3,256
Views
3
CrossRef citations to date
0
Altmetric
Infectious Diseases

A systematic literature review on the humanistic burden of cytomegalovirus

ORCID Icon, ORCID Icon, , ORCID Icon, , , ORCID Icon, , ORCID Icon & ORCID Icon show all
Pages 739-750 | Received 29 Jul 2022, Accepted 13 Mar 2023, Published online: 23 Apr 2023

References

  • Zuhair M, Smit GSA, Wallis G, et al. Estimation of the worldwide seroprevalence of cytomegalovirus: a systematic review and meta-analysis. Rev Med Virol. 2019;29(3):e2034.
  • Gupta M, Shorman M. Cytomegalovirus. Treasure Island (FL): StatPearls Publishing; 2021.
  • Fowler K, Mucha J, Neumann M, et al. A systematic literature review of the global seroprevalence of cytomegalovirus: possible implications for treatment, screening, and vaccine development. BMC Public Health. 2022;22(1):1659. 2022/09/01
  • Griffiths P, Reeves M. Pathogenesis of human cytomegalovirus in the immunocompromised host. Nat Rev Microbiol. 2021;19(12):759–773.
  • Eddleston M, Peacock S, Juniper M, et al. Severe cytomegalovirus infection in immunocompetent patients. Clin Infect Dis. 1997;24(1):52–56.
  • Simanek AM, Dowd JB, Pawelec G, et al. Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States. PLOS One. 2011;6(2):e16103.
  • Nielsen CM, White MJ, Bottomley C, et al. Impaired NK cell responses to pertussis and H1N1 influenza vaccine antigens in human cytomegalovirus-infected individuals. J Immunol. 2015;194(10):4657–4667.
  • Rahman M, Dastmalchi F, Karachi A, et al. The role of CMV in glioblastoma and implications for immunotherapeutic strategies. Oncoimmunology. 2019;8(1):e1514921.
  • Osawa R, Singh N. Cytomegalovirus infection in critically ill patients: a systematic review. Crit Care. 2009;13(3):R68.
  • Khan N, Shariff N, Cobbold M, et al. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J Immunol. 2002;169(4):1984–1992.
  • Naumenko VA, Tyulenev YA, Yakovenko SA, et al. Detection of human cytomegalovirus in motile spermatozoa and spermatogenic cells in testis organotypic culture. Herpesviridae. 2011;2(1):7.
  • van der Heijden YF, Zhang B, Chougnet CA, et al. Cytomegalovirus infection is associated with increased prevalence of latent tuberculosis infection. Open Forum Infect Dis. 2021;8(11):ofab539.
  • Velentgas P, Dreyer NA, Nourjah P, et al. Developing a protocol for observational comparative effectiveness research: a user’s guide. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013.
  • Pass RF, Arav-Boger R. Maternal and fetal cytomegalovirus infection: diagnosis, management, and prevention. F1000Res. 2018;7:255.
  • Boppana SB, Ross SA, Fowler KB. Congenital cytomegalovirus infection: clinical outcome. Clin Infect Dis. 2013;57(Suppl 4):S178–S181.
  • Cannon MJ, Hyde TB, Schmid DS. Review of cytomegalovirus shedding in bodily fluids and relevance to congenital cytomegalovirus infection. Rev Med Virol. 2011;21(4):240–255.
  • Centers for Disease Control and Prevention. Congenital CMV infection. 2020 [updated 2020 Apr 28; cited 2021 Aug 16]. Available from: https://www.cdc.gov/cmv/clinical/congenital-cmv.html
  • Kabani N, Ross SA. Congenital cytomegalovirus infection. J Infect Dis. 2020;221(Suppl 1):S9–S14.
  • Fowler KB. Congenital cytomegalovirus infection: audiologic outcome. Clin Infect Dis. 2013;57(Suppl 4):S182–S184.
