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Cardiovascular Medicine

Homozygosity of the TT methylenetetrahydrofolate reductase C677T genotype is an independent long-term predictor of cardiac death in patients with premature myocardial infarction

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Pages 1079-1084 | Received 25 Nov 2020, Accepted 31 Mar 2021, Published online: 21 Apr 2021

References

  • Santilli F, Davì G, Patrono C. Homocysteine, methylenetetrahydrofolate reductase, folate status and atherothrombosis: a mechanistic and clinical perspective. Vascul Pharmacol. 2016;78:1–9.
  • Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA. 2002;288:2015–2022.
  • Rallidis LS, Kosmas N, Rallidi T, et al. Homocysteine is an independent predictor of long-term cardiac mortality in patients with stable coronary artery disease in the era of statins. Coron Artery Dis. 2020;31(2):152–156.
  • Klerk M, Verhoef P, Clarke R, et al. MTHFR 677C->T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA. 2002;288(16):2023–2031.
  • Hou X, Chen X, Shi J. Genetic polymorphism of MTHFR C677T and premature coronary artery disease susceptibility: a meta-analysis. Gene. 2015;565(1):39–44.
  • Mager A, Lalezari S, Shohat T, et al. Methylenetetrahydrofolate reductase genotypes and early-onset coronary artery disease. Circulation. 1999;100(24):2406–2410.
  • Lewis SJ, Ebrahim S, Smith GD. Meta-analysis of MTHFR 677C→T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate? Br Med J. 2005;331(7524):1053–1056.
  • Rallidis LS, Gialeraki A, Komporozos C, et al. Role of methylenetetrahydrofolate reductase 677C->T polymorphism in the development of premature myocardial infarction. Atherosclerosis. 2008;200(1):115–120.
  • Heijmans BT, Gussekloo J, Kluft C, et al. Mortality risk in men is associated with a common mutation in the methylene-tetrahydrofolate reductase gene (MTHFR)). Eur J Hum Genet. 1999;7(2):197–204.
  • Yang Q, Bailey L, Clarke R, et al. Prospective study of methylenetetrahydrofolate reductase (MTHFR) variant C677T and risk of all-cause and cardiovascular disease mortality among 6000 US adults. Am J Clin Nutr. 2012;95(5):1245–1253.
  • Roest M, Van Der Schouw YT, Grobbee DE, et al. Methylenetetrahydrofolate reductase 677 C/T genotype and cardiovascular disease mortality in postmenopausal women. Am J Epidemiol. 2001;153(7):673–679.
  • Pereira AC, Miyakawa AA, Lopes NHM, et al. Dynamic regulation of MTHFR mRNA expression and C677T genotype modulate mortality in coronary artery disease patients after revascularization. Thromb Res. 2007;121(1):25–32.
  • Osmak GJ, Titov BV, Matveeva NA, et al. Impact of 9p21.3 region and atherosclerosis-related genes’ variants on long-term recurrent hard cardiac events after a myocardial infarction. Gene. 2018;647:283–288.
  • Andreassi MG, Adlerstein D, Carpeggiani C, et al. Individual and summed effects of high-risk genetic polymorphisms on recurrent cardiovascular events following ischemic heart disease. Atherosclerosis. 2012;223(2):409–415.
  • Botto N, Andreassi MG, Rizza A, et al. C677T polymorphism of the methylenetetrahydrofolate reductase gene is a risk factor of adverse events after coronary revascularization. Int J Cardiol. 2004;96(3):341–345.
  • Garcia-Pinilla JM, Espinosa-Caliani S, Jimenez-Navarro M, et al. Influence of 677 C–>T polymorphism of methylenetetrahydrofolate reductase on medium-term prognosis after acute coronary syndromes. Heart Inst J. 2007;34:142–147.
  • Vulapalli R, Liang C, Zareba W, et al. Recurrent coronary events are not increased in postinfarction patients with methylenetetrahydrofolate reductase gene C677T polymorphism. Am J Cardiol. 2001;87(11):1289–1292.
  • Koch W, Ndrepepa G, Mehilli J, et al. Homocysteine status and polymorphisms of methylenetetrahydrofolate reductase are not associated with restenosis after stenting in coronary arteries. Arterioscler Thromb Vasc Biol. 2003;23(12):2229–2234.
  • Verdoia M, Schaffer A, Cassetti E, et al. MTHFR polymorphism and risk of periprocedural myocardial infarction after coronary stenting. Nutr Metab Cardiovasc Dis. 2014;24(5):532–537.
  • Rallidis LS, Gialeraki A, Triantafyllis AS, et al. Characteristics and long-term prognosis of patients ≤35 years of age with ST segment elevation myocardial infarction and “Normal or near normal” coronary arteries. Am J Cardiol. 2017;120(5):740–746.
  • Peng HY, Man CF, Xu J, et al. Elevated homocysteine levels and risk of cardiovascular and all-cause mortality: a meta-analysis of prospective studies. J Zhejiang Univ Sci B. 2015;16(1):78–86.
  • Martí-Carvajal AJ, Solà I, Lathyris D, et al. Homocysteine-lowering interventions for preventing cardiovascular events. Cochrane Database Syst Rev. 2017;8:CD006612.
  • Zhao JV, Schooling CM. Homocysteine-reducing B vitamins and ischemic heart disease: a separate-sample Mendelian randomization analysis. Eur J Clin Nutr. 2017;71(2):267–273.
  • Frederiksen J, Juul K, Grande P, et al. Methylenetetrahydrofolate reductase polymorphism (C677T), hyperhomocysteinemia, and risk of ischemic cardiovascular disease and venous thromboembolism: prospective and case-control studies from the Copenhagen City Heart Study. Blood. 2004;104(10):3046–3051.
  • Clarke R, Bennett DA, Parish S, et al. Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias. PLoS Med. 2012;9(2):e1001177.
  • Botto LD, Yang Q. 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol. 2000;151(9):862–877.
  • Xuan C, Bai XY, Gao G, et al. Association between polymorphism of methylenetetrahydrofolate reductase (MTHFR) C677T and risk of myocardial infarction: a meta-analysis for 8,140 cases and 10,522 controls. Arch Med Res. 2011;42(8):677–685.
  • Meleady R, Ueland PM, Blom H, et al. Thermolabile methylenetetrahydrofolate reductase, homocysteine, and cardiovascular disease risk: the European Concerted Action Project. Am J Clin Nutr. 2003;77(1):63–70.

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