The ultimate local failure rate after the watch-and-wait strategy for rectal cancer: a systematic review of literature and meta-analysis

References

• van der Valk MJM, Hilling DE, Bastiaannet E, et al. Long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer in the international watch & wait database (IWWD): an international multicentre registry study. Lancet. 2018;391(10139):2537–2545. doi: 10.1016/S0140-6736(18)31078-X.
   PubMed Web of Science ®Google Scholar
• Garcia-Aguilar J, Patil S, Gollub MJ, et al. Organ preservation in patients with rectal adenocarcinoma treated with total neoadjuvant therapy. J Clin Oncol. 2022;40(23):2546–2556. doi: 10.1200/JCO.22.00032.
   PubMed Web of Science ®Google Scholar
• Kong JC, Guerra GR, Warrier SK, et al. Outcome and salvage surgery following “watch and wait” for rectal cancer after neoadjuvant therapy: a systematic review. Dis Colon Rectum. 2017;60(3):335–345. doi: 10.1097/DCR.0000000000000754.
   PubMed Web of Science ®Google Scholar
• Bahadoer RR, Dijkstra EA, van Etten B, et al. RAPIDO collaborative investigators. Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial. Lancet Oncol. 2021;22(1):29–42. doi: 10.1016/S1470-2045(20)30555-6.
   PubMed Web of Science ®Google Scholar
• Conroy T, Bosset JF, Etienne PL, et al. Neoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal cancer (UNICANCER-PRODIGE 23): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol. 2021;22(5):702–715. doi: 10.1016/S1470-2045(21)00079-6.
   PubMed Web of Science ®Google Scholar
• Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. doi: 10.1136/bmj.n71.
   PubMed Web of Science ®Google Scholar
• Gerard JP, Barbet N, Schiappa R, et al. Neoadjuvant chemoradiotherapy with radiation dose escalation with contact x-ray brachytherapy boost or external beam radiotherapy boost for organ preservation in early cT2-cT3 rectal adenocarcinoma (OPERA): a phase 3, randomised controlled trial. Lancet Gastroenterol Hepatol. 2023;8(4):356–367. doi: 10.1016/S2468-1253(22)00392-2.
   PubMed Web of Science ®Google Scholar
• Garant A, Vasilevsky C-A, Boutros M, et al. MORPHEUS phase II-III study: a pre-planned interim safety analysis and preliminary results. Cancers (Basel). 2022;14:3665. doi: 10.3390/cancers14153665.
   PubMed Web of Science ®Google Scholar
• Wells GA, Shea B, O’Connell D, et al. The Newcastle-Ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa: Ottawa Hospital Research Institute, 2011. [cited 2023 March 25]. Available from: https://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
   Google Scholar
• Furuya-Kanamori L, Barendregt JJ, Doi SAR. A new improved graphical and quantitative method for detecting bias in meta-analysis. Int J Evid Based Healthc. 2018;16(4):195–203. doi: 10.1097/XEB.0000000000000141.
   PubMed Web of Science ®Google Scholar
• Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group. JAMA. 2000;283(15):2008–2012. doi: 10.1001/jama.283.15.2008.
   PubMed Web of Science ®Google Scholar
• Habr-Gama A, Sabbaga J, Gama-Rodrigues J, et al. Watch and wait approach following extended neoadjuvant chemoradiation for distal rectal cancer: are we getting closer to anal cancer management? Dis Colon Rectum. 2013;56(10):1109–1117. doi: 10.1097/DCR.0b013e3182a25c4e.
   PubMed Web of Science ®Google Scholar
• Appelt AL, Pløen J, Harling H, et al. High-dose chemoradiotherapy and watchful waiting for distal rectal cancer: a prospective observational study. Lancet Oncol. 2015;16(8):919–927. doi: 10.1016/S1470-2045(15)00120-5.
   PubMed Web of Science ®Google Scholar
• Wang L, Zhang XY, Zhao YM, et al. Intentional watch & wait or organ preservation surgery following neoadjuvant chemoradiotherapy plus consolidation CAPEOX for MRI-defined low-risk rectal cancer: findings from a prospective phase 2 trial (PKUCH-R01 trial, NCT02860234). Ann Surg. 2023;277(4):647–654. doi: 10.1097/SLA.0000000000005507.