  • World Health Organization. Deafness and hearing loss. 2022. [cited 2023 Jan 5]. Available from: https://www.who.int/news-room/fact-sheets/detail/deafness-and-hearing-loss
  • Thörn M, Rorsman F, Rönnblom A, et al. Active cytomegalovirus infection diagnosed by real-time PCR in patients with inflammatory bowel disease: a prospective, controlled observational study (.). Scand J Gastroenterol. 2016;51(9):1075–1080.
  • Gugliesi F, Pasquero S, Griffante G, et al. Human cytomegalovirus and autoimmune diseases: where are we? Viruses. 2021;13(2):260.
  • Barnes LL, Capuano AW, Aiello AE, et al. Cytomegalovirus infection and risk of Alzheimer disease in older black and white individuals. J Infect Dis. 2015;211(2):230–237.
  • Gow AJ, Firth CM, Harrison R, et al. Cytomegalovirus infection and cognitive abilities in old age. Neurobiol Aging. 2013;34(7):1846–1852.
  • Rawlinson WD, Boppana SB, Fowler KB, et al. Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy. Lancet Infect Dis. 2017;17(6):e177–e188.
  • Kotton CN, Kumar D, Caliendo AM, et al. The third international consensus guidelines on the management of cytomegalovirus in solid-organ transplantation. Transplantation. 2018;102(6):900–931.
  • Hakki M, Aitken SL, Danziger-Isakov L, et al. American Society for Transplantation and Cellular Therapy series: #3-Prevention of cytomegalovirus infection and disease after hematopoietic cell transplantation. Transplant Cell Ther. 2021;27(9):707–719.
  • Panel on Opportunistic Infections in Adults and Adolescents with HIV. Guidelines for the prevention and treatment of opportunistic infections in adults and adolescents with HIV: recommendations from the Centers for Disease Control and Prevention, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. 2022.
  • Shahar-Nissan K, Pardo J, Peled O, et al. Valaciclovir to prevent vertical transmission of cytomegalovirus after maternal primary infection during pregnancy: a randomised, double-blind, placebo-controlled trial. Lancet. 2020;396(10253):779–785.
  • Stratton KR, Durch JS, Lawrence RS, editors. Vaccines for the 21st century: a tool for decisionmaking. Washington (DC): National Academies Press; 2000.
  • Diaz-Decaro J, Meyers E, Mucha J, et al. A Systematic Literature Review of the Economic and Healthcare Resource Burden of Cytomegalovirus. In preparation.
  • Korndewal MJ, Oudesluys-Murphy AM, Kroes ACM, et al. Congenital cytomegalovirus infection: child development, quality of life and impact on daily life. Pediatr Infect Dis J. 2017;36(12):1141–1147.
  • Katusic MZ, Mensah-Bonsu NE, Miller JA, et al. The impact of asymptomatic congenital cytomegalovirus on adult quality of life. J Dev Behav Pediatr. 2021;42(1):46–54.
  • Smit GSA, Padalko E, Van Acker J, et al. Public health impact of congenital toxoplasmosis and cytomegalovirus infection in Belgium, 2013: a systematic review and data synthesis. Clin Infect Dis. 2017;65(4):661–668.
  • Albright CM, Werner EF, Hughes BL. Cytomegalovirus screening in pregnancy: a cost-effectiveness and threshold analysis. Am J Perinatol. 2019;36(7):678–687.
  • Strandberg TE, Pitkälä KH, Tilvis RS. Associations between cytomegalovirus infection, comorbidity, quality of life, and functional impairment in older people. J Am Geriatr Soc. 2012;60(7):1387–1389.
  • Lyutenski S, Götz F, Giourgas A, et al. Does severity of cerebral MRI lesions in congenital CMV infection correlates with the outcome of cochlear implantation? Eur Arch Otorhinolaryngol. 2017;274(3):1397–1403.
  • Kraaijenga VJC, Van Houwelingen F, Van der Horst SF, et al. Cochlear implant performance in children deafened by congenital cytomegalovirus: a systematic review. Clin Otolaryngol. 2018;43(5):1283–1295.
