Should adjuvant radiotherapy be used in atypical meningioma (WHO grade 2) following gross total resection? A systematic review and Meta-analysis

References

• Ostrom QT, Gittleman H, Farah P, et al. BTRUS statistical report: Primary brain and Central nervous system tumors diagnosed in the United States in 2006–2010. Neuro Oncol. 2013;15 (Suppl 2):ii1–56.
   PubMed Web of Science ®Google Scholar
• Holleczek B, Zampella D, Urbschat S, et al. Incidence, mortality and outcome of meningiomas: a population-based study from Germany. Cancer Epidemiol. 2019;62:101562.
   PubMed Web of Science ®Google Scholar
• Backer-Grøndahl T, Moen BH, Torp SH. The histopathological spectrum of human meningiomas. Int J Clin Exp Pathol. 2012;5(3):231–242.
   PubMed Web of Science ®Google Scholar
• Louis DN, Perry A, Reifenberger G, et al. The 2016 world health organization classification of tumors of the Central nervous system: a summary. Acta Neuropathol. 2016;131(6):803–820.
   PubMed Web of Science ®Google Scholar
• Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumours of the Central nervous system. Acta Neuropathol. 2007;114(2):97–109.
   PubMed Web of Science ®Google Scholar
• Alghamdi M, Li H, Olivotto I, et al. Atypical meningioma: Referral patterns, treatment and adherence to guidelines. Can J Neurol Sci. 2017;44(3):283–287.
   PubMed Web of Science ®Google Scholar
• Willis J, Smith C, Ironside JW, et al. The accuracy of meningioma grading: a 10-year retrospective audit. Neuropathol Appl Neurobiol. 2005;31(2):141–149.
   PubMed Web of Science ®Google Scholar
• Rogers L, Gilbert M, Vogelbaum MA. Intracranial meningiomas of atypical (WHO grade II) histology. J Neurooncol. 2010;99(3):393–405.
   PubMed Web of Science ®Google Scholar
• Jääskeläinen J, Haltia M, Servo A. Atypical and anaplastic meningiomas: radiology, surgery, radiotherapy, and outcome. Surg Neurol. 1986;25(3):233–242.
   PubMed Web of Science ®Google Scholar
• Louis DN, Perry A, Wesseling P, et al. The 2021 WHO classification of tumors of the Central nervous system: a summary. Neuro Oncol. 2021;23(8):1231–1251.
   PubMed Web of Science ®Google Scholar
• Jenkinson MD, Weber DC, Haylock BJ, et al. Atypical meningoma: current management dilemmas and prospective clinical trials. J Neurooncol. 2015;121(1):1–7.
   PubMed Web of Science ®Google Scholar
• Engenhart-Cabillic R, Farhoud A, Sure U, et al. Clinicopathologic features of aggressive meningioma emphasizing the role of radiotherapy in treatment. Strahlenther Onkol. 2006;182(11):641–646.
   PubMed Web of Science ®Google Scholar
• Pearson BE, Markert JM, Fisher WS, et al. Hitting a moving target: evolution of a treatment paradigm for atypical meningiomas amid changing diagnostic criteria. Neurosurg Focus. 2008;24(5):E3.
   PubMed Web of Science ®Google Scholar
• Aghi MK, Carter BS, Cosgrove GR, et al. Long-term recurrence rates of atypical meningiomas after gross total resection with or without postoperative adjuvant radiation. Neurosurgery. 2009;64(1):56–60; discussion.
   PubMed Web of Science ®Google Scholar
• Jenkinson MD, Waqar M, Farah JO, et al. Early adjuvant radiotherapy in the treatment of atypical meningioma. J Clin Neurosci. 2016;28:87–92.
   PubMed Web of Science ®Google Scholar
• Durand A, Labrousse F, Jouvet A, et al. WHO grade II and III meningiomas: a study of prognostic factors. J Neurooncol. 2009;95(3):367–375.
   PubMed Web of Science ®Google Scholar
• Komotar RJ, Iorgulescu JB, Raper DM, et al. The role of radiotherapy following gross-total resection of atypical meningiomas. J Neurosurg. 2012;117(4):679–686.
