1,025
Views
2
CrossRef citations to date
0
Altmetric
Real-World Evidence and Medical Affairs

Extemporaneous combination therapy with amlodipine/zofenopril in hypertensive patients: a real-world data analysis in Italy

, , & ORCID Icon
Pages 1593-1601 | Received 18 Nov 2022, Accepted 15 Mar 2023, Published online: 28 Mar 2023

References

  • World Health Organization. [accessed 2022 June 1]. Available from: http://www.emro.who.int/media/world-health-day/public-health-problem-factsheet-2013.html.
  • Tocci G, Nati G, Cricelli C, et al. Prevalence and control of hypertension in the general practice in Italy: updated analysis of a large database. J Hum Hypertens. 2017;31(4):258–262.
  • Tocci G, Muiesan ML, Parati G, et al. Trends in prevalence, awareness, treatment, and control of blood pressure recorded From 2004 to 2014 during world hypertension day in Italy. J Clin Hypertens. 2016;18(6):551–556.
  • Levi M, Pasqua A, Cricelli I, et al. Patient adherence to olmesartan/amlodipine combinations: fixed versus extemporaneous combinations. J Manag Care Spec Pharm. 2016;22(3):255–262.
  • Mennini FS, Marcellusi A, von der Schulenburg JM, et al. Cost of poor adherence to anti-hypertensive therapy in five European countries. Eur J Health Econ. 2015;16(1):65–72.
  • Burnier M, Egan BM. Adherence in hypertension. Circ Res. 2019;124(7):1124–1140.
  • Williams B, Mancia G, Spiering W, et al. 2018 ESC/ESH guidelines for the management of arterial hypertension. Eur Heart J. 2018;39(33):3021–3104.
  • Murdoch D, Heel RC. Amlodipine: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in cardiovascular disease. Drugs. 1991;41(3):478–505.
  • Fares H, DiNicolantonio JJ, O’Keefe JH, et al. Amlodipine in hypertension: a first-line agent with efficacy for improving blood pressure and patient outcomes. Open Heart. 2016;3(2):e000473.
  • Nissen SE, Tuzcu EM, Libby P, et al. Effect of antihypertensive agents on cardiovascular events in patients with coronary disease and normal blood pressure: the CAMELOT study: a randomized controlled trial. JAMA. 2004;292(18):2217–2225.
  • Chrysant SG. The ALLHAT study: results and clinical implications. QJM. 2003;96(10):771–773.
  • Jamerson K, Weber MA, Bakris GL, et al. Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients. N Engl J Med. 2008;359(23):2417–2428.
  • Dahlof B, Sever PS, Poulter NR, et al. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian cardiac outcomes Trial-Blood pressure lowering arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet. 2005;366(9489):895–906.
  • Miranda RD, Mion D Jr, Rocha JC, et al. An 18-week, prospective, randomized, double-blind, multicenter study of amlodipine/ramipril combination versus amlodipine monotherapy in the treatment of hypertension: the assessment of combination therapy of amlodipine/ramipril (ATAR) study. Clin Ther. 2008;30(9):1618–1628.
  • Fogari R, Mugellini A, Derosa G. Efficacy and tolerability of candesartan cilexetil/hydrochlorothiazide and amlodipine in patients with poorly controlled mild-to-moderate essential hypertension. J Renin Angiotensin Aldosterone Syst. 2007;8(3):139–144.
  • Evangelista S, Manzini S. Antioxidant and cardioprotective properties of the sulphydryl angiotensin-converting enzyme inhibitor zofenopril. J Int Med Res. 2005;33(1):42–54.
  • Ambrosioni E. Defining the role of zofenopril in the management of hypertension and ischemic heart disorders. Am J Cardiovasc Drugs. 2007;7(1):17–24.
  • Borghi C, Cicero AF. Fixed combination of zofenopril plus hydrochlorothiazide in the management of hypertension: a review of available data. Vasc Health Risk Manag. 2006;2(4):341–349.
  • Guerrero-Garcia C, Rubio-Guerra AF. Combination therapy in the treatment of hypertension. DIC. 2018;7:1–9.
  • Borghi C, Omboni S, Reggiardo G, et al. Efficacy of zofenopril in combination with amlodipine in patients with acute myocardial infarction: a pooled individual patient data analysis of four randomized, double-blind, controlled, prospective studies. Curr Med Res Opin. 2018;34(10):1869–1874.
