Follitropin Alpha for assisted reproduction: an analysis based on a non-interventional study in Greece

References

• Worl Health Organisation. Infertility. Available from: https://www.who.int/news-room/fact-sheets/detail/infertility.
   Google Scholar
• Vander Borght M, Wyns C. Fertility and infertility: definition and epidemiology. Clin Biochem. 2018;62:2–10.
   PubMed Web of Science ®Google Scholar
• Greil AL, Shreffler KM, Schmidt L, et al. Variation in distress among women with infertility: evidence from a population-based sample. Hum Reprod. 2011;26(8):2101–122112.
   PubMed Web of Science ®Google Scholar
• Massarotti C, Gentile G, Ferreccio C, et al. Impact of infertility and infertility treatments on quality of life and levels of anxiety and depression in women undergoing in vitro fertilization. Gynecol Endocrinol. 2019;35(6):485–489.
   PubMed Web of Science ®Google Scholar
• Sominsky L, Hodgson DM, McLaughlin EA, et al. Linking stress and infertility: a novel role for ghrelin. Endocr Rev. 2017;38(5):432–467.
   PubMed Web of Science ®Google Scholar
• Fragoulakis V, Pescott CP, Smeenk JMJ, et al. Economic evaluation of three frequently used gonadotrophins in assisted reproduction techniques in the management of infertility in The Netherlands. Appl Health Econ Health Policy. 2016;14(6):719–727.
   PubMed Web of Science ®Google Scholar
• Inhorn MC, Patrizio P. Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century. Hum Reprod Update. 2015;21(4):411–426.
   PubMed Web of Science ®Google Scholar
• Rossi BV, Abusief M, Missmer SA. Modifiable risk factors and infertility: What are the connections? Am J Lifestyle Med. 2014;10(4):220–231.
   PubMedGoogle Scholar
• Bundhun PK, Janoo G, Bhurtu A, et al. Tobacco smoking and semen quality in infertile males: a systematic review and Meta-analysis. BMC Public Health. 2019;19(1):36.
   PubMed Web of Science ®Google Scholar
• Amirkhani JY-DS, Mirlohi SM, Nasiri SM, et al. Correlation between abortion and infertility among nonsmoking women with a history of passive smoking in childhood and adolescence. Int J Reprod Med. 2014;2014:678530.
   PubMedGoogle Scholar
• Boeri LC, Ventimiglia E, et al. Heavy cigarette smoking and alcohol consumption are associated with impaired sperm parameters in primary infertile men. Asian J Androl. 2019;21(5):478–485.
   PubMed Web of Science ®Google Scholar
• Imterat M, Agarwal A, Esteves SC, et al. Impact of body mass index on female fertility and ART outcomes. Panminerva Med. 2019;61(1):58–67.
   PubMed Web of Science ®Google Scholar
• Gaskins AJ. Recent advances in understanding the relationship between long- and short-term weight change and fertility. F1000Res. 2018;7:1702.
   Google Scholar
• Salas-Huetos A, Bulló M, Salas-Salvadó J. Dietary patterns, foods and nutrients in male fertility parameters and fecundability: a systematic review of observational studies. Hum Reprod Update. 2017;23(4):371–389.
   PubMed Web of Science ®Google Scholar
• James-Todd TM, Chiu YH, Zota AR. Racial/ethnic disparities in environmental endocrine disrupting chemicals and women’s reproductive health outcomes: epidemiological examples across the life course. Curr Epidemiol Rep. 2016;3(2):161–180.
   PubMedGoogle Scholar
• Alves MG, Martins AD, Rato L, et al. Molecular mechanisms beyond glucose transport in diabetes-related male infertility. Biochim Biophys Acta. 2013;1832(5):626–635.
   PubMed Web of Science ®Google Scholar
• Monteleone P, Parrini D, Faviana P, et al. Female infertility related to thyroid autoimmunity: the ovarian follicle hypothesis. Am J Reprod Immunol. 2011;66(2):108–114.
   PubMed Web of Science ®Google Scholar
• Balasch J. Ageing and infertility: an overview. Gynecol Endocrinol. 2010;26(12):855–860.
   PubMed Web of Science ®Google Scholar
• Bracke A, Peeters K, Punjabi U, et al. A search for molecular mechanisms underlying male idiopathic infertility. Reprod Biomed Online. 2018;36(3):327–339.
