Hyponatremia associates with poor outcome in metastatic renal cell carcinoma patients treated with everolimus: prognostic impact

References

• Motzer RJ, Escudier B, Bukowski R, et al. Prognostic factors for survival in 1059 patients treated with sunitinib for metastatic renal cell carcinoma. Br J Cancer. 2013;108:2470–2477.
   PubMed Web of Science ®Google Scholar
• Heng DY, Xie W, Regan MM, et al. Prognostic factors for overall survival in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted agents: results from a large, multicenter study. J Clin Oncol. 2009;27:5794–5799.
   PubMed Web of Science ®Google Scholar
• Soerensen AV, Geertsen PF, Christensen IJ, et al. A five-factor biomarker profile obtained week 4-12 of treatment for improved prognostication in metastatic renal cell carcinoma: results from DARENCA study 2. Acta Oncol. 2016;55:341–348.
   PubMed Web of Science ®Google Scholar
• Donskov F, Michaelson MD, Puzanov I, et al. Sunitinib-associated hypertension and neutropenia as efficacy biomarkers in metastatic renal cell carcinoma patients. Br J Cancer. 2015;113:1571–1580.
   PubMed Web of Science ®Google Scholar
• Rautiola J, Donskov F, Peltola K, et al. Sunitinib-induced hypertension, neutropaenia and thrombocytopaenia as predictors of good prognosis in patients with metastatic renal cell carcinoma. BJU Int. 2016;117:110–117.
   PubMed Web of Science ®Google Scholar
• Luca A, Angermayr B, Bertolini G, et al. An integrated MELD model including serum sodium and age improves the prediction of early mortality in patients with cirrhosis. Liver Transpl. 2007;13:1174–1180.
   PubMed Web of Science ®Google Scholar
• Rossi J, Bayram M, Udelson JE, et al. Improvement in hyponatremia during hospitalization for worsening heart failure is associated with improved outcomes: insights from the Acute and Chronic Therapeutic Impact of a Vasopressin Antagonist in Chronic Heart Failure (ACTIV in CHF) trial. Acute Card Care 2007;9:82–86.
   PubMedGoogle Scholar
• Rusinaru D, Tribouilloy C, Berry C, et al. Relationship of serum sodium concentration to mortality in a wide spectrum of heart failure patients with preserved and with reduced ejection fraction: an individual patient data meta-analysis(dagger): Meta-Analysis Global Group in Chronic heart failure (MAGGIC). Eur J Heart Fail 2012;14:1139–1146.
   PubMed Web of Science ®Google Scholar
• Nair V, Niederman MS, Masani N, et al. Hyponatremia in community-acquired pneumonia. Am J Nephrol. 2007;27:184–190.
   PubMed Web of Science ®Google Scholar
• Chao YN, Chiu NC, Huang FY. Clinical features and prognostic factors in childhood pneumococcal meningitis. J Microbiol Immunol Infect. 2008;41:48–53.
   PubMedGoogle Scholar
• Selmer C, Madsen JC, Torp-Pedersen C, et al. Hyponatremia, all-cause mortality, and risk of cancer diagnoses in the primary care setting: a large population study. Eur J Int Med. 2016;36:36–43.
   PubMed Web of Science ®Google Scholar
• Holland-Bill L, Christiansen CF, Farkas DK, et al. Diagnosis of hyponatremia and increased risk of a subsequent cancer diagnosis: results from a nationwide population-based cohort study. Acta Oncol. 2018;57:522–527.
   PubMed Web of Science ®Google Scholar
• Huo TI, Lin HC, Hsia CY, et al. The MELD-Na is an independent short- and long-term prognostic predictor for hepatocellular carcinoma: a prospective survey. Digest Liver Dis. 2008;40:882–889.
   Web of Science ®Google Scholar
• Kim HS, Yi SY, Jun HJ, et al. Clinical outcome of gastric cancer patients with bone marrow metastases. Oncology. 2007;73:192–197.
   PubMed Web of Science ®Google Scholar
• Gandhi L, Johnson BE. Paraneoplastic syndromes associated with small cell lung cancer. J Natl Compr Canc Netw. 2006;4:631–638.
   PubMedGoogle Scholar
• Hermes A, Waschki B, Reck M. Hyponatremia as prognostic factor in small cell lung cancer-a retrospective single institution analysis. Respir Med. 2012;106:900–904.
   PubMed Web of Science ®Google Scholar
• Aggerholm-Pedersen N, Rasmussen P, Dybdahl H, et al. Serum natrium determines outcome of treatment of advanced GIST with imatinib: a retrospective study of 80 patients from a single institution. ISRN Oncol. 2011;2011:523915.