   PubMed Web of Science ®Google Scholar
• Asoglu O, Bulut A, Aliyev V, et al. Chemoradiation and consolidation chemotherapy for rectal cancer provides a high rate of organ preservation with a very good long-term oncological outcome: a single-center cohort series. World J Surg Oncol. 2022;20(1):358. doi: 10.1186/s12957-022-02816-7.
   PubMed Web of Science ®Google Scholar
• Asoglu O, Tokmak H, Bakir B, et al. The impact of total neo-adjuvant treatment on nonoperative management in patients with locally advanced rectal cancer: the evaluation of 66 cases. Eur J Surg Oncol. 2020;46(3):402–409. doi: 10.1016/j.ejso.2019.07.012.
   PubMed Web of Science ®Google Scholar
• Pinto JC, Pereira AD, Pimenta A, et al. Low rectal cancer treatment strategies: a cohort study assessing watch and wait. J Cancer Res Clin Oncol. 2020;146(10):2631–2638. doi: 10.1007/s00432-020-03248-0.
   PubMed Web of Science ®Google Scholar
• van der Sande ME, Figueiredo N, Beets GL. Management and outcome of local regrowths in a watch-and-wait prospective cohort for complete responses in rectal cancer. Ann Surg. 2021;274(6):e1056–e1062. doi: 10.1097/SLA.0000000000003738.
   PubMed Web of Science ®Google Scholar
• Habr-Gama A, Gama-Rodrigues J, São Julião GP, et al. Local recurrence after complete clinical response and watch and wait in rectal cancer after neoadjuvant chemoradiation: impact of salvage therapy on local disease control. Int J Radiat Oncol Biol Phys. 2014;88(4):822–828. doi: 10.1016/j.ijrobp.2013.12.012.
   PubMed Web of Science ®Google Scholar
• Martens MH, Maas M, Heijnen LA, et al. Long-term outcome of an organ preservation program after neoadjuvant treatment for rectal cancer. J Natl Cancer Inst. 2016;108:djw171. doi: 10.1093/jnci/djw171.
   PubMedGoogle Scholar
• Bitterman DS, Resende Salgado L, Moore HG, et al. Predictors of complete response and disease recurrence following chemoradiation for rectal cancer. Front Oncol. 2015;5:286. doi: 10.3389/fonc.2015.00286.
   PubMed Web of Science ®Google Scholar
• Dalton RS, Velineni R, Osborne ME, et al. A single-Centre experience of chemoradiotherapy for rectal cancer: is there potential for nonoperative management? Colorectal Dis. 2012;14(5):567–571. doi: 10.1111/j.1463-1318.2011.02752.x.
   PubMed Web of Science ®Google Scholar
• Torres-Mesa PA, Oliveros R, Mesa J, et al. Desenlaces del manejo no quirúrgico posterior a neoadyuvancia del cáncer localmente avanzado de recto. Rev Colomb Cancerol. 2014;18(3):109–119. doi: 10.1016/j.rccan.2014.05.003.
   Google Scholar
• Gossedge G, Montazeri A, Nandhra A, et al. Complete clinical response to chemoradiotherapy for rectal cancer. Is it safe to ‘watch and wait’? Colorectal Dis. 2012;14(Suppl 2):20–21.
   Google Scholar
• Dickson-Lowe RA, Hanek P, Kalaskar S, et al. Non-operative management of low rectal cancer with complete response to standard neoadjuvant chemoradiotherapy. Gut. 2015;64(Suppl 1):A554–A555. doi: 10.1136/gutjnl-2015-309861.1217.
   PubMedGoogle Scholar
• Coraglio MF, Eleta MA, Kujaruk MR, et al. Analysis of long-term oncological results of clinical versus pathological responses after neoadjuvant treatment in locally advanced rectal cancer. World J Surg Oncol. 2020;18(1):313. doi: 10.1186/s12957-020-02094-1.
   PubMed Web of Science ®Google Scholar
• Lee JK, Cho JR, Song KS, et al. Oncologic comparison between nonradical management and total mesorectal excision in good responders after chemoradiotherapy in patients with mid-to-low rectal cancer. Ann Surg Treat Res. 2021;101(2):93–101. doi: 10.4174/astr.2021.101.2.93.
   PubMed Web of Science ®Google Scholar
• Yeom SS, Lee SY, Kim CH, et al. Non-operative treatment outcome for rectal cancer patient with clinical complete response after neoadjuvant chemoradiotherapy. Asian J Surg. 2019;42(8):823–831. doi: 10.1016/j.asjsur.2018.12.007.