  • Yoshida H, Kanda Y, Takahashi H, et al. Cochlear implantation in children with congenital cytomegalovirus infection. Otol Neurol. 2009;30(6):725–730.
  • Iwasaki S, Nakanishi H, Misawa K, et al. Cochlear implant in children with asymptomatic congenital cytomegalovirus infection. Audiol Neurotol. 2009;14(3):146–152.
  • Alarcon A, Martinez-Biarge M, Cabañas F, et al. Clinical, biochemical, and neuroimaging findings predict long-term neurodevelopmental outcome in symptomatic congenital cytomegalovirus infection. J Pediatr. 2013;163(3):828–834.e1.
  • Fukushima S, Morioka I, Ohyama S, et al. Prediction of poor neurological development in patients with symptomatic congenital cytomegalovirus diseases after oral valganciclovir treatment. Brain Dev. 2019;41(9):743–750.
  • Farkas N, Hoffmann C, Ben-Sira L, et al. Does normal fetal brain ultrasound predict normal neurodevelopmental outcome in congenital cytomegalovirus infection? Prenat Diagn. 2011;31(4):360–366.
  • Löfkvist U, Anmyr L, Henricson C, et al. Executive functions, pragmatic skills, and mental health in children with congenital cytomegalovirus (CMV) infection with cochlear implants: a pilot study. Front Psychol. 2019;10:2808.
  • Turriziani Colonna A, Buonsenso D, Pata D, et al. Long-term clinical, audiological, visual, neurocognitive and behavioral outcome in children with symptomatic and asymptomatic congenital cytomegalovirus infection treated with valganciclovir. Front Med. 2020;7:268.
  • Bevot A, Hamprecht K, Krägeloh-Mann I, et al. Long-term outcome in preterm children with human cytomegalovirus infection transmitted via breast milk. Acta Paediatr. 2012;101(4):e167–e172.
  • Goelz R, Meisner C, Bevot A, et al. Long-term cognitive and neurological outcome of preterm infants with postnatally acquired CMV infection through breast milk. Arch Dis Child Fetal Neonatal Ed. 2013;98(5):F430–F433.
  • Gunkel J, de Vries LS, Jongmans M, et al. Outcome of preterm infants with postnatal cytomegalovirus infection. Pediatrics. 2018;141(2):e20170635.
  • Lee SM, Mitchell R, Knight JA, et al. Early-childhood cytomegalovirus infection and children’s neurocognitive development. Int J Epidemiol. 2021;50(2):538–549.
  • Hamdani N, Daban-Huard C, Godin O, et al. Effects of cumulative Herpesviridae and Toxoplasma gondii infections on cognitive function in healthy, bipolar, and schizophrenia subjects. J Clin Psychiatry. 2017;78(01):e18–e27.
  • Chvátalová V, Šebánková B, Hrbáčková H, et al. Differences in cognitive functions between cytomegalovirus-infected and cytomegalovirus-free university students: a case control study. Sci Rep. 2018;8(1):5322.
  • Torniainen-Holm M, Suvisaari J, Lindgren M, et al. Association of cytomegalovirus and Epstein-Barr virus with cognitive functioning and risk of dementia in the general population: 11-year follow-up study. Brain Behav Immun. 2018;69:480–485.
  • George KM, Folsom AR, Norby FL, et al. No association found between midlife seropositivity for infection and subsequent cognitive decline: the atherosclerosis risk in communities neurocognitive study (ARIC-NCS). J Geriatr Psychiatry Neurol. 2020;33(1):15–21.
  • Aiello AE, Haan M, Blythe L, et al. The influence of latent viral infection on rate of cognitive decline over 4 years. J Am Geriatr Soc. 2006;54(7):1046–1054.
  • Di Benedetto S, Gaetjen S, Müller L. The modulatory effect of gender and cytomegalovirus-seropositivity on circulating inflammatory factors and cognitive performance in elderly individuals. Int J Mol Sci. 2019;20(4):990.
