Post-COVID-19 syndrome, low-grade inflammation and inflammatory markers: a cross-sectional study

References

• World Health Organization (WHO). Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020. [cited 2020 February 12]. Available from: http://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-.
   Google Scholar
• Costanzo M, De Giglio MAR, Roviello GN. Anti-coronavirus vaccines: past investigations on SARS-CoV-1 and MERS-CoV, the approved vaccines from BioNTech/Pfizer, Moderna, Oxford/AstraZeneca and others under development against SARS-CoV-2 infection. Curr Med Chem. 2022;29(1):4–18.
   PubMed Web of Science ®Google Scholar
• Kim AY, Gandhi RT. Coronavirus disease 2019 (COVID-19): management in hospitalized adults. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc; 2022.
   Google Scholar
• Borbone N, Piccialli G, Roviello GN, et al. Nucleoside analogs and nucleoside precursors as drugs in the fight against SARS-CoV-2 and other coronaviruses. Molecules. 2021;26(4):986.
   PubMed Web of Science ®Google Scholar
• Meeting the challenge of long COVID (editorial). Nat Med. 2020;26(12):1803.
   PubMed Web of Science ®Google Scholar
• Brodin P. Immune determinants of COVID-19 disease presentation and severity. Nat Med. 2021;27(1):28–33.
   PubMed Web of Science ®Google Scholar
• Akbarialiabad H, Taghrir MH, Abdollahi A, et al. Long COVID, a comprehensive systematic scoping review. Infection. 2021;49(6):1163–1186.
   PubMed Web of Science ®Google Scholar
• Evans RA, McAuley H, Harrison EM, et al. Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study. Lancet Respir Med. 2021;9(11):1275–1287.
   PubMed Web of Science ®Google Scholar
• Understanding long COVID: a modern medical challenge (editorial). Lancet. 2021;398(10302):725.
   PubMed Web of Science ®Google Scholar
• Mikkelsen ME, Abramoff B. COVID-19: evaluation and management of adults following acute viral illness. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. (Accessed on October 30, 2021.
   Google Scholar
• de Sire A, Andrenelli E, Negrini F, et al. International multiprofessional steering committee of Cochrane rehabilitation REH-COVER action. Rehabilitation and COVID-19: update of the rapid living systematic review by Cochrane rehabilitation field as of August 31st, 2021. Eur J Phys Rehabil Med. 2021;57(6):1045–1048.
   PubMed Web of Science ®Google Scholar
• Ferraro F, Calafiore D, Dambruoso F, et al. COVID-19 related fatigue: which role for rehabilitation in post-COVID-19 patients? A case series. J Med Virol. 2021;93(4):1896–1899.
   PubMed Web of Science ®Google Scholar
• Decary S, Dugas M, Stefan T, et al. Care Models for Long COVID - A Rapid Systematic Review. SPOR Evidence Alliance, COVID-END Network. 2021.
   Google Scholar
• O'Connor RJ, Preston N, Parkin A, et al. The COVID-19 Yorkshire Rehabilitation Scale (C19-YRS): application and psychometric analysis in a post-COVID-19 syndrome cohort. J Med Virol. 2022;94(3):1027–1034.
   PubMed Web of Science ®Google Scholar
• Klok FA, Boon GJ, Barco S, et al. The Post-COVID-19 functional status scale: a tool to measure functional status over time after COVID-19. Eur Respir J. 2020;56(1):2001494.
   PubMed Web of Science ®Google Scholar
• Altmann DM, Boyton RJ. Confronting the pathophysiology of long COVID. London: BMJ Opinion; 2020.
   Google Scholar
• Castanares-Zapatero D, Chalon P, Van den Heede K. Pathophysiology of long COVID: a preliminary report. COVID-19 KCE contributions. Belgian Health Care Knowledge Centre. 2021.
   Google Scholar
• Yong SJ. Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments. Infect Dis. 2021;53(10):737–754.