   PubMedGoogle Scholar
• Abu Zeinah GF, Al-Kindi SG, Hassan AA, et al. Hyponatraemia in cancer: association with type of cancer and mortality. Eur J Cancer Care (Engl). 2015;24:224–231.
   PubMed Web of Science ®Google Scholar
• Vasudev NS, Brown JE, Brown SR, et al. Prognostic factors in renal cell carcinoma: association of preoperative sodium concentration with survival. Clin Cancer Res. 2008;14:1775–1781.
   PubMed Web of Science ®Google Scholar
• Jeppesen AN, Jensen HK, Donskov F, et al. Hyponatremia as a prognostic and predictive factor in metastatic renal cell carcinoma. Br J Cancer. 2010;102:867–872.
   PubMed Web of Science ®Google Scholar
• Furukawa J, Miyake H, Kusuda Y, et al. Hyponatremia as a powerful prognostic predictor for Japanese patients with clear cell renal cell carcinoma treated with a tyrosine kinase inhibitor. Int J Clin Oncol. 2015;20:351–357.
   PubMed Web of Science ®Google Scholar
• Kawashima A, Tsujimura A, Takayama H, et al. Impact of hyponatremia on survival of patients with metastatic renal cell carcinoma treated with molecular targeted therapy. Int J Urol. 2012;19:1050–1057.
   PubMed Web of Science ®Google Scholar
• Schutz FA, Xie W, Donskov F, et al. The impact of low serum sodium on treatment outcome of targeted therapy in metastatic renal cell carcinoma: results from the International Metastatic Renal Cell Cancer Database Consortium. Eur Urol. 2014;65:723–730.
   PubMed Web of Science ®Google Scholar
• Brugarolas J. Renal-cell carcinoma-molecular pathways and therapies. N Engl J Med. 2007;356:185–187.
   PubMed Web of Science ®Google Scholar
• Escudier B, Porta C, Schmidinger M, et al. Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2016;27:v58–v68.
   PubMed Web of Science ®Google Scholar
• Eisenhauer EA, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 2009;45:228–247.
   PubMed Web of Science ®Google Scholar
• Berardi R, Santoni M, Newsom-Davis T, et al. Hyponatremia normalization as an independent prognostic factor in patients with advanced non-small cell lung cancer treated with first-line therapy. Oncotarget. 2017;8:23871–23879.
   PubMedGoogle Scholar
• Penttila P, Donskov F, Rautiola J, et al. Everolimus-induced pneumonitis associates with favourable outcome in patients with metastatic renal cell carcinoma. Eur J Cancer. 2017;81:9–16.
   PubMed Web of Science ®Google Scholar
• Davis ID, Xie W, Pezaro C, et al. Efficacy of second-line targeted therapy for renal cell carcinoma according to change from baseline in international metastatic renal cell carcinoma database consortium prognostic category. Eur Urol. 2017;71:970–978.
   PubMed Web of Science ®Google Scholar
• SØRensen JB, Andersen MK, Hansen HH. Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in malignant disease. J Intern Med. 1995;238:97–110.
   PubMed Web of Science ®Google Scholar
• Talmi YP, Wolf GT, Hoffman HT, et al. Elevated arginine vasopressin levels in squamous cell cancer of the head and neck. Laryngoscope. 1996;106:317–321.
   PubMed Web of Science ®Google Scholar
• Goel A, Kalra OP. Hyponatremia in older individuals. J Assoc Physicians India. 2010;58:663–664.
   PubMedGoogle Scholar
• Bichet D, Szatalowicz V, Chaimovitz C, et al. Role of vasopressin in abnormal water excretion in cirrhotic patients. Ann Intern Med. 1982;96:413–417.
   PubMed Web of Science ®Google Scholar
• Hamdi T, Latta S, Jallad B, et al. Cisplatin-induced renal salt wasting syndrome. South Med J. 2010;103:793–799.
   PubMed Web of Science ®Google Scholar
• Sahay M, Sahay R. Hyponatremia: a practical approach. Ind J Endocrinol Metab. 2014;18:760–771.
   PubMedGoogle Scholar
• Spital A. Diuretic-induced hyponatremia. Am J Nephrol. 1999;19:447–452.
   PubMed Web of Science ®Google Scholar
• Oren RM. Hyponatremia in congestive heart failure. Am J Cardiol. 2005;95:2b–7b.
   PubMed Web of Science ®Google Scholar