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ORIGINAL ARTICLES: CLINICAL ONCOLOGY

Geriatric impairments are prevalent and predictive of survival in older patients with cancer receiving radiotherapy: a prospective observational study

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Pages 393-402 | Received 24 Jun 2021, Accepted 17 Nov 2021, Published online: 07 Dec 2021

References

  • Norway CRO. Cancer in Norway 2017 - cancer incidence, mortality, survival and prevalence in Norway. Oslo: Cancer Registry of Norway; 2018.
  • UK Cr. Cancer incidence by age [updated 20.032020. Available from: https://www.cancerresearchuk.org/health-professional/cancer-statistics/incidence/age#heading-Zero.
  • Handforth C, Clegg A, Young C, et al. The prevalence and outcomes of frailty in older cancer patients: a systematic review. Ann Oncol. 2015;26(6):1091–1101.
  • Hutchins LF, Unger JM, Crowley JJ, et al. Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med. 1999;341(27):2061–2067.
  • Hurria A, Dale W, Mooney M, Cancer and Aging Research Group, et al. Designing therapeutic clinical trials for older and frail adults with cancer: U13 conference recommendations. J Clin Oncol. 2014;32(24):2587–2594.
  • Ludmir EB, Mainwaring W, Lin TA, et al. Factors associated with age disparities among cancer clinical trial participants. JAMA Oncol. 2019;5(12):1769.
  • Repetto L, Fratino L, Audisio RA, et al. Comprehensive geriatric assessment adds information to Eastern cooperative oncology group performance status in elderly cancer patients: an italian group for geriatric oncology study. J Clin Oncol. 2002;20(2):494–502.
  • Mohile SG, Dale W, Somerfield MR, et al. Practical assessment and management of vulnerabilities in older patients receiving chemotherapy: ASCO guideline for geriatric oncology. J Clin Oncol. 2018;36(22):2326–2347.
  • Popescu T, Karlsson U, Vinh-Hung V, et al. Challenges facing radiation oncologists in the management of older cancer patients: Consensus of the international geriatric radiotherapy group. Cancers (Basel). 2019;11(3):371.
  • Wildiers H, Heeren P, Puts M, et al. International society of geriatric oncology consensus on geriatric assessment in older patients with cancer. J Clin Oncol. 2014;32(24):2595–2603.
  • O'Donovan A, Mohile SG, Leech M. Expert consensus panel guidelines on geriatric assessment in oncology. Eur J Cancer Care (Engl)). 2015;24(4):574–589.
  • Pal SK, Katheria V, Hurria A. Evaluating the older patient with cancer: understanding frailty and the geriatric assessment. CA Cancer J Clin. 2010;60(2):120–132.
  • Hamaker ME, Schiphorst AH, ten Bokkel Huinink D, et al. The effect of a geriatric evaluation on treatment decisions for older cancer patients-a systematic review. Acta Oncol. 2014;53(3):289–296.
  • Kristjansson SR, Nesbakken A, Jordhoy MS, et al. Comprehensive geriatric assessment can predict complications in elderly patients after elective surgery for colorectal cancer: a prospective observational cohort study. Crit Rev Oncol Hematol. 2010;76(3):208–217.
  • Hurria A, Togawa K, Mohile SG, et al. Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. J Clin Oncol. 2011;29(25):3457–3465.
  • Hamaker ME, Vos AG, Smorenburg CH, et al. The value of geriatric assessments in predicting treatment tolerance and all-cause mortality in older patients with cancer. Oncologist. 2012;17(11):1439–1449.
  • Szumacher E, Sattar S, Neve M, et al. Use of comprehensive geriatric assessment and geriatric screening for older adults in the radiation oncology setting: a systematic review. Clin Oncol (R Coll Radiol)). 2018;30(9):578–588.
  • O'Donovan A, Leech M, Gillham C. Assessment and management of radiotherapy induced toxicity in older patients. J Geriatr Oncol. 2017;8(6):421–427.
  • Slotman BJ, Cottier B, Bentzen SM, et al. Overview of national guidelines for infrastructure and staffing of radiotherapy. ESTRO-QUARTS: work package 1. Radiother Oncol. 2005;75(3):349–354.
  • Somasundar P, Mourey L, Lozza L, et al. Advances in geriatric oncology: a multidisciplinary perspective. Tumori. 2018;104(4):252–257.
  • Bruijnen CP, van Harten-Krouwel DG, Koldenhof JJ, et al. Predictive value of each geriatric assessment domain for older patients with cancer: a systematic review. J Geriatr Oncol. 2019;10(6):859–873.
