155
Views
0
CrossRef citations to date
0
Altmetric
Psychiatrys

Early outcomes, associated factors and predictive values of clinical outcomes of tandospirone in generalized anxiety disorder: a post-hoc analysis of a randomized, controlled, multicenter clinical trial

, , , , , , & show all
Pages 597-603 | Received 07 Sep 2022, Accepted 31 Jan 2023, Published online: 26 Feb 2023

References

  • Huang YQ, Wang Y, Wang H, et al. Prevalence of mental disorders in China:a cross-sectional epidemiological study. Lancet Psychiatry. 2019;6(3):211–224.
  • Gelder M, Mayou R, Cowen P, et al. Oxford psychiatry [M]. 4th ed. China: Sichuan University Press; 2001.
  • Wittchen HU.Generalized anxiety disorder: prevalence, burden, and cost to society. Depress Anxiety. 2002;16(4):162–171.
  • DeMartini J, Patel G, Fancher TL. Generalized anxiety disorder. Ann Intern Med. 2019;170(7):ITC49–ITC64.
  • Kujanpää TS, Jokelainen J, Auvinen JP, et al. The association of generalized anxiety disorder and somatic symptoms with frequent attendance to health care services: a cross-sectional study from the Northern Finland Birth Cohort 1966. Int J Psychiatry Med. 2017;52(2):147–159.
  • Baoyan Z. Current status and progress in the pharmacological treatment of generalized anxiety disorder. Elect J Clin Med Lit. 2015;(28):5964–5965.
  • Wu WY, Zhang MY, Fang YR, et al. 5-HT1A receptor partial agonists and anxiety disorders: clinical application of 5-HT1A receptor clinical application progress of partial agonists. Chin J Psych. 2016;49(5):344–346.
  • Huang X, Yang J, Yang S, et al. Role of tandospirone, a 5-HT1A receptor partial agonist, in the treatment of Central nervous system disorders and the underlying mechanisms. Oncotarget. 2017; 78(60):102705–102720.
  • Chinese medicine and health culture association, psychosomatic medicine research branch, expert recommendations on the clinical application of tandospirone in the treatment of patients with anxiety states in general hospitals. China Med. 2019;6(14):935–939.
  • Katzman MA, Bleau P, Blier P, et al. Canadian clinical practice guidelines for the management of anxiety, posttranmatic stress and obsessive compulsive disorders. BMC Psychiatry. 2014;14(Suppl 1):S1.
  • Locke AB, Kirst N, Shuhz CG, et al. Diagnosis and management of generalized anxiety disorder and panic disorder in adults. Am Fam Physician. 2015;9l(9):617–624.
  • Bejuela HR, Osser DN. The psychopharmacology algorithm project at the Harvard South shore program: an algorithm for generalized anxiety disorder. Harv Rev Psychiatry. 2016;24(4):243–256.
  • Lin J, Su Y, Wang C, et al. Effects of tandospirone augmentation in major depressive disorder patients with high anxiety: a multicenter, randomized, parallel-controlled, openlabel study. J Psychiatr Res. 2018;99:104–110.
  • Chen H, Lin Q, Lin T, et al. A controlled study of the efficacy and safety of tandospirone combined with escitalopram in the treatment of vascular depression: a pilot randomized controlled trial at a single-center in China. J Psychiatr Res. 2019;114:133–140.
  • Gao Q, Li CX, Yang YL, et al. SSRIs combined with different doses of tandospirone in the treatment of depression with anxiety efficacy and safety. Chongqing Med. 2018;47(32):4126–4129.
  • Hengartner MP, Davies J, Read J. Antidepressant withdrawal – the tide is finally turning. Epidemiol Psychiatr Sci. 2019;29:e52.
  • Lam RW. The importance of early symptom relief in antidepressant treatment: focus on agomelatine. J Psychopharmacol. 2010;24(2 Suppl):27–30.
  • Machado-Vieira R, Salvadore G, Luckenbaugh DA, et al. Rapid onset of antidepressant action: a new paradigm in the research and treatment of major depressive disorder. J Clin Psychiatry. 2008;69(6):946–958.
  • Nishitsuji K, To H, Murakami Y, et al. Tandospirone in the treatment of generalised anxiety disorder and mixed anxiety-depression: results of a comparatively high dosage trial. Clin Drug Investig. 2004;24(2):121–126.