   PubMed Web of Science ®Google Scholar
• Salmon-Ceron D, Slama D, De Broucker T, et al. Clinical, virological and imaging profile in patients with prolonged forms of COVID-19: a cross-sectional study. J Infect. 2021;82(2):e1–e4.
   PubMed Web of Science ®Google Scholar
• Torjesen I. Covid-19: middle aged women face greater risk of debilitating long term symptoms. BMJ. 2021;372:n829.
   PubMed Web of Science ®Google Scholar
• Yeoh YK, Zuo T, Lui GC, et al. Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19. Gut. 2021;70(4):698–706.
   PubMed Web of Science ®Google Scholar
• Amenta EM, Spallone A, Rodriguez-Barradas MC, et al. Postacute COVID-19: an overview and approach to classification. Open Forum Infect Dis. 2020;7(12):ofaa509.
   PubMed Web of Science ®Google Scholar
• British Society for Immunology. Report: Long-term immunological health consequences of COVID-19; 2020.
   Google Scholar
• Saini G, Aneja R. Cancer as a prospective sequela of long COVID-19. Bioessays. 2021;43(6):e2000331.
   PubMed Web of Science ®Google Scholar
• Furman D, Campisi J, Verdin E, et al. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019;25(12):1822–1832.
   PubMed Web of Science ®Google Scholar
• Pahwa R, Goyal A, Bansal P, et al. Chronic inflammation. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2021.
   Google Scholar
• Townsend L, Dyer AH, Jones K, et al. Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection. PLOS One. 2020;15(11):e0240784.
   PubMed Web of Science ®Google Scholar
• Halpin S, O'Connor R, Sivan M. Long COVID and chronic COVID syndromes. J Med Virol. 2021;93(3):1242–1243.
   PubMed Web of Science ®Google Scholar
• World Health Organization (WHO) Publications: Clinical management of COVID-19: living guidance (2nd version); 2021.
   Google Scholar
• Centers for Disease Control and Prevention (CDC) Science Brief: Coronavirus Disease 2019 (COVID-19): Evidence used to update the list of underlying medical conditions that increase a person's risk of severe illness from COVID-19. 2021.
   Google Scholar
• Jin X, Lian JS, Hu JH, et al. Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms. Gut. 2020;69(6):1002–1009.
   PubMed Web of Science ®Google Scholar
• National Institute for Care and Excellence (NICE) guideline [NG188]: managing the long–term effects of COVID-19; 2020.
   Google Scholar
• Brenner DR, Scherer D, Muir K, et al. A review of the application of inflammatory biomarkers in epidemiologic cancer research. Cancer Epidemiol Biomarkers Prev. 2014;23(9):1729–1751.
   PubMed Web of Science ®Google Scholar
• Luyendyk JP, Schoenecker JG, Flick MJ. The multifaceted role of fibrinogen in tissue injury and inflammation. Blood. 2019;133(6):511–520.
   PubMed Web of Science ®Google Scholar
• Wannamethee SG, Whincup PH, Lennon L, et al. Associations between fibrin D-dimer, markers of inflammation, incident self-reported mobility limitation, and all-cause mortality in older men. J Am Geriatr Soc. 2014;62(12):2357–2362.
   PubMed Web of Science ®Google Scholar
• Dinh KM, Kaspersen KA, Mikkelsen S, et al. Low-grade inflammation is negatively associated with physical Health-Related quality of life in healthy individuals: results from the Danish Blood Donor Study (DBDS). PLOS One. 2019;14(3):e0214468.
   PubMed Web of Science ®Google Scholar
• Imtiaz F, Shafique K, Mirza SS, et al. Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med. 2012;5(1):2.
   PubMedGoogle Scholar
• Mandrekar JN. Receiver operating characteristic curve in diagnostic test assessment. J Thorac Oncol. 2010;5(9):1315–1316.
   PubMed Web of Science ®Google Scholar
• Tang D, Kang R, Coyne CB, et al. PAMPs and DAMPs: signal 0s that spur autophagy and immunity. Immunol Rev. 2012;249(1):158–175.