  • Kawasaki M, Arai Y, Takayama M, et al. Carotid atherosclerosis, cytomegalovirus infection, and cognitive decline in the very old: a community-based prospective cohort study. Age. 2016;38(2):29.
  • Nimgaonkar VL, Yolken RH, Wang T, et al. Temporal cognitive decline associated with exposure to infectious agents in a population-based, aging cohort. Alzheimer Dis Assoc Disord. 2016;30(3):216–222.
  • Warren-Gash C, Forbes HJ, Williamson E, et al. Human herpesvirus infections and dementia or mild cognitive impairment: a systematic review and meta-analysis. Sci Rep. 2019;9(1):4743–4743.
  • Watson AM, Prasad KM, Klei L, et al. Persistent infection with neurotropic herpes viruses and cognitive impairment. Psychol Med. 2013;43(5):1023–1031.
  • Ford BN, Yolken RH, Aupperle RL, et al. Association of early-life stress with cytomegalovirus infection in adults with major depressive disorder. JAMA Psychiatry. 2019;76(5):545–547.
  • Jonker I, Rosmalen JGM, Schoevers RA. Childhood life events, immune activation and the development of mood and anxiety disorders: the TRAILS study. Transl Psychiatry. 2017;7(5):e1112–e1112.
  • Novotná M, Hanusova J, Klose J, et al. Probable neuroimmunological link between toxoplasma and cytomegalovirus infections and personality changes in the human host. BMC Infect Dis. 2005;5(1):54.
  • Phillips AC, Carroll D, Khan N, et al. Cytomegalovirus is associated with depression and anxiety in older adults. Brain Behav Immun. 2008;22(1):52–55.
  • Rector JL, Dowd JB, Loerbroks A, et al. Consistent associations between measures of psychological stress and CMV antibody levels in a large occupational sample. Brain Behav Immun. 2014;May;38:133–141.
  • Vadini F, Tracanna E, Polilli E, et al. Post-traumatic stress in pregnant women with primary cytomegalovirus infection and risk of congenital infection in newborns. BJPsych Open. 2016;2(6):373–376.
  • Temple RO, Pass RF, Boll TJ. Neuropsychological functioning in patients with asymptomatic congenital cytomegalovirus infection. J Dev Behav Pediatr. 2000;21(6):417–422.
  • Bartlett AW, McMullan B, Rawlinson WD, et al. Hearing and neurodevelopmental outcomes for children with asymptomatic congenital cytomegalovirus infection: a systematic review. Rev Med Virol. 2017;27(5):e1938.
  • Townsend CL, Forsgren M, Ahlfors K, et al. Long-term outcomes of congenital cytomegalovirus infection in Sweden and the United Kingdom. Clin Infect Dis. 2013;56(9):1232–1239.
  • Kotovich D, Guedalia JSB, Hoffmann C, et al. Apparent diffusion coefficient value changes and clinical correlation in 90 cases of cytomegalovirus-infected fetuses with unremarkable fetal MRI results. Am J Neuroradiol. 2017; Jul38(7):1443–1448.
  • Amir J, Atias J, Linder N, et al. Follow-up of infants with congenital cytomegalovirus and normal fetal imaging. Arch Dis Child Fetal Neonatal Ed. 2016;101(5):F428–F432.
  • Yamazaki H, Yamamoto R, Moroto S, et al. Cochlear implantation in children with congenital cytomegalovirus infection accompanied by psycho-neurological disorders. Acta Otolaryngol. 2012;132(4):420–427.
  • Alarcon A, Martinez-Biarge M, Cabañas F, et al. A prognostic neonatal neuroimaging scale for symptomatic congenital cytomegalovirus infection. Neonatology. 2016;110(4):277–285.
  • Vollmer B, Seibold-Weiger K, Schmitz-Salue C, et al. Postnatally acquired cytomegalovirus infection via breast milk: effects on hearing and development in preterm infants. Pediatr Infect Dis J. 2004;23(4):322–327.