  • fylkeskommune I. Fakta om Innlandet 2020. [updated 19.06.2020]. Available from: https://innlandetfylke.no/om-fylkeskommunen/om-innlandet/fakta-om-innlandet/.
  • Puts MTE, Alibhai SMH. Fighting back against the dilution of the comprehensive geriatric assessment. J Geriatr Oncol. 2018;9(1):3–5.
  • Charlson ME, Pompei P, Ales KL, et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373–383.
  • Sundararajan V, Henderson T, Perry C, et al. New ICD-10 version of the charlson comorbidity index predicted in-hospital mortality. J Clin Epidemiol. 2004;57(12):1288–1294.
  • Rubenstein LZ, Harker JO, Salva A, et al. Screening for undernutrition in geriatric practice: developing the short-form mini-nutritional assessment (MNA-SF). J Gerontol A Biol Sci Med Sci. 2001;56(6):M366–72.
  • Kaiser MJ, Bauer JM, Ramsch C, MNA-International Group, et al. Validation of the mini nutritional assessment short-form (MNA-SF): a practical tool for identification of nutritional status. J Nutr Health Aging. 2009;13(9):782–788.
  • Podsiadlo D, Richardson S. The timed "up & go": a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 1991;39(2):142–148.
  • Mahoney FI, Barthel DW. Functional evaluation: the barthel index. Md State Med J. 1965;14:61–65.
  • Gladman JR, Lincoln NB, Adams SA. Use of the extended ADL scale with stroke patients. Age Ageing. 1993;22(6):419–424.
  • Nasreddine ZS, Phillips NA, Bedirian V, et al. The montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695–699.
  • Sheikh JI, Yesavage JA. Geriatric depression scale (GDS): recent evidence and development of a shorter version. Clinical Gerontologist: The Journal of Aging and Mental Health. 1986;5(1-2):165–173.
  • Mohile SG, Epstein RM, Hurria A, et al. Communication with older patients with cancer using geriatric assessment: a Cluster-Randomized clinical trial from the national cancer institute community oncology research program. JAMA Oncol. 2020;6(2):196–204.
  • Gutiérrez-Valencia M, Izquierdo M, Cesari M, et al. The relationship between frailty and polypharmacy in older people: a systematic review. Br J Clin Pharmacol. 2018;84(7):1432–1444.
  • Borland E, Nägga K, Nilsson PM, et al. The montreal cognitive assessment: Normative data from a large swedish Population-Based cohort. JAD. 2017;59(3):893–901.
  • Jolly TA, Deal AM, Nyrop KA, et al. Geriatric assessment-identified deficits in older cancer patients with normal performance status. Oncologist. 2015;20(4):379–385.
  • Owusu C, Koroukian SM, Schluchter M, et al. Screening older cancer patients for a comprehensive geriatric assessment: a comparison of three instruments. J Geriatr Oncol. 2011;2(2):121–129.
  • Kristjansson SR, Jordhøy MS, Nesbakken A, et al. Which elements of a comprehensive geriatric assessment (CGA) predict post-operative complications and early mortality after colorectal cancer surgery? Journal of Geriatric Oncology. 2010;1(2):57–65.
  • Pocklington C, Gilbody S, Manea L, et al. The diagnostic accuracy of brief versions of the geriatric depression scale: a systematic review and Meta-analysis. Int J Geriatr Psychiatry. 2016;31(8):837–857.
  • Vermeiren S, Vella-Azzopardi R, Beckwée D, Gerontopole Brussels Study group, et al. Frailty and the prediction of negative health outcomes: a Meta-Analysis. J Am Med Dir Assoc. 2016;17(12):1163.e1–1163.e17.
  • Hamaker ME, Oosterlaan F, van Huis LH, et al. Nutritional status and interventions for patients with cancer - A systematic review. J Geriatr Oncol. 2021:12(1):6–21.
  • Bo Y, Wang K, Liu Y, et al. The geriatric nutritional risk index predicts survival in elderly esophageal squamous cell carcinoma patients with radiotherapy. PLoS One. 2016;11(5):e0155903.
  • Extermann M, Hurria A. Comprehensive geriatric assessment for older patients with cancer. J Clin Oncol. 2007 May 10;25(14):1824–1831.
  • Connolly D, Garvey J, McKee G. Factors associated with ADL/IADL disability in community dwelling older adults in the irish longitudinal study on ageing (TILDA). Disabil Rehabil. 2017;39(8):809–816.
  • Rostoft S, O'Donovan A, Soubeyran P, et al. Geriatric assessment and management in cancer. J Clin Oncol. 2021;39(19):2058–2067.
  • O'Donovan A, Leech M. Personalised treatment for older adults with cancer: the role of frailty assessment. Tech Innov Patient Support Radiat Oncol. 2020;16:30–38.

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