholar
• Dubois LJ, Lieuwes NG, Janssen MH, et al. Preclinical evaluation and validation of [18F]HX4, a promising hypoxia marker for PET imaging. Proc Natl Acad Sci USA. 2011;108:14620–14625.
   PubMed Web of Science ®Google Scholar
• van Loon J, Janssen MH, Ollers M, et al. PET imaging of hypoxia using [18F]HX4: a phase I trial. Eur J Nucl Med Mol Imaging. 2010;37:1663–1668.
   PubMed Web of Science ®Google Scholar
• Zegers CM, van Elmpt W, Reymen B, et al. In vivo quantification of hypoxic and metabolic status of NSCLC tumours using [18F]HX4 and[18F]FDG-PET/CT imaging. Clin Cancer Res. 2014;20:6389–6397.
   PubMed Web of Science ®Google Scholar
• Peeters SG, Zegers CM, Lieuwes NG, et al. A comparative study of the hypoxia PET tracers [18F]HX4, [18F]FAZA, and [18F]FMISO in a preclinical tumor model. Int J Radiat Oncol Biol Phys. 2015;91:351–359.
   PubMed Web of Science ®Google Scholar
• Zegers CM, van Elmpt W, Wierts R, et al. Hypoxia imaging with [18F]HX4 PET in NSCLC patients: defining optimal imaging parameters. Radiother Oncol. 2013;109:58–64.
   PubMed Web of Science ®Google Scholar
• Even AJ, van der Stoep J, Zegers CM, et al. PET-based dose painting in non-small cell lung cancer: comparing uniform dose escalation with boosting hypoxic and metabolically active sub-volumes. Radiother Oncol. 2015;116:281.
   PubMed Web of Science ®Google Scholar
• Toma-Dasu I, Uhrdin J, Dasu A, et al. Therapy optimization based on non-linear uptake of PET tracers versus ‘linear dose painting’. IFMBE Proc. 2009;25:221–224.
   Google Scholar
• Lindblom E, Dasu A, Uhrdin J, et al. Defining the hypoxic target volume based on positron emission tomography for image guided radiotherapy—the influence of the choice of the reference region and conversion function. Acta Oncol. 2017;56:819–825.
   PubMed Web of Science ®Google Scholar
• Nunn A, Linder K, Strauss HW. Nitroimidazoles and imaging hypoxia. Eur J Nucl Med. 1995;22:265–280.
   PubMedGoogle Scholar
• Toma-Dasu I, Dasu A, Brahme A. Dose prescription and optimisation based on tumour hypoxia. Acta Oncol. 2009;48:1181–1192.
   PubMed Web of Science ®Google Scholar
• Toma-Dasu I, Uhrdin J, Antonovic L, et al. Dose prescription and treatment planning based on FMISO-PET hypoxia. Acta Oncol. 2012;51:222–230.
   PubMed Web of Science ®Google Scholar
• Ljungkvist AS, Bussink J, Kaanders JH, et al. Dynamics of hypoxia, proliferation and apoptosis after irradiation in a murine tumor model. Radiat Res. 2006;165:326–336.
   PubMed Web of Science ®Google Scholar
• Brahme A. Dosimetric precision requirements in radiation therapy. Acta Radiol Oncol. 1984;23:379–391.
   PubMed Web of Science ®Google Scholar
• Partridge M, Ramos M, Sardaro A, et al. Dose escalation for non-small cell lung cancer: analysis and modelling of published literature. Radiother Oncol. 2011;99:6–11.
   PubMed Web of Science ®Google Scholar
• Wack LJ, Monnich D, van Elmpt W, et al. Comparison of [18F]-FMISO, [18F]-FAZA and [18F]-HX4 for PET imaging of hypoxia—a simulation study. Acta Oncol. 2015;54:1370–1377.
   PubMed Web of Science ®Google Scholar
• Meijer G, Steenhuijsen J, Bal M, et al. Dose painting by contours versus dose painting by numbers for stage II/III lung cancer: practical implications of using a broad or sharp brush. Radiother Oncol. 2011;100:396–401.
   PubMed Web of Science ®Google Scholar
• Thoeny HC, Ross BD. Predicting and monitoring cancer treatment response with diffusion-weighted MRI. J Magn Reson Imaging. 2010;32:2–16.
   PubMed Web of Science ®Google Scholar
• Höckel M, Vaupel P. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst. 2001;93:266–276.
   PubMed Web of Science ®Google Scholar