Advanced search
Publication Cover
Current Medical Research and Opinion Volume 36, 2020 - Issue 3
Submit an article Journal homepage
513
Views
9
CrossRef citations to date
0
Altmetric
Neurology

Real-world evidence of the safety and efficacy profile of suvorexant in elderly patients with insomnia: a sub-analysis of the post-marketing drug-use results survey in Japan

Yuko TakeuchiMedical Information, Medical Affairs, MSD K.K., Tokyo, Japan; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-2701-3840
ORCID Icon,
Hideki SanoMedical Information, Medical Affairs, MSD K.K., Tokyo, Japan; ORCID Iconhttp://orcid.org/0000-0002-1964-5824
ORCID Icon,
Yuko AsaiPharmacovigilance, MSD K.K., Tokyo, Japan
,
Makoto MiyazakiPharmacovigilance, MSD K.K., Tokyo, Japan
,
Mika IwakuraPharmacovigilance, MSD K.K., Tokyo, Japan
&
Yoshikazu MaedaPharmacovigilance, MSD K.K., Tokyo, Japan
Pages 465-471 | Received 22 May 2019, Accepted 30 Nov 2019, Published online: 20 Dec 2019

References

  • Ford ES, Cunningham TJ, Giles WH, et al. Trends in insomnia and excessive daytime sleepiness among U.S. adults from 2002 to 2012. Sleep Med. 2015;16(3):372–378.
  • Morin CM, Belanger L, LeBlanc M, et al. The natural history of insomnia: a population-based 3-year longitudinal study. Arch Intern Med. 2009;169(5):447–453.
  • Sateia MJ, Buysse DJ, Krystal AD, et al. Clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults: An American Academy of Sleep Medicine clinical practice guideline. JCSM. 2017;13(02):307–349.
  • Kojima T, Akishita M, Kameyama Y, et al. High risk of adverse drug reactions in elderly patients taking six or more drugs: analysis of inpatient database. Geriatr Gerontol Int. 2012;12(4):761–762.
  • Patel D, Steinberg J, Patel P. Insomnia in the elderly: a review. JCSM. 2018;14(06):1017–1024.
  • Olfson M, King M, Schoenbaum M. Benzodiazepine use in the United States. JAMA Psych. 2015;72(2):136–142.
  • Rudolph U, Knoflach F. Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes. Nat Rev Drug Discov. 2011;10(9):685–697.
  • Donnelly K, Bracchi R, Hewitt J, et al. Benzodiazepines, Z-drugs and the risk of hip fracture: a systematic review and meta-analysis. PLoS One. 2017;12(4):e0174730.
  • Billioti de Gage S, Begaud B, Bazin F, et al. Benzodiazepine use and risk of dementia: prospective population-based study. BMJ. 2012;345(sep27 4):e6231.
  • Glass J, Lanctot KL, Herrmann N, et al. Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits. BMJ. 2005;331(7526):1169.
  • MSD K.K. Belsomra® tablets package insert. Revised November 2018. 6th ed. Tokyo: MSD K.K.; 2016 (in Japanese). Available from: https://www.info.pmda.go.jp/go/pdf/170050_1190023F1024_1_11
  • Herring WJ, Connor KM, Snyder E, et al. Suvorexant in patients with Insomnia: pooled analyses of three-month data from phase-3 randomized controlled clinical trials. JCSM. 2016;12(09):1215–1225.
  • Herring WJ, Connor KM, Snyder E, et al. Suvorexant in elderly patients with insomnia: Pooled analyses of data from phase III randomized controlled clinical trials. Am J Geriatr Psychiatry. 2017;25(7):791–802.
  • Asai Y, Sano H, Miyazaki M, et al. Suvorexant (Belsomra® tablets 10 mg,15 mg, and 20 mg): Japanese drug-use results survey. Drugs R D. 2019;19(1):27–46.
  • Herring WJ, Connor KM, Ivgy-May N, et al. Suvorexant in patients with insomnia: results from two 3-month randomized controlled Ccinical trials. Biol Psychiatry. 2016;79(2):136–148.
  • Ray WA, Thapa PB, Gideon P. Benzodiazepines and the risk of falls in nursing home residents. J Am Geriatr Soc. 2000;48(6):682–685.
  • Kaneita Y, Ohida T, Uchiyama M, et al. Excessive daytime sleepiness among the Japanese general population. J Epidemiol. 2005;15(1):1–8.
  • Hellström A, Hagell P, Fagerström C, et al. Measurement properties of the Minimal Insomnia Symptom Scale (MISS) in an elderly population in Sweden. BMC Geriatr. 2010;10(1):84.
  • MSD K.K. New drug application [NDA] report. Japan: Pharmaceuticals and medical devices agency [PMDA] [cited 2014 Sep 26]. Available from: http://www.pmda.go.jp/drugs/2014/P201400117/170050000_22600AMX01302_K101_1.pdf.
  • Sano H. Use of suvorexant a dual orexin receptor antagonist, for the treatment of insomnia in elderly patients based on clinical trial results. J New Rem. Clin. 2017;2:134–143.
  • Takeshima N, Ogawa Y, Hayasaka Y, et al. Continuation and discontinuation of benzodiazepine prescriptions: a cohort study based on a large claims database in Japan. Psychiatry Res. 2016;237:201–207.
  • Hata T, Kanazawa T, Hamada T, et al. What can predict and prevent the long-term use of benzodiazepines? J Psychiatr Res. 2018;97:94–100.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.