   PubMed Web of Science ®Google Scholar
• Al-Najami I, Jones HJ, Dickson EA, et al. Rectal cancer: watch-and-wait and continuing the rectal-preserving strategy with local excision for incomplete response or limited regrowth. Surg Oncol. 2021;37:101574. doi: 10.1016/j.suronc.2021.101574.
   PubMed Web of Science ®Google Scholar
• Wang QX, Zhang R, Xiao WW, et al. The watch-and-wait strategy versus surgical resection for rectal cancer patients with a clinical complete response after neoadjuvant chemoradiotherapy. Radiat Oncol. 2021;16(1):16. doi: 10.1186/s13014-021-01746-0.
   PubMed Web of Science ®Google Scholar
• Nilsson PJ, Ahlberg M, Kordnejad S, et al. Organ preservation following short-course radiotherapy for rectal cancer. BJS Open. 2021;5:zrab093. doi: 10.1093/bjsopen/zrab093.
   PubMed Web of Science ®Google Scholar
• Cotti GC, Pandini RV, Braghiroli OFM, et al. Outcomes of patients with local regrowth after nonoperative management of rectal cancer after neoadjuvant chemoradiotherapy. Dis Colon Rectum. 2022;65(3):333–339. doi: 10.1097/DCR.0000000000002197.
   PubMed Web of Science ®Google Scholar
• Lee SY, Chang HK, Young JK, et al. Oncologic outcomes according to the treatment strategy in radiologic complete responders after neoadjuvant chemoradiation for rectal cancer. Oncology. 2015;89(6):311–318. doi: 10.1159/000439279.
   PubMed Web of Science ®Google Scholar
• Hsu YJ, Chern YJ, Lai IL, et al. Usefulness of close surveillance for rectal cancer patients after neoadjuvant chemoradiotherapy. Open Med. 2022;17(1):1438–1448. doi: 10.1515/med-2022-0555.
   Web of Science ®Google Scholar
• Neşşar G, Demirbağ AE, Mısırlıoğlu HC, et al. “Watch and wait" approach in rectal cancer patients following complete clinical response to neoadjuvant chemoradiotherapy does not compromise oncologic outcomes. Turk J Gastroenterol. 2019;30(11):951–956. doi: 10.5152/tjg.2019.18984.
   PubMed Web of Science ®Google Scholar
• Sposato LA, Lam Y, Karapetis C, et al. Observation of “complete clinical response” in rectal cancer after neoadjuvant chemoradiation: the flinders experience. Asia Pac J Clin Oncol. 2018;14(6):439–445. doi: 10.1111/ajco.12993.
   PubMed Web of Science ®Google Scholar
• D'Amata G, Manzi F, Florio G, et al. The “watch and wait” approach following chemoradiotherapy for rectal cancer: a case series and review of literature. Ann Ital Chir. 2021;10:S0003469X2103534X.
   PubMedGoogle Scholar
• Beard BW, Rettig RL, Ryoo JJ, et al. Watch-and-Wait compared to operation for patients with complete response to neoadjuvant therapy for rectal cancer. J Am Coll Surg. 2020;231(6):681–692. doi: 10.1016/j.jamcollsurg.2020.08.775.
   PubMed Web of Science ®Google Scholar
• Dai D, Liu G, Liu H, et al. Clinical feasibility of the therapeutic strategies total neoadjuvant therapy and “watch and wait” in the treatment of rectal cancer patients with recurrence after clinical complete response. Front Surg. 2022;9:1006624. doi: 10.3389/fsurg.2022.1006624.
   PubMed Web of Science ®Google Scholar
• Engineer R, Saklani A, D'souza A, et al. Watch and wait approach after neoadjuvant chemoradiotherapy in rectal cancer: initial experience in the Indian subcontinent. Indian J Surg Oncol. 2021;12(4):664–670. doi: 10.1007/s13193-021-01421-6.
   PubMed Web of Science ®Google Scholar
• Simpson G, Hopley P, Wilson J, et al. Long-term outcomes of real world 'watch and wait’ data for rectal cancer after neoadjuvant chemoradiotherapy. Colorectal Dis. 2020;22(11):1568–1576. doi: 10.1111/codi.15177.
