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Current Medical Research and Opinion Volume 35, 2019 - Issue 6
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Diabetes

Impact of dose capping in insulin glargine/lixisenatide fixed-ratio combination trials in patients with type 2 diabetes

Wolfgang SchmiderSanofi Germany, Frankfurt, Germany; Correspondence[email protected]
,
Rene BelderSanofi US, Inc., Bridgewater, NJ, USA;
,
Michelle LeeSanofi US, Inc., Bridgewater, NJ, USA;
,
Elisabeth NiemoellerSanofi Germany, Frankfurt, Germany;
,
Elisabeth SouhamiSanofi Paris, Paris, France;
&
Juan P. FriasNational Research Institute, Los Angeles, CA, USA
Pages 1081-1089 | Received 20 Jun 2018, Accepted 11 Dec 2018, Published online: 11 Jan 2019

References

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  • Rosenstock J, Aronson R, Grunberger G, et al. Benefits of LixiLan, a titratable fixed-ratio combination of insulin glargine plus lixisenatide, versus insulin glargine and lixisenatide monocomponents in type 2 diabetes inadequately controlled on oral agents: the LixiLan-O randomized trial. Diabetes Care. 2016;39(11):2026–2035.
  • Rosenstock J, Diamant M, Aroda VR, et al. Efficacy and safety of LixiLan, a titratable fixed-ratio combination of lixisenatide and insulin glargine, versus insulin glargine in type 2 diabetes inadequately controlled on metformin monotherapy: the LixiLan proof-of-concept randomized trial. Diabetes Care. 2016;39(9):1579–1586.
  • Khunti K, Millar-Jones D. Clinical inertia to insulin initiation and intensification in the UK: a focused literature review. Prim Care Diabetes. 2017;11(1):3–12.
  • Reid T, Gao L, Gill J, et al. How much is too much? Outcomes in patients using high-dose insulin glargine. Int J Clin Pract. 2016;70(1):56–65.

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