   PubMed Web of Science ®Google Scholar
• Harper J, Geraedts J, Borry P, et al. Current issues in medically assisted reproduction and genetics in Europe: research, clinical practice, ethics, legal issues and policy. Hum Reprod. 2014;29(8):1603–1609.
   PubMed Web of Science ®Google Scholar
• Patki A, Bavishi H, Kumari C, et al. Urinary versus recombinant gonadotropins for ovarian stimulation in women undergoing treatment with assisted reproductive technology. J Hum Reprod Sci. 2018;11(2):119–124.
   PubMedGoogle Scholar
• Šprem Goldštajn M, Mikuš M, Ćorić M, et al. The pharmacoeconomic impact of follitropin alpha biosimilars in IVF therapy in Europe: a report of the literature. Expert Rev Pharmacoecon Outcomes Res. 2021;21(4):553–558.
   PubMed Web of Science ®Google Scholar
• Buhler K. Managing infertility with the follitropin alfa prefilled pen injector – patient considerations. Ther Clin Risk Manag. 2015;11:995–1001.
   PubMed Web of Science ®Google Scholar
• Nahuis M, van der Veen F, Oosterhuis J, et al. Review of the safety, efficacy, costs and patient acceptability of recombinant follicle-stimulating hormone for injection in assisting ovulation induction in infertile women. Int J Womens Health. 2010;1:205–211.
   PubMedGoogle Scholar
• Kokkinidis T. 2019. Available from: https://greece.greekreporter.com/2019/03/12/greek-fertility-rate-among-the-lowest-in-the-eu/.
   Google Scholar
• The lancet public H. Greece—the cost of recovery. The Lancet Public Health. 2018;3(8):e351.
   PubMedGoogle Scholar
• Agency EM. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000071/WC500023744.pdf.
   Google Scholar
• Malehi AS, Pourmotahari F, Angali KA. Statistical models for the analysis of skewed healthcare cost data: a simulation study. Health Econ Rev. 2015;5:11.
   PubMed Web of Science ®Google Scholar
• Companies HAoP. Ministry of Health News. Available from: https://www.sfee.gr/category/press-en/latest-news/ministry-of-health-en/?lang=en.
   Google Scholar
• Huber M, Hadziosmanovic N, Berglund L, et al. Using the ovarian sensitivity index to define poor, normal, and high response after controlled ovarian hyperstimulation in the long gonadotropin-releasing hormone-agonist protocol: suggestions for a new principle to solve an old problem. Fertil Steril. 2013;100(5):1270–1276.
   PubMed Web of Science ®Google Scholar
• Steyerberg E. Study design for prediction models. In: Steyerberg E, editor. Clinical prediction models: a practical approach to development, validation and updating. New York (NY): Springer; 2009. p. 195–196.
   Google Scholar
• Heinze G, Wallisch C, Dunkler D. Variable selection – a review and recommendations for the practicing statistician. Biom J. 2018;60(3):431–449.
   PubMed Web of Science ®Google Scholar
• Saduf MAW. Comparative study of back propagation learning algorithms for neural networks. Int J Comput Sci Inf Technol Res. 2013;5(4):93–107.
   Google Scholar
• Hajian-Tilaki K. Receiver operating characteristic (ROC) curve analysis for medical diagnostic test evaluation. Caspian J Intern Med. 2013;4(2):627–635.
   PubMedGoogle Scholar
• Sordo M. Introduction to neural networks in healthcare. Open Clinical Document ed. 2002. Available from: https://www.academia.edu/20719514/Introduction_to_neural_networks_in_healthcare
   Google Scholar
• Bouwmans CA, Lintsen BM, Eijkemans MJ, et al. A detailed cost analysis of in vitro fertilization and intracytoplasmic sperm injection treatment. Fertil Steril. 2008;89(2):331–341.
   PubMed Web of Science ®Google Scholar
• Teoh PJ, Maheshwari A. Low-cost in vitro fertilization: current insights. Int J Womens Health. 2014;6:817–827.
   PubMedGoogle Scholar
• Paraskou A, George BP. The market for reproductive tourism: an analysis with special reference to Greece. Glob Health Res Policy. 2017; 2017/06/122(1):16.
   Google Scholar
• Fragoulakis V, Maniadakis N. Estimating the long-term effects of in vitro fertilization in Greece: an analysis based on a lifetime-investment model. Clinicoecon Outcomes Res. 2013;5:247–255.
   PubMedGoogle Scholar
• Chambers GM, Sullivan EA, Ishihara O, et al. The economic impact of assisted reproductive technology: a review of selected developed countries. Fertil Steril. 2009;91(6):2281–2294.