  • Karachaliou M, Chatzi L, Roumeliotaki T, et al. Common infections with polyomaviruses and herpesviruses and neuropsychological development at 4 years of age, the rhea birth cohort in Crete. J Child Psychol Psychiatr. 2016;57(11):1268–1276.
  • Brecht KF, Goelz R, Bevot A, et al. Postnatal human cytomegalovirus infection in preterm infants has long-term neuropsychological sequelae. J Pediatr. 2015;166(4):834–839.e1. e1.
  • Milewska-Bobula B, Zebrowska J, Olszaniecka M, et al. Evaluation of intellectual development of children following congenital, mildly symptomatic cytomegalovirus (CMV) infection. A prospective study. Med Wieku Rozwoj. 2010;14(4):370–373.
  • Lopez AS, Lanzieri TM, Claussen AH, et al. Intelligence and academic achievement with asymptomatic congenital cytomegalovirus infection. Pediatrics. 2017;140(5):e20171517.
  • Noyola DE, Demmler GJ, Nelson CT, et al. Early predictors of neurodevelopmental outcome in symptomatic congenital cytomegalovirus infection. J Pediatr. 2001;138(3):325–331.
  • Tarter KD, Simanek AM, Dowd JB, et al. Persistent viral pathogens and cognitive impairment across the life course in the third national health and nutrition examination survey. J Infect Dis. 2014;209(6):837–844.
  • Inaba Y, Motobayashi M, Nishioka M, et al. Correlation between white matter lesions and intelligence quotient in patients with congenital cytomegalovirus infection. Pediatr Neurol. 2016;55:52–57.
  • Hart CK, Wiley S, Choo DI, et al. Developmental disabilities and intracranial abnormalities in children with symptomatic cytomegalovirus and cochlear implants. ISRN Otolaryngol. 2012;2012:1–6.
  • Malik V, Bruce IA, Broomfield SJ, et al. Outcome of cochlear implantation in asymptomatic congenital cytomegalovirus deafened children. Laryngoscope. 2011;121(8):1780–1784.
  • Corazzi V, Ciorba A, Bianchini C, et al. Outcome of cochlear implantation in children with congenital cytomegalovirus infection: a retrospective case control study. Int J Pediatr Otorhinolaryngol. 2020;138:110364.
  • Yoshida H, Takahashi H, Kanda Y, et al. Long-term outcomes of cochlear implantation in children with congenital cytomegalovirus infection. Otol Neurotol. 2017;38(7):e190–e194.
  • Jonker I, Klein HC, Duivis HE, et al. Association between exposure to HSV1 and cognitive functioning in a general population of adolescents. The TRAILS study. PLOS One. 2014;9(7):e101549.
  • Cameron NA, Gormley ME Jr, Deshpande S. Severity of disability in patients with cerebral palsy secondary to symptomatic congenital cytomegalovirus encephalopathy. J Pediatr Rehabil Med. 2013;6(4):239–242.
  • Maes L, De Kegel A, Van Waelvelde H, et al. Comparison of the motor performance and vestibular function in infants with a congenital cytomegalovirus infection or a connexin 26 mutation: a preliminary study. Ear Hear. 2017;38(1):e49–e56.
  • Slawinski BL, Talge N, Ingersoll B, et al. Maternal cytomegalovirus sero-positivity and autism symptoms in children. Am J Reprod Immunol. 2018;79(5):e12840.
  • Laccourreye L, Ettienne V, Prang I, et al. Speech perception, production and intelligibility in french-speaking children with profound hearing loss and early cochlear implantation after congenital cytomegalovirus infection. Eur Ann Otorhinolaryngol Head Neck Dis. 2015;132(6):317–320.
  • Lee DJ, Lustig L, Sampson M, et al. Effects of cytomegalovirus (CMV) related deafness on pediatric cochlear implant outcomes. Otolaryngol Head Neck Surg. 2005;133(6):900–905.
  • National CMV Foundation. Newborn Screening. 2022 [cited 2023 Jan 5]. Available from: https://www.nationalcmv.org/overview/newborn-screening