   PubMed Web of Science ®Google Scholar
• Hug EB, Devries A, Thornton AF, et al. Management of atypical and malignant meningiomas: role of high-dose, 3D-conformal radiation therapy. J Neurooncol. 2000;48(2):151–160.
   PubMed Web of Science ®Google Scholar
• Palma L, Celli P, Franco C, et al. Long-term prognosis for atypical and malignant meningiomas: a study of 71 surgical cases. J Neurosurg. 1997;86(5):793–800.
   PubMed Web of Science ®Google Scholar
• Mair R, Morris K, Scott I, et al. Radiotherapy for atypical meningiomas. J Neurosurg. 2011;115(4):811–819.
   PubMed Web of Science ®Google Scholar
• Perego C, Sbolli M, Specchia C, et al. Utility of restricted mean survival time analysis for heart failure clinical trial evaluation and interpretation. JACC Heart Fail. 2020;8(12):973–983.
   PubMed Web of Science ®Google Scholar
• Uno H, Claggett B, Tian L, et al. Moving beyond the hazard ratio in quantifying the between-group difference in survival analysis. J Clin Oncol. 2014;32(22):2380–2385.
   PubMed Web of Science ®Google Scholar
• Moher D, Liberati A, Tetzlaff J, PRISMA Group, et al. Group P. Preferred reporting items for systematic reviews and Meta-analyses: the PRISMA statement. Int J Surg. 2010;8(5):336–341.
   PubMed Web of Science ®Google Scholar
• Moher D, Altman DG, Liberati A, et al. PRISMA statement. Epidemiology. 2011;22(1):128. author reply
   PubMed Web of Science ®Google Scholar
• Sterne JAC, Savović J, Page MJ, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898.
   PubMed Web of Science ®Google Scholar
• Dohm A, McTyre ER, Chan MD, et al. Early or late radiotherapy following gross or subtotal resection for atypical meningiomas: Clinical outcomes and local control. J Clin Neurosci. 2017;46:90–98.
   PubMed Web of Science ®Google Scholar
• Hammouche S, Clark S, Wong AH, et al. Long-term survival analysis of atypical meningiomas: survival rates, prognostic factors, operative and radiotherapy treatment. Acta Neurochir (Wien). 2014;156(8):1475–1481.
   PubMed Web of Science ®Google Scholar
• Keric N, Kalasauskas D, Freyschlag CF, et al. Impact of postoperative radiotherapy on recurrence of primary intracranial atypical meningiomas. J Neurooncol. 2020;146(2):347–355.
   PubMed Web of Science ®Google Scholar
• Lee KD, DePowell JJ, Air EL, et al. Atypical meningiomas: is postoperative radiotherapy indicated? Neurosurg Focus. 2013;35(6):E15.
   PubMed Web of Science ®Google Scholar
• Pant S, Tonse R, Kannan S, et al. Impact of timing of radiation therapy on outcomes in atypical meningioma: a clinical audit. Pract Radiat Oncol. 2018;8(5):e275–e284.
   PubMed Web of Science ®Google Scholar
• Shakir SI, Souhami L, Petrecca K, et al. Prognostic factors for progression in atypical meningioma. J Neurosurg. 2018;129(5):1240–1248.
   PubMed Web of Science ®Google Scholar
• Sun SQ, Kim AH, Cai C, et al. Management of atypical cranial meningiomas, part 1: predictors of recurrence and the role of adjuvant radiation after gross total resection. Neurosurgery. 2014;75(4):347–354. discussion 54-5; quiz 55.
   PubMed Web of Science ®Google Scholar
• Park HJ, Kang HC, Kim IH, et al. The role of adjuvant radiotherapy in atypical meningioma. J Neurooncol. 2013;115(2):241–247.
   PubMed Web of Science ®Google Scholar
• Graffeo CS, Leeper HE, Perry A, et al. Revisiting adjuvant radiotherapy after gross total resection of world health organization grade II meningioma. World Neurosurg. 2017;103:655–663.