   PubMed Web of Science ®Google Scholar
• Rega D, Granata V, Romano C, et al. Watch and wait approach for rectal cancer following neoadjuvant treatment: the experience of a high volume cancer center. Diagnostics. 2021;11:1507. doi: 10.3390/diagnostics11081507.
   Web of Science ®Google Scholar
• Chapman BC, Lai S, Friedrich T, et al. Rectal cancer: clinical and molecular predictors of a complete response to total neoadjuvant therapy. Dis Colon Rectum. 2023;66(4):521–530. doi: 10.1097/DCR.0000000000002245.
   PubMed Web of Science ®Google Scholar
• Smith JJ, Strombom P, Chow OS, et al. Assessment of a watch-and-Wait strategy for rectal cancer in patients with a complete response after neoadjuvant therapy. JAMA Oncol. 2019;5(4):e185896. doi: 10.1001/jamaoncol.2018.5896.
   PubMed Web of Science ®Google Scholar
• Smith RK, Fry RD, Mahmoud NN, et al. Surveillance after neoadjuvant therapy in advanced rectal cancer with complete clinical response can have comparable outcomes to total mesorectal excision. Int J Colorectal Dis. 2015;30(6):769–774. doi: 10.1007/s00384-015-2165-2.
   PubMed Web of Science ®Google Scholar
• Dijkstra EA, Nilsson PJ, Hospers GAP, et al. Locoregional failure during and after short-course radiotherapy followed by chemotherapy and surgery compared to long-course chemoradiotherapy and surgery – A five-year follow-up of the RAPIDO trial. Ann Surg. 2023;4:e288. doi: 10.1097/SLA.0000000000005799.
   Google Scholar
• Renehan AG, Malcomson L, Emsley R, et al. Watch-and-wait approach versus surgical resection after chemoradiotherapy for patients with rectal cancer (the OnCoRe project): a propensity-score matched cohort analysis. Lancet Oncol. 2016;17(2):174–183. doi: 10.1016/S1470-2045(15)00467-2.
   PubMed Web of Science ®Google Scholar
• Maas M, Nelemans PJ, Valentini V, et al. Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data. Lancet Oncol. 2010;11(9):835–844. doi: 10.1016/S1470-2045(10)70172-8.
   PubMed Web of Science ®Google Scholar
• Jankowski M, Pietrzak L, Rupiński M, et al. Watch-and-wait strategy in rectal cancer: is there a tumour size limit? Results from two pooled prospective studies. Radiother Oncol. 2021;160:229–235. doi: 10.1016/j.radonc.2021.05.014.
   PubMed Web of Science ®Google Scholar
• Bulens PP, Smets L, Debucquoy A, et al. Nonoperative versus operative approach according to the response to neoadjuvant chemoradiotherapy for rectal cancer: a prospective cohort study. Clin Transl Radiat Oncol. 2022;36:113–120. doi: 10.1016/j.ctro.2022.07.009.
   PubMed Web of Science ®Google Scholar
• Garant A, Magnan S, Devic S, et al. Image guided adaptive endorectal brachytherapy in the nonoperative management of patients with rectal cancer. Int J Radiat Oncol Biol Phys. 2019;105(5):1005–1011. doi: 10.1016/j.ijrobp.2019.08.042.
   PubMed Web of Science ®Google Scholar
• Martens MH, van Heeswijk MM, van den Broek JJ, et al. Prospective, multicenter validation study of magnetic resonance volumetry for response assessment after preoperative chemoradiation in rectal cancer: can the results in the literature be reproduced? Int J Radiat Oncol Biol Phys. 2015;93(5):1005–1014. doi: 10.1016/j.ijrobp.2015.09.008.
   PubMed Web of Science ®Google Scholar
• Fernandez LM, São Julião GP, Renehan AG, et al. The risk of distant metastases in patients with clinical complete response managed by watch and wait after neoadjuvant therapy for rectal cancer: the influence of local regrowth in the international watch and wait database. Dis Colon Rectum. 2023;66(1):41–49. doi: 10.1097/DCR.0000000000002494.
   PubMed Web of Science ®Google Scholar
• Socha J, Kępka L, Michalski W, et al. The risk of distant metastases in rectal cancer managed by a watch-and-wait strategy – A systematic review and meta-analysis. Radiother Oncol. 2020;144:1–6. doi: 10.1016/j.radonc.2019.10.009.
   PubMed Web of Science ®Google Scholar