   PubMed Web of Science ®Google Scholar
• Huang L, Lu Q, Du J, et al. Cumulative live birth rates of in vitro fertilization/intracytoplasmic sperm injection after multiple complete cycles in China. J Biomed Res. 2020;34(5):361–368.
   PubMed Web of Science ®Google Scholar
• McLernon DJ, Maheshwari A, Lee AJ, et al. Cumulative live birth rates after one or more complete cycles of IVF: a population-based study of linked cycle data from 178,898 women. Hum Reprod. 2016;31(3):572–581.
   PubMed Web of Science ®Google Scholar
• Smith A, Tilling K, Nelson SM, et al. Live-birth rate associated with repeat in vitro fertilization treatment cycles. Jama. 2015;314(24):2654–2662.
   PubMed Web of Science ®Google Scholar
• Chambers GM, Paul RC, Harris K, et al. Assisted reproductive technology in Australia and New Zealand: cumulative live birth rates as measures of success. Med J Aust. 2017;207(3):114–118.
   PubMed Web of Science ®Google Scholar
• Maheshwari A, McLernon D, Bhattacharya S. Cumulative live birth rate: time for a consensus? Hum Reprod. 2015;30(12):2703–2707.
   PubMed Web of Science ®Google Scholar
• Nargund G, Fauser BCJM. Mild ovarian stimulation for IVF is the smartest way forward. Reprod Biomed Online. 2020;41(4):569–571.
   PubMed Web of Science ®Google Scholar
• Miller LM, Wallace G, Birdsall MA, et al. Dropout rate and cumulative birth outcomes in couples undergoing in vitro fertilization within a funded and actively managed system of care in New Zealand. Fertil Steril. 2021;116(1):114–122.
   PubMed Web of Science ®Google Scholar
• Schats R, Sutter PD, Bassil S, et al. Ovarian stimulation during assisted reproduction treatment: a comparison of recombinant and highly purified urinary human FSH. Hum Reprod. 2000;15(8):1691–1697.
   PubMed Web of Science ®Google Scholar
• Dickey RP, Nichols JE, Steinkampf MP, et al. Highly purified human-derived follicle-stimulating hormone (Bravelle) has equivalent efficacy to follitropin-beta (follistim) in infertile women undergoing in vitro fertilization. Reprod Biol Endocrinol. 2003;1(1):63–63.
   PubMedGoogle Scholar
• Jayaprakasan K, Hopkisson J, Campbell B, et al. A randomised controlled trial of 300 versus 225 IU recombinant FSH for ovarian stimulation in predicted normal responders by antral follicle count. BJOG. 2010;117(7):853–862.
   PubMed Web of Science ®Google Scholar
• A double-blind clinical trial comparing a fixed daily dose of 150 and 250 IU of recombinant follicle-stimulating hormone in women undergoing in vitro fertilization. Fertil Steril. 2001;76(5):950–956.
   PubMed Web of Science ®Google Scholar
• Ramezanzadeh F, Aghssa MM, Abedinia N, et al. A survey of relationship between anxiety, depression and duration of infertility. BMC Womens Health. 2004;4(1):9.
   PubMedGoogle Scholar
• Wu F, Liu F, Guan Y, et al. A nomogram predicting clinical pregnancy in the first fresh embryo transfer for women undergoing in vitro fertilization and intracytoplasmic sperm injection (IVF/ICSI) treatments. J Biomed Res. 2019;33(6):422–429.
   Web of Science ®Google Scholar
• Moragianni VA, Penzias AS. Cumulative live-birth rates after assisted reproductive technology. Curr Opin Obstet Gynecol. 2010;22(3):189–192.
   PubMed Web of Science ®Google Scholar
• Rittenberg V, Seshadri S, Sunkara SK, et al. Effect of body mass index on IVF treatment outcome: an updated systematic review and Meta-analysis. Reprod Biomed Online. 2011;23(4):421–439.
   PubMed Web of Science ®Google Scholar
• Sermondade N, Huberlant S, Bourhis-Lefebvre V, et al. Female obesity is negatively associated with live birth rate following IVF: a systematic review and meta-analysis. Hum Reprod Update. 2019;25(4):439–451.
   PubMed Web of Science ®Google Scholar
• Weghofer A, Barad DH, Darmon SK, et al. The ovarian sensitivity index is predictive of live birth chances after IVF in infertile patients. Hum Reprod Open. 2020;2020(4):hoaa049.
   PubMedGoogle Scholar