   PubMed Web of Science ®Google Scholar
• Zhi M, Girvigian MR, Miller MJ, et al. Long-Term outcomes of newly diagnosed resected atypical meningiomas and the role of adjuvant radiotherapy. World Neurosurg. 2019;122:e1153–e1161.
   PubMed Web of Science ®Google Scholar
• Chen WC, Magill ST, Wu A, et al. Histopathological features predictive of local control of atypical meningioma after surgery and adjuvant radiotherapy. J Neurosurg. 2019;130(2):443–450.
   Web of Science ®Google Scholar
• Goldbrunner R, Stavrinou P, Jenkinson MD, et al. EANO guideline on the diagnosis and management of meningiomas. Neuro Oncol. 2021;23(11):1821–1834.
   PubMed Web of Science ®Google Scholar
• Rogers L, Zhang P, Vogelbaum MA, et al. Intermediate-risk meningioma: initial outcomes from NRG oncology RTOG 0539. J Neurosurg. 2018;129(1):35–47.
   PubMed Web of Science ®Google Scholar
• Weber DC, Ares C, Villa S, et al. Adjuvant postoperative high-dose radiotherapy for atypical and malignant meningioma: a phase-II parallel non-randomized and observation study (EORTC 22042-26042). Radiother Oncol. 2018;128(2):260–265.
   PubMed Web of Science ®Google Scholar
• Hasan S, Young M, Albert T, et al. The role of adjuvant radiotherapy after gross total resection of atypical meningiomas. World Neurosurg. 2015;83(5):808–815.
   PubMed Web of Science ®Google Scholar
• Pereira BJA, de Almeida AN, Paiva WS, et al. Impact of radiotherapy in atypical meningioma recurrence: literature review. Neurosurg Rev. 2019;42(3):631–637.
   PubMed Web of Science ®Google Scholar
• He L, Zhang B, Zhang J, et al. Effectiveness of postoperative adjuvant radiotherapy in atypical meningioma patients after gross total resection: a Meta-Analysis study. Front Oncol. 2020;10:556575.
   PubMed Web of Science ®Google Scholar
• Zoli M, Della Pepa GM, Carretta A, et al. Adjuvant radiotherapy in grossly total resected grade II atypical meningiomas: a protective effect on recurrence? J Neurosurg Sci. 2022;66(3):240–250.
   PubMed Web of Science ®Google Scholar
• Song D, Xu D, Han H, et al. Postoperative adjuvant radiotherapy in atypical meningioma patients: a Meta-Analysis study. Front Oncol. 2021;11:787962.
   PubMed Web of Science ®Google Scholar
• Jenkinson MD, Javadpour M, Haylock BJ, et al. The ROAM/EORTC-1308 trial: Radiation versus observation following surgical resection of atypical meningioma: study protocol for a randomised controlled trial. Trials. 2015;16:519.
   PubMed Web of Science ®Google Scholar
• Nassiri F, Liu J, Patil V, et al. A clinically applicable integrative molecular classification of meningiomas. Nature. 2021;597(7874):119–125.
   PubMed Web of Science ®Google Scholar
• Modha A, Gutin PH. Diagnosis and treatment of atypical and anaplastic meningiomas: a review. Neurosurgery. 2005;57(3):538–550. discussion -50.
   PubMed Web of Science ®Google Scholar
• Perry A, Stafford SL, Scheithauer BW, et al. The prognostic significance of MIB-1, p53, and DNA flow cytometry in completely resected primary meningiomas. Cancer. 1998;82(11):2262–2269.
   PubMed Web of Science ®Google Scholar
• Liu N, Song SY, Jiang JB, et al. The prognostic role of Ki-67/MIB-1 in meningioma: a systematic review with Meta-analysis. Medicine. 2020;99(9):e18644.
   PubMed Web of Science ®Google Scholar
• Chun SW, Kim KM, Kim MS, et al. Adjuvant radiotherapy versus observation following gross total resection for atypical meningioma: a systematic review and Meta-analysis. Radiat Oncol. 2021;16(1):34.
   PubMed Web of Science ®Google Scholar