Pudendal nerve injury impairs anorectal function and health related quality of life measures ≥2 years after 3D conformal radiotherapy for prostate cancer

References

• Jani AB, Hellman S. Early prostate cancer: clinical decision-making. Lancet. 2003;361:1045–1053.
   PubMed Web of Science ®Google Scholar
• Widmark A, Klepp O, Solberg A, et al. Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial. Lancet. 2009;373:301–308.
   PubMed Web of Science ®Google Scholar
• Smeenk RJ, The BS, Butler EB, et al. Is there a role for endorectal balloons in prostate radiotherapy? A systematic review. Radiother Oncol. 2010;96:277–282.
   PubMedGoogle Scholar
• al-Abany M, Helgason AR, Cronqvist AK, et al. Long-term symptoms after external beam radiation therapy for prostate cancer with three or four fields. Acta Oncol. 2002;41:532–542.
   PubMed Web of Science ®Google Scholar
• Heemsbergen WD, Hoogeman MS, Hart GA, et al. Gastrointestinal toxicity and its relation to dose distributions in the anorectal region of prostate cancer patients treated with radiotherapy. Int J Radiat Oncol Biol Phys. 2005;61:1011–1018.
   PubMed Web of Science ®Google Scholar
• Maeda Y, Hoyer M, Lundby L, et al. Faecal incontinence following radiotherapy for prostate cancer: a systematic review. Radiother Oncol. 2011;98:145–153.
   PubMed Web of Science ®Google Scholar
• Yeoh E, Tam W, Schoeman M, et al. Argon plasma coagulation therapy versus topical formalin for intractable rectal bleeding and anorectal dysfunction after radiotherapy for prostate carcinoma. Int J Radiat Oncol Biol Phys. 2013;87:954–959.
   PubMed Web of Science ®Google Scholar
• Yeoh EK, Holloway RH, Fraser RJ, et al. Pathophysiology and natural history of anorectal sequelae following radiation therapy for carcinoma of the prostate. Int J Radiat Oncol Biol Phys. 2012;84:e593–e599.
   PubMed Web of Science ®Google Scholar
• Krol R, Hopman WP, Smeenk RJ, et al. Increased rectal wall stiffness after prostate radiotherapy: relation with fecal urgency. Neurogastroenterol Motil. 2012;24:339–e166.
   PubMed Web of Science ®Google Scholar
• Yeoh EK, Bartholomeusz DL, Holloway RH, et al. Disturbed colonic motility contributes to anorectal symptoms and dysfunction after radiotherapy for carcinoma of the prostate. Int J Radiat Oncol Biol Phys. 2010;78:773–780.
   PubMed Web of Science ®Google Scholar
• Loganathan A, Schloithe AC, Hutton J, et al. Pudendal nerve injury in men with fecal incontinence after radiotherapy for prostate cancer. Acta Oncol. 2015;54:882–888.
   PubMed Web of Science ®Google Scholar
• Geinitz H, Zimmermann FB, Thamm R, et al. Late rectal symptoms and quality of life after conformal radiotherapy for prostate cancer. Radiother Oncol. 2006;79:341–347.
   PubMed Web of Science ®Google Scholar
• Denham JW, Wilcox C, Joseph D, et al. Quality of life in men with locally advanced prostate cancer treated with leuprorelin and radiotherapy with or without zoledronic acid (TROG 03.04 RADAR): secondary endpoints from a randomised phase 3 factorial trial. Lancet Oncol. 2012;13:1260–1270.
   PubMed Web of Science ®Google Scholar
• Yeoh EE, Holloway RH, Fraser RJ, et al. Anorectal dysfunction increases with time following radiation therapy for carcinoma of the prostate. Am J Gastroenterol. 2004;99:361–369.
   PubMed Web of Science ®Google Scholar
• Bright T, Kapoor R, Voyvodich F, et al. The use of a balloon catheter to improve evaluation in anorectal manometry. Colorectal Dis. 2005;7:47.
   PubMed Web of Science ®Google Scholar
• Pettersson N, Johansson K-A, Alsadius D, et al. A method to estimate composite doses for organs at risk in prostate cancer patients treated with EBRT in combination with HDR brachytherapy. Acta Oncol. 2014;53:815–821.
   PubMed Web of Science ®Google Scholar
• Aaronson NK, Ahmedzai S, Bergman B, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality of life instrument for use in international clinical trials in Oncology. J Natl Cancer Inst. 1993;85:365–376.
   PubMed Web of Science ®Google Scholar
• Voyvodic F, Rieger NA, Skinner S, et al. Endosonographic imaging of anal sphincter injury: does the size of the tear correlate with the degree of dysfunction? Dis Colon Rectum. 2003;46:735–741.
   PubMed Web of Science ®Google Scholar
• Botten R, DiMAtteo AC, Sharma KG, et al. Endorectal balloon during image guided radiation therapy for carcinoma of the prostate reduces rectal bleeding and sensory dysfunction and improves health related quality of life outcomes at 2 years. Gastroenterology. 2016;150:S937.
   Web of Science ®Google Scholar
• Yeoh EK, Krol R, Dhillon VS, et al. Predictors of radiation-induced morbidity following radiotherapy for carcinoma of the prostate. Acta Oncol. 2016;55:604–610.
   PubMed Web of Science ®Google Scholar
• Smeenk RJ, Hoffman AL, Hopman, et al. Dose effect relationships of individual pelvic floor muscles and anorectal complaints after pelvic radiotherapy. Int J Radiat Oncol Biol Phys. 2012;83:636–644.
   PubMed Web of Science ®Google Scholar
• Alsadius D, Hedelin M, Lundstedt D, et al. Mean absorbed dose to the anal-sphincter region and fecal leakage among irradiated prostate cancer survivors. Int J Radiat Oncol Biol Phys. 2012;84:e181–e185.
   PubMed Web of Science ®Google Scholar
• Steineck G, Sjoberg F, Skokic V, et al. Late radiation-induced bowel syndromes, tobacco smoking, age at treatment and time since treatment – gynecological cancer survivors. Acta Oncol. 2017;65:682–691.
   Google Scholar
• Waldenstrom A-C, Alsadius D, Pettersson N, et al. Variations in position and volume of organs at risk in the small pelvis. Acta Oncol. 2010;49:491–499.
   PubMed Web of Science ®Google Scholar