   PubMed Web of Science ®Google Scholar
• Shenoy S. Coronavirus (covid-19) sepsis: revisiting mitochondrial dysfunction in pathogenesis, aging, inflammation, and mortality. Inflamm Res. 2020;69(11):1077–1085.
   PubMed Web of Science ®Google Scholar
• Cicco S, Cicco G, Racanelli V, et al. Neutrophil Extracellular Traps (NETs) and Damage-Associated Molecular Patterns (DAMPs): two potential targets for COVID-19 treatment. Mediators Inflamm. 2020;2020:7527953.
   PubMed Web of Science ®Google Scholar
• Low RN, Low RJ, Akrami A. A Cytokine-based Model for the Pathophysiology of Long COVID Symptoms. OSF preprints. 2020.
   Google Scholar
• Doykov I, Hällqvist J, Gilmour KC, et al. The long tail of covid-19' – the detection of a prolonged inflammatory response after a SARS-CoV-2 infection in asymptomatic and mildly affected patients. F1000Res. 2020;9:1349.
   PubMedGoogle Scholar
• Holmes E, Wist J, Masuda R, et al. Incomplete systemic recovery and metabolic phenoreversion in post-acute-phase nonhospitalized COVID-19 patients: implications for assessment of post-acute COVID-19 syndrome. J Proteome Res. 2021;20(6):3315–3329.
   PubMed Web of Science ®Google Scholar
• Sudre CH, Murray B, Varsavsky T, et al. Attributes and predictors of long COVID. Nat Med. 2021;27(4):626–631.
   PubMed Web of Science ®Google Scholar
• Lopez-Leon S, Wegman-Ostrosky T, Perelman C, et al. More than 50 long-term effects of COVID-19: a systematic review and meta-analysis. Sci Rep. 2021;11(1):16144.
   PubMed Web of Science ®Google Scholar
• Soehnlein O, Steffens S, Hidalgo A, et al. Neutrophils as protagonists and targets in chronic inflammation. Nat Rev Immunol. 2017;17(4):248–261.
   PubMed Web of Science ®Google Scholar
• Nguyen NN, Hoang VT, Lagier JC, et al. Long-term persistence of olfactory and gustatory disorders in COVID-19 patients. Clin Microbiol Infect. 2021;27(6):931–932.
   PubMed Web of Science ®Google Scholar
• Han AY, Mukdad L, Long JL, et al. Anosmia in COVID-19: mechanisms and significance. Chem Senses. 2020;17:bjaa040.
   Google Scholar
• Klein SL, Marriott I, Fish EN. Sex-based differences in immune function and responses to vaccination. Trans R Soc Trop Med Hyg. 2015;109(1):9–15.
   PubMed Web of Science ®Google Scholar
• Gupta S, Nakabo S, Blanco LP, et al. Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism. Proc Natl Acad Sci USA. 2020;117(28):16481–16491.
   PubMed Web of Science ®Google Scholar
• Saussez S, Lechien JR, Hopkins C. Anosmia: an evolution of our understanding of its importance in COVID-19 and what questions remain to be answered. Eur Arch Otorhinolaryngol. 2021;278(7):2187–2191.
   PubMed Web of Science ®Google Scholar
• Caielli S, Banchereau J, Pascual V. Neutrophils come of age in chronic inflammation. Curr Opin Immunol. 2012;24(6):671–677.
   PubMed Web of Science ®Google Scholar
• Wåhlén K, Ernberg M, Kosek E, et al. Significant correlation between plasma proteome profile and pain intensity, sensitivity, and psychological distress in women with fibromyalgia. Sci Rep. 2020;10(1):12508.
   PubMed Web of Science ®Google Scholar
• Rosin DL, Okusa MD. Dangers within: DAMP responses to damage and cell death in kidney disease. J Am Soc Nephrol. 2011;22(3):416–425.
   PubMed Web of Science ®Google Scholar
• Takahashi T, Wong P, Ellingson MK, et al. Sex differences in immune responses that underlie COVID-19 disease outcomes. Nature. 2020;588(7837):315–320.
   PubMed Web of Science ®Google Scholar