  • Yang ZZ. Controlled observation of high-dose versus low-dose tandospirone in the treatment of generalized anxiety. Chinese Foreign Med. 2010;29(29):131.
  • Li Q, Zhang H, Lin G, et al. Relative safety and efficacy of two doses of tandospirone citrate for generalized anxiety disorder: a multicenter randomized controlled trial. Neuropsychiatr Dis Treat. 2022;18:1653–1664.
  • Hamilton M. The assessment of anxiety states by rating. Br J Med Psychol. 1959;32(1):50–55.
  • Guy W. 1976. ECDEU assessment manual for psychopharmacology, revised. Rockville, MD: National Institute of Mental Health.
  • Ware J, Jr,Kosinski M, Keller SD. 12-Item ShortForm health survey: construction of scales and preliminary tests of reliability and validity. Med Care. 1996;34(3):220–233.
  • Szegedi A, Jansen WT, van Willigenburg APP, et al. Early improvement in the first 2 weeks as a predictor of treatment outcome in patients with major depressive disorder: a meta-analysis including 6562 patients. J Clin Psychiatry. 2009;70(3):344–353.
  • Kim J-M, Kim S-Y, Stewart R, et al. Improvement within 2 weeks and later treatment outcomes in patients with depressive disorders: the CRESCEND study. J Affect Disord. 2011;129(1–3):183–190.
  • Shan S, Nan C, Yongzhu H. Advances in the pharmacological treatment of generalized anxiety disorder.J Trans Med. 2016;3(3):51–54.
  • Qian M, Shen Z, Lin M, et al. Early improvement predicts 8‐week treatment outcome in patients with generalized anxiety disorder treated with escitalopram or venlafaxine. Asia Pac Psychiatry. 2017;9(4). DOI:10.1111/appy.12270
  • Katzman MA, Nierenberg AA, Wajsbrot DB, et al. Speed of improvement in symptoms of depression with desvenlafaxine 50 mg and 100 mg compared with placebo in patients with major depressive disorder. J Clin Psychopharmacol. 2017;37(5):555–561.
  • Yuan J, Li XT, Liu Y, et al. Research progress on the onset of action of antidepressant drugs[J]. Neurological Disorders and Mental Health. 2020;20(8):561–566.
  • Jisheng H, Jinping D, Yantong X. Advances in the research of fast-acting antidepressants[J]. Chinese Journal of New Drugs. 2015;24(23):2669–2676.
  • Lam RW. Onset, time course and trajectories of improvement with antidepressants. Eur Neuropsychopharmacol. 2012;22(Suppl3):S492–S498.
  • Tadic A, Helmreich I, Mergl R, et al. Early improvement is a predictor of treatment outcome in patients with mild major, minor or subsyndromal depression. J Affect Disord. 2010;120(1–3):86–93.
  • Vermeiden M, Kamperman AM, Vulink ME, et al. Early improvement as a predictor of eventual antidepressant treatment response in severely depressed inpatients. Psychopharmacology (Berl). 2015;232(8):1347–1356.
  • Kudlow PA, Cha DS, McIntyre RS. Predicting treatment response in major depressive disorder: the impact of early symptomatic improvement. Can J Psychiatry. 2012;57(12):782–788.
  • Pollack A MH, Kornstein B SG, Spann C ME, et al. Early improvement during duloxetine treatment of generalized anxiety disorder predicts response and remission at endpoint. J Psychiatr Res. 2008;42(14):1176–1184.
  • Allen TA, Lam RW, Milev R, et al. Early change in reward and punishment sensitivity as a predictor of response to antidepressant treatment for major depressive disorder: a CAN-BIND-1 report. Psychol Med. 2019;49(10):1629–1639.
  • Nelson JC, Portera L, Leon AC. Are there differences in the symptoms that respond to a selective serotonin or norepinephrine reuptake inhibitor? Biol Psychiatry. 2005;57(12):1535–1542.
  • Yang WC, Lin CH, Wang FC, et al. Factors related to the improvement in quality of life for depressed inpatients treated with fluoxetine. BMC Psychiatry. 2017;17(1):309.
  • Ninan PT. Dissolving the burden of generalized anxiety disorder. J Clin Psyc. 2001;62(Suppl. 19):5–10.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.