  • An J, Derington CG, Luong T, et al. Fixed-dose combination medications for treating hypertension: a review of effectiveness, safety, and challenges. Curr Hypertens Rep. 2020;22(11):95.
  • Ravera M, Cannavo R, Noberasco G, et al. High performance of a risk calculator that includes renal function in predicting mortality of hypertensive patients in clinical application. J Hypertens. 2014;32(6):1245–1254.
  • Volpe M, Pegoraro V, Peduto I, et al. Extemporaneous combination therapy with nebivolol/zofenopril in hypertensive patients: usage in Italy. Curr Med Res Opin. 2022;38(10):1673–1681.
  • IQVIA. Osservatorio sull’impatto della pandemia COVID-19 sull’accesso alle cure. Periodo dati: 2019-2020 2021 [cited 2022 Oct 24]. Available from: https://www.farmindustria.it/app/uploads/2021/03/Osservatorio-IQVIA-sullimpatto-pandemia-sullaccesso-alle-cure_Marzo-2021.pdf
  • Prieto-Merino D, Mulick A, Armstrong C, et al. Estimating proportion of days covered (PDC) using real-world online medicine suppliers’ datasets. J Pharm Policy Pract. 2021;14(1):113.
  • Asamoah-Boaheng M, Osei Bonsu K, Farrell J, et al. Measuring medication adherence in a population-based asthma administrative pharmacy database: a systematic review and meta-analysis. Clin Epidemiol. 2021;13:981–1010.
  • Mancia G, Volpe R, Boros S, et al. Cardiovascular risk profile and blood pressure control in Italian hypertensive patients under specialist care. J Hypertens. 2004;22(1):51–57.
  • Peacock E, Krousel-Wood M. Adherence to antihypertensive therapy. Med Clin North Am. 2017;101(1):229–245.
  • Mazzaglia G, Ambrosioni E, Alacqua M, et al. Adherence to antihypertensive medications and cardiovascular morbidity among newly diagnosed hypertensive patients. Circulation. 2009;120(16):1598–1605.
  • Ho PM, Bryson CL, Rumsfeld JS. Medication adherence: its importance in cardiovascular outcomes. Circulation. 2009;119(23):3028–3035.
  • Krousel-Wood M, Holt E, Joyce C, et al. Differences in cardiovascular disease risk when antihypertensive medication adherence is assessed by pharmacy fill versus self-report: the cohort study of medication adherence among older adults (CoSMO). J Hypertens. 2015;33(2):412–420.
  • Conn VS, Ruppar TM, Chase JA, et al. Interventions to improve medication adherence in hypertensive patients: systematic review and meta-analysis. Curr Hypertens Rep. 2015;17(12):94.
  • Rea F, Savare L, Franchi M, et al. Adherence to treatment by initial antihypertensive mono and combination therapies. Am J Hypertens. 2021;34(10):1083–1091.
  • Parati G, Kjeldsen S, Coca A, et al. Adherence to single-pill versus free-equivalent combination therapy in hypertension: a systematic review and meta-analysis. Hypertension. 2021;77(2):692–705.
  • ESH ESC Task Force for the Management of Arterial Hypertension. 2013 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC): ESH/ESC task force for the management of arterial hypertension. J Hypertens. 2013;31(10):1925–1938.
  • Unger T, Borghi C, Charchar F, et al. 2020 International society of hypertension global hypertension practice guidelines. J Hypertens. 2020;38(6):982–1004.
  • Whelton PK, Carey RM, Aronow WS, et al. ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines. J Am Coll Cardiol. 2017;71(19):e127–e248.
  • Hypertension Canada. [accessed 2022 Jun 7]. Available from: https://guidelines.hypertension.ca/chep-resources/
  • Dusing R, Waeber B, Destro M, et al. Triple-combination therapy in the treatment of hypertension: a review of the evidence. J Hum Hypertens. 2017;31(8):501–510.
  • Effectiveness and safety of combination of amlodipine and zofenopril in hypertensive patients versus each monotherapy (masolino) [cited 2023 Mar 2]. Available from: https://www.clinicaltrials.gov/ct2/show/NCT05279807
  • Borghi C, Ambrosio G, Van De Borne P, et al. Zofenopril: blood pressure control and cardio-protection. Cardiol J. 2022;29(2):305–318.